Home About us Contact
|
Home About us Contact | ||
|
|
||
Research Developments (research + development)
Selected AbstractsDecision-making method using a visual approach for cluster analysis problems; indicative classification algorithms and grouping scopeEXPERT SYSTEMS, Issue 3 2007Ran M. Bittmann Abstract: Currently, classifying samples into a fixed number of clusters (i.e. supervised cluster analysis) as well as unsupervised cluster analysis are limited in their ability to support ,cross-algorithms' analysis. It is well known that each cluster analysis algorithm yields different results (i.e. a different classification); even running the same algorithm with two different similarity measures commonly yields different results. Researchers usually choose the preferred algorithm and similarity measure according to analysis objectives and data set features, but they have neither a formal method nor tool that supports comparisons and evaluations of the different classifications that result from the diverse algorithms. Current research development and prototype decisions support a methodology based upon formal quantitative measures and a visual approach, enabling presentation, comparison and evaluation of multiple classification suggestions resulting from diverse algorithms. This methodology and tool were used in two basic scenarios: (I) a classification problem in which a ,true result' is known, using the Fisher iris data set; (II) a classification problem in which there is no ,true result' to compare with. In this case, we used a small data set from a user profile study (a study that tries to relate users to a set of stereotypes based on sociological aspects and interests). In each scenario, ten diverse algorithms were executed. The suggested methodology and decision support system produced a cross-algorithms presentation; all ten resultant classifications are presented together in a ,Tetris-like' format. Each column represents a specific classification algorithm, each line represents a specific sample, and formal quantitative measures analyse the ,Tetris blocks', arranging them according to their best structures, i.e. best classification. [source] Leadership in research development in nursingINTERNATIONAL NURSING REVIEW, Issue 4 2008Editor, Jane J. A. Robinson FRCN No abstract is available for this article. [source] An exploration of research into substance misuse and psychiatric disorder in the UK: what can we learn from history?CRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 4 2007Ilana B. Crome Background and aim,This review explores UK-based research developments in substance misuse and mental illness over the last 25 years. The main body of work comprises policy-orientated projects funded by the Department of Health from the late 1990s. Early research tended to focus on alcohol, especially alcoholic hallucinosis: the relationship of the latter with schizophrenia-like illness was examined, with the finding that very few cases did develop into schizophrenia. Method and implications,Parallels are drawn with the current debate around the link between cannabis and psychosis, urging caution in too rapid an assertion that cannabis is necessarily ,causal'. The clinical and policy implications of the misinterpretation of evidence are discussed. A proposal is put forward that the genesis of psychotic illness in alcohol misuse be revisited using more sophisticated research methodologies. Given the changing landscape of substance use in the UK, particularly the fashion of polysubstance use and the recognition that this is associated with psychotic illness, other drugs that are associated with psychotic illness should be similarly investigated to determine whether there is a common mechanism that might throw light on understanding the relationship between substance use and psychotic illness or schizophrenia. Copyright © 2007 John Wiley & Sons, Ltd. [source] Monoamine reuptake inhibitors: highlights of recent research developmentsDRUG DEVELOPMENT RESEARCH, Issue 3 2005Magnus W. WalterArticle first published online: 21 NOV 200 Abstract Monoamine reuptake inhibitors are in clinical use for the treatment of major psychiatric disorders. Selective serotonin reuptake inhibitors are widely used in the treatment of depression. Selective norepinephrine reuptake inhibitors are used in the treatment of ADHD and depression. Compounds that enhance multiple monoamines appear to have synergistic effects and have been used for various indications. This review presents highlights from the literature on monoamine reuptake inhibitors published between 2000 and July 2005. It focuses on novel structure-activity relationship studies in established classes of monoamine reuptake inhibitors and structurally novel types. Drug Dev. Res. 65:97,118, 2005. © 2005 Wiley-Liss, Inc. [source] Bacteria used in the biological control of plant-parasitic nematodes: populations, mechanisms of action, and future prospectsFEMS MICROBIOLOGY ECOLOGY, Issue 2 2007Baoyu Tian Abstract As a group of important natural enemies of nematode pests, nematophagous bacteria exhibit diverse modes of action: these include parasitizing; producing toxins, antibiotics, or enzymes; competing for nutrients; inducing systemic resistance of plants; and promoting plant health. They act synergistically on nematodes through the direct suppression of nematodes, promoting plant growth, and facilitating the rhizosphere colonization and activity of microbial antagonists. This review details the nematophagous bacteria known to date, including parasitic bacteria, opportunistic parasitic bacteria, rhizobacteria, Cry protein-forming bacteria, endophytic bacteria and symbiotic bacteria. We focus on recent research developments concerning their pathogenic mechanisms at the biochemical and molecular levels. Increased understanding of the molecular basis of the various pathogenic mechanisms of the nematophagous bacteria could potentially enhance their value as effective biological control agents. We also review a number of molecular biological approaches currently used in the study of bacterial pathogenesis in nematodes. We discuss their merits, limitations and potential uses. [source] Barriers to, and facilitators of, research utilisation: a survey of Hong Kong registered nursesINTERNATIONAL JOURNAL OF EVIDENCE BASED HEALTHCARE, Issue 2 2006David R Thompson RN BSc MA PhD MBA FRCN FESC Abstract Aim, Despite increasing efforts to promote the utilisation of research in daily nursing practice it is apparent that there are a number of obstacles to address. This paper reports a study to examine the barriers to, and facilitators of, research utilisation among registered nurses in Hong Kong. Methods, A survey design and a random sampling method was used. The final sample consisted of 1487 registered nurses working in