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Research Data (research + data)

Distribution by Scientific Domains

Medical Sciences	37%
Humanities and Social Sciences	24%
Psychology	10%
Education	10%
Life Sciences	6%
3 Other Domains	13%

Selected Abstracts

Costa Rican Research Experiences: Mid-1950s and Early 1960s

FAMILY & CONSUMER SCIENCES RESEARCH JOURNAL, Issue 2 2008
Linda Nelson
Qualitative research projects with rural Costa Rican women in two different villages are reported. One dealt with possessed, desired, and (by default) rejected kitchen facilities. A pictorial method was used to prompt the homemakers' decisions. The other research explored time activity patterns of homemakers based on observed activities compared to their predictions and recollections of their activities for the day observed. Time use goals were inferred from the data. Detailed methodological procedures are provided for each study. Research data as well as field journal quotations are included to illustrate the cultural learning experiences and the work is written in first person. [source]

Preservice teachers' pedagogical content knowledge of using particle models in teaching chemistry

JOURNAL OF RESEARCH IN SCIENCE TEACHING, Issue 8 2005
Onno De Jong
In this article, we describe the results of a study of the pedagogical content knowledge (PCK) of preservice chemistry teachers in the context of a postgraduate teacher education program. A group of preservice teachers (n,=,12) took part in an experimental introductory course module about the use of particle models to help secondary school students understand the relationship between phenomena (e.g., properties of substances, physical and chemical processes) and corpuscular entities (e.g., atoms, molecules, ions). The module emphasized learning from teaching by connecting authentic teaching experiences with institutional workshops. Research data were obtained from answers to written assignments, transcripts of workshop discussions, and reflective lesson reports, written by the participants. The outcomes of the study revealed that, initially, all participants were able to describe specific learning difficulties, such as problems secondary school students have in relating the properties of substances to characteristics of the constituent particles. Also, at this stage, all preservice teachers acknowledged the potential importance of using models of molecules and atoms to promote secondary school students' understanding of the relationship between phenomena and corpuscular entities. After teaching, all preservice teachers demonstrated a deeper understanding of their students' problems with the use of particle models. In addition, about half of the participants had become more aware of the possibilities and limitations of using particle models in specific teaching situations. Through learning from teaching, the preservice teachers further developed their PCK of using particle models, although this development varied among preservice teachers studied. © 2005 Wiley Periodicals, Inc. J Res Sci Teach 42: 947,964, 2005 [source]

Endocrine Aspects of Female Sexual Dysfunction

THE JOURNAL OF SEXUAL MEDICINE, Issue 1 2004
Susan R. Davis MD
ABSTRACT Introduction., Various endogenous hormones, including estrogen, testosterone, progesterone and prolactin, may influence female sexual function. Aim., To provide recommendations for the diagnosis and treatment of women with endocrinologic sexual difficulties. Methods., The Endocrine Aspects of Female Sexual Dysfunction Committee was part of a multidisciplinary International Consultation. It included four experts from two countries and several peer reviewers. Main Outcome Measure., Expert opinion was based on committee discussion, a comprehensive literature review and evidence-based grading of available publications. Results., The impact of hormones on female sexual function and their etiological roles in dysfunction is complex. Research data are limited as studies have been hampered by lack of precise hormonal assays and validated measures of sexual function in women. Sex steroid insufficiency is associated with urogenital atrophy and may also adversely affect central sexual thought processes. Systemic estrogen/estrogen progestin therapy alleviates climacteric symptoms but there is no evidence that this therapy specifically improves hypoactive sexual desire disorder (HSDD) in premenopausal or postmenopausal women. Exogenous testosterone has been shown in small randomized controlled trials (RCT) to improve sexual desire, arousal and sexual satisfaction in both premenopausal and postmenopausal women. However, as there is no biochemical measure that clearly identifies who to treat, use of exogenous testosterone should be considered only after other causes of HSDD have been excluded, such as depression, relationship problems and ill health. The clinical assessment of HSDD should include detailed medical, gynecologic, sexual and psychosocial history and physical examination including the external/internal genitalia. Hormonal therapy should be individualized and risks/benefits fully discussed, and all treated women should be carefully followed up and monitored for therapeutic side effects. Conclusions., There is a need for prospective, multi-institutional clinical trials to define safe and effective endocrine treatments for female sexual dysfunction. [source]

