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Selected AbstractsThe Cartagena Protocol: Implications for Regional Trade and Technology Development in AfricaDEVELOPMENT POLICY REVIEW, Issue 1 2008E. Jane Morris The majority of African countries have ratified or acceded to the Cartagena Protocol on Biosafety, and many have received support through the Global Environment Facility and the UN Environment Programme for development of their National Biosafety Frameworks. This article examines the extent to which these frameworks are aligned with the goals of the Regional Economic and Regional Research Communities of which they are members. Many national approaches lack alignment with regional trade, economic, science and technology policies. The strict application of the precautionary principle and the imposition of costly administrative hurdles are likely to hinder intra-regional trade and technology development. [source] The science commons in life science research: structure, function, and value of access to genetic diversityINTERNATIONAL SOCIAL SCIENCE JOURNAL, Issue 188 2006Robert Cook-Deegan Innovation in the life sciences depends on how much information is produced as well as how widely and easily it is shared. Policies governing the science commons , or alternative, more restricted informational spaces , determine how widely and quickly information is distributed. The purpose of this paper is to highlight why the science commons matters and to analyse its structure and function. The main lesson from our analysis is that both the characteristics of the physical resources (from genes to microbes, plants and animals) and the norms and beliefs of the different research communities , think of the Bermuda rules in the human genome case or the Belem declaration for bioprospecting , matter in the institutional choices made when organising the science commons. We also show that the science commons contributes to solving some of the collective action dilemmas that arise in the production of knowledge in Pasteur's Quadrant, when information is both scientifically important and practically applicable. We show the importance of two of these dilemmas for the life sciences, which we call respectively the diffusion,innovation dilemma (how readily innovation diffuses) and the exploration,exploitation dilemma (when application requires collective action). [source] Metaphor and the Dynamics of Knowledge in Organization Theory: A Case Study of the Organizational Identity Metaphor*JOURNAL OF MANAGEMENT STUDIES, Issue 4 2006Joep P. Cornelissen abstract Despite the increased salience of metaphor in organization theory, there is still very little conceptual machinery for capturing and explaining how metaphor creates and/or reorders knowledge within organization theory. Moreover, prior work on metaphor has insufficiently accounted for the context of interpreting a metaphor. Many metaphors in organization theory, including the ,organizational identity' metaphor, have often been treated in singular and monolithic terms; seen to offer a similar or largely synonymous interpretation to theorists and researchers working along the entire spectrum of disciplines (e.g. organizational behaviour, organizational psychology) in organization theory. We argue in this paper that contextual variation however exists in the interpretation of metaphors in organization theory. This argument is developed by proposing and elaborating on a so-called image-schematic model of metaphor, which suggests that the image-schemata (abstract imaginative structures) that are triggered by the metaphorical comparison of concepts may vary among individuals. Accordingly, once different schemata are triggered the completion and interpretation of a metaphor may equally vary among different individuals or, indeed, research communities. These points associated with the image-schematic model of metaphor are illustrated with a case study of the ,organizational identity' metaphor. The case study shows that this particular metaphor has spiralled out into different research communities and has been comprehended in very different ways as different communities work from very different conceptions, or image-schemata, of ,organization' and ,identity', and use different theoretical frameworks and constructs as a result. The implications of the image-schematic view of metaphor for knowledge development and theoretical progress in organization theory are discussed. [source] CONTEXTUALIZING LEARNING OBJECTS USING ONTOLOGIESCOMPUTATIONAL INTELLIGENCE, Issue 3 2007Phaedra Mohammed Educational research over the past three years has intensified such that the context of learning resources needs to be properly modeled. Many researchers have described and even mandated the use of ontologies in the research being conducted, yet the process of actually connecting one or more ontologies to a learning object has not been extensively discussed. This paper describes a practical model for associating multiple ontologies with learning objects while making full use of the IEEE LOM specification. The model categorizes these ontologies according to five major categories of context based on the most popular fields of study actively being pursued by the educational research community: Thematic context, Pedagogical context, Learner context, Organizational context, and Historical/Statistical context. [source] The LEAD Portal: a TeraGrid gateway and application service architectureCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 6 2007Marcus Christie Abstract The Linked Environments for Atmospheric Discovery (LEAD) Portal is a science application portal designed to enable effective use of Grid resources in exploring mesoscale meteorological phenomena. The aim of the LEAD Portal is to provide a more productive interface for doing experimental work by the meteorological research community, as well as bringing weather research to a wider class of users, meaning pre-college students in grades 6,12 and undergraduate college students. In this paper, we give an overview of the LEAD