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Research And Development (research + and_development)
Kinds of Research And Development Terms modified by Research And Development Selected AbstractsInnovation and Knowledge Management: The Long ViewCREATIVITY AND INNOVATION MANAGEMENT, Issue 3 2001Michael Lester The challenge of the e,Economy is one of technological change and the innovation process affords insights into how this new knowledge can be harnessed across the economy to increase productivity and generate wealth. The conceptual framework for this paper is National Systems of Innovation (NSI) as applied to Australia Edquist (1997); Freeman (1995). NSI allows us to take a holistic view of innovation that realistically blends technology with institutional elements, particularly including issues of collaboration. Taking a Long View (Schwartz (1991), that is, looking back on the legacy of experience with the innovation process, will also facilitate looking forward strategically from Australia's current practices, and to speculate on the prospects. This paper illustrates selectively and not comprehensively, from my own direct experience, the evolution of innovation policies in Australia and speculates on their implications for collaboration in the e,Economy by drawing on selected case studies in Research and Development, Industry and Trade, and the e,Economy. It also draws upon work for my doctorate in knowledge management at the University of Technology. The selection and synthesis of theory inevitably also reflect, however idiosyncratically, my academic training in engineering, politics and economics. [source] Trials update in walesCYTOPATHOLOGY, Issue 2007A. Fiander Three ongoing studies will be presented and discussed. Prevalence of Human Papillomavirus Infection in a South Wales Screening population Methods: A total of 10 000 consecutive, anonymous liquid based cytology screening samples were collected over a five month period in 2004. Age, cytology result and social deprivation score was provided for each specimen. The methodology was chosen to ensure inclusion of all women attending routine cervical screening, avoiding potential constraints associated with obtaining individual informed consent. The liquid based cytology samples were processed and reported by the receiving cytology laboratory and the residual specimens sent to the HPV Research Laboratory, Wales College of Medicine, where they were processed and stored at -80°C until analysis. High risk and low risk HPV Typing was undertaken using PCR , EIA (Jacobs et al 1997). Full high risk typing was performed on HPV positive specimens. Results: The study population had a mean age of 38 years with 92% negative, 5% borderline and 3% dyskaryotic cytology. The average social deprivation score was 17.4 (based upon the Welsh Index of multiple deprivation). The following results will be presented: HPV prevalence by age. HPV prevalence by cytology result. Type specific HPV prevalence in single and multiple infection. Conclusion: This study represents the largest type specific HPV Prevalence Study in the UK to date. As such it will form a useful base line against which to access performance of marketed HPV tests and evaluating the impact following implementation of HPV vaccination. [Funded by Welsh Office for Research and Development] CRISP , 1 Study (Cervical Randomized Intervention Study Protocol -1) Background: Indole-3-carbinol (I3C) and Diindolylmethane (DIM) are found in cruciferous vegetables and have been identified as compounds that could potentially prevent or halt carcinogenesis. I3C spontaneously forms DIM in vivo during acid digestion. I3C has been shown to prevent the development of cervical cancer in HPV 16 transgenic mice and both I3C and DIM have been shown to promote cell death in cervical cancer cell models. DIM is the major active bi-product of I3C and preliminary data indicate that DIM is active in cervical dysplasia and may be better tolerated than I3C. Aim: To investigate chemoprevention of high grade cervical neoplasia using Diindolylmethane (DIM) supplementation in women with low grade cytological abnormalities on cervical cytology. Objectives: To observe any reduction in the prevalence of histological proven high-grade cervical intraepithelial neoplasia (CIN) after 6 months of supplementation. ,,To observe any reduction in the prevalence of cytological abnormalities. ,,To observe any changes in the clinical appearance of the cervix. To assess acceptability and monitor any side effects of DIM supplementation. ,,To assess whether any benefit is seen in relation to Human Papillomavirus (HPV) status including HPV Type, Viral load and integration. Methods: This is a double blind randomized placebo-controlled trial involving 600,700 women with low grade cytological abnormalities on a cervical smear. Randomization is in the ratio of 2 : 1 in favour of active medication. Women with first mildly dyskaryotic smear or second borderline smear are eligible. They are asked to take two capsules daily for 6 months. At the end of 6 months they undergo repeat cervical cytology, HPV testing and colposcopy. Results: A progress report will be given for this ongoing study. [Funded: - Cancer Research UK] Type Specific HPV Infection in Welsh Cervical Cancers Background: Whilst there have been numerous studies of HPV infection associated with cervical cancer and on prevalence of Human Papillomavirus in diverse populations there have been no studies of these variables in the same population. Against a background of prophylactic HPV vaccination it is important to assess potential protection against cervical cancer within a given population. The most comprehensive analysis of HPV type specific cervical cancer is a meta-analysis published by the IARC in 2003. This however included only three UK based studies, totalling 118 cases, 75 