DEVELOPMENT OF ORAL HEALTH TRAINING FOR RURAL AND REMOTE ABORIGINAL HEALTH WORKERS

AUSTRALIAN JOURNAL OF RURAL HEALTH, Issue 3 2001
Tom Pacza
Abstract: Research data exists that highlight the discrepancy between the medical/dental status experienced by Aboriginal people compared with that of their non-Aboriginal counterparts. This, coupled with a health system that Aboriginal people often find alienating and difficult to access, further exacerbates the many health problems they face. Poor oral health and hygiene is an issue often overlooked that can significantly impact on a person's quality of life. In areas where Aboriginal people find access to health services difficult, the implementation of culturally acceptable forms of primary health care confers significant benefits. The Aboriginal community has seen that the employment and training of Aboriginal health workers (AHW), particularly in rural and remote regions, is significantly beneficial in improving general health. In the present study, an oral health training program was developed and trialed. This training program was tailored to the needs of rural and remote AHWs. The primary objective was to institute a culturally appropriate basic preventative oral health delivery program at a community level. It is envisaged that through this dental training program, AHWs will be encouraged to implement long-term preventive measures at a local level to improve community dental health. They will also be encouraged to pursue other oral health-care delivery programs. Additionally, it is considered that this project will serve to strengthen a trust-based relationship between Aboriginal people and the health-care profession. [source]

The dynamics of an online knowledge building community: A 5-year longitudinal study

BRITISH JOURNAL OF EDUCATIONAL TECHNOLOGY, Issue 3 2010
Jarkko Mylläri
This paper reports a 5-year design experiment on cumulative knowledge building as part of an international project. Through a longitudinal study and analysis of cumulative research data, we sought to answer the question, ,what happened and why in knowledge building?' Research data constitute messages which participants have written into a shared knowledge building database. A multi-method approach combing quantitative and qualitative data was adopted which integrated analysis of message generation, content analysis, network analysis, structure of message threads, discourse analysis and interviews. Conclusions are based on analysis of almost 2000 messages. Qualitative content analysis reveals 14 main categories of data. When the content of the messages are analysed, quantitatively cumulative trends emerge. When the frequencies of messages are plotted against time, peaks and troughs of message writing are revealed. The explanations for these patterns and variations are sought through interviews. Social network analysis shows that the network is centralised. The research literature suggests that decentralised networks are ideal, but in this particular case, the expert centralisation was beneficial for knowledge building in the collaborative and associated professional networks. The reasons for this are discussed. [source]

Access to hematopoietic stem cell transplantation

CANCER, Issue 14 2010
Effect of race
Abstract BACKGROUND: The purpose of the current study was to determine whether the use of hematopoietic stem cell transplantation (HCT) to treat leukemia, lymphoma, or multiple myeloma (MM) differs by race and sex. METHODS: The annual incidence of leukemia, lymphoma, and MM was estimated in the United States in people aged <70 years by race and sex using the Surveillance, Epidemiology, and End Results (SEER) cancer registry between 1997 and 2002 and US census reports for the year 2000. The annual incidence of autologous, human leukocyte antigen (HLA) identical sibling, and unrelated HCT performed in these groups was estimated using Center for International Blood and Marrow Transplant Research data from 1997 through 2002. Logistic regression analysis was used to calculate the age-adjusted odds ratio (OR) of receiving HCT for Caucasians versus African Americans and for men versus women. RESULTS: The likelihood of undergoing HCT was found to be higher for Caucasians than for African Americans (OR, 1.40; 95% confidence interval [95% CI], 1.34-1.46). This difference existed for each type of HCT: autologous (OR, 1.24; 95% CI, 1.19-1.30), HLA identical sibling (OR, 1.59; 95% CI, 1.46-1.74), and unrelated donor (OR, 2.02; 95% CI, 1.75-2.33). Overall, men were more likely than women to receive HCT (OR, 1.07; 95% CI, 1.05-1.1 [P < .0001]); however, this difference was found to be significant only for autologous HCT (OR, 1.10; 95% CI, 1.07-1.13 [P < .0001]). CONCLUSIONS: HCT is more frequently used to treat leukemia, lymphoma, and MM in Caucasians than in African American individuals. African Americans have lower rates of both autologous and allogeneic HCT, indicating that donor availability cannot fully explain the differences. Women are less likely than men to receive autologous HCT for reasons unexplained by age or disease status. Cancer 2010. © 2010 American Cancer Society. [source]

Is there a SSRI dose response in treating major depression?