project and the role that LEAD portal is playing in reaching its goals. We then describe the various technologies we are using to bring powerful and complex scientific tools to educational and research users. These technologies,a fine-grained capability based authorization framework, an application service factory toolkit, and a Web services-based workflow execution engine and supporting tools,enable our team to deploy these once inaccessible, stovepipe scientific codes onto a Grid where they can be collectively utilized. Copyright © 2006 John Wiley & Sons, Ltd. [source] Transgenic mice for studies of the renin,angiotensin system in hypertensionACTA PHYSIOLOGICA, Issue 4 2004J. L. Lavoie Abstract Hypertension is a polygenic and multi-factorial disorder that is extremely prevalent in western societies, and thus has received a great deal of attention by the research community. The renin,angiotensin system has a strong impact on the control of blood pressure both in the short- and long-term, making it one of the most extensively studied physiological systems. Nevertheless, despite decades of research, the specific mechanisms implicated in its action on blood pressure and electrolyte balance, as well as its integration with other cardiovascular pathways remains incomplete. The production of transgenic models either over-expressing or knocking-out specific components of the renin,angiotensin system has given us a better understanding of its role in the pathogenesis of hypertension. Moreover, our attention has recently been refocused on local tissue renin,angiotensin systems and their physiological effect on blood pressure and end-organ damage. Herein, we will review studies using genetic manipulation of animals to determine the role of the endocrine and tissue renin,angiotensin system in hypertension. We will also discuss some untraditional approaches to target the renin,angiotensin system in the kidney. [source] Piloting the zebrafish genome browserDEVELOPMENTAL DYNAMICS, Issue 3 2006Anthony DiBiase Abstract This correspondence is a primer for the zebrafish research community on zebrafish tracks available in the UCSC Genome Browser at http://genome.ucsc.edu based on Sanger's Zv4 assembly. A primary capability of this facility is comparative informatics between humans (as well as many other model organisms) and zebrafish. The zebrafish genome sequencing project has played important roles in mutant mapping and cloning, and comparative genomic research projects. This easy-to-use genome browser aims to display and download useful genome sequence information for zebrafish mutant mapping and cloning projects. Its user-friendly interface expedites annotation of the zebrafish genome sequence. Developmental Dynamics 235:747,753, 2006. © 2005 Wiley-Liss, Inc. [source] Does the Emergency Exception from Informed Consent Process Protect Research Subjects?ACADEMIC EMERGENCY MEDICINE, Issue 11 2005Nicole M. Delorio MD Abstract Although subject protection is the cornerstone of medical ethics, when considered in the context of research using emergency exception from informed consent, its success is debatable. The participants of a breakout session at the 2005 Academic Emergency Medicine Consensus Conference discussed the issues surrounding subject protection and advanced the following recommendations. 1) There are no outcome measures that define "protection"; therefore, it is not currently known whether or not subjects are protected under the current rules. 2) Care must be taken to protect not only the individual from harm during research but also to protect society from unregulated research in other countries and an inability to appropriately advance medical knowledge. 3) Some surrogate markers/methods of protection whose efficacies are debatable include data safety monitoring board activity, the community consultation and public notification (CC/PN) process, and institutional review board approval. 4) Minimal-risk studies should be held to different standards of protection than those that involve more significant risk to the subject. 5) A handful of studies have been published regarding community consultation and notification, and the majority are case studies. Those that are specifically designed to discover the most successful methods are hindered by a lack of formal outcomes measures and tend to have negative results. 6) Follow-up data from the CC/PN process should be disclosed to the Food and Drug Administration and incorporated into study designs. 7) Focus groups and/or random-digit dialing have been suggested as promising methods for fulfilling the CC/PN requirements. 8) Studies need to be funded and performed that formally investigate the best means of CC/PN. 9) More funding for this research should be a priority in the emergency medicine and critical care communities. More data regarding terminated studies should be made available to the research community. 10) Quantifiable markers of success for CC/PN must be validated so that research may determine the most successful methods. 11) Data regarding subjects' and family members' experiences with exception from informed consent studies need to be obtained. [source] An active role for patients in clinical research?DRUG DEVELOPMENT RESEARCH, Issue 3 2006Deirdre O'Connell Abstract In the context of stricter control of clinical research, more informed patients, and a growing number of patient organizations, an active role for patients in clinical research has more than one meaning. Patient involvement in research as subjects is insufficient and can be improved by the information provided by patient groups and by better collaboration between the research community and patient groups. Knowledge about and understanding of clinical trials is central to greater participation. Involvement in the research process provides another role for patients and patient groups and a number of studies have examined such involvement. Patient advocacy groups are involved in training initiatives to enable effective patient involvement in the administration and conduct of clinical