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Research Institute (research + institute)
Kinds of Research Institute Selected AbstractsEpidermoid cyst of the intrapancreatic accessory spleen producing CA19-9DIGESTIVE ENDOSCOPY, Issue 3 2004Hiroyuki Watanabe We report a rare case of an epidermoid cyst in an accessory spleen at the pancreatic tail with producing CA19-9. A 55-year-old female was admitted to our hospital, Cancer Research Institute, Kanazawa University, for close examination of a cystic lesion at the pancreatic tail and a high serum CA19-9-value (176 U/mL). There were almost no abdominal symptoms related to the cystic lesion. A cystic tumor approximately 3 cm in diameter and composed of multilocular cysts without a protruding portion of the inner surface was found at the pancreatic tail by ultrasound sonography, computed tomography, and magnetic resonance imaging. Endoscopic retrograde pancreatography revealed that the main pancreatic duct shifted at the pancreatic tail and there was no communication between the main pancreatic duct and cystic lesion. Based on a preoperative diagnosis of mucinous cystic tumor, distal pancreatectomy with splenectomy was performed. Histological ,ndings suggested an epidermoid cyst (3.5 × 3.0 cm) originating from an intrapancreatic accessory spleen. Immunohistochemical analysis of CA19-9 in the epidermoid cyst showed clear staining of the inner epithelium of the cyst and amorphous or hyalinous cystic contents. The serum CA19-9 value was con,rmed to decline to normal 2 months after resection. Physicians should not forget this disease during differential diagnosis related to pancreatic cystic lesions with elevated levels of serum tumor markers, such as CA19-9 or carcinoembryonic antigen, although this disease is extremely rare. [source] 1985 and all that: The establishment of Australia's Drug StrategyDRUG AND ALCOHOL REVIEW, Issue 2 2009NEAL BLEWETT Abstract A national drug summit in the mid-1980s played a pivotal role in the establishment of Australia's National Drug Strategy. It transformed the delivery of drug policies in Australia and gave us the instruments to understand our drug problem, namely national Centres of Excellence, including the National Drug Research Institute. This paper examines how a ,bundle of compromises' came together in the political context of the mid-1980s to give rise to, for the first time, a cooperative national campaign that continues to drive Australia's drug strategy today.[Blewett N. 1985 and all that: The establishment of Australia's Drug Strategy. Drug Alcohol Rev 2009;28:96,98] [source] Nonprofit organizations and pharmaceutical research and developmentDRUG DEVELOPMENT RESEARCH, Issue 7 2009Walter H. Moos Abstract Not-for-profit or nonprofit organizations (NPOs) are playing an increasingly important role in providing solutions to the significant challenges faced by both large pharmaceutical and smaller biotechnology companies in today's world. NPOs chartered for the public benefit are common in the United States and in selected other parts of the world. The largest NPOs in the U.S. with bioscience programs include Battelle, the Midwest Research Institute, the Research Triangle Institute, Southern Research, and SRI International. To provide a perspective on NPO business models, 10 SRI case studies spanning a broad range of technical and business initiatives are summarized herein, including basic and contract research, discovery of new drugs and biologics, pharmaceutical and biotech R&D services, technology pivots, company spin-ins and spin-outs, and the creation of new NPOs. The article concludes with lessons learned and food for thought for both pharmaceutical companies and outsourcing participants. Drug Dev Res 70: 461,471, 2009. © 2009 Wiley-Liss, Inc. [source] Testing of the SIBERIA landscape evolution model using the Tin Camp Creek, Northern Territory, Australia, field catchmentEARTH SURFACE PROCESSES AND LANDFORMS, Issue 2 2002G. R. Hancock Abstract The SIBERIA landscape evolution model was used to simulate the geomorphic development of the Tin Camp Creek natural catchment over geological time. Measured hydrology, erosion and geomorphic data were used to calibrate the SIBERIA model, which was then used to make independent predictions of the landform geomorphology of the study site. The catchment, located in the Northern Territory, Australia is relatively untouched by Europeans so the hydrological and erosion processes that shaped the area can be assumed to be the same today as they have been in the past, subject to the caveats regarding long-term climate fluctuation. A qualitative, or visual comparison between the natural and simulated catchments indicates that SIBERIA can match hillslope length and hillslope profile of the natural catchments. A comparison of geomorphic and hydrological statistics such as the hypsometric curve, width function, cumulative area distribution and area,slope relationship indicates that SIBERIA can model the geomorphology of the selected Tin Camp Creek catchments. Copyright 2002 © Environmental Research Institute of the Supervising Scientist, Commonwealth of Australia. [source] Consistency of dynamic site response at Port IslandEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 6 2001Laurie G. Baise Abstract System identification (SI) methods are used to determine empirical Green's functions (EGF) for soil intervals at the Port Island Site in Kobe, Japan and in shake table model tests performed by the Port and Harbor Research Institute (PHRI) to emulate the site during the 17 January 1995 Hyogo-ken Nanbu earthquake. The model form for the EGFs is a parametric auto-regressive moving average (ARMA) model mapping the ground motions recorded at the base of a soil interval to the top of that interval, hence capturing the effect of the soil on the through-passing wave. The consistency of site response at Port Island before, during, and after the mainshock is examined by