DEPRESSION AND ANXIETY, Issue 1 2003
The case for re-analysis of current data, for enhancing future study design
Abstract It has been widely stated that the available research data has not demonstrated a SSRI dose response for major depression. We re-evaluated the methods used to analyze the SSRI data by clarifying two key alternative definitions of dose response and their implications for enhancing analysis of currently available data as well as future study design. We differentiated "potential" dose response, which focuses exclusively on response excluding tolerability effects and asks whether differences in dose can result in significant differences in response, from "expressed" dose response, which incorporates all tolerability effects currently associated with dose (including those caused by study protocol or treatment practice) and asks whether differences in dose do result in significant differences in response. To analyze potential dose response for all studies, one should use a "dose-tolerant" sample, i.e., an ITT sample from which dropouts due to adverse events have been removed. To analyze an expressed dose response, an ITT sample is the optimum sample if the study conforms to several design specifications. In the absence of conformance to these specifications, an ITT sample may be an approximation of the appropriate sample. Given design limitations of currently available studies, a dose-tolerant sample may provide a more informative approximation of an optimal sample to be used in evaluating the expressed dose response that could be expected in the best clinical practice. Future studies of dose-response relations could be enhanced by taking into account the principles noted above, and currently available data should be reanalyzed based on these principles. This re-analysis is performed in a companion article [Baker et al. 2003, Depress Anxiety 17:1-9]. Depression and Anxiety 17:10,18, 2003. © 2003 Wiley-Liss, Inc. [source]

A review of drug prevention system development in Romania and its impact on youth drug consumption trends, 1995,2005

DRUG AND ALCOHOL REVIEW, Issue 4 2009
CSABA L. DÉGI
Abstract Issues. A tremendous growth occurred in the reported drug use and abuse in Romania from 1995 to 1999. Lack of concern by government and little policy attention contributed to the surprising delay of drug policy and drug prevention system development. General public stigmatize drug users and drug consumption is considered a matter of personal fault and responsibility. There is some but not sufficient research and evaluation on drug use, abuse problem. Approach. Drug use, abuse and prevention are discussed from research-based, user-focused and prevention system development perspectives. Prevalence and trends of drug use, abuse in the past decade (1995,2005) are summarized. Prevention issues are discussed based on research data from adolescents, parents and teachers. The Romanian primary drug prevention system has been evaluated based on our experiences in drug use prevention activities carried out in schools and recreational environments. Key Findings. Public and scientific perspectives on drug consumption in Romania, between 1995 and 1999, were dominated by an idealistic, non-realistic perception. Since 1995, drug use among adolescents increased almost four times in less than 4 years. The first law against drug traffic and consumption was issued only in 2000. Now primary drug prevention strategies are in action, but in general they are lacking standard evaluation procedures. Implications/Conclusion. Conclusions are drafted for new perspectives in prevention activities. More long-term, user-focused, demand-centred prevention activities should be carried out in more and more diversified settings and evaluation should be thoroughly considered.[Dégi CL. A review of drug prevention system development in Romania and its impact on youth drug consumption trends, 1995,2005. Drug Alcohol Rev 2009;28:419,425] [source]

The effectiveness of brief alcohol interventions in primary care settings: A systematic review

DRUG AND ALCOHOL REVIEW, Issue 3 2009
EILEEN F. S. KANER
Abstract Issues. Numerous studies have reported that brief interventions delivered in primary care are effective in reducing excessive drinking. However, much of this work has been criticised for being clinically unrepresentative. This review aimed to assess the effectiveness of brief interventions in primary care and determine if outcomes differ between efficacy and effectiveness trials. Approach. A pre-specified search strategy was used to search all relevant electronic databases up to 2006. We also hand-searched the reference lists of key articles and reviews. We included randomised controlled trials (RCT) involving patients in primary care who were not seeking alcohol treatment and who received brief intervention. Two authors independently abstracted data and assessed trial quality. Random effects meta-analyses, subgroup and sensitivity analyses and meta-regression were conducted. Key Findings. The primary meta-analysis included 22 RCT and evaluated outcomes in over 5800 patients. At 1 year follow up, patients receiving brief intervention had a significant reduction in alcohol consumption compared with controls [mean difference: ,38 g week,1, 95%CI (confidence interval): ,54 to ,23], although there was substantial heterogeneity between trials (I2 = 57%). Subgroup analysis confirmed the benefit of brief intervention in men but not in women. Extended intervention was associated with a non-significantly increased reduction in alcohol consumption compared with brief intervention. There was no significant difference in effect sizes for efficacy and effectiveness trials. Conclusions. Brief interventions can reduce alcohol consumption in men, with benefit at a year after intervention, but they are unproven in women for whom there is insufficient research data. Longer counselling has little additional effect over brief intervention. The lack of differences in outcomes between efficacy and effectiveness trials suggests that the current literature is relevant to routine primary care. [Kaner EFS, Dickinson HO, Beyer F, Pienaar E, Schlesinger C, Campbell F, Saunders JB, Burnand B, Heather N. The effectiveness of brief alcohol interventions in primary care settings: A systematic review. Drug Alcohol Rev 2009;28:301,323] [source]