of which were only investigated by HPV type PCR for four high risk types. None of this data was presented with associated population based prevalence data. Therefore, the research objectives for this study in combination with the first study above, are as follows: To determine the frequency of specific HPV types in cervical cancers in Wales. To compare the distribution of specific HPV types amongst cervical cancers with their prevalence in the general population. This will allow accurate delineation of the relationship between prevalence of specific HPV types in the general population and their association with clinically relevant disease. This information is a pre-requisite to assess the potential impact of prophylactic vaccination against HPV infection in Wales. Methods: Welsh Cervical Cancer specimens from 2000,2005 will be identified from pathology departments within Wales. The pathology of each tumour will be reviewed by a single Gynaecological Pathologist. The age of the patient and pathological features of the tumour will be noted. DNA will be extracted from the paraffin sections and HPV typed by PCR-EIA. Results: A progress report will be given for this ongoing study. [Funded by Welsh Office for Research and Development] [source] Ecological research in the office of research and development at the U.S. Environmental Protection Agency: An overview of new directions,,ENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 4 2000Rick A. Linthurst Abstract In virtually every major environmental act, Congress has required that the U.S. Environmental Protection Agency (U.S. EPA) ensure not only that the air be safe to breathe, the water safe to drink, and the food supply free of contamination, but also that the environment be protected. In response, the U.S. EPA's Office of Research and Development (ORD) has established research to improve ecosystem risk assessment and management, identifying it as one of the highest priority research areas for investment over the next 10 years. The research is intended to provide environmental managers with new tools and flexible guidance that reflect a holistic environmental management perspective of science and that can be applied both to common and unique problems. In keeping with its responsibility to provide the U.S. EPA with science that supports a dynamic changing regulatory agenda, the ORD has set the goal of its Ecological Research Program to "provide the scientific understanding required to measure, model, maintain and/or restore, at multiple scales, the integrity and sustainability of ecosystems now, and in the future." In the context of this program, ecological integrity is defined in relative terms as the maintenance of ecosystem structure and function characteristic of a reference condition deemed appropriate for its use by society, and sustainability is defined as the ability of an ecosystem to maintain relative ecological integrity into the future. Therefore, the research program will emphasize relative risk and consider the impact of multiple stressors, at multiple scales and at multiple levels of biological organization. The program will also shift from chemical to biological and physical stressors to a far greater extent than in the past. The purpose of this paper is to provide an introduction to the U.S. EPA's changing ecological research program. [source] Cocaine Rapid Efficacy Screening Trial (CREST): a paradigm for the controlled evaluation of candidate medications for cocaine dependenceADDICTION, Issue 2005Deborah B. Leiderman ABSTRACT Aim Development of effective medications for the treatment of cocaine dependence remains a major priority for the National Institute on Drug Abuse (NIDA) at the National Institutes of Health. The Cocaine Rapid Efficacy Screening Trial (CREST) paradigm was developed by the Division of Treatment Research and Development (DT R&D) at NIDA with the goal of enhancing pilot clinical trial validity when systematically assessing a range of medications and drug classes for potential utility in treatment of cocaine dependence. Design CREST utilizes a randomized, controlled, parallel group, blinded methodology for comparing one or more marketed medications against a standard, pharmaceutical grade placebo. The trial design is comprised of a flexible 2,4-week screening/baseline period followed by randomization to an 8-week treatment period. Measures Standard measures of outcomes for the CREST included urinary benzoylecgonine (primary metabolite of cocaine), retention, cocaine craving, depression, clinical global impression and HIV-risk behaviors. In order to facilitate comparisons of data from the CREST studies across sites, drug classes and time, standardized procedures, measures and psychosocial counseling were used. Results A total of 19 medications were evaluated in out-patient treatment research clinics in Boston, Cincinnati, Los Angeles, New York and Philadelphia. Conclusions Findings supported decisions to move forward three medications (cabergoline, reserpine, tiagabine) using full-scale, adequately powered, randomized placebo-controlled trial designs. Lessons learned from the CREST experience continue to shape cocaine pharmacotherapy trial design and execution. [source] Cocaine Rapid Efficacy Screening Trials (CREST): lessons learnedADDICTION, Issue 2005Kyle M. Kampman ABSTRACT Aims The Cocaine Rapid Efficacy Screening Trials (CREST) were designed by the National Institute on Drug Abuse Division of Treatment Research and Development (NIDA, DT R&D) to rapidly screen a number of medications potentially useful for the treatment of cocaine dependence. Design Each CREST trial was designed to compare several medications in a single trial against an unmatched placebo. The placebo group was included in each trial to avoid the nearly universal positive response to medications seen in open-label trials. In addition, a