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Research Strategies (research + strategy)
Kinds of Research Strategies Selected AbstractsI. INVESTIGATING THE IMPACT OF EARLY INSTITUTIONAL DEPRIVATION ON DEVELOPMENT: BACKGROUND AND RESEARCH STRATEGY OF THE ENGLISH AND ROMANIAN ADOPTEES (ERA) STUDYMONOGRAPHS OF THE SOCIETY FOR RESEARCH IN CHILD DEVELOPMENT, Issue 1 2010Michael Rutter First page of article [source] II. THE PRESENT STUDY: RESEARCH STRATEGY AND METHODSMONOGRAPHS OF THE SOCIETY FOR RESEARCH IN CHILD DEVELOPMENT, Issue 3 2005Article first published online: 16 DEC 200 First page of article [source] Journeying to professionalism: The case of Irish nursing and midwifery researchINTERNATIONAL JOURNAL OF NURSING PRACTICE, Issue 4 2004Sarah L Condell RGN RM RNT BNS MA This paper gives a ,discursive' account of the contemporary development of nursing and midwifery research in the Republic of Ireland in the context of advancing professionalism. Initially, the paper views the landscape by placing research in the current framework of Irish nursing and midwifery. It then examines the map of our present location by documenting a baseline. It ascertains the signposts that are in place by exploring the strategic direction for development. Finally, it uses the compass to orienteer the route through the various obstacles by examining the challenges of the role of the joint appointee leading the implementation of the national Research Strategy for Nursing and Midwifery in Ireland. [source] Water Splitting on Semiconductor Catalysts under Visible-Light IrradiationCHEMSUSCHEM CHEMISTRY AND SUSTAINABILITY, ENERGY & MATERIALS, Issue 6 2009Rufino Abstract Splitting image: Sustainable hydrogen production is a key target for the development of alternative, future energy systems that will provide a clean and affordable energy supply. This Minireview focuses on the development of semiconductor catalysts that enable hydrogen production via water splitting upon visible-light irradiation. Sustainable hydrogen production is a key target for the development of alternative, future energy systems that will provide a clean and affordable energy supply. The Sun is a source of silent and precious energy that is distributed fairly all over the Earth daily. However, its tremendous potential as a clean, safe, and economical energy source cannot be exploited unless the energy is accumulated or converted into more useful forms. The conversion of solar energy into hydrogen via the water-splitting process, assisted by photo-semiconductor catalysts, is one of the most promising technologies for the future because large quantities of hydrogen can potentially be generated in a clean and sustainable manner. This Minireview provides an overview of the principles, approaches, and research progress on solar hydrogen production via the water-splitting reaction on photo-semiconductor catalysts. It presents a survey of the advances made over the last decades in the development of catalysts for photochemical water splitting under visible-light irradiation. The Minireview also analyzes the energy requirements and main factors that determine the activity of photocatalysts in the conversion of water into hydrogen and oxygen using sunlight. Remarkable progress has been made since the pioneering work by Fujishima and Honda in 1972, but he development of photocatalysts with improved efficiencies for hydrogen production from water using solar energy still faces major challenges. Research strategies and approaches adopted in the search for active and efficient photocatalysts, for example through new materials and synthesis methods, are presented and analyzed. [source] THE MOLECULAR FUTURE IN CYTOLOGYCYTOPATHOLOGY, Issue 2006M. Salto-Tellez Molecular diagnosis is the application of molecular biology techniques and knowledge of the molecular mechanisms of disease to diagnosis, prognostication and treatment of diseases. Molecular Diagnosis is, arguably, the fastest growing area of diagnostic medicine. The US market for molecular testing generated $1.3 billion in 2000, which was predicted to increase to about $4.2 billion by 2007.1 We proposed the term Diagnostic Molecular Cytopathology to define the application of molecular diagnosis to cytopathology2. Diagnostic Molecular Cytopathology is essential for the following reasons: (i) Molecular testing is sometimes indispensable to establish an unequivocal diagnosis on cell preparations; (ii) Molecular testing provides extra information on the prognosis or therapy of diseases diagnosed by conventional cytology; (iii) Molecular testing provides genetic information on the inherited nature of diseases that can be directly investigated in cytology samples, by either exfoliation or by fine needle aspiration; (iv) Sometimes the cytopathology sample is the most convenient (or the only available) source of material for molecular testing; (v). Direct molecular interrogation of cells allows for a diagnostic correlation that would otherwise not be possible. Parallel to this direct diagnostic implication, cytopathology is increasing important in the validation of biomarkers for specific diseases, and in therefore of significant importance in the overall translational research strategies. We illustrate its application in some of the main areas of oncology molecular testing, such as molecular fingerprinting of neoplasms,3 lymphoreticular diseases,2 sarcomas4 and lung cancer,5 as well as translational research using diagnostic cytopathology techniques. The next years will see the consolidation of Diagnostic Molecular Cytopathology, a process that will lead to a change of many paradigms. In general, diagnostic pathology departments will have to reorganize molecular testing to pursue a cost-efficient operation. Sample preparation will have to take into account optimal preservation of nuclear acids. The training of technical staff and the level of laboratory quality control and quality assurance would have to follow strict clinical (not research) laboratory parameters. And, most importantly, those pathologists undertaking molecular diagnosis as a discipline would have to develop their professional expertise within the same framework of fellowships and professional credentials that is offered in other sub-specialties. The price to pay if this effort is not undertaken is too important