Research Ethics: Ethical Issues of Data Reporting and the Quest for Authenticity

ACADEMIC EMERGENCY MEDICINE, Issue 6 2000
Catherine A. Marco MD
Abstract. The search for truth and its unbiased reporting are ultimate goals of conducting scientific research. Ideally, the reporting of research data ought to be an objective task. In practice, however, it is fraught with numerous statistical and ethical pitfalls, seldom addressed in formal emergency medicine training. The lure of academic celebrity and related influences may persuade researchers to report results in ways that make data appear more interesting, or worthy of publication. Several examples of potentially misleading data reporting are illustrated, including using inappropriate statistical tests, neglecting negative results, omitting missing data points, failing to report actual numbers of eligible subjects, using inappropriate graph labels or terminology, data dredging, and others. Although potentially inaccurate or inflated methods of data reporting may not constitute overt scientific misconduct, the intentional misrepresentation of data is a form of fraud or deception. Publicly funded academic inquiry is a privilege and honor enjoyed by a trusted few. Regardless of outcome, every effort should be made to report data in the most scientifically accurate method. To this end, the Society for Academic Emergency Medicine Code of Conduct and American College of Emergency Physicians Code of Ethics provide important guidance toward the accurate, compassionate, competent, impartial, and honest conduct of scientific research. Accuracy and authenticity in data reporting are first and foremost a matter of individual integrity, and are crucial to the preservation of academic credibility, the protection of future patients, and the public's trust in the medical research enterprise. [source]

Using Websites to Disseminate Research on Urban Spatialities

GEOGRAPHY COMPASS (ELECTRONIC), Issue 6 2009
Gillian Rose
This paper reviews a selection of websites that explore urban geographies. Many sites use the web as a depository for large amounts of research data. However, many are using websites to disseminate research findings, and the paper focuses on these. It suggests that, thus far, there are three significant ways in which urban researchers are exploiting the potentialities of web technologies to interpret urban spaces: by evoking a sense of the complexity of urban spatialities; by inviting site visitors to engage actively and performatively with the research materials; and by emphasising the sensory qualities of urban spaces. The paper discusses how one website in particular invites its visitors to engage with complex, sensory urban spatialities. The paper compares geographers' use of collage and montage as part of this discussion, and ends by reflecting on current work and commenting on its future development. [source]

Climatology at Urban Long-Term Ecological Research Sites: Baltimore Ecosystem Study and Central Arizona,Phoenix

GEOGRAPHY COMPASS (ELECTRONIC), Issue 1 2009
Anthony J. Brazel
The Baltimore Ecosystem Study (BES) and Central Arizona,Phoenix (CAP) Long-Term Ecological Research (LTER) programs, established in 1997, are part of an international National Science Foundation long-term ecology monitoring and research network. The study sites are excellent laboratories to integrate ideas on climate of urban areas and how climate change and local variability of climate relate to social, political, economic, and ecological processes over a long time period. A large variety of research data are available online from individual LTER Web sites and a combined database called CLIMDB/HYDRODB is available for climate and ecology researchers and others, to investigate climate and hydrology in LTER study regions including those of BES and CAP. The basic program, climate aspects of these two areas, selected past research, and current ongoing work is briefly reviewed. A large benefit of this National Science Foundation program is the maintenance of support over a very long period of time. With the advent of a National Ecological Observatory Network, continuing collection of climate and environmental information over the coming decades at the local and regional scales, and maintenance of protocols of measurement, it is hoped that a more meaningfully integrated urban climatology with urban ecology will emerge. This will better prepare scientists to gage the impending rapid global warming expected not only of natural environments, but also of burgeoning urban places around the world. [source]

Evidence of Early Language Discrimination Abilities in Infants From Bilingual Environments

