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Research Lines (research + line)
Selected AbstractsBase isolation for retrofitting historic buildings: Evaluation of seismic performance through experimental investigationEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 8 2001Antonello De Luca Abstract An experimental test program on a full-scale model representing a sub-assemblage of the cloister facade of the Sao Vicente de Fora monastery, retrofitted through base isolation, has been recently carried out at the European Laboratory for Structural Assessment of the Joint Research Centre of the European Commission. In this paper an overview of the laboratory model and the experimental results is provided. In particular, firstly the test model is described, including the geometry and mechanical properties of the masonry specimen and the design of the isolation devices; then the testing method and the sub-structuring of the isolation system are described and the seismic inputs adopted for the pseudo-dynamic tests are defined. Finally, the experimental results are discussed and compared to the analogous results obtained on the ,as is', fixed-base sub-assemblage model. The implications of the test outcomes are emphasized and developments of this research line are presented. Copyright © 2001 John Wiley & Sons, Ltd. [source] The role of stem cells in suppurative environmentsEXPERIMENTAL DERMATOLOGY, Issue 6 2006Dolores Herreros Purpose:,The management of suppurative perianal lesions presents an extremely challenging problem. Stem cells (SC) extracted from certain tissues, such as adipose tissue, can differentiate into various cell types. Therefore, we have tried to use such cells to stimulate healing in a purulent environment. Methods:,In the beginning, we designed a phase I clinical trial, involving five patients with Crohn's disease. We inoculated nine fistulas in four patients with autologous adipose-derived stem cells (ADSC) and were followed at least 8 weeks. Seventy-five percent became healed, and 25% showed a decrease in output flow. No adverse effects were observed in any patient. This study evidenced that such cells are safe. Then, we started a research line using SC in different suppurative environments. During the course of these studies, we had the opportunity to treat a patient with perianal hidradenitis suppurativa using our current protocol of ADSC transplantation. Eight weeks after injection, patient had no perianal suppuration, and a year later remains well. Discussion:,The biological mechanism that underlies the therapeutic success of ADSC transplantation is unknown. Cell differentiation, secretion of growth factors or immunomodulatory effects have been suggested. No ethical conflicts were identified by our Ethics Committee, because the cells were autologous. Conclusions:,Our study shows that ADSC are safe for the treatment of suppurative processes. The actual number of patients included and the uncontrolled nature of these pilot studies do not allow demonstration of the effectiveness of the treatment. However, the results encourage the performance of further studies. [source] Sequential innovation, patents, and imitationTHE RAND JOURNAL OF ECONOMICS, Issue 4 2009James Bessen We argue that when innovation is "sequential" (so that each successive invention builds in an essential way on its predecessors) and "complementary" (so that each potential innovator takes a different research line), patent protection is not as useful for encouraging innovation as in a static setting. Indeed, society and even inventors themselves may be better off without such protection. Furthermore, an inventor's prospective profit may actually be enhanced by competition and imitation. Our sequential model of innovation appears to explain evidence from a natural experiment in the software industry. [source] Examining the association between media coverage of organ donation and organ transplantation ratesCLINICAL TRANSPLANTATION, Issue 2 2007Brian L. Quick Abstract:, Research addressing the organ shortage in the USA has examined multiple factors influencing one's decision to become an organ donor. One of these research lines addresses media coverage of organ donation. The present investigation seeks to advance this research line by examining the association between organ donation media coverage and organ transplantation rates. A content analysis spanning January 1990 to December 2005 of three television networks reveals an overall positive association between coverage and transplantation rates. The implications of our findings are discussed along with recommendations for practitioners and advocates alike. [source] Downstream from calcium signalling: mitochondria, vacuoles and pancreatic acinar cell damageACTA PHYSIOLOGICA, Issue 1 2009S. Voronina Abstract Ca2+ is one of the most ancient and ubiquitous second messengers. Highly polarized pancreatic acinar cells serve as an important cellular model for studies of Ca2+ signalling and homeostasis. Downstream effects of Ca2+ signalling have been and continue to be an important research avenue. The primary functions regulated by Ca2+ in pancreatic acinar cells , exocytotic secretion and fluid secretion , have been defined and extensively characterized in the second part of the last century. The role of cytosolic Ca2+ in cellular pathology and the related question of the interplay between Ca2+ signalling and bioenergetics are important current research lines in our and other laboratories. Recent findings in these interwoven research areas are discussed in the current review. [source] Examining dispositional and situational effects on outgroup attitudes,EUROPEAN JOURNAL OF PERSONALITY, Issue 4 2009Joke Meeus Two research lines have dominated the quest for the antecedents of outgroup attitudes. Whereas the first has viewed outgroup attitudes as a result of individual differences, the second stressed the importance of the intergroup situation. In order to investigate the interplay of individual differences and situational characteristics, key predictors of the individual differences perspective (i.e. right-wing authoritarianism or RWA, and social dominance orientation or SDO) and the intergroup relations perspective (i.e. ingroup identification and ingroup threat) were simultaneously tested. Two studies revealed additive but no interaction effects of RWA and SDO, ingroup identification and threat. Additionally, Study 1 showed that threat effects remain limited to the outgroup that is portrayed as threatening and do not generalize to other outgroups. Copyright © 2009 John Wiley & Sons, Ltd. [source] Improving interpretability in approximative fuzzy models via multiobjective evolutionary algorithmsINTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS, Issue 9 