common set of procedures and outcome measures were employed throughout to increase comparability of results obtained from different trials and from different times. Participants In all, 18 medications were screened in seven different trials, conducted in four different sites throughout the United States involving 398 cocaine-dependent patients. Findings Three medications were found to be promising enough to include in subsequent larger trials. Common statistical procedures for evaluating medications were developed to facilitate comparisons across sites and across time. A portion of the data were pooled and analyzed, which yielded some useful insights into cocaine dependence and its treatment. Finally, a review of individual trials together with the pooled analysis revealed several potential improvements for future screening trials. Conclusions Overall, the CREST trials proved to be useful for rapidly screening medications for treatment of cocaine dependence, but several modifications in design should be made before this framework is applied further. [source] Mathematical modelling of fire development in cable installationsFIRE AND MATERIALS, Issue 4 2001P. Van Hees In 1996 DG XII of the European Commission (Research and Development) approved a 3 year project on the fire performance of electrical cables. Within this FIPEC project, a major part of the work involved correlation and mathematical modelling of flame spread and heat release rate in cable installations. The FIPEC project has developed different levels of testing ranging from a small-scale, cone calorimeter test procedures developed for cables and materials, a full-scale-test procedure based on the IEC 60332-3, but utilizing HRR and SPR measurements, and a real scale test conducted on model cable installations. Links through statistical correlations and mathematical fire modelling between these levels were investigated and the findings are presented in this paper. These links could form the scientific foundations for standards upon which fire performance measurements can be based and for new fire engineering techniques within fire performance based codes. Between each testing level correlation, numerical and mathematical models were performed. All of the models were based on the cone calorimeter test method. The complexity of the models varied from correlation models to advanced physical pyrolysis models which can be used in CFD codes. The results will allow advanced prediction of cable fires in the future. Also a bench mark was established for the prediction of cable performance by means of data obtained from the constituent materials. Copyright © 2002 John Wiley & Sons, Ltd. [source] A Strategy for Nursing Research and DevelopmentINTERNATIONAL JOURNAL OF NURSING PRACTICE, Issue 1 2001David R Thompson Professor No abstract is available for this article. [source] Exploratory factor analysis of the research and development culture index among qualified nursesJOURNAL OF CLINICAL NURSING, Issue 9 2005Bill Watson MSc Aims and objectives., This paper presents the exploratory factor analysis of a rating instrument for assessing the strength of organizational Research and Development (R&D) culture. Background., Despite nursing's limited research capacity, the discipline is capitalising upon opportunities to become involved in research and is making strong progress. Within the context of the debate on nursing research capacity, the R&D Culture Index was developed as a means of appraising R&D culture within health care organizations. Design., Factor analysis was carried out on data collected from 485 nursing staff. The method of extraction was Principal Components Analysis with oblique rotation. Methods., The Index was developed from the findings of qualitative research conducted with NHS staff. Eighteen items, encompassing the main themes from the data, were initially included in the Index. This pilot instrument was distributed to nursing staff within three different types of NHS Trust. Factor analysis resulted in rejection of two items and the analysis was repeated using the remaining 16 items. Results., Three latent factors were extracted accounting for 58·0% of the variance in the data. The factors were: R&D Support, describing the perceived support within the working environment for R&D activity; Personal R&D Skills and Aptitude, describing an individual's perception of their ability towards R&D activity; and Personal R&D Intention, describing an individual's willingness to engage in R&D activity. Each factor had good internal reliability, as did the overall index. Conclusion., The R&D Culture Index provides an efficient means of assessing the strength of an organization's R&D culture in a way that captures the role of the individual practitioner and the organizational environment. Relevance to practice., These findings suggest that the continuing promotion of R&D within health care organizations is dependent upon a multi-faceted approach that addresses the learning needs of the organization as well as those of the individual practitioners. [source] Does the Capitalization of Development Costs Improve Analyst Forecast Accuracy?JOURNAL OF INTERNATIONAL FINANCIAL MANAGEMENT & ACCOUNTING, Issue 1 2010Evidence from the UK It has been documented that investments in Research and Development (R&D) are associated with increased errors and inaccuracy in earnings forecasts made by financial analysts. These deficiencies have been generally attributed to information complexity and the uncertainty of the future benefits of R&D. This paper examines whether the capitalization of development costs can reduce analyst uncertainty about the future economic outcome of R&D investments, provide outsiders with a better matching of future R&D-related revenues and costs, and therefore promote accuracy in analyst forecasts. UK data is used, because accounting