for the future of diagnostic pathology in general. The increasing characterization of molecular biomarkers with diagnostic, prognostic or therapeutic value is making the analysis of tissue and cell samples prior to treatment a more complex exercise. If cytopathologists and histopathologists allow others to take charge of molecular diagnosis, our overall contribution to the diagnostic process will be diminished. We may not become less important, but we may become less relevant. However, those within the discipline of diagnostic pathology who can combine the clinical background of diseases with the morphological, immunocytochemical and molecular diagnostic interpretation will represent bona fide diagnostic specialists. Such ,molecular cytopathologists' would place themselves at the centre of clinical decision-making. Reference:, 1. Liz Fletcher. Roche leads molecular diagnostics charge. Nature Biotechnol 20, 6,7; 2002 2. Salto-Tellez M and Koay ESC. Molecular Diagnostic Cytopathology - Definitions, Scope and Clinical Utility. Cytopathology 2004; 15:252,255 3. Salto-Tellez M, Zhang D, Chiu LL, Wang SC, Nilsson B, and Koay ESC. Immunocytochemistry Versus Molecular Fingerprinting of Metastases. Cytopathology, 2003 Aug; 14(4):186,90. 4. Chiu LL, Koay SCE, Chan NL and Salto-Tellez M. Molecular Cytopathology: Sequencing of the EWS-WT1 Gene Fusion Transcript in the Peritoneal Effusion of a Patient with Desmoplastic Small Round Cell Tumour. Diagnostic Cytopathology, 2003 Dec; 29(6): 341,3. 5. TM Chin, D Anuar, R Soo, M Salto-Tellez, WQ Li, B Ahmad, SC Lee, BC Goh, K Kawakami, A Segal, B Iacopetta, R Soong. Sensitive and Cost-Effective deptection of epidermal growth factor Receptor Mutations in Small Biopsies by denaturing High Performance Liquid Chromatography. (In press). [source] Curiosity and cure: Translational research strategies for neural repair-mediated rehabilitationDEVELOPMENTAL NEUROBIOLOGY, Issue 9 2007Bruce H. Dobkin Abstract Clinicians who seek interventions for neural repair in patients with paralysis and other impairments may extrapolate the results of cell culture and rodent experiments into the framework of a preclinical study. These experiments, however, must be interpreted within the context of the model and the highly constrained hypothesis and manipulation being tested. Rodent models of repair for stroke and spinal cord injury offer examples of potential pitfalls in the interpretation of results from developmental gene activation, transgenic mice, endogeneous neurogenesis, cellular transplantation, axon regeneration and remyelination, dendritic proliferation, activity-dependent adaptations, skills learning, and behavioral testing. Preclinical experiments that inform the design of human trials ideally include a lesion of etiology, volume and location that reflects the human disease; examine changes induced by injury and by repair procedures both near and remote from the lesion; distinguish between reactive molecular and histologic changes versus changes critical to repair cascades; employ explicit training paradigms for the reacquisition of testable skills; correlate morphologic and physiologic measures of repair with behavioral measures of task reacquisition; reproduce key results in more than one laboratory, in different strains or species of rodent, and in a larger mammal; and generalize the results across several disease models, such as axonal regeneration in a stroke and spinal cord injury platform. Collaborations between basic and clinical scientists in the development of translational animal models of injury and repair can propel experiments for ethical bench-to-bedside therapies to augment the rehabilitation of disabled patients. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007 [source] Early behavioral screening for antidepressants and anxiolyticsDRUG DEVELOPMENT RESEARCH, Issue 9 2006Vincent Castagné Abstract Early preclinical behavioral testing is an essential stage during the development of substances with potential antidepressant and/or anxiolytic activity. With the growing cost of drug development, optimal research strategies are needed to detect potential new treatments with high efficacy and minimal side effects and to confirm in vitro pharmacological studies. In the following article, we present simple rodent tests used for early behavioral testing for antidepressant-like and anxiolytic-like activity. Unpublished results from our laboratory are discussed with reference to published data to illustrate the predictive validity of several behavioral screening tests. Drug Dev. Res. 67:729,742, 2006. © 2006 Wiley-Liss, Inc. [source] Allocating treatment options to patient profiles: clinical art or science?ADDICTION, Issue 5 2006Gerhard Bühringer ABSTRACT Background For many researchers, the disappointing results of Project MATCH were the death blow for any further activities in the field of patient,treatment interactions. On the other hand, we have an increased knowledge of patient heterogeneity and a greater variety of treatment options than before, and allocation guidelines for an ongoing process of patient-placement decisions are of high practical relevance. Aims To analyse deficits in the current research and to provide suggestions for future action. Findings It is argued that (1) certain major design aspects of Project MATCH and other research studies,such as stringent patient exclusion criteria and low treatment ,dosage',minimize the chances of detecting possible patient,treatment interactions and (2) Project MATCH obscures our view of previous treatment-allocation research findings., Conclusions Several research strategies and specific research topics are suggested for (1) improving the theoretical and methodological basis for detecting possible patient,treatment interactions and (2) stimulating research on major treatment decision needs, such as site, setting, time in treatment (extensiveness and intensity), service components and specific treatment modules. More international research cooperation is needed to clarify the inconsistent findings. [source] The clinical outcomes of neonatal and childhood stroke: review of the literature and implications for future researchEUROPEAN JOURNAL OF NEUROLOGY, Issue 7 2004C. Härtel A detailed assessment of clinical outcomes after ischemic stroke in childhood is necessary to evaluate