application of small motion foreshock EGFs to incoming ground motions over these time intervals. The prediction errors (or misfits) for the foreshocks, the mainshock, and the aftershocks, are assessed to determine the extent of altered soil response as a result of liquefaction of the ground during the mainshock. In addition, the consistency of soil response between field and model test is verified by application of EGFs calculated from the shake table test to the 17 January input data. The prediction error is then used to assess the consistency of behaviour between the two cases. By using EGFs developed for small-amplitude foreshock ground motions, ground motions were predicted for all intervals of the vertical array except those that liquefied with small error. Analysis of the post-liquefied ground conditions implies that the site response gradually returns to a pre-earthquake state. Site behaviour is found to be consistent between foreshocks and the mainshock for the native ground (below 16 m in the field) with a normalized mean square error (NMSE) of 0.080 and a peak ground acceleration (PGA) of 0.5g. When the soil actually liquefies (change of state), recursive models are needed to track the variable soil behaviour for the remainder of the shaking. The recursive models are shown to demonstrate consistency between the shake table tests and the field with a NMSE of 0.102 for the 16 m to surface interval that liquefied. The aftershock ground response was not modelled well with the foreshock EGF immediately after the mainshock (NMSE ranging from 0.37 to 0.92). One month after the mainshock, the prediction error from the foreshock modeled was back to the foreshock error level. Copyright © 2001 John Wiley Sons, Ltd. [source] A chip-based miniaturized format for protein-expression profiling: The exploitation of comprehensively produced antibodiesELECTROPHORESIS, Issue 18 2006Hisashi Koga Dr. Abstract Numerous antibodies have been developed and validated in recent years, and show promise for use in novel functional protein assays. Such assays would be an alternative to pre-existing comprehensive assays, such as DNA microarrays. Antibody microarrays are thought to represent those functional protein assays. While a variety of attempts have been made to apply DNA microarray technology to antibody microarrays, a fully optimized protocol has not been established. We have been conducting a project to comprehensively produce antibodies against mouse KIAA ("KI" stands for "Kazusa DNA Research Institute" and "AA" are reference characters) proteins. Using our library of antibodies, we established a novel antibody microarray format that utilizes surface plasmon resonance (SPR) technology. A label-free real-time measurement of protein expression in crude cell lysates was achieved by direct readout of the bindings using SPR. Further refinement of the antibody microarray format enabled us to detect a smaller quantity of target proteins in the lysate without the bulk effect. In this review, we first summarize available antibody array formats and then describe the above-mentioned format utilizing updated SPR technology. [source] Estimating within-field variation using a nonparametric density algorithmENVIRONMETRICS, Issue 5 2006A. Castrignanò Abstract The application of site-specific techniques and technologies in precision farming requires subdividing a field into a generally small number of contiguous homogeneous zones. The proposed algorithm of clustering is based on nonparametric density estimate, where a cluster is defined as a region surrounding a local maximum of the probability density function. Soil samples were collected in a 2-ha field of the experimental farm of the Agricultural Research Institute, located in Foggia (Southern Italy) and some of the most production-affecting soil properties were interpolated by using the geostatistical techniques of kriging and cokriging. The application of the clustering approach to the (co)kriged surface variables produced the subdivision of the field into five distinct classes. The proposed algorithm proves quite promising in identifying spatially contiguous zones, which are more homogeneous in soil properties than the whole-field. Its great advantage consists in giving an additional description of the residual variation within the class and such a piece of information is very useful in precision farming as a basis for the variable-rate application of agronomic inputs. Copyright © 2005 John Wiley & Sons, Ltd. [source] Equine clinical genomics: A clinician's primerEQUINE VETERINARY JOURNAL, Issue 7 2010M. M. BROSNAHAN Summary The objective of this review is to introduce equine clinicians to the rapidly evolving field of clinical genomics with a vision of improving the health and welfare of the domestic horse. For 15 years a consortium of veterinary geneticists and clinicians has worked together under the umbrella of The Horse Genome Project. This group, encompassing 22 laboratories in 12 countries, has made rapid progress, developing several iterations of linkage, physical and comparative gene maps of the horse with increasing levels of detail. In early 2006, the research was greatly facilitated when the US National Human Genome Research Institute of the National Institutes of Health added the horse to the list of mammalian species scheduled for whole genome sequencing. The genome of the domestic horse has now been sequenced and is available to researchers worldwide in publicly accessible databases. This achievement creates the potential for transformative change within the horse industry, particularly in the fields of internal medicine, sports medicine and reproduction. The genome sequence has enabled the development of new genome-wide tools and resources for studying inherited diseases of the horse. To date, researchers have identified 11 mutations causing 10 clinical syndromes in the horse. Testing is commercially available for all but one of these