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Research Focus (research + focus)
Selected AbstractsThe Sociology of Adolescence and Youth in the 1990s: A Critical CommentaryJOURNAL OF MARRIAGE AND FAMILY, Issue 4 2000Frank F. Furstenberg The 1990s saw considerable advances in the state of research on adolescence and youth. This article provides a critical commentary on a subset of this research, focusing on the causes and consequences of the lengthened period in which the transition to adulthood occurs. It provides a brief history of adolescence research, identifying a select set of topics, themes, and research problems that will guide research on adolescence and youth over the next decade. These research foci, which include peer group relations, biological influences on adolescence, employment experiences, increased autonomy, and racial and gender differences, are described as representing either continuities or advances in adolescence research. The strengths and shortcomings of this research are detailed. The paper concludes by suggesting promising areas for future research and by providing guidelines for undertaking such research. [source] Beyond Trauma-Focused Psychiatric Epidemiology: Bridging Research and Practice With War-Affected PopulationsAMERICAN JOURNAL OF ORTHOPSYCHIATRY, Issue 4 2006Kenneth E. Miller PhD This article examines the centrality of trauma-focused psychiatric epidemiology (TFPE) in research with war-affected populations. The authors question the utility of the dominant focus on posttraumatic stress disorder and other disorders of Western psychiatry, and they identify a set of critical research foci related to mental health work with communities affected by political violence. Core assumptions of TFPE and its roots in logical positivism and the biomedical model of contemporary psychiatry are explored. The authors suggest that an alternative framework,social constructivism,can serve as a bridge between researchers and practitioners by helping to refocus research efforts in ways that are conceptually and methodologically more attuned to the needs of war-affected communities and those working to address their mental health needs. [source] Seeking red herrings in the wood: tending the shared spaces of environmental and feminist geographiesTHE CANADIAN GEOGRAPHER/LE GEOGRAPHE CANADIEN, Issue 1 2007MAUREEN G. REED In this article I argue the need for feminist and environmental geographers to work more diligently to find, mind and tend the intersections of their research agendas to enrich scholarship and deepen impacts on public policy. Such a project requires us to move beyond an obvious call to acknowledge one another's work and towards the boundaries of our respective fields in order to co-create ,boundary objects' that provide opportunities for mutual exchange, collaboration and learning. Rather than being ,red herrings' or diversions from our main research foci, boundary objects bring new insights to taken-for-granted concepts. I focus on one example to argue that social sustainability of rural places is better understood by an integrated understanding of what constitutes a ,worker' in a forestry community. A redefinition of the worker that draws on insights and interests from both environmental and feminist geographers reveals an underlying gender bias in environmental decision-making processes and illustrates how the concept of social sustainability has been artificially restricted in practice. Nevertheless, collaborations are never easy. I draw attention to potential challenges of such collaborations that include the need to establish mutually agreeable protocols, joint commitment to constructive, respectful debate and strategies to ensure that research provides meaningful contributions to theory and public policy. Dans cet article, je vais tenter de montrer que les géographes féministes et les géographes de l'environnement auront à travailler avec plus d'acharnement pour reconnaître, étudier et entretenir les points communs de leurs agendas de recherche en vue d'augmenter la valeur scientifique des études et d'accroître les retombées sur les politiques publiques. Un tel projet exige que nous puissions dépasser le stade de la reconnaissance de nos travaux et se tourner ainsi vers les frontières de nos disciplines afin de co-créer des ,objets frontaliers' qui offrent des possibilités d'échanges d'idées, de collaboration et d'apprentissage. Plutôt qu'être des ,fausses pistes' ou des déviations de nos principaux thèmes de recherche, ces objets frontaliers pourraient apporter un éclairage nouveau sur des concepts tenus pour acquis. À l'aide d'un exemple, j'avance que pour mieux comprendre la durabilité sociale en milieux ruraux, il faut acquérir une compréhension intégrée de l'ensemble des dimensions d'un ,ouvrier' membre d'une communauté forestière. L'ouvrier est redéfini en mettant à contribution les connaissances et intérêts des géographes environnementaux et féministes. Cette définition met au jour un parti pris fondé sur le sexe dans les processus décisionnels en matière d'environnement et démontre de quelle façon le concept de la durabilité sociale s'en trouve artificiellement restreint dans la pratique. Les collaborations ne sont cependant jamais faciles àétablir. J'attire l'attention sur les difficultés potentielles de ces collaborations concernant notamment la mise en place de protocoles acceptables pour les deux parties, la promesse de tenir des débats constructifs et respectueux, et les stratégies visant à garantir que la recherche participe de manière vitale autant au développement de la théorie que des politiques publiques. [source] Integrating ecology with hydromorphology: a priority for river science and managementAQUATIC CONSERVATION: MARINE AND FRESHWATER ECOSYSTEMS, Issue 1 2009I.P. Vaughan Abstract 1.The assessment of links between ecology and physical habitat has become a major