research. Various national and European research and regulatory organizations now work with patient representatives, often providing training for them. A third role for patient organizations lies in supporting the research community in lobbying for increased funding, especially for independent clinical research. The area of clinical research outside randomized clinical trials needs also to be carefully considered, in particular the Outcomes Research field. Drug Dev. Res. 67:188,192, 2006. © 2006 Wiley-Liss, Inc. [source] Scaling up evolutionary responses to elevated CO2: lessons from ArabidopsisECOLOGY LETTERS, Issue 5 2004Joy K. Ward Abstract Results from norm of reaction studies and selection experiments indicate that elevated CO2 will act as a selective agent on natural plant populations, especially for C3 species that are most sensitive to changes in atmospheric CO2 concentration. Evolutionary responses to CO2 may alter plant physiology, development rate, growth, and reproduction in ways that cannot be predicted from single generation studies. Moreover, ecological and evolutionary changes in plant communities will have a range of consequences at higher spatial scales and may cause substantial deviations from ecosystem level predictions based on short-term responses to elevated CO2. Therefore, steps need to be taken to identify the plant traits that are most likely to evolve at elevated CO2, and to understand how these changes may affect net primary productivity within ecosystems. These processes may range in scale from molecular and physiological changes that occur among genotypes at the individual and population levels, to changes in community- and ecosystem-level productivity that result from the integrative effects of different plant species evolving simultaneously. In this review, we (1) synthesize recent studies investigating the role of atmospheric CO2 as a selective agent on plants, (2) discuss possible control points during plant development that may change in response to selection at elevated CO2 with an emphasis at the primary molecular level, and (3) provide a quantitative framework for scaling the evolutionary effects of CO2 on plants in order to determine changes in community and ecosystem productivity. Furthermore, this review points out that studies integrating the effects of plant evolution in response to elevated CO2 are lacking, and therefore more attention needs be devoted to this issue among the global change research community. [source] A case of late-onset dependence on cocaine and crackADDICTION, Issue 4 2007Christos Kouimtsidis ABSTRACT Aims To raise awareness among the professional clinical and research community of the risk of cocaine misuse among elderly patients. Methods Case report of a male patient, aged 72 years, who presented to a community substance misuse service with cocaine use disorder (hydrochloride and base form). Results The development of the disorder was marked by high levels of cocaine (and later crack cocaine use), repeated periods of abstinence followed by relapse in the past 4 years, with severe consequences to the patient and his family. Treatment involved a close collaboration between several specialist addictions and old-age psychiatry teams in National Health Service. Implications Although dependence on cocaine among the elderly is considered very rare, clinical management can be challenging and is likely to require the involvement of several specialist and general health services. [source] Delivering on the Potential of the New CAPEUROCHOICES, Issue 2 2005Mariann Fischer Boel Recent discussions on the CAP have focused on the budget. However, in the public debate the policy itself is often still a caricature of the old CAP that existed until the early 1990s. The CAP has changed fundamentally over the past decade. The recent direction of the CAP , markets and rural development , was set by the European Council in Göteborg and Lisbon. Strong economic performance must go hand in hand with the sustainable use of natural resources. The key elements of the new CAP are a market policy where intervention is a safety net, income stabilisation is delivered through decoupled aids subject to cross-compliance, and a reinforced rural development policy that focuses on jobs, growth and sustainability. We must use the new CAP to unlock the potential for growth, jobs and innovation and put good ideas into practice. We need to work in partnership with farmers, foresters, the agrifood business, NGOs, the population of rural areas, the research community and of course public authorities. But to achieve all of this we need a stable budgetary environment, in which farmers and businesses can plan. In short, we need the resources to deliver on the potential of the new CAP. Les discussions sur la PAC, récemment, se sont focalisées sur le budget. En même temps, le contenu politique de la réforme, tel qu'il est vu dans le débat public, n'est rien d'autre que la caricature de l'ancienne PAC telle qu'elle existait avant les années 90. Or, au cours de la dernière décennie, la PAC a radicalement changé. Son nouveau cours , axé sur les marchés et le développement rural , a été défini lors des conseils européens de Göteborg et de Lisbonne. Les bonnes performances économiques doivent aller de concert avec l'utilisation durable des ressources naturelles. Une politique de marché, pour laquelle l'intervention n'est qu'un filet de sécurité, une stabilisation des revenus qui prend la forme d'aides découplées sous réserve d'application de normes, un développement rural renforcé, enfin, centré sur les emplois, la croissance et la durabilité, voilà les clés de la nouvelle PAC. Celle-ci doit être utilisée pour déchaîner les possibilités en matière de croissance d'emplois, d'innovation et de durabilité. Il faut pour cela s'appuyer sur les agriculteurs, les forestiers, les industries agroalimentaires, les organisations non gouvernementales, les populations des zones rurales, les chercheurs, et bien sûr les autorités publiques. Mais pour réaliser tout cela, il faut encore un