prognostic factors. Previous studies are difficult to compare because of differences in test instruments, study design, heterogeneity of cohorts and number of included cases. Depending on neurodevelopmental assessment methods, major and subtle/minor disabilities, especially in infants, may not have been detected. Most outcome studies reveal only limited information about behavioral changes and quality of life in children with ischemic stroke. Thus the assumption that children make a better recovery from stroke than adults due to the immature brain's capacity to reorganize function is not evidence-based. We systematically review the current literature with regard to the neurological and psychosocial development of affected children as well as their quality of life. Implications for future research strategies follow the review to encourage further clinical study of the neurobehavioral trajectory of childhood stroke. [source] Discussion on ,Personality psychology as a truly behavioural science' by R. Michael FurrEUROPEAN JOURNAL OF PERSONALITY, Issue 5 2009Article first published online: 14 JUL 200 Yes We Can! A Plea for Direct Behavioural Observation in Personality Research MITJA D. BACK and BORIS EGLOFF Department of Psychology, Johannes Gutenberg University Mainz, Germany mback@uni-leipzig.de Furr's target paper (this issue) is thought to enhance the standing of personality psychology as a truly behavioural science. We wholeheartedly agree with this goal. In our comment we argue for more specific and ambitious requirements for behavioural personality research. Specifically, we show why behaviour should be observed directly. Moreover, we illustratively describe potentially interesting approaches in behavioural personality research: lens model analyses, the observation of multiple behaviours in diverse experimentally created situations and the observation of behaviour in real life. Copyright © 2009 John Wiley & Sons, Ltd. The Categories of Behaviour Should be Clearly Defined PETER BORKENAU Department of Psychology, Martin-Luther University Halle-Wittenberg, Germany p.borkenau@psych.uni-halle.de The target paper is helpful by clarifying the terminology as well as the strengths and weaknesses of several approaches to collect behavioural data. Insufficiently considered, however, is the clarity of the categories being used for the coding of behaviour. Evidence is reported showing that interjudge agreement for retrospective and even concurrent codings of behaviour does not execeed interjudge agreement for personality traits if the categories being used for the coding of behaviour are not clearly defined. By contrast, if the behaviour to be registered is unambiguously defined, interjudge agreement may be almost perfect. Copyright © 2009 John Wiley & Sons, Ltd. Behaviour Functions in Personality Psychology PHILIP J. CORR Department of Psychology, Faculty of Social Sciences, University of East Anglia, Norwich, UK Philip.Corr@btopenworld.com Furr's target paper highlights the importance, yet under-representation, of behaviour in published articles in personality psychology. Whilst agreeing with most of his points, I remain unclear as to how behaviour (as specifically defined by Furr) relates to other forms of psychological data (e.g. cognitive task performance). In addition, it is not clear how the functions of behaviour are to be decided: different behaviours may serve the same function; and identical behaviours may serve different functions. To clarify these points, methodological and theoretical aspects of Furr's proposal would benefit from delineation. Copyright © 2009 John Wiley & Sons, Ltd. On the Difference Between Experience-Sampling Self-Reports and Other Self-Reports WILLIAM FLEESON Department of Psychology, Wake Forest University, Winston-Salem, NC, USA fleesonW@wfu.edu Furr's fair but evaluative consideration of the strengths and weaknesses of behavioural assessment methods is a great service to the field. As part of his consideration, Furr makes a subtle and sophisticated distinction between different self-report methods. It is easy to dismiss all self-reports as poor measures, because some are poor. In contrast, Furr points out that the immediacy of the self-reports of behaviour in experience-sampling make experience-sampling one of the three strongest methods for assessing behaviour. This comment supports his conclusion, by arguing that ESM greatly diminishes one the three major problems afflicting self-reports,lack of knowledge,and because direct observations also suffer from the other two major problems afflicting self-reports. Copyright © 2009 John Wiley & Sons, Ltd. What and Where is ,Behaviour' in Personality Psychology? LAURA A. KING and JASON TRENT Department of Psychology, University of Missouri, Columbia, USA kingla@missouri.edu Furr is to be lauded for presenting a coherent and persuasive case for the lack of behavioural data in personality psychology. While agreeing wholeheartedly that personality psychology could benefit from greater inclusion of behavioural variables, here we question two aspects of Furr's analysis, first his definition of behaviour and second, his evidence that behaviour is under-appreciated in personality psychology. Copyright © 2009 John Wiley & Sons, Ltd. Naturalistic Observation of Daily Behaviour in Personality Psychology MATTHIAS R. MEHL Department of Psychology, University of Arizona, Tucson, AZ, USA mehl@email.arizona.edu This comment highlights naturalistic observation as a specific method within Furr's (this issue) cluster direct behavioural observation and discusses the Electronically Activated Recorder (EAR) as a naturalistic observation sampling method that can be used in relatively large, nomothetic studies. Naturalistic observation with a method such as the EAR can inform researchers' understanding of personality in its relationship to daily behaviour in two important ways. It can help calibrate personality effects against act-frequencies of real-world behaviour and provide ecological, behavioural personality criteria that are independent of self-report. Copyright © 2009 John Wiley & Sons, Ltd. Measuring Behaviour D. S. MOSKOWITZ and JENNIFER J. RUSSELL Department of Psychology, McGill University, Montreal, Canada dsm@psych.mcgill.ca Furr (this issue) provides an illuminating comparison of the strengths and weaknesses