rules in the United Kingdom permitted firms to conditionally capitalize development costs even before the introduction of the International Financial Reporting Standards. The choice to expense R&D rather than conditionally capitalize development costs is found to relate positively to signed analyst forecast errors. This finding is robust to controlling for the influence of other factors that may affect errors, as well as for the influence of R&D investments on forecast errors. The decision to capitalize versus expense is not observed to have a significant influence on analyst forecast revisions. The findings are interpreted as evidence that the choice to capitalize as opposed to expense may help to reduce deficiencies in analyst forecasts; hence, is informative for users of financial statements. Increased informativeness is expected to have repercussions for the effectiveness with which analysts produce earnings forecasts, and, as a result, market efficiency. [source] Recollections of Irving H. Sher 1924,1996: Polymath/information scientist extraordinaireJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 14 2001Eugene Garfield Over a 35-year period, Irving H. Sher played a critical role in the development and implementation of the Science Citation Index® and other ISI® products. Trained as a biochemist, statistician, and linguist, Sher brought a unique combination of talents to ISI as Director of Quality Control and Director of Research and Development. His talents as a teacher and mentor evoked loyalty. He was a particularly inventive but self-taught programmer. In addition to the SCI,® Social Sciences Citation Index,® and Arts and Humanities Citation Index,® Sher was involved with the development of the first commercial SDI system, the Automatic Subject Citation Alert, now called Research Alert,® and Request-A-Print Cards. Together we developed the journal impact factor and the Journal Citation Reports.® Sher was also the inventor of the SYSTABAR System of coding references and Sherhand. He was involved in key reports on citation-based historiography, forecasting Nobel prizes, and served as a referee for JASIS over a 20-year period. [source] Preface: phys. stat. sol. (c) 1/10PHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue 10 2004Eun-Kyung Suh The Fifth International Symposium on Blue Laser and Light Emitting Diodes (ISBLLED-2004) was held in Gyeongju, Korea from 15,19 March 2004. Gyeongju, the ancient capital of the thousand-year Silla kingdom (57 B.C. to 935 A.D.) provided additional pleasure to the participants as an exceptional open-air museum with antique treasures scattered all around the city. During the last decade we have witnessed remarkable developments in wide-gap semiconductors and light emitting devices in the spectral range from the visible to deep UV. The purpose of the Symposium was to provide a forum for intensive discussion on the issues and main progress especially in optoelectronic devices, material growth and characterization, and quantum structures of wide bandgap semiconductors. A total of 243 papers including 220 contributed and 23 invited ones were presented and discussed by 487 participants from 17 countries world-wide. Among them, 154 manuscripts were submitted and reviewed by the usual evaluation process of physica status solidi. Some were rejected or withdrawn, and finally 139 papers are published in the special issues of physica status solidi (a), (b), and (c). We gratefully acknowledge the referees for their careful review. The papers are grouped into 7 categories. The subheadings and the number of papers in each are as follows: Optoelectronic devices, 43; Growth and characterization, 45; Nano and quantum structures, 21; Contacts, 8; Zinc oxide, 9; Indium nitride and indium rich InGaN, 6; Others, 7. The special session of the Symposium, "The LED Highlight", designed partially to meet the challenging targets of the technology, i.e., energy savings and clean environment preservation, drew much attention and is edited as a special coloured section in this issue. The next symposium is scheduled for Montpellier, France, in 2006. We wish the organizers of that symposium the best of luck and hope to see all of the ISBLLED-2004 participants again at ISBLLED-2006. ISBLLED-2004 was sponsored by The Research Society for the Wide-gap Semiconductors, Korean Physical Society, Office of Naval Research, Korea Science and Engineering Foundation, Korea Research Foundation, Korea Association for Photonics Industry Development, Asian Office of Aerospace Research and Development, and Korea Photonics Technology Institute. We would like to thank Ms. E. S. Hwang for her devotion to the preparation and the Proceedings of the symposium including the manuscript handling for publication. [source] Integrating art as a trans-boundary element in a radical innovation frameworkR & D MANAGEMENT, Issue 1 2010Christian Stüer Companies have learned that radical innovations (RIs) are a prerequisite to grow organically. However, companies struggle to identify and introduce RIs, as their inherent high uncertainties and novelty challenge established organisations and management routines. To address the first challenge, companies need to take a holistic approach and design a trans-boundary environment of creativity, trans-disciplinary and entrepreneurial spirit. This environment attracts and retains visionary people, fosters generation of new opportunities and cultivates adaptability. By adapting evaluation metrics for RI, setting up flexible processes, and promoting trans-disciplinary exchange, the second challenge can be addressed. Increased research has concentrated on several aspects of RI lately, but so far a combining framework is missing. Our paper bridges this gap by developing an improved theoretical framework, enhancing the existing literature and introducing art as a