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Distribution by Scientific Domains
Life Sciences33%
Medical Sciences22%
Engineering22%

Selected Abstracts

Cover Picture: Electrophoresis 7'09

ELECTROPHORESIS, Issue 7 2009
Article first published online: 16 APR 200
Issue no. 7 is a special issue on "Biomarker Discovery and Related Topics". It has 18 articles distributed among four parts including genomic, proteomic, glycoproteomic and metabolomic markers. "New separation technologies, improvements of existing methods and intuitive, elegant applications are providing a representative snapshot on the "state-of-the-art" of the bioanalytical aspects of biomarker discovery today". In addition, as recognition of his significant contribution to the field, this special issue is dedicated to the 70th birthday of Professor Barry L. Karger. [source]

Cover Picture: Electrophoresis 21'2008

ELECTROPHORESIS, Issue 21 2008
Article first published online: 14 NOV 200
This issue has an emphasis on "Proteomics and Related Topics". It comprises 11 research articles including the "Fast Track" article on the topic of proteomics, glycoproteomics, proteins and peptides. The "Fast Track" article describes a CE-LIF detection-based assay for the simultaneous measurements of the electrophoretic mobility, catalytic activity and the variation of activity over time of the individual enzymes molecules of Escherichia coli beta-galactosidase. The remaining 10 research articles of the Emphasis deal with the development of sensitive fluorescent staining for proteomic analysis, depletion of high abundance proteins form human serum, lectin affinity chromatography in the identification of rat urinary glycoproteome, lab-on-chip screening strategy of mouse serum samples prior to proteomics analysis, identification of proteins from membrane preparations, capillary coating for CE of proteins, characterization of rabbit liver apothioneins by CE-ESI-MS, quantitative analysis of recombinant protein charge heterogeneity by imaging CIEF, dye staining and immunodetection of proteins on a PVDF membrane, and separation of multiphosphorylated peptide isomers by CZE. [source]

A digital simulation of the vibration of a two-mass two-spring system

COMPUTER APPLICATIONS IN ENGINEERING EDUCATION, Issue 3 2010
Wei-Pin Lee
Abstract In this study, we developed a computer program to simulate the vibration of a two-mass two-spring system by using Visual BASIC. Users can enter data for the two-mass two-spring system. The software will derive the eigenvalue problem from the input data. Then the software solves the eigenvalue problem and illustrates the results numerically and graphically on the screen. In addition, the program uses animation to demonstrate the motions of the two masses. The displacements, velocities, and accelerations of the two bodies can be shown if the corresponding checkboxes are selected. This program can be used in teaching courses, such as Linear Algebra, Advanced Engineering Mathematics, Vibrations, and Dynamics. Use of the software may help students to understand the applications of eigenvalue problems and related topics such as modes of vibration, natural frequencies, and systems of differential equations. © 2009 Wiley Periodicals, Inc. Comput Appl Eng Educ 18: 563,573, 2010; View this article online at wileyonlinelibrary.com; DOI 10.1002/cae.20241 [source]

Development of swallowing and feeding: Prenatal through first year of life

DEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 2 2008
Amy L. Delaney
Abstract The development of feeding and swallowing involves a highly complex set of interactions that begin in embryologic and fetal periods and continue through infancy and early childhood. This article will focus on swallowing and feeding development in infants who are developing normally with a review of some aspects of prenatal development that provide a basis for in utero sucking and swallowing. Non-nutritive sucking in healthy preterm infants, nipple feeding in preterm and term infants, and selected processes of continued development of oral skills for feeding throughout the first year of life will be discussed. Advances in research have provided new information in our understanding of the neurophysiology related to swallowing, premature infants' sucking and swallowing patterns, and changes in patterns from preterm to near term to term infants. Oral skill development as texture changes are made throughout the second half of the first year of life is an under studied phenomenon. Knowledge of normal developmental progression is essential for professionals to appreciate differences from normal in infants and children with feeding and swallowing disorders. Additional research of infants and children who demonstrate overall typical development in oral skills for feeding is encouraged and will provide helpful reference points in increasing understanding of children who exhibit differences from typical development. It is hoped that new technology will provide noninvasive means of delineating all phases of sucking and swallowing from prenatal through infancy. Further related topics in other articles of this issue provide a comprehensive review of factors influencing oral intake, growth, nutrition, and neurodevelopmental status of children. © 2008 Wiley-Liss, Inc. Dev Disabil Res Rev 2008;14:105,117. [source]

The Role of Government Policy on Entrepreneurial Activity: Productive, Unproductive, or Destructive?