issue in river research and management. Key drivers include concerns about the conservation implications of human modifications (e.g. abstraction, climate change) and the explicit need to understand the ecological importance of hydromorphology as prescribed by the EU's Water Framework Directive. Efforts are focusing on the need to develop ,eco-hydromorphology' at the interface between ecology, hydrology and fluvial geomorphology. Here, the scope of this emerging field is defined, some research and development issues are suggested, and a path for development is sketched out. 2.In the short term, major research priorities are to use existing literature or data better to identify patterns among organisms, ecological functions and river hydromorphological character. Another early priority is to identify model systems or organisms to act as research foci. In the medium term, the investigation of pattern,processes linkages, spatial structuring, scaling relationships and system dynamics will advance mechanistic understanding. The effects of climate change, abstraction and river regulation, eco-hydromorphic resistance/resilience, and responses to environmental disturbances are likely to be management priorities. Large-scale catchment projects, in both rural and urban locations, should be promoted to concentrate collaborative efforts, to attract financial support and to raise the profile of eco-hydromorphology. 3.Eco-hydromorphological expertise is currently fragmented across the main contributory disciplines (ecology, hydrology, geomorphology, flood risk management, civil engineering), potentially restricting research and development. This is paradoxical given the shared vision across these fields for effective river management based on good science with social impact. A range of approaches is advocated to build sufficient, integrated capacity that will deliver science of real management value over the coming decades. Copyright © 2007 John Wiley & Sons, Ltd. [source] Sowing the Seeds: Anthropological Contributions to Agrobiodiversity StudiesCULTURE, AGRICULTURE, FOOD & ENVIRONMENT, Issue 2 2009James R. Veteto Abstract Agrobiodiversity studies have been a longstanding and current research focus of anthropological inquiry. This article gives an overview of important ongoing anthropological topics of agrobiodiversity research including conservation, cultural memory, farmer decision making, and homegarden studies. It also points to future directions in agrobiodiversity research that have been understudied to date including agrobiodiversity and its relationship to climate change and migration, the potential marriage of agrobiodiversity and food studies, agrobiodiversity in the Global North, and the incorporation of agrobiodiversity into emergent sustainable/alternative agriculture systems. Agricultural anthropology is suggested as a potential holistic subdiscipline for incorporating anthropological studies of agrobiodiversity, which are currently not unified by any theoretical framework. [source] The Role of Interest in Fostering Sixth Grade Students' Identities As Competent LearnersCURRICULUM INQUIRY, Issue 1 2000Jean C. Mcphail The combined works of John Dewey and Jerome Bruner provide a framework spanning a century of educational thought which can inform curriculum decisions concerning students' educational development, especially for middle school students whose waning of motivation toward school has been well documented by researchers and has long concerned parents and teachers. This framework, combined with recent contributions of motivation and interest researchers, can create broad understandings of how to collaboratively construct effective educational contexts. As early as 1913, Dewey specifically looked at the pivotal role of students' genuine interests in Interest and Effort in Education. Our current research focus on how students' interest can inform curricular contexts marks the recent shift showing an increased use of interest in education research since 1990. In this article, we discuss our study of a team-taught double classroom of sixth grade students whose interests were determined through a series of brainstorming sessions, and individual and focus group interviews. Students' interests fell into six categories centering around subject areas such as Drama, Science, and Animal Studies. Learning contexts were constructed around four of these subject areas. Students participated in their first or second choice of subject area group. We found significantly higher scores on measures of Affect and Activation if students participated in their first choice group. We found intra-group unities of preferred and dispreferred ways of learning which distinguished each group from the class as a whole. Finally, our findings indicated that students reliably described their genuine interests over time. Students' interests were found to be effective tools for informing curriculum decisions in the creation of sixth grade learning contexts. [source] Resilience thinking: Interview with Brian WalkerECOLOGICAL MANAGEMENT & RESTORATION, Issue 2 2007Tein McDonald Summary This interview with Brian Walker, chair of the research-based Resilience Alliance, outlines the main concepts and propositions behind ,resilience thinking' and touches on the importance of this paradigm for individuals and organizations involved in managing complex social-ecological systems. It refers to the origins, work and publications of the Resilience Alliance, listing and elaborating the key case studies used to illustrate the Alliance's main proposition that complex social-ecological systems do not behave in a predictable linear fashion. Rather, research indicates it is normal for complex systems to go through cycles of increasing and decreasing resilience and to have potential to shift, (in a self-organising way) to potentially undesirable states or entirely new systems