method to advance trans-disciplinary interchange. In a case-study approach, we have applied our framework to the research and development department of Vodafone Research and Development, Germany, as they integrate art methodically in their research and development process. Analysing their RI capabilities, we identify the trans-disciplinary exchange with artists as a novel initiator and driver of RI, which has not yet been adequately considered. [source] Steady-state field-scale gas permeability estimation and pore-gas velocity calculation in a domain open to the atmosphereREMEDIATION, Issue 4 2000Dominic C. Digiulio Field-scale estimation of gas permeability and subsequent computation of pore-gas velocity profiles are critical elements of sound soil venting design. It has been our experience, however, in U.S. Environmental Protection Agency's (EPA's) technical assistance program, provided by the Office of Research and Development in support EPA regional offices, that many venting practitioners are unaware of equations and data interpretation methods appropriate for gas permeability estimation and pore-gas velocity computation. To ameliorate this situation, we use data collected at a U.S. Coast Guard Station in Traverse City, Michigan, to demonstrate gets permeability estimation and pore-gas velocity calculation for steady-state, axisymmetric, two-dimensional gas flow in a domain open to the atmosphere. For gas permeability estimation, we use random guesses constrained with decreasing intervals of radial and vertical permeabilityand analysis of root mean square errors to ensure attainment of a global versus local minimum. We demonstrate confidence in permeability estimation by providing plots of observed versus simulated pressure response. Finally, we illustrate how plots of pore-gas velocity as a function of distance and flow rate can be helpful in venting design. [source] STOCK MARKET VALUATIONS OF R&D AND ELECTRONICS FIRMS DURING TAIWAN'S RECENT ECONOMIC TRANSITIONTHE DEVELOPING ECONOMIES, Issue 1 2006CHAOSHIN CHIAO G12; O33 The objective of the present study is to investigate the market valuation of Research and Development (R&D) investments in the Taiwanese stock market from July 1988 to June 2002. The motivation stems from Taiwan's recent economic transition from a labor-intensive, then to a capital-intensive, and currently to a technology-based economy. The results support not only the existence, but also the persistence of R&D-associated mispricing. More importantly, it has become stronger as the electronics industry gradually dominates the economy. First, R&D-intensive stocks tend to outperform stocks with little or no R&D. Second, the R&D-intensity effect cannot fully be attributed to firm size. Third, the R&D-intensity effect is more pronounced for firms in the electronics industry after 1996. [source] FROM EXPERIENCE: Creating Synergy between Marketing and Research and Development,THE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 1 2004Gail L. Rein The tensions between marketing and research and development (R&D) are so common that we have come to accept them as the way organizations are. If we remain resigned like this, how will we ever reap some of the benefits that can accrue from these groups working better together? If we can improve the working relationships between marketing and R&D, researchers promise a variety of desirable organizational outcomes, such as cycle-time reduction and new product success. This article describes in detail the changes that a Fortune 500 company made to its product development process to foster synergy between marketing and R&D. The modified process formalized the roles of marketing and R&D at both the front and back ends of the product development process, increasing productive interaction between the groups. The company found that at the front end, marketing and R&D needed to work together (1) to clarify the market requirements implicit in the market attack plan and (2) to develop a technical strategy that responded to the market requirements and that consequently implemented the market attack plan. At the back end, the groups needed to work together (3) to formulate the value messages used to market the company's products. The synergy created between marketing and R&D through the new process is credited for enabling the company to compete successfully in a market it never before had entered. [source] Research and Development, Regional Spillovers and the Location of Economic ActivitiesTHE MANCHESTER SCHOOL, Issue 4 2004Alberto Franco Pozzolo I present an endogenous growth model that studies the effects of local inter-industry and intra-industry knowledge spillovers in R&D on the allocation of economic activities between two regions. The equilibrium is the result of a tension between a centripetal force, the cost of transporting goods from one region to the other, and a centrifugal force, the cost increase associated with life in a more crowded area. The presence of local knowledge spillovers, which determines the concentration of the R&D activities within one region, also introduces a further centripetal force that makes a symmetric allocation of the economic activities impossible. The concentration of R&D fosters the equilibrium rate of growth of the economy with respect to the case of no-integration, by increasing the positive effect of local knowledge spillovers. Contrary to the findings of the majority of models in the new economic geography literature, within this framework a reduction in transport costs may be associated with a more even geographical distribution of economic activities. [source] Transformative Education: Chronicling a Pedagogy for Social ChangeANTHROPOLOGY & EDUCATION QUARTERLY, Issue 1 2008Miguel Guajardo This article chronicles the work of the Llano Grande Center for Research and Development, an educational