diseases. Future research will probably identify the genetic bases for other equine diseases, produce new diagnostic tests and generate novel therapeutics for some of these conditions. This will enable equine clinicians to play a critical role in ensuring the thoughtful and appropriate application of this knowledge as they assist clients with breeding and clinical decision-making. [source] What becomes of dental research trainees once they leave the Dental Research Institute?EUROPEAN JOURNAL OF DENTAL EDUCATION, Issue 2 2008An analysis over 53 years Abstract The careers of 131 dental research trainees were followed (1954,2007) to establish whether and how they utilised their research training in keeping with clinical research workforce needs. The Dental Research Institute database was used to obtain trainee demographic, teaching and research outputs which were examined according to degree types: PhD (18); MSc (55); MDent (42) and dropout (16). Current careers show that 48% are in exclusive private practice and 15% in exclusive academia with further 15% practitioners having academic links via sessional teaching or research at a dental school. Most (63%) have remained in South Africa but emigration is high amongst the PhD and MSc groups. Forty-one per cent of the cohort is of age ,55 years and 16% <40 years old. The 131 trainees have published 2287 peer-reviewed journal papers over their careers: quantity of research output is skewed towards degree type (PhD) and individuals (10% trainees produced 65% of all publications). Recent trainees have little research experience prior to their training and a lower subsequent research output than earlier trainees. PhDs have participated in research for the greatest length of time (29.1 years). Academic teaching is heavily reliant on older and PhD trainees. It is proposed that a threshold of four publications be used to indicate minimum research skills and a period of formal academic teaching taken into account when advocating criteria to assess clinical research workforce requirements. [source] Mass and size distribution of firebrands generated from burning Korean pine (Pinus koraiensis) treesFIRE AND MATERIALS, Issue 1 2009Samuel L. Manzello Abstract The present study reports on a series of real-scale fire experiments that were performed to determine the mass and size distribution of firebrands generated from Korean Pine (Pinus koraiensis), a common conifer species indigenous to China, Japan, and Korea. The experiments were performed at the Building Research Institute in Tsukuba, Japan. The total tree height was fixed at 4.0,m and tree moisture content was varied to examine the influence that this parameter has on the mass and size distribution of the firebrands that are produced, under ambient wind conditions. The firebrands were collected using an array of pans. The pans used for firebrand collection were filled with water. This ensured that firebrands would be quenched as soon as they made contact with the pans. The firebrands were subsequently dried and the mass and size of more than 500 firebrands were measured. The Korean pine trees were also mounted on load cells during burning to determine the temporally resolved mass loss profiles. The mass loss data were used to compare the total amount of mass collected as firebrands with the total amount of mass burned. Results of this study are presented and compared with the mass and size distribution of firebrands collected from burning Douglas-fir trees, a conifer tree species indigenous to the U.S.A. Copyright © 2008 John Wiley & Sons, Ltd. [source] Long-term retention of coded wire tags in juvenile Arctic charr Salvelinus alpinusFISHERIES MANAGEMENT & ECOLOGY, Issue 3 2006I. KOLARI Abstract, A hatchery experiment was organised to find out if the high loss rate of coded wire tags, noticed in connection with an Arctic charr Salvelinus alpinus (L.) restocking programme, was size-dependent and also to test head moulds for future taggings. Six moulds made by Northwest Marine Technology Inc. and five moulds made at the Finnish Game and Fisheries Research Institute were used. A total of 100 charr were tagged with standard-length coded wire tags using each mould. One-summer old charr at tagging were held for 534 days and two-summer old charr for 320 days. The tag loss rate varied between 0% and 54% and was negatively related to the size of the charr at tagging. The high loss rate was connected with the poor alignment of some moulds, such that a large proportion of the tags were located in the nasal cavity instead of the nasal cartilage. Testing of the moulds and careful grading of the fish for tagging is emphasised, especially if Arctic charr smaller than 20 g in weight are to be tagged. [source] Volatile constituents of the flowerheads of three Echinacea species cultivated in IranFLAVOUR AND FRAGRANCE JOURNAL, Issue 2 2006Mohammad Hossein Mirjalili Abstract Three medicinal species of the genus Echinacea (Asteraceae), i.e. E. purpurea, E. pallida and E. angustifolia, were cultivated in the experimental field of the Medicinal Plants and Drugs Research Institute of Shahid Beheshti University (Tehran, Iran). The essential oil of flowerheads of the studied species was isolated by hydrodistillation. The essential oils were analyzed by GC and GC-MS. In total, 36, 30 and 36 constituents were identified and quantified in E. purpurea, E. pallida and E. angustifolia, respectively. Sesquiterpene hydrocarbons were the main group of compounds in E. purpurea (70.9%), E. angustifolia (70%) and E. pallida (62.6%). The content of germacrene-D in E. purpurea (57%) was higher than that in E. pallida (51.4%) and E. angustifolia (49.6%) as the principal component in all samples. Also, the monoterpene hydrocarbons were observed in the oil of E. purpurea (6.4%) and E. angustifolia (1.2%), while these compounds were completely absent in E. pallida oil. Copyright © 2006 John Wiley & Sons, Ltd. [source] Seasonal differences in the