if certain component variables are severely impacted by management. Such shifts can be novel and ,surprising', and are often not beneficial or desirable for societies. This is particularly the case where small-scale solutions push the problem upwards in a system, causing loss of resilience at a global scale. Predicting thresholds is therefore important to managers and is a key research focus for members of the Resilience Alliance who are currently building an accessible database to support decision-making in global natural resource management. [source] University of Michigan Addiction Research Center (UMARC): development, evolution, and directionADDICTION, Issue 6 2010Robert A. Zucker ABSTRACT A historical summary is provided of the evolution of the University of Michigan Addiction Research Center (UMARC) since its origins in 1988. Begun as an National Institutes of Health (NIH) research center within a Department of Psychiatry and focused solely upon alcohol and aging, early work emphasized treatment efficacy, differential outcome studies and characterization of the neurophysiological and behavioral manifestations of chronic alcoholism. Over the last 15 years, UMARC has extended its research focus along a number of dimensions: its developmental reach has been extended etiologically by studies of risk early in the life span, and by way of work on earlier screening and the development of early, brief treatment interventions. The addiction focus has expanded to include other drugs of abuse. Levels of analysis have also broadened, with work on the molecular genetics and brain neurophysiology underlying addictive processes, on one hand, and examination of the role of the social environment in long-term course of disorder on the other hand. Activities have been facilitated by several research training programs and by collaborative relationships with other universities around the United States and in Poland. Since 2002, a program for research infrastructure development and collaboration has been ongoing, initially with Poland and more recently with Ukraine, Latvia and Slovakia. A blueprint for the future includes expanded characterization of the neurobiology and genetics of addictive processes, the developmental environment, as well as programmatic work to address the public health implications of our ability to identify risk for disorder very early in life. [source] Patterns and causes of species richness: a general simulation model for macroecologyECOLOGY LETTERS, Issue 9 2009Nicholas J. Gotelli Abstract Understanding the causes of spatial variation in species richness is a major research focus of biogeography and macroecology. Gridded environmental data and species richness maps have been used in increasingly sophisticated curve-fitting analyses, but these methods have not brought us much closer to a mechanistic understanding of the patterns. During the past two decades, macroecologists have successfully addressed technical problems posed by spatial autocorrelation, intercorrelation of predictor variables and non-linearity. However, curve-fitting approaches are problematic because most theoretical models in macroecology do not make quantitative predictions, and they do not incorporate interactions among multiple forces. As an alternative, we propose a mechanistic modelling approach. We describe computer simulation models of the stochastic origin, spread, and extinction of species' geographical ranges in an environmentally heterogeneous, gridded domain and describe progress to date regarding their implementation. The output from such a general simulation model (GSM) would, at a minimum, consist of the simulated distribution of species ranges on a map, yielding the predicted number of species in each grid cell of the domain. In contrast to curve-fitting analysis, simulation modelling explicitly incorporates the processes believed to be affecting the geographical ranges of species and generates a number of quantitative predictions that can be compared to empirical patterns. We describe three of the ,control knobs' for a GSM that specify simple rules for dispersal, evolutionary origins and environmental gradients. Binary combinations of different knob settings correspond to eight distinct simulation models, five of which are already represented in the literature of macroecology. The output from such a GSM will include the predicted species richness per grid cell, the range size frequency distribution, the simulated phylogeny and simulated geographical ranges of the component species, all of which can be compared to empirical patterns. Challenges to the development of the GSM include the measurement of goodness of fit (GOF) between observed data and model predictions, as well as the estimation, optimization and interpretation of the model parameters. The simulation approach offers new insights into the origin and maintenance of species richness patterns, and may provide a common framework for investigating the effects of contemporary climate, evolutionary history and geometric constraints on global biodiversity gradients. With further development, the GSM has the potential to provide a conceptual bridge between macroecology and historical biogeography. [source] Geographies of Financialization in Disarray: The Dutch Case in Comparative PerspectiveECONOMIC GEOGRAPHY, Issue 1 2010Ewald Engelen abstract The securitization crisis that started in mid-2007 has demonstrated that we are indeed living in a "global financial village" and are all subject to the vagaries of financialization. Nevertheless, the fallout from the credit crisis has not been homogeneous across space. That some localities were hit harder than others suggests that there are distinct geographies of financialization. Combining insights from the "varieties of capitalism" literature with those from the literature on "financialization studies," the article offers a first take