environnement budgétaire stable, permettant aux agriculteurs et aux industriels de planifi er leurs actions. En d'autres termes, il faut des ressources pour que la nouvelle PAC tienne ses promesses. Die jüngsten Diskussionen über die GAP konzentrierten sich auf den Haushalt. In der öffentlichen Debatte ist die Politik selbst jedoch häufig noch ein Zerrbild der alten GAP, wie diese sich bis in die frühen 1990er Jahre darstellte. In den letzten zehn Jahren hat sich die GAP von Grund auf verändert. Die jüngste Richtung der GAP , Märkte und die Entwicklung des ländlichen Raums , wurde vom Europäischen Rat in Göteborg und Lissabon vorgegeben. Eine hohe wirtschaftliche Leistungsfähigkeit muss mit der nachhaltigen Nutzung der natürlichen Ressourcen Hand in Hand gehen. Die Schlüsselelemente der neuen GAP sind eine Marktpolitik, in der die Intervention als Sicherheitsnetz dient und eine Einkommensstabilisierung mittels entkoppelter Beihilfen erfolgt, für die Cross Compliance gilt; sowie eine gestärkte Politik zur Entwicklung des ländlichen Raums, welche sich auf Arbeitsplätze, Wachstum sowie Nachhaltigkeit konzentriert. Wir müssen die neue GAP dazu verwenden, das Potenzial für Wachstum, Arbeitsplätze und Innovationen frei zu setzen, und gute Ideen in die Tat umsetzen. Wir müssen partnerschaftlich mit den Landwirten, Förstern, Unternehmen der Agrar- und Ernährungswirtschaft, Nicht-Regierungsorganisationen (NRG), der Landbevölkerung, der Forschungsgemeinschaft und natürlich der öffentlichen Verwaltung zusammen arbeiten. Dafür benötigen wir jedoch eine stabile Haushaltssituation, die es den Landwirten und Unternehmen ermöglicht zu planen. Kurzum: Wir benötigen die Ressourcen, um das Potenzial der GAP auszuschöpfen. [source] The Emergence and Institutionalisation of the European Higher Education and Research AreaEUROPEAN JOURNAL OF EDUCATION, Issue 4 2008ERIC BEERKENS Since the European unification project started in the 1950s, rules, regulations and policies have been formulated by the European Union (and its predecessors) to facilitate the flow of products and people; those who benefited from the increasing transnational exchange urged European actors to remove remaining obstacles and further facilitate European trade and mobility. In the field of higher education and research, this transnational activity has led to the emergence of European rules, a strengthening of European institutions and the development of a European higher education and research community. In other words, it has led to the institutionalisation of the European higher education and research area (EHERA). The argument put forward in this article is that these three dimensions and the increase in transnational activity shape a dynamic process of which further integration of the EHERA is likely to be a result. [source] Craving: what can be done to bring the insights of neuroscience, behavioral science and clinical science into synchronyADDICTION, Issue 8s2 2000Roger E. Meyer Alcohol self-administration behavior is the common thread that is necessary to bring the insights of neuroscience, behavioral science and clinical science into synchrony around the concept of craving. Animal models should address the molecular and cellular changes that take place in behaviorally relevant brain regions of rats consequent to chronic self-administration of ethanol. Animal models can focus on the biology of the anticipatory state in alcohol preferring/consuming rats, as well as studies of the effects of possible medications on this state in the animal model, on actual alcohol consuming behavior, and on the residual effects of chronic alcohol on the non-human mammalian brain. In human studies of craving, cue-reactivity in the absence of the opportunity to drink alcohol does not have the same salience as cue-reactivity in which drinking is possible. Moreover, actual drinking behavior serves to validate self-reports of craving. Studies of limited alcohol self-administration in the laboratory are an essential element in screening new medications for the treatment of alcoholism. Studies to date suggest no adverse reaction to the participation of alcoholic subjects in limited alcohol self-administration studies, but the research community should continue to monitor carefully the outcomes of alcohol-dependent subjects who participate in this type of research, and efforts should always be made to encourage these subjects to enter active treatment. In outpatient clinical trials of new treatments for alcoholism, the assessment of craving should include queries regarding symptoms and signs of protracted abstinence such as sleep disturbances, as well as questions regarding situational craving. Field observations of alcoholics in their favorite drinking environments would contribute greatly to our understanding of the real-world phenomenology of craving. [source] The Candida Genome Database: Facilitating research on Candida albicans molecular biologyFEMS YEAST RESEARCH, Issue 5 2006Maria C. Costanzo Abstract The Candida Genome Database (CGD; http://www.candidagenome.org) is a resource for information about the Candida albicans genomic sequence and the molecular biology of its encoded gene products. CGD collects and organizes data from the biological literature concerning C. albicans, and provides tools for viewing, searching, analysing, and downloading these data. CGD also serves as an organizing centre for the C. albicans research community, providing a gene-name registry, contact information, and research community news. This article describes the information contained in CGD and how to access it, either from the perspective of a bench scientist interested in the function of one or a few genes, or from the perspective of a biologist or bioinformatician interpreting large-scale functional genomic datasets. [source] Is high strength concrete more susceptible to explosive spalling than normal strength concrete in fire?FIRE AND MATERIALS, Issue 3 2002Faris Ali There is a belief, within the fire research community, that high strength concrete is more susceptible to