nonprofit organization in South Texas, by following the narrative of one of its students and two of the authors, who are also founders of Llano Grande. Through the use of ethnography, visuals, and storytelling, they present an emerging theory of practice and a hybrid methodology that has contributed to the development of the work, the school, and the community. An activist agenda informed by practice and supported with theory is woven through the text in biographical form. The text also documents the cornerstones of the work: building strong relationships; work originating from self, place, and community; and engaging in meaningful work. When integrated into a seamless practice, this combination of guiding principles yields a certain power that youth and adults alike begin to negotiate within and between their peers, teachers, and community for change. This sense of self, efficacy, and power then informs much of their work as adults.,[Latino epistemology and education, activist ethnography, Llano Grande Center, storytelling, community as text, pedagogy of hope] [source] Camouflage as Aesthetic SustainabilityARCHITECTURAL DESIGN, Issue 6 2006Dagmar Richter Abstract A textile approach to architecture offers unique opportunities to explore a structure's surface and texture. Through a discussion of the history of the technique of camouflage and her own projects with Design Research and Development (DR_D), Dagmar Richter demonstrates the potential for surface enrichment to exceed mere ornament or patterning. A ,performative texture', camouflage interacts with its context mimicking the natural and effectively disguising whatever it covers. With a now long military association, camouflage also provides anything but a neutral background for its cover. Copyright © 2006 John Wiley & Sons, Ltd. [source] The Need for International Communications in Artificial Organs Research and Development and Clinical PracticeARTIFICIAL ORGANS, Issue 1 2004Paul S. Malchesky D.Eng. No abstract is available for this article. [source] Fractionation technology for the petroleum refining industryASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING, Issue 4 2007Albert Hug Abstract Distillation Research and Development is moving rapidly with the utilization of computational fluid dynamic (CFD) modeling. Previously, a potential fractionation application would first be developed and fabricated. Then many hours of pilot plant testing would be required to finalize the design. The time line for the development of new distillation equipment has been reduced, leading to advances in fractionation equipment. Current applications of trays, packings, distributors and feed inlets can be optimized utilizing CFD modeling. CFD Modeling has improved the current generation of fractionation equipment. This modeling is also particularly important in maximizing capacity in tower revamps where the diameter of the tower is fixed. This paper will review the current-generation fractionation equipment and the utilization of the same in the petroleum refining industry. Copyright © 2007 Curtin University of Technology and John Wiley & Sons, Ltd. [source] Numerical Determination of Heat Distribution and Castability Simulations of as Cast Mg,Al Alloys,ADVANCED ENGINEERING MATERIALS, Issue 3 2009Shehzad Saleem Khan Magnesium alloys offer a large potential as lightweight structures especially in the automotive industry. Research and development of magnesium alloys depend largely on the metallurgist's understanding and ability to control the microstructure of the as cast part. This research work comprises the determination of experimental parameters to simulate fluidity and microstructure of magnesium/aluminum binary alloys. [source] Research and development at the health and social care interface in primary care: a scoping exercise in one National Health Service regionHEALTH & SOCIAL CARE IN THE COMMUNITY, Issue 6 2002Jo Cooke MA Abstract The present project aimed to identify research activity at the health and social care interface in primary care within one National Health Service region, and to determine levels of research capacity and support within social services. The study was commissioned by a primary care research network (PCRN) in order to assess opportunities to increase research capacity within social services. Data were collected in two phases from 61 managers, team leaders and senior practitioners in social care, and six public health representatives in health authorities, using telephone interviews and focus groups. The findings highlighted a lack of infrastructure and support for research and development in social care. However, many social care respondents wanted opportunities to develop research skills with healthcare colleagues. Despite poor support, many small-scale projects were described, and many respondents showed an enthusiasm for engaging with research. Methods in use included surveys, action research, needs analysis and evaluation of service developments. Many examples of user involvement were given. Interface projects were usually instigated by interagency forums and funded from multiple sources. Most project work was motivated by service improvement or development, rather than aiming to produce generalisable knowledge. Barriers to conducting research included lack of confidence, research skills and time, as well as workload demands, lack of cover to release staff for research and lack of supervision. Research was not seen as legitimate work in some social care environments or as part of a career path. Existing joint working initiatives (such as the National Service Frameworks) were highlighted as flashpoints for potential research and evaluation activity. The findings suggest clear opportunities for PCRNs to develop research capacity at the interface with social care; for example, by signposting available resources, providing