on what may explain these different geographies on the basis of an informal comparison of the trajectories of financialization and their political repercussions in the United States, Germany, and the Netherlands. The article ends with some reflections on how economic geography could be enriched by combining comparative studies on institutionalism and financialization, while its distinct research focus,detailed spatial analysis endowed with a well-developed sensitivity for geographic variegation,may help overcome the methodological nationalism of much comparative institutionalism. [source] Personality and absenteeism: a meta-analysis of integrity testsEUROPEAN JOURNAL OF PERSONALITY, Issue S1 2003Deniz S. Ones Until recently, research focus has been on a variety of demographic, attitudinal, and organizational variables in predicting and explaining absenteeism. If personality traits predict absenteeism, then it may be possible to use measures of these traits to identify and select job applicants and thereby reduce absenteeism rates. In this research, our goal was to examine whether integrity tests could be used to predict absenteeism. Meta-analysis was applied to studies of the validity of pre-employment integrity tests for predicting voluntary absenteeism. Twenty-eight studies based on a total sample of 13,972 were meta-analysed. The estimated mean predictive validity of personality-based integrity tests was 0.33. This operational validity generalized across various predictor scales, organizations, settings, and jobs (SD,,=,0.00). Overt integrity tests, however, showed much lower predictive validity for absenteeism and greater variability than personality-based tests (,,=,0.09; SD,,=,0.16). The results indicate that a personnel selection approach to reducing absenteeism in organizations may be a useful strategy, particularly if personality-based integrity tests are utilized. Potential explanations for differences between these results and those found for Big Five measures of personality are offered. Future research investigating models of absenteeism should incorporate the personality constructs assessed by integrity tests. Copyright © 2003 John Wiley & Sons, Ltd. [source] Chlorophyll fluorescence, predawn water potential and photosynthesis in precipitation pulse-driven ecosystems , implications for ecological studiesFUNCTIONAL ECOLOGY, Issue 3 2008V. Resco Summary 1A major research focus in population and community ecology is to establish a mechanistic understanding of plant interactions and demographic responses. The first step towards this mechanistic approach relies on understanding the differences in stress caused by different environmental conditions. Leaf-level photosynthetic rate (A) within and among plant populations provides important insight into population and community processes, but is difficult to acquire with sufficient replication under field conditions. Instead, chlorophyll fluorescence (Fv/Fm) and predawn water potential (,pd) are often used in arid and semi-arid ecosystems. 2Fv/Fm reflects the photoactivation status of photosystem II (PSII), whereas ,pd indicates water availability in the rhizosphere. Here we compare these indices with A in two perennial C4 grasses (native Heteropogon contortus and invasive Eragrostis lehmanniana) and in seedlings of the C3 shrub Prosopis velutina growing on highly contrasting sandy loam and loamy clay soils in experimental plots. Measurements were made the day prior to and up to 7 days following a 39-mm rainfall pulse after 2 months of drought. 3A was more sensitive across a broad range of environmental conditions, whereas Fv/Fm and ,pd only responded to periods of protracted drought. The use of these measures was further complicated because their values varied daily and we observed different time-lags in their response to precipitation pulses. 4We suggest sampling schemes and a priori measurements to capture the value that is representative for the question of interest, and that match the pulsed biological activity in these ecosystems. Finally, we suggest the use of these measures in combination with measurements providing integration over longer time periods, such as ,13C, ,18O and N concentration in bulk leaf tissue. [source] A multidimensional conceptual framework for analysing public involvement in health services researchHEALTH EXPECTATIONS, Issue 1 2008Sandy R. Oliver BA PhD Abstract Objective To describe the development of a multidimensional conceptual framework capable of drawing out the implications for policy and practice of what is known about public involvement in research agenda setting. Background Public involvement in research is growing in western and developing countries. There is a need to learn from collective experience and a diverse literature of research, policy documents and reflective reports. Methods Systematic searches of research literature, policy and lay networks identified reports of public involvement in research agenda setting. Framework analysis, previously described for primary research, was used to develop the framework, which was then applied to reports of public involvement in order to analyse and compare these. Findings The conceptual framework takes into account the people involved; the people initiating the involvement; the degree of public involvement; the forum for exchange; and methods used for decision making. It also considers context (in terms of the research focus and the historical, geographical or institutional setting), and theoretical basis. Conclusions The framework facilitates learning across diverse experiences, whether reported in policy documents, reflections or formal research, to generate a policy- and practice-relevant overview. A further advantage is that it identifies gaps in the literature which need to be filled in order to inform future research about public involvement. [source] Lifting the Curse: Overcoming