INFANCY, Issue 1 2001
Laura Bosch
Previous research data indicate that soon after birth, infants from monolingual families can discriminate utterances drawn from languages that differ prosodically, but discrimination between rhythmically similar languages, such as English and Dutch, has not yet been established by 2 months of age. In the case of bilinguals, the question of how early they can distinguish between the languages of exposure remains unanswered. The goal of this study was to analyze language discrimination capacities in 4-month-old bilingual infants simultaneously exposed to 2 Romance languages belonging to the same rhythmic category, Spanish and Catalan. Using a familiarization-preference procedure, 2 groups of bilingual-to-be infants showed a capacity to discriminate between these 2 familial languages. Moreover, when compared with 2 groups of infants from monolingual environments, the size of the observed effects was the same. These results can be taken as initial evidence of an early capacity to distinguish languages in simultaneous bilingual exposure, thus challenging the hypothesis that language discrimination capacities are delayed in bilinguals. [source]

Policy utilisation of research results in Cameroon*

INTERNATIONAL SOCIAL SCIENCE JOURNAL, Issue 179 2004
Charly Gabriel Mbock
Using knowledge by taking account of the results of scientific research is a preoccupation of the scientific community on which this article proposes to shed light by considering the case of Cameroon. Within the theoretical framework of actionism, the study is based on a questionnaire survey administered to a sample of 200 researchers, decision-makers, and research-commissioning bodies, complemented by interviews. The data cover commissioning, evaluation and utilisation practices over the period 1990,2001. The results show considerable differences in judgement between researchers, decision-makers, and commissioning bodies with regard to existing practices and desirable usage. The differences reflect the lack of connection between properly academic concerns and policy prospects, as well as a research funding structure in Cameroon that separates problem definition from solution implementation. Given inadequate utilisation of scientific research data in public policy, the article proposes renewed institutional forms that might encourage academicism to take account of the practical requirements of social engineering. [source]

Fourier analysis methodology of trabecular orientation measurement in the human tibial epiphysis

JOURNAL OF ANATOMY, Issue 2 2001
M. HERRERA
Methods to quantify trabecular orientation are crucial in order to assess the exact trajectory of trabeculae in anatomical and histological sections. Specific methods for evaluating trabecular orientation include the ,point counting' technique (Whitehouse, 1974), manual tracing of trabecular outlines on a digitising board (Whitehouse, 1980), textural analysis (Veenland et al. 1998), graphic representation of vectors (Shimizu et al. 1993; Kamibayashi et al. 1995) and both mathematical (Geraets, 1998) and fractal analysis (Millard et al. 1998). Optical and computer-assisted methods to detect trabecular orientation of bone using the Fourier transform were introduced by Oxnard (1982) later refined by Kuo & Carter (1991) (see also Oxnard, 1993, for a review), in the analysis of planar sections of vertebral bodies as well as in planar radiographs of cancellous bone in the distal radius (Wigderowitz et al. 1997). At present no studies have applied this technique to 2-D images or to the study of dried bones. We report a universal computer-automated technique for assessing the preferential orientation of the tibial subarticular trabeculae based on Fourier analysis, emphasis being placed on the search for improvements in accuracy over previous methods and applied to large stereoscopic (2-D) fields of anatomical sections of dried human tibiae. Previous studies on the trajectorial architecture of the tibial epiphysis (Takechi, 1977; Maquet, 1984) and research data about trabecular orientation (Kamibayashi et al. 1995) have not employed Fourier analysis. [source]

Establishing a standardized dental record-keeping system for a small investigational colony of rhesus monkeys (Macaca mulatta)

JOURNAL OF MEDICAL PRIMATOLOGY, Issue 2008
B.W. Gibson
Abstract Background, Dental hygiene is becoming an increasingly important component of quality health care for laboratory animals, especially non-human primates (NHPs). One key to a successful health care program is an effective and efficient record-keeping system. Methods, To standardize a dental hygiene program for a small colony of NHPs, we developed a dental recording chart specific for rhesus monkeys. This dental chart was developed using the modified Triadan system. This system numbers teeth across species according to location. Results, An illustrative case report was presented to demonstrate the accurate record keeping and spatial relationship generated from this Old World NHP dental chart design. Conclusion, The development and implementation of a standardized dental chart, as part of a dental hygiene program will help minimize variables that may affect research data. [source]

The development of a facet analysis system to identify and measure the dimensions of interaction in online learning

JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 11 2007
Shawne D. Miksa
The development of a facet analysis system to code and analyze data in a mixed-method study is discussed. The research goal was to identify the dimensions of interaction that contribute to student satisfaction in online Web-supported courses. The study was conducted between 2000 and 2002 at the Florida State University School of Information Studies. The researchers developed a facet analysis system that meets S. R. Ranganathan's (1967) requirements for articulation on three planes (idea, verbal, and notational). This system includes a codebook (verbal), coding procedures, and formulae (notational) for quantitative analysis of logs of chat sessions and postings to discussion boards for eight master's level courses taught online during the fall 2000 semester. Focus group interviews were subsequently held with student participants to confirm that results of the facet analysis reflected their experiences with the courses. The system was developed through a process of emergent coding. The researchers have been unable to identify any prior use of facet analysis for the analysis of research data as in this study. Identifying the facet analysis system was a major breakthrough in the research process, which, in turn, provided the researchers with a lens through which to analyze and interpret the data. In addition, identification of the faceted nature of the system opens up new possibilities for automation of the coding process. [source]

Fyn is a novel target of (,)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation,

MOLECULAR CARCINOGENESIS, Issue 3 2008
Zhiwei He
Abstract The cancer preventive action of (,)-epigallocatechin gallate (EGCG), found in green tea, is strongly supported by epidemiology and laboratory research data. However, the mechanism by which EGCG inhibits carcinogenesis and cell transformation is not clear. In this study, we report that EGCG suppressed epidermal growth factor (EGF)-induced cell transformation in JB6 cells. We also found that EGCG inhibited EGF-induced Fyn kinase activity and phosphorylation in vitro and in vivo. Fyn was implicated in the process because EGF-induced JB6 cell transformation was inhibited by small interfering RNA (siRNA)-Fyn-JB6 cells. With an in vitro protein-binding assay, we found that EGCG directly bound with the GST-Fyn-SH2 domain but not the GST-Fyn-SH3 domain. The Kd value for EGCG binding to the Fyn SH2 domain was 0.367,±,0.122 µM and Bmax was 1.35,±,0.128 nmol/mg. Compared with control JB6 Cl41 cells, EGF-induced phosphorylation of p38 MAP kinase (p38 MAPK) (Thr180/Tyr182), ATF-2 (Thr71) and signal transducer and activator of transcription 1 (STAT1) (Thr727) was decreased in siRNA-Fyn-JB6 cells. EGCG could inhibit the phosphorylation of p38 MAPK, ATF-2, and STAT1. The DNA binding ability of AP-1, STAT1, and ATF-2 was also decreased in siRNA-Fyn-JB6 cells. Overall, these results demonstrated that EGCG interacted with Fyn and inhibited Fyn kinase activity and thereby regulated EGF-induced cell transformation. Inhibition of Fyn kinase activity is a novel and important mechanism that may be involved in EGCG-induced inhibition of cell transformation. © 2007 Wiley-Liss, Inc. [source]

Getting the fundamentals wrong: woes of public,private partnerships in solid waste collection in three Ghanaian cities

PUBLIC ADMINISTRATION & DEVELOPMENT, Issue 3 2004
Nicholas Awortwi
Until over a decade ago, concerted efforts at involving private agents to deliver solid waste collection services did not feature in local government's (LG's) policies and practices in Ghana. The LGs had over the years directly delivered the services with their labour, materials and equipment. The purpose of entering into partnerships with private contractors was to improve service delivery. This comes at a time when the private sector is generally viewed as more efficient and effective than the public sector. There is abundant literature on potential benefits of private sector participation in public service delivery; yet, figures of efficiency gains are often accepted without challenge. More advantages but fewer disadvantages are cited and anecdotal evidence is used only to illustrate successful applications of the concept of public,private partnerships (PPPs). Using research data from three cities (Accra, Kumasi and Tema) in Ghana, this article exposes the contrast between policy expectations and outcomes of PPPs. The article argues that simply turning over public service delivery to private agents without ensuring that the fundamentals that make them successful are put in place leads to a worse situation than portrayed in literature about the benefit of PPPs. Copyright © 2004 John Wiley & Sons, Ltd. [source]