2007A.F. Gómez-Skarmeta Current research lines in fuzzy modeling mostly tackle improving the accuracy in descriptive models and improving of the interpretability in approximative models. This article deals with the second issue, approaching the problem by means of multiobjective optimization in which accuracy and interpretability criteria are simultaneously considered. Evolutionary algorithms are especially appropriated for multiobjective optimization because they can capture multiple Pareto solutions in a single run of the algorithm. We propose a multiobjective evolutionary algorithm to find multiple Pareto solutions (fuzzy models) showing a trade-off between accuracy and interpretability. Additionally, neural-network-based techniques in combination with ad hoc techniques for improving interpretability are incorporated into the multiobjective evolutionary algorithm to improve the efficiency of the algorithm. © 2007 Wiley Periodicals, Inc. Int J Int Syst 22: 943,969, 2007. [source] Goal Programming: realistic targets for the near futureJOURNAL OF MULTI CRITERIA DECISION ANALYSIS, Issue 3-4 2009Rafael Caballero Abstract Goal Programming (GP) can be regarded as one of the most widely used multicriteria decision-making techniques. In this paper, two surveys are carried out. First, the evolution of GP since its birth to the present time, in terms of number of publications, references, journals, etc., has been studied. Second, a more in-depth survey has been carried out, which covers the publications from year 2000 to the present time. All the references are listed, and some conclusions and future research lines have been extracted about the late trends of GP. Copyright © 2010 John Wiley & Sons, Ltd. [source] Preface: phys. stat. sol. (c) 1/S2PHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue S2 2004E. F. da Silva Jr. The papers in this special issue of physica status solidi (c) are selected manuscripts including diverse research lines presently in development in the ambit of the NanoSemiMat network in Brazil. The 3rd Workshop on Semiconductor Nanodevices and Nanostructured Materials (NanoSemiMat-3) took place in Salvador, Bahia, Brazil, at the Catussaba Resort Hotel, during the period of 24,27 March 2004. The NanoSemiMat network is part of the Brazilian Initiative on Nanoscience and Nanotechnology (N&N), with strategic cooperative research support in this area. The initiative started in 2001, through the formation of four research networks nationwide in different scientific fields associated to NanoScience and Nanotechnology (N&N). The 3rd Workshop on Nanodevices and Nanostructured Materials (NanoSemiMat-3) is an evolution of the two previous meetings which were held in Recife, PE, Brazil and Natal, RN, Brazil in 2002 and 2003, respectively. The meeting comprised 16 invited plenary talks, each 30 minutes long, given by eminent researchers from Brazil, Canada, France, Germany and the United States of America. These invited talks extend through different topics of N&N associated to Nanodevices and Nanostructured Materials: Photodetectors, Lasers and LEDs, Porous Materials, New Materials, and New Technologies, among others. There were short talks presented by representatives of the other N&N networks in Brazil dealing with Molecular Technology and Interfaces, Nanostructured Materials and Nanobiotechnology. Also a poster session, with about 60 presentations, highlighted the main research activities presently being developed by the network members at the different sites which constitute the NanoSemiMat network. The presentations reflected theoretical and experimental research lines which lead to the development of basic and applied research in nanostructured semiconductor materials such as III,V and II,VI, Si and SiC based nanodevices, wide gap materials, ceramics, polymers, porous materials, optical and transport properties of low dimensional structures, magnetic nanostructures and structures under the influence of high fields, spintronics and sensor applications. The participants of the workshop came from 20 research institutions within Brazil and from 7 research laboratories and universities in Europe and North America. In total about 120 researchers, members of the network, invited researchers, representatives of supporting and funding agencies in Brazil, undergraduate and graduate students, technical staff and supporting personal as well as researchers from complementary fields were present. The realization of the NanoSemiMat-3 was possible due to the financial support of the Brazilian Ministry of Science and Technology (MCT) and the Brazilian National Research Council (CNPq) and the logistic support of Federal University of Bahia. All activities during the NanoSemiMat-3 were open to the general public with interest in nanoscience and nanotechnology. In this third workshop of the series, we highlight the expansion of its format, with plenary and invited talks, poster sessions, as well as the presence of seven invited speakers from abroad. We expect that the continuation of the NanoSemiMat series will be a forum for discussions of state-of-the-art research developed in Brazil on N&N and the multidisciplinary field of semiconductor nanodevices and nanostructured materials as well as its superposition to other branches of science. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Genome-wide genetic diversity of ,Nici', the DNA source for the CHORI-260 turkey BAC library and candidate for whole genome sequencingANIMAL GENETICS, Issue 3 2009L. D. Chaves Summary Vertebrate whole genome sequence assembly can benefit from a priori knowledge of variability in the target genome, with researchers often selecting highly inbred individuals for sequencing. However, for most species highly inbred research lines are lacking, requiring the use of an outbred individual(s). Here we examined the source DNA [Nicholas inbred (Nici)] of the CHORI-260 turkey bacterial artificial chromosome (BAC) library through analysis of microsatellites and BAC sequences. Heterozygosity of Nici was compared with that of individuals from several breeder lines. Seventy-eight microsatellites were screened for polymorphism in a total of 43 birds, identifying an average individual heterozygosity of 0.39, with Nici at 0.35. Additional loci (total of 147) were examined on a subset of individuals to obtain better genome coverage. The mean heterozygosity for this subset was 0.33 with Nici at 0.31. Examination of approximately 200 kb of genome sequence identified SNPs in the order of one per 200 bp in Nici. These data suggest that the heterozygosity of Nici is comparable to other birds of selected breeder lines and that whole genome sequencing would result in an abundant resource of genome-wide polymorphisms. [source] | ||||||||||||||||