Persistent Undernutrition in IndiaIDS BULLETIN, Issue 4 2009Lawrence Haddad With rapid economic growth and little progress in banishing undernutrition, India is an economic powerhouse and a nutritional weakling. This article surveys the others in this collection and concludes that such a situation represents a failure of governance at many levels. The article suggests a number of ways in which the state and civil society in India can strengthen the governance of nutrition in terms of capability, responsiveness and accountability. It also calls for more frequent data collection on nutrition service delivery and nutrition outcomes so that the state and civil society can sustain pressure on the need to improve nutrition. Finally, the outlines of a new research focus are described. [source] Tightest constraint first: An efficient delay sensitive multicast routing algorithmINTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS, Issue 7 2005Gang FengArticle first published online: 1 APR 200 Abstract As a key issue in multicast routing with quality of service (QoS) support, constrained minimum Steiner tree (CMST) problem has been a research focus for more than a decade, and tens of heuristics have been developed to solve this NP-complete problem. Among all the previously proposed algorithms, the bounded shortest path algorithm (BSMA) (IEEE INFOCOM'95 1995; 1:377,385) have been proved to be capable of producing a multicast tree that has on average the lowest cost. However, such an excellent cost performance is accompanied with an extremely high time complexity. Recently, Feng et al. presented an alternative implementation of BSMA, which makes use of the latest research results on the delay-constrained least cost (DCLC) routing problem. Simulations indicate that, in comparison with the original implementation, the alternative implementation has a much lower time complexity with virtually identical cost performance, and it also runs much faster than many renowned heuristics such as KPP (IEEE/ACM Trans. Networking 1993; 1(3):286,292) and CAO (The design and evaluation of routing algorithms for real-time channels. Technical Report ICSI TR-94-024, International Computer Science Institute, University of California at Berkeley, June 1994). In this paper, we propose a brand new heuristic TCF, which is based on an idea called ,tightest constraint first.' TCF runs a DCLC heuristic only once for each destination and therefore has a provably low time complexity. We further propose an iterative heuristic ITCF, which uses TCF to obtain an initial tree and then gradually refines it. Extensive simulations demonstrate that, in the average sense, TCF can achieve a cost performance comparable to or better than that of BSMA, the cost performance of ITCF is even better than that of TCF, TCF runs approximately twice as fast as ITCF, and ITCF runs 2,4 times as fast as the best implementation of BSMA. Copyright © 2005 John Wiley & Sons, Ltd. [source] The Swiss Federal Dairy Research StationINTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY, Issue 1 2003Max Rüegg The Federal Dairy Research Station (FAM) was established at the beginning of the last century. It is one of six agricultural research stations of the Swiss Department of Agriculture and the leading national research institute in dairy technology and consulting. It is part of the Swiss Centre of Competence for Animal Production and Foods of Animal Origin. Its mission is to improve the competitive position of the Swiss milk producers and dairy industry. The institute is organized into three functional areas corresponding to its well-established core competencies: (1) production of raw milk cheese and microorganisms for fermentation, (2) knowledge transfer and consultation for the dairy industry and beekeeping, and (3) testing of, and providing expertise on dairy and bee products. Research work is carried out using a multidisciplinary approach in a matrix organization. Two product- and customer-orientated technology units and one unit for consulting, contractual work and other services for the dairy industry are supported in their projects by three scientific and technical units (microbiology; chemistry, physics and sensory analysis; engineering and production) as well as by a unit offering central services. The 4-year research programmes are based on the strategic goals of the agricultural policy as well as on the current needs of the dairy industry. An advisory board oversees the preparation and execution of the projects. FAM is connected to an international network for both scientific work and supervisory tasks. Work is carried out within the background of the political strategy of a sustainable development including economic, ecological and social aspects. A primary research focus is therefore the avoidance of excessive processing of milk and dairy products, and keeping products natural and free of residues by applying only minimal, unavoidable treatments and additives. [source] Archaeology of a Naval Battlefield: H. L. Hunley and USS HousatonicINTERNATIONAL JOURNAL OF NAUTICAL ARCHAEOLOGY, Issue 1 2006David L. Conlin The American Civil War shipwrecks H. L. Hunley and USS Housatonic have been the focus of intensive archaeological investigations since the discovery of Hunley in 1995. H. L. Hunley, the world's first successful combat submarine, sank the Union blockader USS Housatonic in 1864, but sank immediately afterwards. In work done prior to the recovery of Hunley in 2000, site-formation processes for both vessels were a primary research focus,a necessary precursor to identifying battlefield behaviour. This paper presents research on the Hunley/Housatonic Naval Engagement Site, where both wrecks are treated as complementary components of a single battlefield site. © 2006 The Authors [source] Organized International Asylum-Seeker Networks: Formation and Utilization by Chinese