adaptability of herbage species to environmental variations in a long-term grazing experimentGRASSLAND SCIENCE, Issue 1 2007Yiruhan Abstract Mixtures of orchardgrass, perennial ryegrass, tall fescue, redtop, Kentucky bluegrass, and white clover were sown in autumn 1973. Two 8-year grazing experiments were conducted at the National Grassland Research Institute (Nasushiobara, Japan) to determine the effects of grazing intensity and nitrogen levels on pasture ecosystems. These experiments involved two different grazing intensities (1974,1981) and two different nitrogen levels (1982,1989). Large spatiotemporal variations in phytomass due to environmental variations were observed in both experiments. Finlay,Wilkinson analysis was applied to clarify seasonal (monthly) differences in the adaptability of the herbage species, as measured by phytomass, to environmental variations by year and treatments in the two experiments. Seasonality in the adaptability to environments differed greatly among species. In this paper, we examined from livestock farmers' standpoint whether seasonality in adaptability of herbage species in the grazing pasture could be satisfied. A significantly high adaptability was shown for: orchardgrass from May to July and November; tall fescue in April, June and July, and November; redtop and Kentucky bluegrass in April; and Zoysia japonica in September and October. In contrast, perennial ryegrass and white clover exhibited very low adaptability in any season. Z. japonica and weeds such as Pennisetum alopecuroides, Eragrostis ferruginea and Digitaria adscendens, which had invaded from surrounding areas, showed low adaptability, except in autumn, when they showed moderate adaptability. [source] The effect of temperature and daylength on heading in tetraploid cultivars of rhodesgrass (Chloris gayana Kunth)GRASSLAND SCIENCE, Issue 4 2005Isao Tarumoto Abstract The present study was conducted to clarify the effect of temperature and daylength on heading in tetraploid cultivars of rhodesgrass (Chloris gayana Kunth). Five cultivars, Tochiraku-kei (2,), Fords Katambora (2,), Callide (4,), Masaba (4,) and Pokot (4,), were planted on three dates at 1-month intervals (4 May, 4 June and 4 July) in three of the Ministry of Agriculture, Forestry and Fisheries research institutions in Ishigaki (Tropical Agriculture Research Center), Nishigoshi (Kyushu National Agricultural Experiment Station) and Nishinasuno (National Grassland Research Institute) in 1978. Three tetraploid cultivars were planted on three dates at 1-month intervals (4 May, 4 June and 4 July) under four daylength-treatments of natural daylength (ND), 12 h daylength [12 h], ND/12 h and 12 h/ND, and changed daylength at the eighth leaf stage, in Nishinasuno in 1978. Under natural daylength, although heading was not observed for Masaba and Pokot, heading was observed in all plots for Tochiraku-kei, Fords Katambora and Callide, and their days to heading (DH) linearly decreased with increases in daily mean temperature (DMT). The result indicated that, under natural daylength in summer, temperature was a major factor in determining DH in tetraploid Callide, which was the same as in diploid rhodesgrass cultivars. Callide reached heading under all four daylength treatments. However, Masaba and Pokot reached heading only under 12 h and ND/12 h treatments, suggesting that Masaba and Pokot have qualitative sensitivity to photoperiods that operate after the ninth leaf stage. These findings would be useful in tetraploid rhodesgrass for estimating foliage harvesting time in the field and for conducting cross-pollination in a greenhouse during winter. [source] Evaluating the adaptability of herbage species to environmental variation through a long-term grazing experimentGRASSLAND SCIENCE, Issue 4 2005Yiruhan Abstract Mixtures of orchard grass, perennial ryegrass, tall fescue, redtop, Kentucky bluegrass and white clover were sown in the autumn of 1973. Two 8-year grazing experiments were carried out at the National Grassland Research Institute (Nasushiobara, Tochigi, Japan) to determine the effects of grazing intensity and nitrogen levels on the pasture ecosystem: two different grazing intensities (1974,1981) and two different nitrogen levels (1982,1989). Large temporal and spatial variations in phytomass were observed in both experiments. To clarify the adaptability of the phytomass of the herbage species to environmental variations in year, season and treatments, we re-examined the data obtained in these two experiments using a Finlay-Wilkinson analysis. Orchard grass and tall fescue achieved significantly higher phytomass in a more fertile environment in that they showed a high adaptability to environmental variation. Redtop and Kentucky bluegrass showed an increase in phytomass proportional to environmental improvement. The phytomass performances of perennial ryegrass and white clover were almost independent of environmental variation in that their adaptability was low. Finally, Zoysia japonica and weeds such as Pennisetum alopecuroides and Digitaria adscendens, which were invaders from the surrounding areas to the experimental site, were not observed in the pasture during the first 8-year period; during the second 8-year period, they showed moderate adaptability. [source] The International Quotidian Dialysis Registry: Annual report 2006HEMODIALYSIS INTERNATIONAL, Issue 3 2006Gihad E. NESRALLAH Abstract Interest in short daily and nocturnal hemodialysis (HD) regimens continues to grow worldwide. Despite growing optimism that these therapies will afford better patient outcomes over conventional HD, the current literature has not been viewed as sufficiently compelling to affect widespread implementation in most jurisdictions. Before these therapies can gain wider acceptance, larger and more rigorous studies will likely be needed. In June 2004, the Quotidian Dialysis Registry, based at the Lawson Health Research Institute at the University