explosive spalling than normal strength concrete. This impression is based on studying concrete properties and collecting experimental data from different research sources. But there are still doubts about the credibility of this conjecture due to the lack of integrated experimental research, particularly designed to address this issue. This paper represents the outcomes of experimental study involving normal and high strength concrete columns tested under fire. The columns were subjected to a constant load and to different values of axial restraint. The paper attempts to address the question of the susceptibility of normal and high strength concrete to explosive spalling under fire. Copyright © 2002 John Wiley & Sons, Ltd. [source] Designed Fabrication of Silica-Based Nanostructured Particle Systems for Nanomedicine Applications,ADVANCED FUNCTIONAL MATERIALS, Issue 23 2008Yuanzhe Piao Abstract Suitably integrating multiple nanomaterials into nanostructured particle systems with specific combinations of properties has recently attracted significant attention in the research community. In particular, numerous particle systems have been designed and fabricated by integrating diverse materials with monodispersed silica nanoparticles. One or more distinct nanomaterials can be assembled on, encapsulated within, or integrated both inside and on the surface of silica nanoparticles using different chemistries and techniques to create multifunctional nanosystems. Research on these particle systems for biomedical applications has progressed rapidly during recent years due to the synergistic advantages of these complexes compared to the use of single components. This feature article surveys recent research progress on the fabrication strategies of these nanoparticle systems and their applications to medical diagnostics and therapy, thereby paving the way for the emerging field of nanomedicine. [source] Current challenges of pharmacovigilance in bleeding disorders: converting the burden to benefitHAEMOPHILIA, Issue 2 2010R. LASSILA Summary., Safety surveillance studies have proven essential in research and development of new biological therapies for bleeding disorders as well as other diseases. Although product safety regarding HIV, hepatitis, and other blood-borne infections is currently excellent, potential new infectious agents require continued vigilant monitoring. Inhibitor development is the most common serious side effect of haemophilia replacement therapy. Several aetiological factors associated with inhibitors have been identified, but their true impact is still largely unknown. Moreover, whether plasma-derived and recombinant factor products differ in their immunogenic profiles is an unresolved issue. Coagulation factor products under development and those currently on the market require uniform, long-term surveillance. The European Haemophilia Safety Surveillance (EUHASS) project was recently established to meet these goals. The pharmaceutical industry and clinicians face common challenges complying with these requirements. In rare diseases like haemophilia, obtaining adequate patient numbers poses a challenge. Another challenge is a lack of methods for assessing disease severity, a surprising deficiency in the era of modern medical and laboratory technology. National and international registries can be used to gather required safety surveillance information. Simultaneously, clinicians benefit from well-organized registry data in their daily practice and harmonize the quality of comprehensive haemophilia care by homogeneous follow-up platforms. Experience with such registries comes, for example, from Europe (PEDNET), the USA (CDC/UDC), the UK (UKHCDO), and Sweden (Malmö). It is important to commit to future pharmacovigilance efforts, aiming at high-quality safety surveillance programmes at both the pharmaceutical research community and clinical levels. [source] The UK National Cancer Research Institute (NCRI) Informatics Initiative: promoting partnership in cancer research,HUMAN MUTATION, Issue 12 2007Fiona Reddington Abstract The vast amount of information emerging from cancer research in recent years has presented a challenge for researchers worldwide. The opportunities for using this data to enhance understanding of the disease and advance the delivery of novel anticancer treatments are greater than ever, but will fail to be fully realized unless the necessary tools to collate and analyze the information are developed. This article describes the work of the National Cancer Research Institute (NCRI) Informatics Initiative which aims to maximize the impact of the results of research funded by NCRI Partner organizations for the benefit of cancer patients by ensuring that data generated through research is put to maximum use by the cancer research community. Hum Mutat 28(12), 1151,1155, 2007. © 2007 Wiley-Liss, Inc. [source] Hydrology and water resources in monsoon Asia: a consideration of the necessity of establishing a standing research community of hydrology and water resources in the Asia Pacific regionHYDROLOGICAL PROCESSES, Issue 14 2003Katumi Musiake Abstract Hydrological and water resources issues appear very differently in different regions, and are strongly affected by geographical conditions. Hydrological knowledge and methodologies obtained in a specific region cannot necessarily be adapted to other regions. The purpose of this paper is to clarify one way to address adequately the regional characteristics of hydrology and water resources in monsoon Asia, especially the ,too much water' problems in the region. For this purpose, geomorphological factors, climatic factors and human intervention in the natural environment are taken into consideration as the three major factors governing the regional characteristics of the hydrology,water resources system. To identify geomorphological features macroscopically between the Asia Pacific region and other continental regions, the concepts ,tectonic zone' and ,stable region', which are two major subdivisions of continental masses in the