Students1INTERNATIONAL MIGRATION REVIEW, Issue 2 2006Jia Gao This article examines the formation and role of international networks formed by Chinese students living in the West in the late 1980s and early 1990s as part of their efforts to obtain the right to remain in Western countries in the immediate aftermath of the Tiananmen Square violence of June 4, 1989. Various forms of migrant social networks have been a research focus in international refugee and migration studies, but international networks formed by asylum seekers themselves, and their role in asylum-seeking processes, have been largely ignored. This article is based on a multi-method comparative study of Chinese students living in Australia and the United States at the time. Their experience provides data for examining and conceptualizing the role of organized international asylum-seeker networks in the asylum-seeking process. The analysis focuses on Chinese student lobbying in 1989, led by an independent Chinese student union, which helped "the Pelosi Bill" to be passed by the U.S. Congress. The main strategies adopted by Chinese students in the United States and Australia, as well as their internationally coordinated actions, are compared. Also examined is the role of two politicized international Chinese student organizations, the Chinese Alliance for Democracy and the Federation for Democratic China, in assisting students with obtaining residence. [source] Coalition Cabinet Decision Making: Institutional and Psychological Factors,INTERNATIONAL STUDIES REVIEW, Issue 1 2008Juliet Kaarbo This essay reviews the intersection between institutional and psychological conditions that occurs in multiparty coalition cabinets and the effects on foreign policy and decision making. Parallel research in social psychology and foreign policy can provide clues to the underlying mechanisms linking institutional context to policymaking and policy choices. The psychological processes involved in group polarization, persuasion, and other influence strategies as well as psychological factors affecting the quality of decision making are important in coalition cabinets and are reinforced by the particular institutional dynamics of multiparty governance. Indeed, this essay proposes that future research focus on contingency factors in the policymaking process, given the competing views on the effects of multiple advocacy on the quality of decision making and on the types of foreign policies associated with multiparty cabinets. More broadly, this essay supports the view that a highly structural understanding of the effects of institutions on politics and policies is incomplete and that research on the interplay among structures and human agents is critical. [source] Annotation: Early intervention and prevention of self-injurious behaviour exhibited by young children with developmental disabilitiesJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 1 2008D. M. Richman Abstract The ontogeny of self-injurious behaviour exhibited by young children with developmental delays or disabilities is due to a complex interaction between neurobiological and environmental variables. In this manuscript, the literature on emerging self-injury in the developmental disability population is reviewed with a focus on an operant conceptual model of how topographies of self-injurious behaviour can change structurally and become sensitive to various environmental consequences. Results of previous studies are reviewed in terms of extending our research focus from a reactive model of assessment and treatment of well-established cases of self-injury to an early intervention and prevention model. [source] Normal and Abnormal Personality Traits: Evidence for Genetic and Environmental Relationships in the Minnesota Study of Twins Reared ApartJOURNAL OF PERSONALITY, Issue 5 2002Kristian E. Markon ABSTRACT Recent studies have demonstrated substantial correlations between normal and abnormal personality traits. Yet little is known about how these correlations are mediated genetically and environmentally: Do normal and abnormal personality traits stem from the same underlying genes and environments? We addressed this question using data from 128 monozygotic and dizygotic twin pairs in the Minnesota Study of Twins Reared Apart (MISTRA). Additive genetic and nonshared environmental correlations between scales of the Minnesota Multiphasic Personality Inventory (MMPI),an index of abnormal personality,and the Multidimensional Personality Questionnaire (MPQ),an index of normal personality,were estimated. Results indicated that phenotypic correlations between normal and abnormal personality were mediated by genetic as well as environmental factors, although the magnitude of genetic mediation tended to be larger overall. Moreover, the patterns of phenotypic, genetic, and environmental relationships among the scales were similar, suggesting that influences on normal and abnormal personality act through systems common to both. It is suggested that future research focus on the neurogenetic substrates of these shared systems and how dysfunction in these systems influences development of disordered personality. [source] Chemokine receptor antagonists: a novel therapeutic approach in allergic diseasesALLERGY, Issue 12 2004J. Elsner The aim of this review is to give an overview of the role of chemokines, particularly ligands of the CC chemokine receptor CCR3, in allergic diseases and to show the new concept in the treatment of allergies using chemokine receptor antagonists. Allergic diseases such as allergic asthma, allergic rhinitis and atopic dermatitis are characterized by a complex interaction of different cell types and mediators. Among this, Th2 cells, mast cells, basophils and eosinophils are found in the inflamed tissue due to the attraction of chemokines. Of all the known chemokine receptors, the chemokine receptor CCR3 seems