of Western Ontario, Canada, began recruiting patients across North America. By using an Internet-based data entry platform, patients from various centers worldwide will eventually be recruited, and studied prospectively. This paper constitutes the second annual update on patient and center recruitment, patient and treatment characteristics, and future directions for the registry. [source] Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: Effects of diagnosis, bias correction, and slice locationHUMAN BRAIN MAPPING, Issue 2 2006Christine Fennema-Notestine Abstract Performance of automated methods to isolate brain from nonbrain tissues in magnetic resonance (MR) structural images may be influenced by MR signal inhomogeneities, type of MR image set, regional anatomy, and age and diagnosis of subjects studied. The present study compared the performance of four methods: Brain Extraction Tool (BET; Smith [2002]: Hum Brain Mapp 17:143,155); 3dIntracranial (Ward [1999] Milwaukee: Biophysics Research Institute, Medical College of Wisconsin; in AFNI); a Hybrid Watershed algorithm (HWA, Segonne et al. [2004] Neuroimage 22:1060,1075; in FreeSurfer); and Brain Surface Extractor (BSE, Sandor and Leahy [1997] IEEE Trans Med Imag 16:41,54; Shattuck et al. [2001] Neuroimage 13:856,876) to manually stripped images. The methods were applied to uncorrected and bias-corrected datasets; Legacy and Contemporary T1 -weighted image sets; and four diagnostic groups (depressed, Alzheimer's, young and elderly control). To provide a criterion for outcome assessment, two experts manually stripped six sagittal sections for each dataset in locations where brain and nonbrain tissue are difficult to distinguish. Methods were compared on Jaccard similarity coefficients, Hausdorff distances, and an Expectation-Maximization algorithm. Methods tended to perform better on contemporary datasets; bias correction did not significantly improve method performance. Mesial sections were most difficult for all methods. Although AD image sets were most difficult to strip, HWA and BSE were more robust across diagnostic groups compared with 3dIntracranial and BET. With respect to specificity, BSE tended to perform best across all groups, whereas HWA was more sensitive than other methods. The results of this study may direct users towards a method appropriate to their T1 -weighted datasets and improve the efficiency of processing for large, multisite neuroimaging studies. Hum. Brain Mapping, 2005. © 2005 Wiley-Liss, Inc. [source] The UK National Cancer Research Institute (NCRI) Informatics Initiative: promoting partnership in cancer research,HUMAN MUTATION, Issue 12 2007Fiona Reddington Abstract The vast amount of information emerging from cancer research in recent years has presented a challenge for researchers worldwide. The opportunities for using this data to enhance understanding of the disease and advance the delivery of novel anticancer treatments are greater than ever, but will fail to be fully realized unless the necessary tools to collate and analyze the information are developed. This article describes the work of the National Cancer Research Institute (NCRI) Informatics Initiative which aims to maximize the impact of the results of research funded by NCRI Partner organizations for the benefit of cancer patients by ensuring that data generated through research is put to maximum use by the cancer research community. Hum Mutat 28(12), 1151,1155, 2007. © 2007 Wiley-Liss, Inc. [source] Japan's strategic contributions to hydro-meteorological disaster mitigation in the world: planning to establish the UNESCO,PWRI CentreHYDROLOGICAL PROCESSES, Issue 6 2006Tetsuya Ikeda Hydro-meteorological disasters such as floods are major challenges that need to be overcome in order to realize sustainable development and poverty alleviation for humankind. Devastating flood disasters have occurring in various locations throughout the world, and there has recently been rising concern that the intensity and frequency of catastrophic floods may be increasing. Being located on the eastern edge of monsoonal Asia and having climatic variations according to the seasonal and regional conditions, Japan has long suffered from numerous flood disasters, and thus has developed advanced flood management policies. This paper aims to discuss flood disasters in Japan and the recently improved flood management policies. In addition, this paper introduces a new plan attempted by the Public Works Research Institute (PWRI) of Japan that takes advantage of the wealth of long accumulated experience and knowledge in the hydro-meteorological field. The PWRI is now working toward the establishment of an International Centre on Water-related Hazard and Risk Management by acquiring UNESCO's auspices. In order to contribute to the global challenge of reducing devastating hydro-meteorological disasters all over the world, this centre aims to conduct research, capacity-building and training programmes, and information networking activities at the local, national, regional and global levels. The aim is to prevent and mitigate hydro-meteorological disasters from the viewpoint of sustainable and integrated river basin management. Copyright © 2006 John Wiley & Sons, Ltd. [source] Structural basis of MHC class I recognition by natural killer cell receptorsIMMUNOLOGICAL REVIEWS, Issue 1 2001Mark W. Sawicki Summary: Natural killer (NK)-cell function is regulated by NK receptors that recognize MHC class I (MHC-I) molecules on target cells. Two structurally distinct families of NK receptors have been identified, the immunoglobulin-like family (killer cell immunoglobulin-like receptors (KIRs), leukocyte immunoglobulin-like receptors (LIRs)) and the C-type lectin-like family (Ly49, CD94/NKG2A, NKG2D, CD69). Recently, the three-dimensional structures of several NK receptors were determined, in free form or bound to MHC-I. These include those of unbound KIRs, NKG2D, CD69, LIR-1 and