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Research Association (research + association)
Selected AbstractsCITIZENSHIP EDUCATION, POLICY, AND THE EDUCATIONALIZATION OF EDUCATIONAL RESEARCHEDUCATIONAL THEORY, Issue 4 2008Naomi Hodgson Hodgson begins by analyzing educational researchers' response to the recent introduction of citizenship education in England, focusing specifically on a review of research, policy, and practice in this area commissioned by the British Educational Research Association (BERA). She argues that the BERA review exemplifies the field of education policy sociology in that it is conducted according to the concepts of its parent discipline of sociology but lacks critical theoretical engagement with them. Instead, such work operationalizes sociological concepts in service of educational policy solutions. Hodgson identifies three dominant discourses of citizenship education within the BERA review, the academic discourse of education policy sociology, contemporary political discourse, and the discourse of inclusive education , and draws attention to the relation of citizenship education to policy initiatives, and thus to educationalization. She then discusses Foucault's concept of normalization in terms of the demand on the contemporary subject to orient the self in a certain relation toward learning informed by the need for competitiveness in the European and global context. Ultimately, Hodgson concludes that the language and rhetoric of education policy sociology implicate such research in the process of educationalization itself. [source] Elemental signals regulating eosinophil accumulation in the lungIMMUNOLOGICAL REVIEWS, Issue 1 2001Paul S. Foster Summary: In this review we identify the elemental signals that regulate eosinophil accumulation in the allergic lung. We show that there are two interwoven mechanisms for the accumulation of eosinophils in pulmonary tissues and that these mechanisms are linked to the development of airways hyperreactivity (AHR). Interleukin-(IL)-5 plays a critical role in the expansion of eosinophil pools in both the bone marrow and blood in response to allergen provocation of the airways. Secondly, IL-4 and IL-13 operate within the allergic lung to control the transmigration of eosinophils across the vascular bed into pulmonary tissues. This process exclusively promotes tissue accumulation of eosinophils. IL-13 and IL-4 probably act by activating eosinophil-specific adhesion pathways and by regulating the production of IL-5 and eotaxin in the lung compartment. IL-5 and eotaxin co-operate locally in pulmonary tissues to selectively and synergistically promote eosinophilia. Thus, IL-5 acts systemically to induce eosinophilia and within tissues to promote local chemotactic signals. Regulation of IL-5 and eotaxin levels within the lung by IL-4 and IL-13 allows Th2 cells to elegantly co-ordinate tissue and peripheral eosinophilia. Whilst the inhibition of either the IL-4/IL-13 or IL-5/ eotaxin pathways resulted in the abolition of tissue eosinophils and AHR, only depletion of IL-5 and eotaxin concurrently results in marked attenuation of pulmonary inflammation. These data highlight the importance of targeting both IL-5 and CCR3 signalling systems for the resolution of inflammation and AHR associated with asthma. S.M. is a Postdoctoral Fellow funded by a grant from the Human Frontiers Foundation to P.S.F. and M.E.R. J.M. is supported by the German Research Association (grant MA 2241/1-1) and S.P.H by a NH&MRC CJ Martin Postdoctoral Fellowship. [source] The Quaternary of the British Isles and adjoining seas,JOURNAL OF QUATERNARY SCIENCE, Issue 4 2010James Rose Abstract This Special Issue of the Journal of Quaternary Science contains a set of 13 papers based on presentations at the Annual Discussion Meeting of the Quaternary Research Association held in London in January 2008. This Special Issue is concerned with four main themes: long-term landscape signatures, river landscapes and responses to climate change, glacial landscapes and Lateglacial landscapes. The papers include substantial new data on the terrestrial and offshore Quaternary of the British Isles and provide a benchmark for aspects of current thinking on this topic. This volume is published in parallel with other special issues based on the 2008 QRA Discussion Meeting. These consist of The Quaternary Geology of the British Isles edited by David Bridgland and Nick Golledge in the Proceedings of the Geologists' Association and Climate variability of the British Isles and surrounding seas edited by Dan Charman and Danny McCarroll in Quaternary Science Reviews. Copyright © 2010 John