to play the major role in allergic diseases which is supported by the detection of this receptor on the cell types mentioned above. Therefore, academic and industrial research focus on compounds to block this receptor. To date, certain chemokine receptor antagonists derived from peptides and small molecules exist to block the chemokine receptor CCR3. However, the in vivo data about these compounds and the mechanisms of receptor interaction are poorly understood, as yet. For the development of additional chemokine receptor antagonists, more details about the interaction between the ligands and their receptors are required. Therefore, additional studies will lead to the identification of novel CCR3 chemokine receptor antagonists, which can be therapeutically used in allergic asthma, allergic rhinitis, and atopic dermatitis. [source] Parentage versus two-generation analyses for estimating pollen-mediated gene flow in plant populationsMOLECULAR ECOLOGY, Issue 8 2005JAROSLAW BURCZYK Abstract Assessment of contemporary pollen-mediated gene flow in plants is important for various aspects of plant population biology, genetic conservation and breeding. Here, through simulations we compare the two alternative approaches for measuring pollen-mediated gene flow: (i) the neighborhood model , a representative of parentage analyses, and (ii) the recently developed twogener analysis of pollen pool structure. We investigate their properties in estimating the effective number of pollen parents (Nep) and the mean pollen dispersal distance (,). We demonstrate that both methods provide very congruent estimates of Nep and ,, when the methods' assumptions considering the shape of pollen dispersal curve and the mating system follow those used in data simulations, although the neighborhood model exhibits generally lower variances of the estimates. The violations of the assumptions, especially increased selfing or long-distance pollen dispersal, affect the two methods to a different degree; however, they are still capable to provide comparable estimates of Nep. The neighborhood model inherently allows to estimate both self-fertilization and outcrossing due to the long-distance pollen dispersal; however, the twogener method is particularly sensitive to inflated selfing levels, which in turn may confound and suppress the effects of distant pollen movement. As a solution we demonstrate that in case of twogener it is possible to extract the fraction of intraclass correlation that results from outcrossing only, which seems to be very relevant for measuring pollen-mediated gene flow. The two approaches differ in estimation precision and experimental efforts but they seem to be complementary depending on the main research focus and type of a population studied. [source] Researching emotion: the need for coherence between focus, theory and methodologyNURSING INQUIRY, Issue 1 2004Jan Savage There is a longstanding awareness of the significance of emotion in nursing and yet it remains one of the more elusive areas of practice. Surprisingly, there has been little discussion in the nursing literature of how the phenomenon of emotion might be understood or studied. This paper gives an overview of theoretical and methodological approaches to emotion, and how the researcher's emotions may inform the research process. In addition, it draws on ethnographic research exploring the role of emotion in the practice and clinical supervision of a group of psychosexual nurses undergoing Balint seminar training to help highlight some of the inherent problems of researching emotion. The paper argues that these sorts of problems may be avoided or reduced by ensuring coherence between the research focus, the way emotion is theorised, and the methodological approach of the study. [source] Urine flowing: A phenomenological study of living with a urinary catheter,RESEARCH IN NURSING & HEALTH, Issue 1 2002Mary H. Wilde Abstract The experience of living with a long-term urinary catheter was investigated with a community-dwelling sample of 14 adults ranging in age from 35 to 95 who had worn a catheter for 6 months to 18 years. Data were obtained by audiotaped face-to-face interviews. Merleau-Ponty's phenomenology and van Manen's methodology guided the study. Living with a urinary catheter was found to be like living with the forces of flowing water. People were keenly aware of the flow of urine through their catheters, and they noticed when their bags needed emptying or when urine drainage seemed sluggish or obstructed. The metaphor of urine flowing like water may provide a teaching heuristic for assisting clients in adjusting to living with a catheter. Implications for further research focus on understanding the relationship between sensitivity to the dynamics of urine flow and urinary tract infection. © 2002 John Wiley & Sons, Res Nurs Health 25:14,24, 2002. [source] Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial,ARTHRITIS & RHEUMATISM, Issue 11 2009Eva C. Koffeman Objective Induction of immune tolerance to maintain clinical control with a minimal drug regimen is a current research focus in rheumatoid arthritis (RA). Accordingly, we are developing a tolerization approach to dnaJP1, a peptide part of a pathogenic mechanism that contributes to autoimmune inflammation in RA. We undertook this study to test 2 hypotheses: 1) that mucosal induction of immune tolerance to dnaJP1 would lead to a qualitative change from a proinflammatory phenotype to a more tolerogenic functional phenotype, and 2) that immune deviation of responses to an inflammatory epitope might translate into clinical improvement. Methods One hundred sixty patients with active RA and with immunologic reactivity to dnaJP1 were enrolled in a pilot phase II trial. They received oral doses of 25 mg of dnaJP1 or placebo daily for 6 months. Results The dnaJP1 peptide was safe and well-tolerated. In response to treatment