world, are introduced. Also, a new climatic subdivision termed ,warm-humid' is proposed to express the abundant precipitation due to the Asian monsoon. Then, hydrological characteristics common or similar in ,warm-humid tectonic zones' in the Asia Pacific region, contrasted with those in stable regions, are enumerated together with the human intervention corresponding to these characteristics, and research targets peculiar to warm-humid tectonic zones are discussed. Finally, the establishment of a standing research community called ,Asia Pacific Association of Hydrology and Water Resources' is proposed to promote the exchange of operational knowledge and experience in water resources management, cooperative research activities, and professional education in the Asia Pacific region. Copyright © 2003 John Wiley & Sons, Ltd. [source] Towards a distinctive body of knowledge for Information Systems experts: coding ISD process knowledge in two IS journalsINFORMATION SYSTEMS JOURNAL, Issue 4 2004Juhani Iivari Abstract., This paper introduces the idea of coding a practically relevant body of knowledge (BoK) in Information Systems (IS) that could have major benefits for the field. In its main part, the paper focuses on the question if and how an underlying body of action-oriented knowledge for IS experts could be distilled from the IS research literature. For this purpose the paper identifies five knowledge areas as the most important parts for an IS expert's BoK. Two of these are claimed as distinct areas of competence for IS experts: IS application knowledge and IS development (ISD) process knowledge. The paper focuses particularly on ISD process knowledge because it allows the organizing of practically relevant IS knowledge in an action-oriented way. The paper presents some evidence for the claim that a considerable body of practically relevant IS process knowledge might, indeed, exist, but also notes that it is highly dispersed in the IS literature. It then argues that the IS research community should take stock of this knowledge and organize it in an action-oriented way. Based on results from prior work it proposes a four-level hierarchical coding scheme for this purpose. In order to test the idea of coding action-oriented knowledge for IS experts, the paper reports the results of a coded literature analysis of ISD research articles published from 1996 to 2000 in two leading IS journals , Information Systems Journal and MIS Quarterly. The results suggest that ISD approaches form a useful framework for organizing practically relevant IS knowledge. [source] A paradigmatic and methodological examination of information systems research from 1991 to 2001INFORMATION SYSTEMS JOURNAL, Issue 3 2004WenShin Chen Abstract., The field of information systems (IS) has evolved for more than three decades. Although many schools of thought have emerged and even become well established, few historical analyses of research paradigms and methodologies have been undertaken. One of the rare exceptions is Orlikowski & Baroudi (1991). Yet, the IS research community has evolved substantially since 1991 in many aspects. A variety of journal outlets have emerged and become well established. More attention has been paid to paradigmatic and methodological issues. Political and professional contexts have also changed noticeably. Therefore, it should be an opportune time for the field to ask: ,What changes are manifested in journal publications?',Is the field making progress regarding pluralism in IS research?',How will the field's publications practices change in the future?' The purpose of this paper is to investigate these questions and, in turn, reflect on the paradigmatic and methodological progress made since 1991. We examined 1893 articles published in eight major IS publication outlets between 1991 and 2001. Our findings suggest that the long-term endeavours of interpretivist researchers might need to continue because the paradigmatic progress appears somewhat inconsequential; positivist research still dominates 81% of published empirical research. In particular, US journals, as opposed to European journals, tend to be more positivist, quantitative, cross-sectional and survey oriented. With respect to research design, survey research is still the most widely used method (41%), although case studies have gained substantial recognition (36%). Further, the increase of qualitative research (30%), empirical studies (61%) and longitudinal cases (33%) at the expense of laboratory experiments (18%) might suggest that IS researchers have become more interested in obtaining scientific knowledge in real world settings. In summary, we suggest that the field has been dominated by the positivist paradigm, despite calls to the contrary. Indeed, if the field was to truly embrace pluralism, it would have to find ways to fundamentally change the publication practices of the journal system, including the current tenure and promotion system, which pose considerable obstacles for the acceptance of alternative paradigms. [source] The Necessity of Studio Art as a Site and Source for Dissertation ResearchINTERNATIONAL JOURNAL OF ART & DESIGN EDUCATION, Issue 1 2008Kristin Baxter The issue raised by the authors in this article question why studio art continues to be ignored as a site and source for research in art education. The necessity of the field to be able to participate within the research community in addressing cultural, social, educational and political concerns is acknowledged. It is argued, however, that the exclusive use of methods of inquiry that align with the conventions of social science research has been done at the expense of fully appreciating the capacity of artistic research undertaken in studio contexts. This tendency is especially prevalent in doctoral research in higher education. Three accounts of dissertation research are given that incorporate studio activity as a central agency of inquiry in conceptualising and theorising issues. Each highlights the capacity of art practice to reveal insights that are a consequence