training grants and secondments for social care staff, and supporting interagency networks with a focus on evaluation. In turn, experience in promoting user involvement in social services could add value to research expertise at the primary care,social care interface. [source] Satellite communications: the contribution of the 5th framework programme and future perspectivesINTERNATIONAL JOURNAL OF SATELLITE COMMUNICATIONS AND NETWORKING, Issue 1 2004Bernard Barani Abstract The telecommunication sector is of key importance for the European economy. Digitization, secure broadband access and mobility are expected to shift an ever-growing proportion of the economy on line, thus creating new markets and business opportunities. With the eEurope 2002 and eEurope 2005 initiatives, the European Union has initiated a number of policy actions aiming at favouring the rapid introduction of innovative communication systems, services and applications. Research and development, as supported under the IST programme of the Union, is closely associated to the overall policy picture. The IST programme is notably instrumental in supporting, with a longer-term approach, key policy orientations such as the pervasive introduction of low cost broadband access, introduction of advanced mobile systems, or migration of networks towards the next generation of Internet protocol, IPv6. Satellite communication form an integral part of this diversified communication landscape, and has also been significantly supported under the 5th Framework Programme. Even if the problematic of the satcom industry are to some extent similar to those of the terrestrial players (e.g. catalysing take up of broadband and advanced mobile markets), the strategies followed by the satcom sector differ from those followed by the terrestrial players. This paper review the current technological approaches of the satcom industry, their relevance in the context of the policy goals of the Union, and how they have been supported under the IST programme. It also introduces briefly how co-ordination with ESA work has been achieved, and the perspectives for further support, notably under the now starting 6th Framework Programme. Copyright © 2004 John Wiley & Sons, Ltd. [source] Techniques for Acute Stroke InterventionJOURNAL OF INTERVENTIONAL CARDIOLOGY, Issue 1 2009RAJAN A.G. PATEL M.D. Stroke or cerebrovascular accident is the second most common cause of death in Western countries. Although stroke is a treatable disease, the majority of patients do not receive intravenous thrombolysis or catheter-based therapy. The lack of treatment is multifactorial. Several treatments have been studied. Research and development in the area of acute stroke treatment are ongoing. [source] Conservation of gullies in susceptible riparian areas of alluvial soil regionsLAND DEGRADATION AND DEVELOPMENT, Issue 3 2002R. C. Yadav Abstract The problem of gully erosion is very severe in the riparian areas of the alluvial deep soil region in India. Research and development have progressed in response to the change in social needs. The earlier strategy of maintenance of law and order has changed to one of reclamation and restoration of the productive capacity of riparian areas. Watershed management in the ravines has been adopted for development of food security, eco-restoration and pollution control. Case studies on the watershed management in watersheds projects initiated in the mid-1980s revealed the scope for bringing increased prosperity through crop diversification and eco-restoration. In consideration of the erosion process, new concepts of management zones and improved conservation and reclamation practices have been developed. The sociological factors have been rationally analysed, as they applied to watershed management in the ravines. A new paradigm of watershed management by group action is necessary in the future. Since the ways of combating the ravine problem and enhancing the productivity of ravine-degraded lands were made on rational process-based approach, there is scope for it to be implemented in other countries with similar land and socio-economic situations. Copyright © 2002 John Wiley & Sons, Ltd. [source] Forecast verification: current status and future directionsMETEOROLOGICAL APPLICATIONS, Issue 1 2008Dr B. Casati Abstract Research and development of new verification strategies and reassessment of traditional forecast verification methods has received a great deal of attention from the scientific community in the last decade. This scientific effort has arisen from the need to respond to changes encompassing several aspects of the verification process, such as the evolution of forecasting systems, or the desire for more meaningful verification approaches that address specific forecast user requirements. Verification techniques that account for the spatial structure and the presence of features in forecast fields, and which are designed specifically for high-resolution forecasts have been developed. The advent of ensemble forecasts has motivated the re-evaluation of some of the traditional scores and the development of new verification methods for probability forecasts. The expected climatological increase of extreme events and their potential socio-economical impacts have revitalized research studies addressing the challenges concerning extreme event verification. Verification issues encountered in the operational forecasting environment have been widely discussed, verification needs for different user communities have been identified, and models to assess the forecast value for specific users have been proposed. Proper verification practice and correct interpretation of verification statistics has been extensively promoted with recent publications and books, tutorials and workshops, and the development of open-source software and verification tools. This