Quality in the outsourcing process: part I. The quality outsourcer

QUALITY ASSURANCE JOURNAL, Issue 4 2001
Yvonne Russell Dr.
Abstract In clinical research, the definition of quality and overall responsibility for ensuring that performance parameters are adequately tracked and the necessary corrective action taken, lies firmly in the hands of the outsourcing project director/manager (outsourcer or sponsor). Meticulous planning of requirements prior to project start and strong ,general management' throughout the life of the outsourced project play a critical role in influencing both the outcome of the study and also in determining the quality of the research data. For ,quality in the outsourcing process', read ,quality outsourcing'. The implementation of a carefully formulated project-specific outsourcing strategy means that macromanagement (general management), not micromanagement (defined here as a form of ,intensive therapy for the ailing project' management), will be the primary task of the sponsor. A research team that is well-defined, with all members (sponsor and vendor alike) mindful of their individual responsibilities, in addition to being well-directed, will achieve consensus of opinion faster and deliver a quality product. An outsourcing strategy for the full clinical development program, clearly defined outsourcing standard operating procedures (SOPs) and a strategy tailored to each individually outsourced project form an integral part of the recipe to outsourcing success. Individual components of an outsourcing strategy and how one can safeguard that an outsourced project is brought to completion successfully, and to the prescribed quality standards, are addressed in detail in this article. Part two of this article, entitled ,Quality in the Outsourcing Process: II. The Vendor Selection Process and The Quality Vendor', will provide the quality outsourcer with tips and tools on how to make a quality decision in the vendor selection process and addresses further issues that are fundamental to the maintenance of quality in the outsourcing process. Copyright © 2001 John Wiley & Sons, Ltd. [source]

Evaluation: Using evaluation research to improve medical education

THE CLINICAL TEACHER, Issue 3 2010
Mohsen Tavakol
Summary Background:, Evaluation research is a form of applied research that scrutinises how well a particular programme, practice, procedure or policy is operating. Evaluation researchers use both quantitative and qualitative research data to construct a collective picture of the programme under evaluation. Context:, Medical educators need to provide information about a particular programme using the methods of evaluation research in order to make a decision on the potential adoption, improvements and refinements of the programme. Improving curricula and pedagogical methods using these methods may enhance health care education. Innovation:, We provide an overview of the methods of evaluation research in the context of medical education. We discuss the application, general methodology, methods of collecting data and analysis for each type of evaluation research. Implications:, The methods of evaluation research described in this article enable medical educators to gain a comprehensive understanding of evaluation research in the context of medical education. The use of evaluation research findings helps medical educators to make informed decisions regarding a programme and any future actions related to it. [source]

The galectin family and digestive disease,

THE JOURNAL OF PATHOLOGY, Issue 1 2008
P Demetter
Abstract The soluble-type lectins or galectins constitute a family of proteins defined by shared consensus amino acid sequence and affinity for beta-galactose-containing oligosaccharides. These molecules are widely distributed in the animal kingdom; to date, 15 mammalian galectins have been described but more are likely to be discovered. These proteins are involved in many biological processes including cell,cell and cell,matrix adhesion, growth regulation, signaling, and cytokine secretion. Over the last decade, a vast amount of reports has shown the importance of several galectins in the development and progression of malignancies in the digestive tract, mainly colorectal cancers. More recent data indicate that some of these molecules are also involved in inflammatory bowel diseases. This review focuses on the current knowledge of galectin expression and putative functions in the oesophagus, stomach, small intestine, and colon. It also highlights that the rapid accumulation of research data promises future scenarios in which individual members of the galectin family and/or their ligands will be used as diagnostic and therapeutic modalities for neoplastic as well as inflammatory disorders. However, the concretization of these potential modalities requires substantial improvements in terms of standardization of galectin expression evaluation together with prospective validation of the present data. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. [source]

Banff '09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups

AMERICAN JOURNAL OF TRANSPLANTATION, Issue 3 2010
B. Sis
The 10th Banff Conference on Allograft Pathology was held in Banff, Canada from August 9 to 14, 2009. A total of 263 transplant clinicians, pathologists, surgeons, immunologists and researchers discussed several aspects of solid organ transplants with a special focus on antibody mediated graft injury. The willingness of the Banff process to adapt continuously in response to new research and improve potential weaknesses, led to the implementation of six working groups on the following areas: isolated v-lesion, fibrosis scoring, glomerular lesions, molecular pathology, polyomavirus nephropathy and quality assurance. Banff working groups will conduct multicenter trials to evaluate the clinical relevance, practical feasibility and reproducibility of potential changes to the Banff classification. There were also sessions on quality improvement in biopsy reading and utilization of virtual microscopy for maintaining competence in transplant biopsy interpretation. In addition, compelling molecular research data led to the discussion of incorporation of omics-technologies and discovery of new tissue markers with the goal of combining histopathology and molecular parameters within the Banff working classification in the near future. [source]