of various methods for assessing behaviour. In the selection of a method for assessing behaviour, there should be a careful analysis of the definition of the behaviour and the purpose of assessment. This commentary clarifies and expands upon some points concerning the suitability of experience sampling measures, referred to as Intensive Repeated Measurements in Naturalistic Settings (IRM-NS). IRM-NS measures are particularly useful for constructing measures of differing levels of specificity or generality, for providing individual difference measures which can be associated with multiple layers of contextual variables, and for providing measures capable of reflecting variability and distributional features of behaviour. Copyright © 2009 John Wiley & Sons, Ltd. Behaviours, Non-Behaviours and Self-Reports SAMPO V. PAUNONEN Department of Psychology, University of Western Ontario, London, Canada paunonen@uwo.ca Furr's (this issue) thoughtful analysis of the contemporary body of research in personality psychology has led him to two conclusions: our science does not do enough to study real, observable behaviours; and, when it does, too often it relies on ,weak' methods based on retrospective self-reports of behaviour. In reply, I note that many researchers are interested in going beyond the study of individual behaviours to the behaviour trends embodied in personality traits; and the self-report of behaviour, using well-validated personality questionnaires, is often the best measurement option. Copyright © 2009 John Wiley & Sons, Ltd. An Ethological Perspective on How to Define and Study Behaviour LARS PENKE Department of Psychology, The University of Edinburgh, Edinburgh, UK lars.penke@ed.ac.uk While Furr (this issue) makes many important contributions to the study of behaviour, his definition of behaviour is somewhat questionable and also lacks a broader theoretical frame. I provide some historical and theoretical background on the study of behaviour in psychology and biology, from which I conclude that a general definition of behaviour might be out of reach. However, psychological research can gain from adding a functional perspective on behaviour in the tradition of Tinbergens's four questions, which takes long-term outcomes and fitness consequences of behaviours into account. Copyright © 2009 John Wiley & Sons, Ltd. What is a Behaviour? MARCO PERUGINI Faculty of Psychology, University of Milan,Bicocca, Milan, Italy marco.perugini@unimib.it The target paper proposes an interesting framework to classify behaviour as well as a convincing plea to use it more often in personality research. However, besides some potential issues in the definition of what is a behaviour, the application of the proposed definition to specific cases is at times inconsistent. I argue that this is because Furr attempts to provide a theory-free definition yet he implicitly uses theoretical considerations when applying the definition to specific cases. Copyright © 2009 John Wiley & Sons, Ltd. Is Personality Really the Study of Behaviour? MICHAEL D. ROBINSON Department of Psychology, North Dakota State University, Fargo, ND, USA Michael.D.Robinson@ndsu.edu Furr (this issue) contends that behavioural studies of personality are particularly important, have been under-appreciated, and should be privileged in the future. The present commentary instead suggests that personality psychology has more value as an integrative science rather than one that narrowly pursues a behavioural agenda. Cognition, emotion, motivation, the self-concept and the structure of personality are important topics regardless of their possible links to behaviour. Indeed, the ultimate goal of personality psychology is to understanding individual difference functioning broadly considered rather than behaviour narrowly considered. Copyright © 2009 John Wiley & Sons, Ltd. Linking Personality and Behaviour Based on Theory MANFRED SCHMITT Department of Psychology, University of Koblenz-Landau, Landau, Germany schmittm@uni-landau.de My comments on Furr's (this issue) target paper ,Personality as a Truly Behavioural Science' are meant to complement his behavioural taxonomy and sharpen some of the presumptions and conclusions of his analysis. First, I argue that the relevance of behaviour for our field depends on how we define personality. Second, I propose that every taxonomy of behaviour should be grounded in theory. The quality of behavioural data does not only depend on the validity of the measures we use. It also depends on how well behavioural data reflect theoretical assumptions on the causal factors and mechanisms that shape behaviour. Third, I suggest that the quality of personality theories, personality research and behavioural data will profit from ideas about the psychological processes and mechanisms that link personality and behaviour. Copyright © 2009 John Wiley & Sons, Ltd. The Apparent Objectivity of Behaviour is Illusory RYNE A. SHERMAN, CHRISTOPHER S. NAVE and DAVID C. FUNDER Department of Psychology, University of California, Riverside, CA, USA funder@ucr.edu It is often presumed that objective measures of behaviour (e.g. counts of the number of smiles) are more scientific than more subjective measures of behaviour (e.g. ratings of the degree to which a person behaved in a cheerful manner). We contend that the apparent objectivity of any behavioural measure is illusory. First, the reliability of more subjective measures of behaviour is often strikingly similar to the reliabilities of so-called objective measures. Further, a growing body of literature suggests that subjective measures of behaviour provide more valid measures of psychological constructs of interest. Copyright © 2009 John Wiley & Sons, Ltd. Personality and Behaviour: A Neglected Opportunity? LIAD UZIEL and ROY F. BAUMEISTER Department of Psychology, Florida State University, Tallahassee, FL, USA Baumeister@psy.fsu.edu Personality psychology has neglected the study of behaviour. Furr's efforts to provide a stricter definition of behaviour will not solve the problem, although they may be helpful in other ways. His articulation of various research strategies for studying behaviour will be more helpful for enabling personality psychology to contribute important insights and principles about behaviour. The neglect of behaviour may have roots in how