the CD94 subunit of the CD94/NKG2A heterodimer. Together, these structures define the basic molecular architecture of both the immunoglobulin-like and C-type lectin-like families of NK receptors. In addition, crystal structures have been reported for the complex between Ly49A and H-2Dd, and for KIR2DL2 bound to HLA-Cw3. The complex structures provide a framework for understanding MHC-I recognition by NK receptors from both families and reveal striking differences in the nature of this recognition, despite the receptors' functional similarity. This research was supported, in part, by National Institutes of Health grants R01 AI47900 and R37 36900 (RAM) and a fellowship from the Cancer Research Institute (MWS). We are grateful to DW Wolan and IA Wilson for providing coordinates of NKG2D prior to publication, and to members of our laboratories for encouragement. [source] Activating and inhibitory nature of the murine paired immunoglobulin-like receptor familyIMMUNOLOGICAL REVIEWS, Issue 1 2001Toshiyuki Takai Summary: Clones for murine paired immunoglobulin-like receptors (PIR) were first isolated as those coding for type I transmembrane glycoproteins with six immunoglobulin-like domains homologous to human Fc,R, bovine Fc,2R, and other related receptors. However, they turned out to bind neither IgA nor other immunoglobulins in the case of the ectopic expression on COS-1 fibroblastic cells. PIR-A and B are expressed on a wide variety of cells in the murine immune system, such as in B cells, mast cells, macrophages, and dendritic cells, mostly in a pairwise fashion. PIR-A requires homodimeric Fc receptor common , chain, which harbors an immunoreceptor tyrosine-based activation motif, for its efficient cell surface expression and for the delivery of activation signaling. In contrast, PIR-B contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic portion and inhibits receptor-mediated activation signaling in vitro upon engagement with other activating-type receptors such as the antigen receptor on B cells and the high affinity Fc receptor for IgE on mast cells. ITIMs of PIR-B on macrophages and B cells have been shown to be constitutively phosphorylated in their tyrosine residues. Although the ligand for PIR still remains unknown, the transgenics and the gene-targeted mice will provide us with valuable information on their physiological roles in the immune regulation. We thank Hiromi Kubagawa for discussion. This work is supported by CREST Program of JST, Virtual Research Institute of Aging funded by Boehringer Ingelheim, and by research grants from the Ministry of Education, Science, Sports and Culture of Japan to T. Takai. [source] The reform of the developmental welfare state in East AsiaINTERNATIONAL JOURNAL OF SOCIAL WELFARE, Issue 2009Huck-ju Kwon This article examines social policy reforms in East Asia and whether the welfare states in the region became more inclusive in terms of social protection while maintaining their developmental credentials. It draws on findings from the United Nations Research Institute for Social Development (UNRISD) project on social policy in East Asia, covering China, Hong Kong Special Administrative Region of China, Japan, Malaysia, the Republic of Korea, Singapore, Taiwan Province of China, and Thailand. It shows that East Asian economies responded differently to the crisis in terms of welfare reform. While Singapore and Hong Kong maintained the basic structure of the selective developmental welfare state, Korea, Taiwan, and, to a lesser extent, Thailand implemented social policy reforms toward a more inclusive one. Despite such different responses, policy changes are explained by the proposition of the developmental welfare state: the instrumentality of social policy for economic development and realization of policy changes through democratization (or the lack of it). [source] Productivity and Sustainability of Cotton (Gossypium hirsutum L.),Wheat (Triticum aestivum L.) Cropping System as Influenced by Prilled Urea, Farmyard Manure and AzotobacterJOURNAL OF AGRONOMY AND CROP SCIENCE, Issue 5 2004A. Das Abstract Field experiments were conducted at Indian Agricultural Research Institute, New Delhi, during 2001,2002 and 2002,2003, to study the effect of inorganic, organic and Azotobacter combined sources of N on cotton (Gossypium hirsutum L.) and their residual effect on succeeding wheat (Triticum aestivum L.) crop. The results indicated considerable increase in yield attributes and mean seed cotton yield (2.33 Mg ha,1) with the combined application of 30 kg N and farmyard manure (FYM) at 12 Mg ha,1 along with Azotobacter (M4). The treatment in cotton that included FYM, especially when fertilizer N was also applied could either improve or maintain the soil fertility status in terms of available N, P and K. Distinct increase in yield attributes and grain yield of wheat was observed with the residual effect of integrated application of 30 kg N ha,1 + FYM at 12 Mg ha,1 + Azotobacter. Direct application of 120 kg N ha,1 resulted 67.4 and 17.7 % increase in mean grain yield of wheat over no N and 60 kg N ha,1, respectively. Integrated application of organic and inorganic fertilizer is therefore, recommended for higher productivity and sustainability of the cotton,wheat system. [source] Fallowing did not disrupt invertebrate fauna in Philippine low-pesticide irrigated rice fieldsJOURNAL OF APPLIED ECOLOGY, Issue 3 2010Kenneth G. Schoenly Summary 1.,Fallowing, a type of rotation where no crop is grown, deprives insect pests of food. In tropical irrigated rice, it is not known whether fallow periods deplete natural enemy populations and reduce their pest control effectiveness in post-fallow crops. We tested the null hypothesis that small-scale synchronous cropping (embedded in asynchronously planted rice landscapes) does not significantly increase pest densities during post-fallow periods in the presence of a large, diverse natural enemy complex undisrupted by insecticides. We tested this null hypothesis by comparing the invertebrate fauna before and after fallowing. 