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Research Fellow (research + fellow)
Selected AbstractsStructure and biology of complement protein C3, a connecting link between innate and acquired immunityIMMUNOLOGICAL REVIEWS, Issue 1 2001Arvind Sahu Summary: Complement protein C3 is a central molecule in the complement system whose activation is essential for all the important functions performed by this system. After four decades of research it is now well established that C3 functions like a double-edged sword: on the one hand it promotes phagocytosis, supports local inflammatory responses against pathogens, and instructs the adaptive immune response to select the appropriate antigens for a humoral response; on the other hand its unregulated activation leads to host cell damage. In addition, its interactions with the proteins of foreign pathogens may provide a mechanism by which these microorganisms evade complement attack. Therefore, a clear knowledge of the molecule and its interactions at the molecular level not only may allow the rational design of molecular adjuvants but may also lead to the development of complement inhibitors and new therapeutic agents against infectious diseases. A.S. is a Wellcome Trust Overseas Senior Research Fellow in Biomedical Science in India. This research was supported by National Institutes of Health grants AI 30040, GM 56698, HL28220, and AI 48487. [source] Parkinson's Disease Society 6th Spring Conference for ResearchersPROGRESS IN NEUROLOGY AND PSYCHIATRY, Issue 6 2009Lynn Bedford The Parkinson's Disease Society's 6th Spring Conference for Researchers was held in London in May, entitled ,Parkinson's Disease:The Pieces of the Puzzle'. Here, Dr Lynn Bedford, Parkinson's Disease Society Senior Research Fellow, reports on some of the highlights of the conference, including the latest genetic research, the importance of pre-motor symptoms and the therapeutic potential of the peptide exendin-4, found in the saliva of a poisonous lizard. Copyright © 2009 Wiley Interface Ltd [source] Social relationships and friendships among young people with Down's syndrome in secondary schoolsBRITISH JOURNAL OF SPECIAL EDUCATION, Issue 2 2002Pat Cuckle More young people with Down's syndrome are being taught in mainstream schools and interest in the educational aspect of inclusion has grown over the last few years. In this article Pat Cuckle, Senior Research Fellow at the University of Leeds, and June Wilson, a support teacher working for Education Leeds, explore patterns of friendship and social relationships among teenagers with Down's syndrome. The young people who took part in the study either attend mainstream schools or resourced provision in mainstream schools. The enquiry provides fascinating insights into the participants' views of friendship and into the range of their social experiences. Pat Cuckle and June Wilson conclude their report with a set of recommendations focusing on the need to create more opportunity for social interaction for young people with special needs. [source] Erratum: MR imaging in assessing cardiovascular interventions and myocardial injuryCONTRAST MEDIA & MOLECULAR IMAGING, Issue 2 2007Alexis Jacquier Contrast Media and Molecular Imaging, MR imaging in assessing cardiovascular interventions and myocardial injury, Alexis Jacquier, Charles B. Higgins and Maythem Saeed, published in CMMI 2:1, DOI: 10.1002/cmmi122, pp1,15. Contract/Grant Sponsor information relating to Dr. A. Jacquier was absent from the published article. It should be noted that Dr. A. Jacquier was supported by the Société Française de Radiologie, Paris, as a research fellow. [source] Connectedness: Developing a Shared Construction of Affect and Cognition in Children with AutismBRITISH JOURNAL OF SPECIAL EDUCATION, Issue 1 2004Dave Sherratt Dave Sherratt and Gill Donald teach children with autism at Mowbray School, North Yorkshire. Dave Sherratt also teaches at the University of Birmingham and is honorary research fellow at the University College of York St John. Gill Donald is also a specialist speech and language therapist for Hambleton and Richmondshire Primary Care Trust. In this article, Dave Sherratt and Gill Donald outline an approach to teaching children who are on the autistic spectrum. They describe the social construction of understanding in normally developing children and suggest ways in which this differs in children with autism. These children may have difficulties in attributing relevance to the aspects of experience that are regarded as significant by most learners. The authors suggest that this may account for the poverty in social engagement or connectedness commonly observed in children with autism. Illustrating their propositions with vivid examples from practice, Dave Sherratt and Gill Donald go on to describe ten teaching structures promoting progress from early social engagement; through a shared understanding of objects and observable processes; to a shared understanding of symbolic representation in play, ideas and language. These structures, rooted in a fascinating evocation of theory, will help practitioners striving to develop a shared understanding of self, others and the environment in children with autistic spectrum disorders. [source] On the Future of Reanimatology,ACADEMIC EMERGENCY MEDICINE, Issue 1 2000Peter