of what the researcher did in the studio setting as issues, ideas and interpretive stances emerged, and problems were re-conceptualised. What is different in these accounts from more mainstream approaches to research is the readiness to accept that constructing new knowledge is a creative and critical process. [source] Development of a New Comprehensive Ocean Atlas for Indian Ocean utilizing ARGO DataINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 2 2010B. Prasad Kumar Abstract The World Ocean Atlas (WOA), also termed ,Levitus Climatology', is a global ocean climatology containing monthly, seasonal and annual means of temperature (T) and salinity (S) fields at standard ocean depths. The monthly climatology for T and S is available for standard depths up to 1000 m. The database used in the preparation of this climatology (WOA) are historical records of Conductivity, Temperature and Depth (CTD) casts and other available marine observations collected in the past. The methodology used in preparation of this WOA is objective analysis which is essentially non-synoptic and widely scattered in the space domain. We understand that ARGO data has so far not been blended with WOA, nor has its impact for improving WOA climatology been attempted. Presently, with the wealth of marine data from ARGO profilers in the Indian Ocean, we propose a new approach to reconstruct T and S fields optimally utilizing the ARGO data. Here we develop a new model using Delaunay Tessellation with QHull algorithm delivering three-dimensional T and S fields from a non-uniform scattered database up to a depth of 1000 m. For gaps in a data-sparse region, we use all available quality-checked Ocean Station Data (OSD) and Profiling Float Data (PFL) information on T and S, in addition to the existing ARGO data. The initiative here was to replace WOA data points with realistic information from ARGO and in situ data, thereby producing a new climatology atlas. We demonstrate the robustness of our approach, and the final climatology on T and S is better compared with the existing state-of-the-art WOA. The advantage of the proposed methodology is the scope of improving the ocean atlas with the addition of more ARGO data in the near future. The clustered approach in modelling enables ocean parameter retrieval in geometrically disconnected regions with an option for hot restart. We believe that the new climatology will benefit the research community immensely. Copyright © 2009 Royal Meteorological Society [source] Spatial sampling requirements for monitoring upper-air climate change with radiosondesINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 8 2008Mark P. McCarthy Abstract The global climate observing system upper air network (GUAN) was established to provide a network of high quality radiosonde stations with sufficient historical data records, and a commitment to future observing, in support of the needs of the climate research community. An assessment of the spatial sampling requirements for such a network in order to monitor large-scale climate changes has been conducted. The GUAN provides adequate coverage for monitoring global, tropical and hemispheric mean climate. Priority stations within the GUAN have been identified based upon their unique contribution to the network. Further sampling improvements to the GUAN may be possible by utilizing radiosonde stations located in India, Africa and northern polar regions. To keep sampling-related trend error below 0.05 K/decade in the troposphere, and 0.1 K/decade in the stratosphere, requires a radiosonde station to be located approximately every 30° longitude and 15° latitude north of 30°N. The inhomogeneous distribution of radiosonde stations in the tropics and southern hemisphere place a stronger requirement of 20° longitude and 10° latitude south of 30°N. The radiosonde network is inadequate for monitoring humidity except in the northern mid-latitudes. © Crown Copyright 2007. Reproduced with the permission of the Controller of HMSO. Published by John Wiley & Sons, Ltd [source] A peer-to-peer IPTV service architecture for the IP multimedia subsystemINTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS, Issue 6-7 2010A. Bikfalvi Abstract During these last years the Internet Protocol Television (IPTV) service and the different peer-to-peer (P2P) technologies have generated an increasing interest for the developers and the research community that find in them the solution to deal with the scalability problem of media streaming and reducing costs at the same time. However, despite of the benefits obtained in Internet-based applications and the growing deployment of commercial IPTV systems, there has been a little effort in combining them both. With the advent of the next-generation-network platforms such as the IP Multimedia Subsystem (IMS), which advocates for an open and inter-operable service infrastructure, P2P emerges as a possible solution in situations where the traditional streaming mechanisms are not possible or not economically feasible. In this paper, we propose an IPTV service architecture for the IMS that combines a centralized control layer and a distributed, P2P-like, media layer that relies on the IMS devices or peers located in the customers' premises to act as streaming forwarding nodes. We extend the existing IMS IPTV standardization work that has already been done in 3GPP and ETSI TISPAN in order to require a minimum number of architectural changes. The objective is to obtain a system with a similar performance to the one in currently deployed systems and with the flexibility of P2P. One of the main challenges is to achieve comparable response times to user actions such as changing and tuning into channels, as well as providing a fast recovery mechanism when streaming nodes leave. To accomplish this we introduce the idea of foster peers as peers having inactive multimedia sessions and reserved resources. These peers are on stand-by until their functionality is required and at that moment, they are able to accept downstream peers at short notice