personality psychologists define the mission of their field, but expanding that mission to encompass behaviour would be a positive step. Copyright © 2009 John Wiley & Sons, Ltd. [source] Research Trends in Textiles and Clothing: An Analysis of Three Journals, 1980,1999FAMILY & CONSUMER SCIENCES RESEARCH JOURNAL, Issue 2 2001Sharron J. Lennon The purpose of this research was to assess trends in research, research strategies, data analysis techniques, funding sources, affiliations, and the use of theoretical frameworks in textiles and clothing research. Empirical research focused on textiles and clothing and published in three home economics,related journals,Journal of Family and Consumer Sciences, Family and Consumer Science Research Journal, and Clothing and Textiles Research Journal,from 1980 to 1999 was content analyzed (N = 586). Although survey methodology and experimentation were the first and second most-used research strategies in all but one 5-year period from 1980 to 1999, fieldwork has increased. Data analysis techniques were primarily quantitative, with increases in the use of some advanced statistical techniques. However, the qualitative treatment of data also increased. Suggestions for graduate education and faculty development are offered. [source] The Marriage of Marx and Darwin?HISTORY AND THEORY, Issue 1 2002Doyne Dawson Recent attempts to develop scientific research strategies for cultural evolution have mostly drawn upon evolutionary biology, but within anthropology there is also an influential tradition of non-biological evolutionary thought whose basic principle is adaptation to the environment. This article is mainly concerned with the "cultural materialist" school of Marvin Harris, but also treats the recent attempt of Jared Diamond to create a more radical model of evolutionary ecology. I argue that the ecological tradition does not represent a real alternative to neo-Darwinism and is in fact a pseudo-Darwinist theory. I also suggest that the bias in favor of materialistic explanation in cultural evolution may not be justified. [source] Knowledge-Based Approach towards Hydrolytic Degradation of Polymer-Based BiomaterialsADVANCED MATERIALS, Issue 32-33 2009Dieter Hofmann Abstract The concept of hydrolytically degradable biomaterials was developed to enable the design of temporary implants that substitute or fulfill a certain function as long as required to support (wound) healing processes or to control the release of drugs. Examples are surgical implants, e.g., sutures, or implantable drug depots for treatment of cancer. In both cases degradability can help to avoid a second surgical procedure for explanation. Although degradable surgical sutures are established in the clinical practice for more than 30 years, still more than 40% of surgical sutures applied in clinics today are nondegradable.1 A major limitation of the established degradable suture materials is the fact that their degradation behavior cannot reliably be predicted by applying existing experimental methodologies. Similar concerns also apply to other degradable implants. Therefore, a knowledge-based approach is clearly needed to overcome the described problems and to enable the tailored design of biodegradable polymer materials. In this Progress Report we describe two methods (as examples for tools for this fundamental approach): molecular modeling combining atomistic bulk interface models with quantum chemical studies and experimental investigations of macromolecule degradation in monolayers on Langmuir,Blodgett (LB) troughs. Finally, an outlook on related future research strategies is provided. [source] Dealing with urban terror: heritages of control, varieties of intervention, strategies of researchINTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, Issue 3 2003Harvey Molotch The events of September 11th bring urgency to problems of urban security, both in terms of finding ways to protect cities from attacks by terrorists and also protecting urban life from repressive measures that form in reaction to those attacks. We outline a rationale for urbanists to participate in analysis and policy-formulation on security issues and examine the utility of past urban research strategies, including criminology, in terms of their relevance to the current challenge. We suggest principles to guide future urban policy in light of past experiences. Les événements du 11 septembre rendent urgents les problèmes de sécurité urbaine, à la fois pour trouver des façons de protéger les villes contre des attaques terroristes et pour préserver la vie urbaine de mesures répressives en réponse à ces attaques. L'article argumente en faveur de la participation d'urbanistes à l'analyse et à la formulation d'une politique publique sur les questions de sécurité. Il examine le parti à tirer des stratégies de recherches urbaines antérieures (y compris en criminologie) en fonction de leur pertinence par rapport au défi actuel. De plus, il suggère des principes permettant d'orienter la politique urbaine future à la lumière des expériences passées. [source] Problems with the use of placebo conditions in psychotherapy research, suggested alternatives, and some strategies for the pursuit of the placebo phenomenonJOURNAL OF CLINICAL PSYCHOLOGY, Issue 7 2005T. D. Borkovec Due to the numerous conceptual, methodological, and ethical problems that are associated with placebo conditions in psychotherapy research, their use should be abandoned, and more powerful therapy outcome designs (dismantling, additive, parametric, and catalytic) that can contribute to basic knowledge through their ability to isolate specific cause-and-effect relationships are recommended. On the other hand, if indeed the placebo effect is a reliable phenomenon, it would be wise to pursue its causal mechanisms, and some research strategies for initiating such pursuit are briefly described. © 2005 Wiley Periodicals, Inc. J Clin Psychol 61: 805,818, 2005. [source] Canine inhertited retinal degenerations: update on molecular genetic research and its clinical applicationJOURNAL OF SMALL ANIMAL PRACTICE, Issue 10 2002C-T. Lin Inherited retinal degenerations in the dog include generalized progressive retinal atrophy, retinal pigment epithelial dystrophy, congenital stationary night blindness and day blindness (hemeralopia). The clinical phenotype