private and public health-care sectors in Hong Kong. A bilingual version of the Research Utilisation Questionnaire, comprising a 31-item barriers scale, and an 8-item facilitators scale was used. The instrument was mailed to participants who were asked to return the completed questionnaire by mail. Results, The highest ranking barriers to research utilisation reported by respondents were related mainly to organisational factors with regards to inadequate facilities, no authority to change procedures, and time constraints. Hong Kong nurses, however, did not appear to see any problem with regards to items related to characteristics of research, such as conclusions drawn from research being justified, research articles not being published fast enough, and literature reporting conflicting results. This indicates that nurses are aware of research developments in nursing and can critically analyse research reports. With regards to facilitators of research utilisation, respondents agreed that managerial and peer support are the greatest facilitators. Conclusions, The results indicate that factors influencing research utilisation are multidimensional and should be taken into account by all involved in the research enterprise: researchers, practitioners, educators, managers and policy-makers. The results of this study provide directions on how to assist nurses in Hong Kong in their efforts to utilise research. [source] Instream Flow Science For Sustainable River Management,JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION, Issue 5 2009Geoffrey E Petts Abstract:, Concerns for water resources have inspired research developments to determine the ecological effects of water withdrawals from rivers and flow regulation below dams, and to advance tools for determining the flows required to sustain healthy riverine ecosystems. This paper reviews the advances of this environmental flows science over the past 30 years since the introduction of the Instream Flow Incremental Methodology. Its central component, Physical HABitat SIMulation, has had a global impact, internationalizing the e-flows agenda and promoting new science. A global imperative to set e-flows, including an emerging trend to set standards at the regional scale, has led to developments of hydrological and hydraulic approaches but expert judgment remains a critical element of the complex decision-making process around water allocations. It is widely accepted that river ecosystems are dependent upon the natural variability of flow (the flow regime) that is typical of each hydro-climatic region and upon the range of habitats found within each channel type within each region. But as the sophistication of physical (hydrological and hydraulic) models has advanced emerging biological evidence to support those assumptions has been limited. Empirical studies have been important to validate instream flow recommendations but they have not generated transferable relationships because of the complex nature of biological responses to hydrological change that must be evaluated over decadal time-scales. New models are needed to incorporate our evolving knowledge of climate cycles and morphological sequences of channel development but most importantly we need long-term research involving both physical scientists and biologists to develop new models of population dynamics that will advance the biological basis for 21st Century e-flow science. [source] Recent research developments in wood plastic compositesJOURNAL OF VINYL & ADDITIVE TECHNOLOGY, Issue 3 2009Laurent M. Matuana [source] Effects of marital conflict on children: recent advances and emerging themes in process-oriented researchTHE JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, Issue 1 2002E. Mark Cummings Background: The effects of marital conflict on children's adjustment are well documented. For the past decade research has increasingly focused on advancing a process-level understanding of these effects, that is, accounting for the particular responses and patterns embedded within specific contexts, histories, and developmental periods that account for children's outcomes over time. Methods: As a vehicle for presenting an update, this review follows the framework for process-oriented research initially proposed by Cummings and Cummings (1988), concentrating on recent research developments, and also considering new and emerging themes in this area of research. Results: In this regard, areas of advancement include (a) greater articulation of the effects of specific context/stimulus characteristics of marital conflict, (b) progress in identifying the psychological response processes in children (e.g., cognitive, emotional, social, physiological) that are affected and their possible role in accounting for relations between marital conflict and child outcomes, (c) greater understanding of the role of child characteristics, family history, and other contextual factors, including effects on children due to interrelations between marital conflict and parenting, and (d) advances in the conceptualization of children's outcomes, including that effects may be more productively viewed as dynamic processes of functioning rather than simply clinical diagnoses. Conclusions: Understanding of the impact of marital conflict on children as a function of time-related processes remains a gap in a process-oriented conceptualization of effects. Based on this review, a revised model for a process-oriented approach on the effects of marital discord on children is proposed and suggestions are made for future research directions. [source] Identification and targeting of cancer stem cellsBIOESSAYS, Issue 10 2009Tobias Schatton Abstract Cancer stem cells (CSC) represent malignant cell subsets in hierarchically organized tumors, which are selectively capable of tumor initiation and self-renewal and give rise to bulk populations of non-tumorigenic cancer cell progeny through differentiation. Robust evidence for the existence of prospectively identifiable CSC among cancer bulk populations has been generated using marker-specific genetic lineage tracking of molecularly defined cancer subpopulations in competitive tumor development models. Moreover, novel mechanisms and relationships have been discovered that link CSC to cancer therapeutic resistance and clinical tumor progression. Importantly, proof-of-principle for the potential therapeutic utility of the CSC concept has recently been provided by demonstrating that selective killing of CSC through a prospective molecular marker can inhibit tumor growth. Herein, we review these novel and translationally relevant research developments and discuss potential strategies for CSC-targeted therapy in the context of resistance mechanisms and molecular pathways preferentially operative in CSC. [source] | |||||||||||||||||||