2.,In six molluscicide-only fields at the International Rice Research Institute (IRRI) in southern Luzon and at Zaragoza in central Luzon, Philippines, canopy and floodwater invertebrates were vacuum-sampled over two cropping seasons, dry and wet. 3.,Thirty-three of the ubiquitous common taxa dominated the samples in both seasons at each site. Most species were natural enemies of rice pests and recyclers of organic matter in the floodwater and waterlogged sediments; some were rice pests. 4.,Fallowing depleted populations of more ubiquitous taxa at Zaragoza (four natural enemies, one detritivore) than at IRRI (one herbivore, one natural enemy). At both sites, only green leafhoppers, Nephotettix virescens and Nephotettix nigropictus, had consistently higher post-fallow densities than pre-fallow densities. 5.,At both sites, fallowing did not affect rice-invertebrate faunas differently between seasons with regard to community structure, trajectories and accumulation rates of guild members. 6.,Synthesis and applications.,In tropical irrigated rice fields, small-scale synchronous fallowing combined with low-pesticide inputs and pest-resistant rice varieties did not induce pest outbreaks or notably diminish populations of natural enemies when embedded in asynchronous cropping on larger, regional scales. Our results suggest that small-scale synchronous fallowing, when embedded in asynchronously planted landscapes, does little harm to biological regulation of the invertebrate faunal community and may be adopted as part of integrated pest management when it serves other purposes. [source] Snailfishes of the central California coast: video, photographic and morphological observationsJOURNAL OF FISH BIOLOGY, Issue 4 2006D. L. Stein Video and photographic images of snailfishes (Liparidae) collected by the Monterey Bay Aquarium Research Institute, augmented by specimens collected simultaneously, were analysed. Nine species in five genera were identified, including Careproctus melanurus, Careproctus ovigerus, Careproctus longifilis, Careproctus gilberti, Careproctus filamentosus, Osteodiscus cascadiae, Nectoliparis pelagicus, Paraliparis dactylosus and Rhinoliparis barbulifer. Voucher specimens were collected of all except C. melanurus, C. gilberti and C. filamentosus. In addition, individuals of the Paraliparis,rosaceus' species group were abundant but could not be identified to species. Many liparids were identified only to family, but an individual of a very distinctive unknown species, presumably undescribed, was videotaped. Relative abundance of C. melanurus was estimated, and several in situ snailfish behaviours are described for the first time. [source] Oxidative-inflammatory damage in cirrhosis: Effect of vitamin E and a fermented papaya preparationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 5 2007Francesco Marotta Abstract Background and Aim:, Oxidative DNA damage occurs as an early event in hepatitis C virus (HCV) infection and is an indication of the potential for carcinogenesis. The aim of this study was to test a novel antioxidant/immunomodulator in patients with HCV-related cirrhosis. Methods:, The study group consisted of 50 patients with HCV-related cirrhosis with transaminase values less than twofold increased (alanine aminotransferase [ALT] < 80 IU/L). Patients underwent a standardized food-vitamin composition assessment and were assessed for dietary intake, nutritional status and iron level. Patients were randomly allocated into two groups and then given either ,-tocopherol 900 IU/day or 9 g/day of a fermented papaya preparation (FPP, Immun-Age, Osato Research Institute, Gifu, Japan) at bedtime for 6 months. Ten healthy subjects served as controls. Patients were checked monthly for: routine tests, redox status (reduced glutathione, glutathione peroxidase, oxidized glutathione, malondialdehyde), plasma ,-tocopherol, 8-hydroxy-deoxy-guanidine (8-OHdG) level in circulating leukocyte DNA and serum levels of cytokines. Results:, Patients with cirrhosis showed a significant imbalance of redox status (low antioxidants/high oxidative stress markers) (P < 0.005 vs controls). Neither treatment regimen affected transaminases as a whole. However, vitamin E supplementation almost normalized ALT only in the limited vitamin-E-deficient subgroup. A significant improvement of redox status was obtained by both regimens. However, only FPP significantly decreased 8-OHdG and the improvement of cytokine balance with FPP was significantly better than with vitamin E treatment (P < 0.05). Conclusions:, Although the present data seem to suggest a potential supportive role of antioxidants/immunomodulators as FPP in HCV patients, more studies are needed to substantiate their effect on the natural history of the disease. [source] Natural resource-collection work and children's schooling in MalawiAGRICULTURAL ECONOMICS, Issue 2-3 2004Flora J. Nankhuni Abstract This paper presents results of research that investigates if long hours of work spent by children in fuel wood and water-collection activities, i. e., natural resource-collection work, influence the likelihood that a child aged 6,14 attends school. Potential endogeneity of resource-collection work hours is corrected for, using two-stage conditional maximum likelihood estimation. Data from the 1997,1998 Malawi Integrated Household Survey (IHS) conducted by the Malawi National Statistics Office (NSO) in conjunction with the International Food Policy Research Institute (IFPRI) are used. The study finds that Malawian children are significantly involved in resource-collection work and their likelihood of attending school decreases with increases in hours allocated to this work. The study further shows that girls spend more hours on resource-collection work and are more likely to be attending school while burdened by this work. Consequently, girls