and pathology of these diseases closely resemble some types of human inherited retinal degeneration, in particular retinitis pigmentosa, one of the most common inherited causes of blindness in man. Molecular genetic investigations aim to identify the genetic mutations underlying the canine inherited retinal degenerations. Two major research strategies, candidate gene analysis and linkage analysis, have been used. To date, candidate gene analysis has definitively identified the genetic mutations underlying nine inherited retinal degenerations, each in a different breed of dog, and linkage studies have identified genetic markers for a further retinal degeneration which is found in at least six different breeds. This review outlines the research strategy behind candidate gene and linkage studies and summarises recent results in the search for genetic causes of canine inherited retinal degenerations. The aim is to increase awareness of this rapidly changing field and to show how the research can be used to develop genetic tests for these diseases and thereby reduce the incidence of inherited eye disease in dogs. [source] Development of ultra short-acting muscle relaxant agents: History, research strategies, and challengesMEDICINAL RESEARCH REVIEWS, Issue 6 2005Laszlo Gyermek Author has reviewed the literature and his own work related to the chemistry, pharmacology, and clinical aspects of new muscle relaxants. Emphasis has been placed on the basic science concepts and technologies (e.g. structure,activity relationships, nicotinic receptor pharmacology, and investigation of side effects) behind the development of rapidly and short acting nondepolarizing muscle relaxants. © 2005 Wiley Periodicals, Inc. [source] Science, Education, and the Ideology of "How"MIND, BRAIN, AND EDUCATION, Issue 2 2010Charles Lang The aim of this work is to relate discussions of ideology and science within the Radical Science movement of the 1960s,1980s with present conversations on the integration of biology, psychology, and education. The argument is that an ideological analysis yields useful direction with respect to how a learning science might develop and how we might appeal to our best aspirations while avoiding our worst. The ideology of "how" in the title refers to beliefs about research strategies: In an ideology of "how," the aim is discovery and there is an appreciation of complexity. This stands in opposition to an ideology of "what," which focuses on diagnosis and categorization. [source] Lung function in infants and young children with chronic lung disease of infancy: The next steps?PEDIATRIC PULMONOLOGY, Issue 1 2007Janet Stocks PhD Abstract Over the past year, a series of papers have reviewed the literature concerning assessment and interpretation of lung function in infants and young children with chronic lung disease of infancy. This manuscript, which represents the final paper in that series, summarizes the findings to date and highlights key areas for future research. Despite the huge literature in this field, interpretation of results and their use in guiding clinical management are still limited by difficulties in ,normalizing data' according to body size and maturation and selection of appropriate control groups. Furthermore, sensitive tests that more closely reflect the underlying pathophysiology of ,new' bronchopulmonary dysplasia, together with simple and reliable methods of assessing lung maturity at birth and true oxygen requirements at specified time points are urgently required. Research in this field is also challenged by the need to separate the independent effects of genetic predisposition, gene,environment interactions, preterm delivery, neonatal respiratory disorders and various treatment strategies on the growing lung. The extent to which disruption of lung growth following premature exposure to the extra-uterine environment leads to an earlier or more aggravated decline in respiratory function in later adult life remains to be elucidated. Whatever its origin, given the increasing survival of smaller and more immature infants, the long term sequelae of neonatal lung disease, are likely to continue to change, requiring ongoing, carefully designed longitudinal studies. Future research strategies need to encompass a multicenter, multi-disciplinary, collaborative approach with closer links between clinicians and basic scientists, to ensure that the most relevant research questions are addressed using appropriate methodology and that findings are implemented into clinical practice in a more timely fashion. Pediatr Pulmonol. 2007; 42:3,9. © 2006 Wiley-Liss, Inc. [source] The State of State Budget ResearchPUBLIC BUDGETING AND FINANCE, Issue 4s 2005IRENE RUBIN This essay examines the research on state budgeting that has appeared in Public Budgeting & Finance since its founding, with a view to summarizing the key themes and outlining what we have yet to learn. It also offers some suggestions for future research strategies, how to pick topics and cases, and theorize about the findings. The goal is not to utilize theories from other fields which may or may not be relevant to budgeting, but to theorize about what we know and get to a deeper level of understanding. [source] W. Lloyd Warner and the Anthropology of Institutions: An Approach to the Study of Work in Late CapitalismANTHROPOLOGY OF WORK REVIEW, Issue 2 2009Marietta L. BabaArticle first published online: 16 SEP 200 Abstract W. Lloyd Warner is re-interpreted as an institutional anthropologist whose approach to the study of work in a capitalist context has relevance to contemporary disciplinary problems and issues. The essay traces the development and influences upon Warner's thought and research strategies from their origin in Durkheim's sociology and Warner's fieldwork among the Murngin, to the Hawthorne Project, where Warner held an intermittent yet significant consultancy, and on to the seminal contributions of the Yankee City Series where, it is argued, the anthropological approach to contemporary institutions took its initial form. Warner's approach to the study of work in formal organizations at Yankee City was ground-breaking because it led away from the more conventional strategy of confining ethnography to a single organization (e.g., Hawthorne) by examining social relations and meanings that cross-cut