with dnaJP1, there was a significant reduction in the percentage of T cells producing tumor necrosis factor , and a corresponding trend toward an increased percentage of T cells producing interleukin-10. Coexpression of a cluster of molecules (programmed death 1 and its ligands) associated with T cell regulation was also found to be a prerequisite for successful tolerization in clinical responders. Analysis of the primary efficacy end point (meeting the American College of Rheumatology 20% improvement criteria at least once on day 112, 140, or 168) showed a difference between treatment groups that became significant in post hoc analysis using generalized estimating equations. Differences in clinical responses were also found between treatment groups on day 140 and at followup. Post hoc analysis showed that the combination of dnaJP1 and hydroxychloroquine (HCQ) was superior to the combination of HCQ and placebo. Conclusion Tolerization to dnaJP1 leads to immune deviation and a trend toward clinical efficacy. Susceptibility to treatment relies on the coexpression of molecules that can down-regulate adaptive immunity. [source] Development of a fully automated macromolecular crystallization/observation robotic system, HTS-80ACTA CRYSTALLOGRAPHICA SECTION D, Issue 6 2005Hideyuki Miyatake A robotic system has been developed to be used for macromolecular crystallization and observation in typical university laboratories with a research focus on protein crystallography. The system consists of three major parts: a dispenser unit, a storage unit and an observation unit. This system is designed to automatically perform all of the processes involved in crystallization and observation without requiring any manual operations. The dispenser and observation units can carry out both sitting-drop vapor-diffusion procedures and microbatch procedures. With this system, the procedures are controlled by a personal computer running GUI-based software. After the dispensing of protein solution into the crystallization plates, they are automatically transferred to the storage units, followed by automatic observation according to a required schedule with arbitrary intervals. At each stage of crystallization, droplets in the crystallization plates are examined by original image-processing software in order to evaluate the appearance of the crystals. [source] Using a research framework to identify knowledge gaps in research on food marketing to children in AustraliaAUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 3 2009Kathy Chapman Abstract Objective: Research in the field of food marketing to children requires a better understanding of the research gaps in order to inform policy development. The purpose of this paper was to propose a framework for classifying food marketing research, using Australian research on food marketing to children to demonstrate how this framework can be used to determine knowledge gaps. Approach: A literature review of research databases and ,grey' material was conducted to identify research from the previous 10 years. Studies were classified according to their research focus, and media type, as either: exposure, including content analyses; effects of exposure, including opinions, attitudes and actions resulting from food marketing exposure; regulations, including the type and level of regulation that applies to food marketing; or breaches of regulations, including instances where marketing regulations have been violated. Conclusion: The majority of Australian research on food marketing to children has focused on television advertising and exposure research. Research has consistently shown that the content of food marketing directed at children is predominately for unhealthy foods. There is a lack of research on the effects of food marketing, which would be valuable to inform policy. Implications: The development of a logical framework for food marketing research allows for the identification of research gaps and enables research priorities to be identified. [source] Functioning and disability in bipolar disorders: a systematic review of literature using the ICF as a referenceBIPOLAR DISORDERS, Issue 5 2010Carolina C Ávila Ávila CC, Cabello M, Cieza A, Vieta E, Ayuso-Mateos JL. Functioning and disability in bipolar disorders: a systematic review of literature using the ICF as a reference. Bipolar Disord 2010: 12: 473,482. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S. Objectives:, To systematically identify and examine the frequency of use of concepts contained in outcome variables across bipolar disorder (BD) studies using the International Classification of Functioning, Disability and Health (ICF) as a reference. Methods:, Original studies published between 2000 and 2006 were located on the MEDLINE and PsycINFO databases and selected according to predetermined criteria. Outcome variables were extracted, and concepts contained therein were linked to the ICF. Results:, A total of 109 final studies were included. The concepts contained in these studies were linked to 145 different ICF categories. ICF category b152, emotional functions, was the most frequently represented category, appearing in 94% of the publications, followed by b126, temperament and personality functions (73%). E110, products or substances for personal consumption, and e580, health services, systems, and policies, appeared in 68% of the studies. Conclusions:, The present systematic review reflects the research focus of the literature on BD in recent years. Most of the studies performed concentrate on body functions rather than activities and participation domains. Experimental studies are mostly pharmacological, reflecting the need to study nonpharmacological interventions. Furthermore, our study shows that outcome variables used in studies with persons with BD can, to a large extent, be mapped to the ICF. [source] | |||||||||||||||||||||||||