Safar MD Abstract: This article is adapted from a presentation given at the 1999 SAEM annual meeting by Dr. Peter Safar. Dr. Safar has been involved in resuscitation research for 44 years, and is a distinguished professor and past initiating chairman of the Department of Anesthesiology and Critical Care Medicine at the University of Pittsburgh. He is the founder and director of the Safar Center for Resuscitation Research at the University of Pittsburgh, and has been the research mentor of many critical care and emergency medicine research fellows. Here he presents a brief history of past accomplishments, recent findings, and future potentials for resuscitation research. Additional advances in resuscitation, from acute terminal states and clinical death, will build upon the lessons learned from the history of reanimatology, including optimal delivery by emergency medical services of already documented cardiopulmonary cerebral resuscitation, basic-advanced,prolonged life support, and future scientific breakthroughs. Current controversies, such as how to best educate the public in life-supporting first aid, how to restore normotensive spontaneous circulation after cardiac arrest, how to rapidly induce mild hypothermia for cerebral protection, and how to minimize secondary insult after cerebral ischemia, are discussed, and must be resolved if advances are to be made. Dr. Safar also summarizes future technologies already under preliminary investigation, such as ultra-advanced life support for reversing prolonged cardiac arrest, extending the "golden hour" of shock tolerance, and suspended animation for delayed resuscitation. [source] Kisspeptin: A Novel Regulator of Reproductive FunctionJOURNAL OF NEUROENDOCRINOLOGY, Issue 8 2008W. S. Dhillo Young Neuroendocrinologists Prize Reviews Michael Harbuz Young Investigator Prize Lecture The UK and international neuroendocrine community was deeply shocked and saddened the unbelievably premature death of Michael Harbuz in Bristol in 2006. Mick was a superb friend and colleague, and played a huge part in the development and activities of the British Neuroendocrine Group/British Society for Neuroendocrinology (BSN), serving as both Membership Secretary and Treasurer between 1999 and 2004. Mick was a leader in the field of neuroendocrine,immune interactions, and brought a great deal of charisma, humour and ability to meetings and conferences. He was also a passionate and committed supporter of the progress of young researchers and of their participation in neuroendocrine events. He recognised that today's postgraduate students and postdoctoral research fellows are tomorrow's neuroendocrine researchers, be it in academia, the health services or industry. To recognise Mick's great commitment to and enthusiasm for postgraduate education both in the University of Bristol and in the BSN, we decided to honour and remember him by instituting the ,Michael Harbuz Young Investigator Prize Lecture' to be delivered annually. Dr Waljit Dhillo from Imperial College London was the inaugural recipient of this award, and presented his lecture at the Annual Meeting of the BSN in Nottingham in September 2007, upon which this review is based. Recent evidence demonstrates that the neuropeptide kisspeptin and its receptor, GPR54, have a fundamental role in initiating the onset of puberty and are important in regulating reproductive function. This review discusses the evidence available from animals and humans demonstrating that kisspeptin potently stimulates the release of gonadotrophins by stimulating the release of gonadotrophin-releasing hormone and that a lack of kisspeptin or GPR54 results in reproductive failure. [source] Use of preventive measures for air travel-related venous thrombosis in professionals who attend medical conferencesJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 11 2006S. KUIPERS Summary.,Background:,Lack of guidelines for prevention of air travel-related venous thrombosis may lead to excessive use of potentially dangerous precautions. Objectives:,To assess the use of preventive measures for air travel-related thrombosis in professionals employed in the field of thrombosis and hemostasis and in other fields. Methods:,A survey amongst delegates of the XXth ISTH Congress, the 15th ISDB Congress and the 13th Cochrane Colloquium, which all took place in Australia 2005. Results:,Two thousand and eighty-nine questionnaires were completed (response 53%). Overall, 80% of the respondents had used preventive measures. Low-molecular-weight heparin and vitamin K antagonists were mostly used by ISTH delegates (10% vs. 1% at the other conferences). Medical doctors used more pharmacological prophylaxis (31%) than research fellows (11%) and non-clinical scientists (22%). Dutch (64%) and Asian respondents (67%) least used any prevention, whereas Israeli used most (94%). Subjects with risk factors for thrombosis more often used prophylaxis (90%) than those without (77%). In a multivariate analysis, conference, nationality, age, presence of risk factors and profession were determinants of prophylaxis use. Conclusion:,Major differences in the use of prophylactic measures for air travel-related thrombosis stress the need for studies of interventions and clear guidelines on prevention of air travel-related venous thrombosis. [source] | ||||||||||