the larger society and in which all formal organizations are embedded (i.e., class, rank, and status). Warner's commitment to rigorous empiricism, and to engaging the problems of an era, led him beyond functionalist theory to the hallmarks of an institutional approach to work in late capitalism that still resonates today. [source] Front and Back Covers, Volume 22, Number 3.ANTHROPOLOGY TODAY, Issue 3 2006June 200 Front and back cover caption, volume 22 issue 3 Front & back cover ANTHROPOLOGY AND SOCIAL MEMORY The front cover shows a statue Of General Francisco Franco In the exhibition 'Franco, Listen!', held at the Museum of Vilafranca del Penedès, Barcelona. The statue was displayed with the aim of stimulating comment, dialogue and action among museum visitors around the time of the 30th anniversary of the dictator's death on 20 November 1975. It was attacked by a group of Catalan pro-independence activists, who poured red paint over Franco's head, invested him with a crown, and hung a sign around his neck reading: 'The Spanish Monarchy is a direct inheritance from Franco - end the hypocrisy.' The back cover shows a formerly unmarked mass grave strewn with floral tributes after a spontaneous ceremony led by relatives of the 46 people killed near Villamayor de los Montes (Burgos), following the exhumation of the bodies in July 2004. In this issue, Francisco Ferrándiz describes the debates taking place in Spain around the exhumation of mass graves from the Civil War (1936-1939). In the last few years the strength of the 'movement for the recovery of historical memory' linked to the exhumations has been such that some on the political right are denouncing the advent of a 'new hegemony of the defeated' that is taking the place of the 'agreement of all' which many believe was the trademark of the Spanish transition to democracy. Proposing that anthropologists visit and address the sites of memory - exhumations, cemeteries, political discourses, laws and commemorations, claims of victimhood, media reports, artistic performances, forensic laboratories, academic meetings and summer schools, historiographical debates, civil associations, historical archives, public and private rituals, narratives of the defeat and old photo albums, to name a few - Ferrándiz encourages anthropology to engage in 'rapid response' research, to diversify fieldwork locations, to modulate research strategies in order to address rapidly evolving problems, to continue visiting the sites of violence, past and present, and to produce the type of knowledge that allows us to participate in substantive ways in social and political debates well beyond our discipline and beyond our academic setting. [source] ATP-Noncompetitive Inhibitors of CDK,Cyclin ComplexesCHEMMEDCHEM, Issue 1 2009Mar Orzáez Dr. Abstract Progression through the cell division cycle is controlled by a family of cyclin-dependent kinases (CDKs), the activity of which depends on their binding to regulatory partners (cyclins A,H). Deregulation of the activity of CDKs has been associated with the development of infectious, neurodegenerative, and proliferative diseases such as Alzheimer's, Parkinson's, or cancer. Most cancer cells contain mutations in the pathways that control the activity of CDKs. This observation led this kinase family to become a central target for the development of new drugs for cancer therapy. A range of structurally diverse molecules has been shown to inhibit the activity of CDKs through their activity as ATP antagonists. Nevertheless, the ATP binding sites on CDKs are highly conserved, limiting the kinase specificity of these inhibitors. Various genetic and crystallographic approaches have provided essential information about the mechanism of formation and activation of CDK,cyclin complexes, providing new ways to implement novel research strategies toward the discovery of new, more effective and selective drugs. Herein we review the progress made in the development of ATP-noncompetitive CDK,cyclin inhibitors. [source] Positive Connections: a programme for children who have a parent with a mental illnessCHILD & FAMILY SOCIAL WORK, Issue 2 2003Nancy A. Orel ABSTRACT Mental health professionals working with parents who suffer from a mental illness often overlook the children within the family. Children whose parents are mentally ill face numerous obstacles to their own emotional development and these children are at higher risk for developing mental illnesses than other children. These risks can be decreased if protective or positive interventions are available for the children. This article will describe the development and implementation of Positive Connections, an effective intervention programme specifically designed for children whose parents have been diagnosed with a mental disorder. The effectiveness of this programme has been evaluated using both qualitative and quantitative research strategies, and the results are presented. [source] Treatment Integrity: Implications for TrainingCLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 4 2005Ellen Flannery-Schroeder Perepletchikova and Kazdin (this issue) reviewed the extant literature on the relationship between treatment integrity and therapy outcomes. The empirical literature on this relationship is inconsistent, and the authors note existing limitations in current research strategies and provide recommendations for future research efforts. This commentary explores the implications that a focus on treatment integrity has for training. As such, comments are offered on a number of conceptual, methodological, and practical issues relating to treatment integrity, instruction in empirically supported treatments, competence, and the training of future clinical psychologists. [source] High-level distribution for the rapid production of robust telecoms software: comparing C++ and ERLANGCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 8 2008J. H. Nyström Abstract Currently most distributed telecoms software is engineered using low- and mid-level distributed technologies, but there is a drive to use high-level distribution. This paper reports the first systematic comparison of a high-level distributed programming language in the context of substantial commercial products. Our research strategy is to reengineer some C++/CORBA telecoms applications in ERLANG, a