ENTREPRENEURSHIP THEORY AND PRACTICE, Issue 5 2008
Maria Minniti
This paper serves as an introduction to the special issue of Entrepreneurship Theory and Practice on government policy and entrepreneurial activity. Entrepreneurship is an important engine of growth. Government policy, in turn, shapes the institutional environment in which entrepreneurial decisions are made. Thus, government policy is important for entrepreneurship. But what policies are more conducive to productive entrepreneurship? In spite of a significant amount of work on this and related topics, there is still much we do not know about this important relationship. After reviewing recent literature on entrepreneurship policy, this paper summarizes the contributions included in this volume and puts them in the context of the ongoing research debate. The goal of the special issue is to address important unanswered questions and trigger a constructive debate among diverging views. [source]

Multi-carrier spread-spectrum and related topics

EUROPEAN TRANSACTIONS ON TELECOMMUNICATIONS, Issue 5 2002
Prof. Dr. Khaled Fazel
No abstract is available for this article. [source]

Smoking habits in adolescents with mild to moderate asthma

PEDIATRIC PULMONOLOGY, Issue 3 2004
Eyal Zimlichman MD
Abstract To study the impact of mild to moderate asthma on smoking habits in adolescents. Specifically, we tested the hypothesis that asthma does not prevent adolescents from smoking. A research questionnaire, filled by a systematic sample of military personnel upon enrolment to service in the Israeli Defense Force (IDF), was analyzed. Conscripts were asked to voluntarily fill (after obtaining a signed informed consent) a research questionnaire about their medical history, and several health related topics including smoking. This database was matched with the military medical profile of the soldier, which includes the patient asthma status. Overall, 38,047 young adults were included in this study. There was a significant increase in the rate of mild to moderate asthma, from the mid-1980's to date. During the 1980's and early 1990's, asthmatics smoked significantly less frequently (20,22%) than non-asthmatics (25,27%). In the mid- to late-1990's, the smoking rates increased relatively more in asthmatics, to the point that in the last 8 years of this study, they were found to be almost identical in both groups, at a rate of approximately 30%. The presence of asthma is not a powerful motivating agent to prevent from smoking. It is likely that smoking asthmatic teenagers are at risk for suboptimal lung growth, and as young adults, they will become at greater risk of lung function deterioration. We suggest that primary care physicians, caring for asthma in children, adolescents, and young adults, should explain the particular risks generated by tobacco smoking. © 2004 Wiley-Liss, Inc. [source]

Visualisation of needle position using ultrasonography

ANAESTHESIA, Issue 2 2006
G. A. Chapman
Summary Anaesthetists and intensivists spend a considerable proportion of their working time inserting needles and catheters into patients. In order to access deeper structures like central veins and nerves, they have traditionally relied on surface markings to guide the needle into the correct position. However, patients may present challenges due to anatomical abnormalities and size. Irrespective of the skill of the operator, there is the ever-present risk of needle misplacement with the potential of damage to structures like arteries, nerve bundles and pleura. Repeated attempts, even if ultimately successful, cause patient suffering and probably increase the risk of infection and other long term complications. Portable and affordable, high-resolution ultrasound scanners, has accelerated the interest in the use of ultrasound guidance for interventional procedures. Ultrasound guidance offers several advantages including a greater likelihood of success, fewer complications and less time spent on the procedure. Even if the target structure is identified correctly there is still the challenge to place the needle or other devices in the optimum site. The smaller and deeper the target, the greater the challenge and potential usefulness of ultrasound guidance. As a result of limited training in the use of ultrasound we believe that many clinicians fail to use it to its full potential. A lack of understanding, with regard to imaging the location of the needle tip remains a major obstacle. Needle visualisation and related topics form the basis for this review. [source]

Oscillations in growth of multicellular tumour spheroids: a revisited quantitative analysis

CELL PROLIFERATION, Issue 4 2010
A. S. Gliozzi
Objectives:, Multicellular tumour spheroids (MTS) provide an important tool for study of the microscopic properties of solid tumours and their responses to therapy. Thus, observation of large-scale volume oscillations in MTS, reported several years ago by two independent groups (1,2), in our opinion represent a remarkable discovery, particularly if this could promote careful investigation of the possible occurrence of volume oscillations of tumours ,in vivo'. Materials and methods:, Because of high background noise, quantitative analysis of properties of observed oscillations has not been possible in previous studies. Such an analysis can be now performed, thanks to a recently proposed approach, based on formalism of phenomenological universalities (PUN). Results:, Results have provided unambiguous confirmation of the existence of MTS volume oscillations, and quantitative evaluation of their properties, for two tumour cell lines. Proof is based not only on quality of fitting of the experimental datasets, but also on determination of well-defined values of frequency and amplitude of the oscillations for each line investigated, which would not be consistent with random fluctuation. Conclusions:, Biological mechanisms, which can be directly responsible for observed oscillations, are proposed, which relates also to recent work on related topics. Further investigations, both at experimental and at modelling levels, are also suggested. Finally, from a methodological point of view, results obtained represent further confirmation of applicability and usefulness of the PUN approach. [source]