may find it difficult to progress well in school. However, girls are not necessarily less likely to be attending school. Results further show that presence of more women in a household is associated with a lower burden of resource-collection work on children and a higher probability of children's school attendance. Finally, the research shows that children from the most environmentally degraded districts of central and southern Malawi are less likely to attend school and relatively fewer of them have progressed to secondary school compared to those-from districts in the north. [source] Identifying women with severe angiographic coronary diseaseJOURNAL OF INTERNAL MEDICINE, Issue 1 2010C. Kreatsoulas Abstract., Kreatsoulas C, Natarajan MK, Khatun R, Velianou JL, Anand SS (McMaster University; CARING Network, McMaster University; Population Health Research Institute, McMaster University and Hamilton Health Sciences; Interventional Cardiology, Hamilton Health Sciences; Eli Lilly Canada,May Cohen Chair in Women's Health, McMaster University; Michael G. DeGroote-Heart and Stroke Foundation of Ontario Chair in Population Health Research, McMaster University; Population Genomics Program, McMaster University; McMaster University, Hamilton, ON, Canada). Identifying women with severe angiographic coronary disease. J Intern Med 2010; 268:66,74. Objectives., To determine sex/gender differences in the distribution of risk factors according to age and identify factors associated with the presence of severe coronary artery disease (CAD). Design., We analysed 23 771 consecutive patients referred for coronary angiography from 2000 to 2006. Subjects., Patients did not have previously diagnosed CAD and were referred for first diagnostic angiography. Outcome measures., Patients were classified according to angiographic disease severity. Severe CAD was defined as left main stenosis ,50%, three-vessel disease with ,70% stenosis or two-vessel disease including proximal left anterior descending stenosis of ,70%. Univariate and multivariate logistic regression was used to assess the association between risk factors and angina symptoms with severe CAD. Results., Women were less likely to have severe CAD (22.3% vs. 36.5%) compared with men. Women were also significantly older (69.8 ± 10.6 vs. 66.3 ± 10.7 years), had higher rates of diabetes (35.0% vs. 26.6%), hypertension (74.8% vs. 63.3%) and Canadian Cardiovascular Society (CCS) class IV angina symptoms (56.7% vs. 47.8%). Men were more likely to be smokers (56.9% vs. 37.9%). Factors independently associated with severe CAD included age (OR = 1.05; 95% CI 1.05,1.05, P < 0.01), male sex (OR = 2.43; CI 2.26,2.62, P < 0.01), diabetes (OR = 2.00; CI 1.86,2.18, P < 0.01), hyperlipidaemia (OR = 1.50; CI 1.39,1.61, P < 0.01), smoking (OR = 1.10; CI 1.03,1.18, P = 0.06) and CCS class IV symptoms (OR = 1.43; CI 1.34,1.53, P < 0.01). CCS Class IV angina was a stronger predictor of severe CAD amongst women compared with men (women OR = 1.82; CI 1.61,2.04 vs. men OR = 1.28; CI 1.18,1.39, P < 0.01). Conclusions., Women referred for first diagnostic angiography have lower rates of severe CAD compared with men across all ages. Whilst conventional risk factors, age, sex, diabetes, smoking and hyperlipidaemia are primary determinants of CAD amongst women and men, CCS Class IV angina is more likely to be associated with severe CAD in women than men. [source] A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstillJOURNAL OF INTERNAL MEDICINE, Issue 1 2004N. Takehara Abstract., Takehara N, Makita N, Kawabe J, Sato N, Kawamura Y, Kitabatake A, Kikuchi K (Asahikawa Medical College, Asahikawa; Hokkaido University Graduate School of Medicine, Sapporo, Japan; and Cardiovascular Research Institute, Newark, NY, USA). A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill (Case Report). J Intern Med 2004; 255: 137,142. Mutations in the cardiac Na+ channel gene SCN5A are responsible for multiple lethal ventricular arrhythmias including Brugada syndrome and congenital long QT syndrome. Here we report a case of Brugada syndrome with ST elevation in the right precordial and inferior leads accompanied by atrial standstill and spontaneous ventricular fibrillation. Atrial standstill and J wave elevation were provoked by procainamide. Genetic analysis revealed a missense mutation (R367H) in SCN5A. The resultant mutant Na+ channel was nonfunctional when expressed heterologously in Xenopus oocytes. Our study suggests that genetic defects in SCN5A may be associated with atrial standstill in combination with ventricular arrhythmias. [source] Yersinia pseudotuberculosis infection in breeding monkeys: detection and analysis of strain diversity by PCRJOURNAL OF MEDICAL PRIMATOLOGY, Issue 3 2002T. Kageyama In the last three decades, several monkeys reared in outdoor/indoor,outdoor breeding colonies and cages of the Primate Research Institute, Kyoto University, died of yersiniosis caused by Yersinia pseudotuberculosis, necessitating introduction of a method to detect the bacteria rapidly and thus allow preventive measures to be undertaken. A rapid nested polymerase chain reaction (PCR) method for identification of Y. pseudotuberculosis in fecal samples and a random amplified polymorphic DNA (RAPD)-PCR approach for distinguishing between bacterial strains were therefore developed. Yersinia pseudotuberculosis isolates from monkey specimens were found to be classifiable into several types. To determine the source of infection, hundreds of fecal samples of wild rats, pigeons, and sparrows were collected from around the breeding colonies and cages, and subjected to PCR analyses. Yersinia pseudotuberculosis was detected in 1.7% of the fecal samples of wild rats. The DNA fingerprints of the bacteria revealed by RAPD-PCR were the same as that of one strain isolated from macaques, suggesting the wild rat to be a possible source of infection. [source] | ||||||||||||||||||||||||||||||||||||||||||||||