high-level distributed language, and make comparative measurements. Investigating the potential advantages of the high-level ERLANG technology shows that two significant benefits are realized. Firstly, robust configurable systems are easily developed using the high-level constructs for fault tolerance and distribution. The ERLANG code exhibits resilience: sustaining throughput at extreme loads and automatically recovering when load drops; availability: remaining available despite repeated and multiple failures; dynamic reconfigurability: with throughput scaling near-linearly when resources are added or removed. Secondly, ERLANG delivers significant productivity and maintainability benefits: the ERLANG components are less than one-third of the size of their C++ counterparts. The productivity gains are attributed to specific language features, for example, high-level communication saves 22%, and automatic memory management saves 11%,compared with the C++ implementation. Investigating the feasibility of the high-level ERLANG technology demonstrates that it fulfils several essential requirements. The requisite distributed functionality is readily specified, even although control of low-level distributed coordination aspects is abrogated to the ERLANG implementation. At the expense of additional memory residency, excellent time performance is achieved, e.g. three times faster than the C++ implementation, due to ERLANG's lightweight processes. ERLANG interoperates at low cost with conventional technologies, allowing incremental reengineering of large distributed systems. The technology is available on the required hardware/operating system platforms, and is well supported. Copyright © 2007 John Wiley & Sons, Ltd. [source] Lithium response across generationsACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2009P. Grof Objective:, To describe and integrate observations from bipolar patients responsive to lithium stabilization and their children. Method:, Selected findings are described from the clinical and biological investigations of adults meeting research criteria for bipolar disorder and for responsiveness to lithium stabilization; and from prospective studies of the children of lithium responders and non-responders. Results:, Response to prophylactic lithium identifies a valid subtype of bipolar disorder, however the search for biological markers of lithium response, while promising, has so far remained inconclusive. Adult responders to lithium stabilization exhibit definable clinical features which are also observable in their affected children. In prospective studies the children of bipolar parents develop symptoms earlier than reported previously, with marked differences between the offspring of lithium responders and non-responders. The illness evolves in predictable clinical stages, first from non-specific sleep and anxiety disorders to mood symptoms and then, often starting in adolescence, major depressive and later activated episodes. Conclusion:, Investigating and comparing unequivocal responders and non-responders to long-term lithium treatment and their offspring is a fertile research strategy for addressing a multitude of clinical and research questions. [source] Toxicity assessment and public policies: An urgent need for research,ENVIRONMENTAL TOXICOLOGY, Issue 5 2010Eric Vindimian Abstract The new European regulation on chemicals triggers a huge number of new testing. However, more than 2 years after the enforcement of this policy, toxicity assessment and risk assessment are still using single species tests that deliver little information. As it is often the case, the link between science and policy seems to be disrupted. However, policy makers need more than ever information on the fate and effects of chemicals on living systems. Without relevant knowledge for decision making, the application of the precautionary principle is the only reasonable way to manage risks. It is necessary to develop new risk assessment strategies using the last innovations from biology: the omics tools, ecology, ecosystem modeling, chemistry, and computing. This article highlights some of the recent trends in ecotoxicology and calls for a new research strategy. This strategy implies research to be funded by its users. © 2010 Wiley Periodicals, Inc. Environ Toxicol, 2010. [source] Linking personality states, current social roles and major life goalsEUROPEAN JOURNAL OF PERSONALITY, Issue 6 2009Wiebke BleidornArticle first published online: 23 JUN 200 Abstract Employing an experience-sampling design, the interplay between personality states, social roles and major life goals was examined as it unfolds in the stream of people's daily lives. Multilevel analyses revealed a considerable amount of both within- and between-person variability in state expressions of personality traits justifying further examination of predictors at both levels of analyses. Roles proved as predictors of current personality states albeit effects differed significantly between individuals. Life goals accounted for between-person differences in average personality states but were not effective in predicting differences in relations between personality states and roles. Altogether, findings testify to the viability of the employed research strategy to analyse the interplay between both dispositional and fluctuating influences on individuals' trait expressions in behaviour. Copyright © 2009 John Wiley & Sons, Ltd. [source] Defining Factors of Successful University-Community Collaborations: An Exploration of One Healthy Marriage ProjectFAMILY RELATIONS, Issue 1 2009Erik L. Carlton This study explored university-community collaborations by examining the workings of 1 healthy marriage initiative. An ethnographic case study research strategy was used to study the process of this initiative, specifically looking at how participants worked through and overcame traditional university-community collaboration challenges. Data consist of qualitative interviews with key initiative collaborators. Findings are organized into a model that offers a new way of looking at university-community collaborations in light of challenge points to be addressed and either resolved or unresolved. The model provides implications for other collaborative efforts and outreach scholarship. [source] | |||||||||||||||||||||||||||||||