for events requiring urgent treatment like channel changing and recovery. Copyright © 2009 John Wiley & Sons, Ltd. [source] Distribution-based anomaly detection in 3G mobile networks: from theory to practiceINTERNATIONAL JOURNAL OF NETWORK MANAGEMENT, Issue 5 2010Alessandro D'Alconzo The design of anomaly detection (AD) methods for network traffic has been intensively investigated by the research community in recent years. However, less attention has been devoted to the issues which eventually arise when deploying such tools in a real operational context. We designed a statistical based change detection algorithm for identifying deviations in distribution time series. The proposed method has been applied to the analysis of a large dataset from an operational 3G mobile network, in the perspective of the adoption of such a tool in production. Our algorithm is designed to cope with the marked non-stationarity and daily/weekly seasonality that characterize the traffic mix in a large public network. Several practical issues emerged during the study, including the need to handle incompleteness of the collected data, the difficulty in drilling down the cause of certain alarms, and the need for human assistance in resetting the algorithm after a persistent change in network configuration (e.g. a capacity upgrade). We report on our practical experience, highlighting the key lessons learned and the hands-on experience gained from such an analysis. Finally, we propose a novel methodology based on semi-synthetic traces for tuning and performance assessment of the proposed AD algorithm. Copyright © 2010 John Wiley & Sons, Ltd. [source] REVIEW: The identification of priority policy options for UK nature conservationJOURNAL OF APPLIED ECOLOGY, Issue 5 2010William J. Sutherland Summary 1.,The conservation of biodiversity depends upon both policy and regulatory frameworks. Here, we identify priority policy developments that would support conservation in the UK in the light of technological developments, changes in knowledge or environmental change. 2.,A team of seven representatives from governmental organizations, 17 from non-governmental organizations and six academics provided an assessment of the priority issues. The representatives consulted widely and identified a long-list of 117 issues. 3.,Following voting and discussion during a 2-day meeting, these were reduced to a final list of 25 issues and their potential policy options and research needs were identified. Many of the policies related to recent changes in approaches to conservation, such as increased interest in ecosystem services, adaptation to climate change and landscape ecology. 4.,We anticipate that this paper will be useful for policy makers, nature conservation delivery agencies, the research community and conservation policy advocates. 5.,Although many of the options have global significance, we suggest that other countries consider an equivalent exercise. We recommend that such an exercise be carried out in the UK at regular intervals, say every 5 years, to explore how biodiversity conservation can best be supported by linked policy development and research in a changing world. 6.,Synthesis and applications. Opportunities for policy development were prioritized and for each of the top 25 we identified the current context, policy options and research questions. These largely addressed new issues relating to developing topics such as ecosystem services, landscape planning and nanotechnology. We envisage that this will largely be used by researchers wishing to make a contribution to potential policy debates. [source] Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?AGING CELL, Issue 5 2009Lynne S. Cox Summary Significant extension of lifespan in important mammalian species is bound to attract the attention not only of the aging research community, but also the media and the wider public. Two recent papers published by Harrison et al. (2009) in Nature and by Colman et al. (2009) in Science report increased longevity of mice fed with rapamycin and of rhesus monkeys undergoing caloric restriction, respectively. These papers have generated considerable debate in the aging community. Here we assess what is new about these findings, how they fit with our knowledge of lifespan extension from other studies and what prospects this new work holds out for improvements in human longevity and human health span. [source] EBM: evidence to practice and practice to evidenceJOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 5 2008Carol A. Isaac PhD PT Abstract Rationale, The purpose of this paper is to explore new perspectives about difficulties academicians may have communicating with clinicians, obtaining subjects, and gaining compliance for their research. Aims and Objectives, Evidence-based medicine (EBM) has been defined as an integration of best research evidence, clinical expertise, and patient values; however, clinical observation and experience are placed last in the evidence hierarchy with the randomized controlled trial held as the standard for clinical intervention. This paper describes how the hierarchical model of power in the research community obstructs new areas of knowledge, and how clinicians create resistance. Methods, Foucault gave new perspectives describing how power circulates through individuals within organizational discourse. Drawing on literature and experience, and using a framework based on postmodern theoretical concepts, this paper examines patterns of discourse, subjectivity, resistance, and power/knowledge within the physical therapy profession. Results, The hierarchical discourse of medical knowledge produces opposition rather than collaboration between researcher, clinician, and patient. Alleviating perceptions of dominance and creating connections produces cohesion within medical communities. Conclusions, Evidence to practice and practice to evidence redefines EBM as a circular integration of best research evidence, clinical expertise, and patient values. [source] | ||||||||||||||||||||||||||||||||||||||||