paper addresses some of the current issues in forecast verification, reviews some of the most recently developed verification techniques, and provides recommendations for future research. Copyright © 2008 Royal Meteorological Society and Crown in the right of Canada. [source] Thin-film solar cells: an overviewPROGRESS IN PHOTOVOLTAICS: RESEARCH & APPLICATIONS, Issue 2-3 2004K. L. Chopra Abstract Thin film solar cells (TFSC) are a promising approach for terrestrial and space photovoltaics and offer a wide variety of choices in terms of the device design and fabrication. A variety of substrates (flexible or rigid, metal or insulator) can be used for deposition of different layers (contact, buffer, absorber, reflector, etc.) using different techniques (PVD, CVD, ECD, plasma-based, hybrid, etc.). Such versatility allows tailoring and engineering of the layers in order to improve device performance. For large-area devices required for realistic applications, thin-film device fabrication becomes complex and requires proper control over the entire process sequence. Proper understanding of thin-film deposition processes can help in achieving high-efficiency devices over large areas, as has been demonstrated commercially for different cells. Research and development in new, exotic and simple materials and devices, and innovative, but simple manufacturing processes need to be pursued in a focussed manner. Which cell(s) and which technologies will ultimately succeed commercially continue to be anybody's guess, but it would surely be determined by the simplicity of manufacturability and the cost per reliable watt. Cheap and moderately efficient TFSC are expected to receive a due commercial place under the sun. Copyright © 2004 John Wiley & Sons, Ltd. [source] IN DEFENCE OF PRIORITY REVIEW VOUCHERSBIOETHICS, Issue 7 2009JORN SONDERHOLM ABSTRACT Infectious and parasitic diseases cause enormous health problems in the developing world whereas they leave the developed one relatively unscathed. Research and development (R&D) of drugs for diseases that mainly affect people in developing countries is limited. The problem that relatively few drugs are available for diseases that cause an enormous burden of disease in the developing world is called the ,availability problem'. In recent years, the availability problem has received quite a bit of attention. A number of proposals have been fielded as to how this problem might be minimized. Wild-card patent extensions, advance market commitments, cash prizes and the Health Impact Fund are prominent examples of such proposals. These proposals can be thought of as pull-mechanisms for R&D of drugs for neglected diseases. What has been coined a ,priority review voucher' is another pull-mechanism. This paper is a critical discussion of this pull-mechanism. First, the original priority review voucher scheme, as proposed by Ridley et al. (2006), is described. A number of objections to this scheme are thereafter presented. A few amendments to the original scheme are then suggested, and it is argued that with these amendments in place, the priority review voucher scheme constitutes an attractive way of stimulating R&D of drugs for neglected diseases. [source] GOLD infrastructure for virtual organizationsCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 11 2008P. Periorellis Abstract The paper discusses the GOLD project (Grid-based Information Models to Support the Rapid Innovation of New High Value-Added Chemicals) whose principal aim is to carry out research and development into enabling technologies to support the formation, operation and termination of virtual organizations. The paper discusses the outcome of this research, which is the GOLD Middleware infrastructure. The infrastructure has been implemented in the form of a set of Middleware components, which address issues such as trust, security, contract monitoring and enforcement, information management and coordination. We discuss all these issues in turn and more importantly we demonstrate how current WS standards can be used to implement these issues. In addition, the paper follows a top down approach starting with a brief outline on the architectural elements derived during the requirements engineering phase and demonstrates how these elements were mapped onto actual services that were implemented according to service-oriented architecture principles and related technologies. Copyright © 2008 John Wiley & Sons, Ltd. [source] The Impact of R&D Intensity on Demand for Specialist Auditor Services,CONTEMPORARY ACCOUNTING RESEARCH, Issue 1 2005JAYNE M. GODFREY Abstract The audit fee research literature argues that auditors' costs of developing brand name reputations, including top-tier designation and recognition for industry specialization, are compensated through audit fee premiums. Audited firms reduce agency costs by engaging high-quality auditors who monitor the levels and reporting of discretionary expenditures and accruals. In this study we examine whether specialist auditor choice is associated with a particular discretionary expenditure - research and development (R&D). For a large sample of U.S. companies from a range of industries, we find strong evidence that R&D intensity is positively associated with firms' choices of auditors who specialize in auditing R&D contracts. Additionally, we find that R&D intensive firms tend to appoint top-tier auditors. We use simultaneous equations to control for interrelationships between dependent variables in addition to single-equation ordinary least squares (OLS) and logistic regression models. Our results are particularly strong in tests using samples of small firms whose auditor choice is not constrained by the need to appoint a top-tier auditor to ensure the auditor's financial independence from the client. 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