Wiley & Sons, Ltd. [source] Profound loss of GABAergic interneurons in the PPT1 knockout mouse model of infantile neuronal ceroid lipofuscinosisNEUROPATHOLOGY & APPLIED NEUROBIOLOGY, Issue 2 2002J. D. Cooper Introduction:, The neuronal ceroid lipofuscinoses (NCL) are progressive neurodegenerative disorders with onset from infancy to adulthood that are manifested by blindness, seizures and dementia. In infantile NCL (INCL), a mutation in the palmitoyl protein thioesterase (PPT1) gene results in loss of PPT1 activity and lysosomal accumulation of autofluorescent proteolipid in the brain and other tissues. We have generated a PPT1 knockout mouse model of INCL (PPT1,/,) and characterized pathological changes in the CNS of these mice, which die by 8 months of age. Results:, 7-month-old PPT1,/, exhibited NCL-like pathology with prominent accumulation of autofluorescent lipopigment throughout the CNS, together with pronounced cerebral atrophy. Staining for phenotypic markers normally present in subpopulations of interneurons in the cortex and hippocampus revealed progressive loss of staining in the cortex and hippocampus, with persisting interneurons exhibiting pronounced hypertrophy and abnormal dendritic morphology. Conclusions:, Taken together with our findings in the other mouse models of NCL and preliminary data from NCL patient derived tissue, these results provide further substantive evidence for the involvement of interneurons in the NCLs. Acknowledgements:, Supported by The Batten's Disease Support and Research Association, The Natalie Fund, The Remy Fund; Batten's Disease Family Association. [source] Most readily usable methods to measure ocular blood flowACTA OPHTHALMOLOGICA, Issue 2009K GUGLETA Purpose SIS Lecture. Methods Literature search. Results Ocular Blood Flow Research Association (OBFRA, recently merged with another organization - ISOCO, into one single Association for Ocular CDirculation - AOC) made a significant contribution to standardization of the blood flow measuring techniques in the field of ophthalmology. A consens was reached on the number of OBF measurements techniques that occured in the past decades. Particular emphasis was placed on the basic technology, specific parameters and interpretation, accuracy and reproducibility, field of clinical applications. Open questions were extensively discussed, limits of each technique clearly postulated. and a consensus statement put together for each of the technique involved. It encompassed techniques like color Doppler imaging, laser Doppler flowmetry (continuous as well as scanning LDF), laser Doppler velocimetry, Retinal Vessel Analyzer, combination of the vessel diameter measurement and the LDV, laser interferometry of the fundus pulsations amplitude, retinal oxymetry, measurements of the pulsatile component of the blood flow, blue field entoptic method and the newest - Doppler OCT. Conclusion There is no overwhelming measuring technique able to cover all the aspects of the research and the daily clinical routine. Various parameters and various vascular beds are involved, which makes the interpretation of the obtained results strenuous. Of particular importance is the capability of OBF measuring techniques to capture one dynamic feature of ocular circulation - its ability to regulate and to response to various challenges. It is widely believed that not the constantly reduced blood flow, but rather the lack of regulation thereof, leads to prevalent ocular diseases. [source] A framework for evidence-based mental health care and policyACTA PSYCHIATRICA SCANDINAVICA, Issue 2006L. Salvador-Carulla Objective:, Care planning integrates a growing number of disciplines, research fields and analysis techniques. A framework of the main areas of interest with regard to evidence-based health care in mental health is provided here. Method:, The framework is based on the experience of working with data analysts and health and social decision makers at the PSICOST/RIRAG network, a Spanish research association which includes psychiatrists, health economists and health policy experts, as well as on a review of the literature. Results:, Three main areas have been identified and described here: outcomes management, knowledge discovery from data, and decision support systems. Their use in mental health care is reviewed. Conclusion:, It is important to promote bridging strategies among these new fields in order to enhance communication and information transfer between the different parts involved in mental health decision making: i) clinicians and epidemiologists, ii) data analysts, iii) care policy makers and other end-users. [source] | ||||||||||