A patent analysis of cluster analysis

APPLIED STOCHASTIC MODELS IN BUSINESS AND INDUSTRY, Issue 4 2009
Jon R. Kettenring
Abstract The application of cluster analysis (CA) to analyze scientific research data has been growing rapidly, especially in the life sciences. Its use for commercial purposes is much more difficult to characterize. A detailed analysis of recent patents provides some revealing insights, however. It points to several areas of patent activity for which CA is widely used. These are discussed in the paper and a number of patents are highlighted to illustrate the diversity of applications. Copyright © 2009 John Wiley & Sons, Ltd. [source]

TWO CONCEPTS OF EMPIRICAL ETHICS

BIOETHICS, Issue 4 2009
MALCOLM PARKER
ABSTRACT The turn to empirical ethics answers two calls. The first is for a richer account of morality than that afforded by bioethical principlism, which is cast as excessively abstract and thin on the facts. The second is for the facts in question to be those of human experience and not some other, unworldly realm. Empirical ethics therefore promises a richer naturalistic ethics, but in fulfilling the second call it often fails to heed the metaethical requirements related to the first. Empirical ethics risks losing the normative edge which necessarily characterizes the ethical, by failing to account for the nature and the logic of moral norms. I sketch a naturalistic theory, teleological expressivism (TE), which negotiates the naturalistic fallacy by providing a more satisfactory means of taking into account facts and research data with ethical implications. The examples of informed consent and the euthanasia debate are used to illustrate the superiority of this approach, and the problems consequent on including the facts in the wrong kind of way. [source]

The dynamics of an online knowledge building community: A 5-year longitudinal study

The role of health professionals in preventing non-accidental head injury

CHILD ABUSE REVIEW, Issue 6 2003
Alison Kemp
Abstract The aim of this paper is to re,ect on the role that the health professions can play in preventing a serious form of physical child abuse. Using research data from a case series study on non-accidental head injury, or shaken baby syndrome, some aspects of child healthcare are reviewed for their potential for prevention. In child protection in the UK, more resources are put into the diagnosis and assessment of child abuse than into interventions designed for prevention. The ,eld of prevention is generally lacking in a theoretical underpinning or systematic means of evaluation and yet the 1996 National Commission of Inquiry into the Prevention of Child Abuse concluded that child abuse ,can almost always be prevented provided the will to do so is there' (National Commission of Inquiry into the Prevention of Child Abuse, 1996). This requires major changes to the way society views and protects children. The focus in this paper is on the very young, mainly babies under 6 months of age. It calls for a lowering of the threshold with which health professionals view a baby's illness for secondary prevention of non-accidental head injury and the need to review approaches to primary prevention, both from the UK and abroad, in order to implement a systematic means to primary prevention. Copyright © 2003 John Wiley & Sons, Ltd. [source]

Genetic knowledge and moral responsibility: ambiguity at the interface of genetic research and clinical practice

CLINICAL GENETICS, Issue 3 2006
D. Pullman
Despite a rapidly expanding literature on the issue of duty to warn at-risk relatives in the context of clinical genetic testing, little has been written on parallel issues with regard to the management of genetic research results. Some might view this lack as an indication that there is little to discuss in this regard. That is, standard practice is that data obtained through medical research should not be treated as though they are clinically relevant, and this standard should hold for genetic research as well. This paper challenges this conclusion and its underlying assumptions. We argue that the line between genetic research and clinical practice is often ambiguous. In some cases, research data gathered from a very small number of subjects could have immediate clinical implications. Hence, it is unethical for genetic researchers to absolve themselves of clinical responsibilities for research subjects and/or their families, on the grounds that the data were obtained for research purposes. Indeed, we argue that it could well be unethical to embark on some forms of genetic research unless advance arrangements have been made for genetic counseling and clinical follow-up. Furthermore, in some cases, it might be unethical to enroll subjects in studies if the subjects are unwilling to receive their individual results. [source]

Ethical Challenges in Practice-Based Mental Health Services Research: Examples From Research With Children and Families

CLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 2 2008
Ann F. Garland
Researchers have been encouraged to improve the practical relevance and utility of their work by conducting research based on "real-world" service settings and collaborating with other stakeholders, such as service providers and consumers. Practice-based research presents multiple ethical challenges, not well addressed in the literature. We discuss ethical challenges in three general categories, derived from our experience in practice-based research on child and family services: (a) multiple roles and potentially competing demands of research and clinical care, (b) multiple potential uses of research data, and (c) policy and fiscal challenges. Suggested directions for future work are also proposed. [source]