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Relevant Indicators (relevant + indicator)
Selected AbstractsPotential multidrug resistance gene POHL: An ecologically relevant indicator in marine spongesENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 1 2001Anatoli Krasko Abstract Sponges are sessile filter feeders found in all aquatic habitats from the tropics to the arctic. Against potential environmental hazards, they are provided with efficient defense systems, e.g., protecting chaperones and/or the P-170/multidrug resistance pump system. Here we report on a further multidrug resistance pathway that is related to the pad one homologue (POH1) mechanism recently identified in humans. It is suggested that proteolysis is involved in the inactivation of xenobiotics by the POH1 system. Two cDNAs were cloned, one from the demosponge Geodia cydoniumand a second from the hexactinellid sponge Aphrocallistes vastus. The cDNA from G. cydonium, termed GCPOHL, encodes a deduced polypeptide with a size of 34,591 Da and that from A. vastus, AVPOHL, a protein of a calculated Mr of 34,282. The two sponge cDNAs are highly similar to each other as well as to the known sequences from fungi (Schizosaccharomyces pombe and Saccharomyces cerevisiae) and other Metazoa (from Schistosoma mansoni to humans). Under controlled laboratory conditions, the expression of the potential multidrug resistance gene POHL is, in G. cydonium, strongly upregulated in response to the toxins staurosporin (20 ,M) or taxol (50 ,M); the first detectable transcripts appear after 1 d and reach a maximum after 3 to 5 d of incubation. The relevance of the expression pattern of the G. cydonium gene POHL for the assessment of pollution in the field was determined at differently polluted sites in the area around Rovinj (Croatia; Mediterranean Sea, Adriatic Sea). The load of the selected sites was assessed by measuring the potency of XAD-7 concentrates of water samples taken from those places to induce the level of benzo[a]pyrene monooxygenase (BaPMO) in fish and to impair the multidrug resistance (MDR)/P-170 extrusion pump in clams. These field experiments revealed that the levels of inducible BaPMO activity in fish and of the MDR potential by the water concentrates are highly correlated with the level of expression of the potential multidrug resistance gene POHL in G. cydonium. This report demonstrates that the detoxification POH pathway, here mediated by the G. cydonium GCPOHL gene, is an additional marker for the assessment of the environmental load in a given marine area. [source] Decrease of enteric micro-organisms from rural sewage sludge during their composting in straw mixtureJOURNAL OF APPLIED MICROBIOLOGY, Issue 3 2005A.-M. Pourcher Abstract Aims:, To study the decrease of enteric micro-organisms including viable nematode eggs, enteroviruses, faecal indicators (Escherichia coli and enterococci) and pathogenic bacteria (Listeria monocytogenes, Salmonella sp. and Clostridium perfringens) of a rural sewage sludge when it is composted for 7 months in mixture with straw. Methods and Results:, Numbers of the test organisms and the physico-chemical parameters were measured on a monthly basis on the mixture, on the compost after being turned, and on the pile in three positions representing the part by which air is incoming, the bottom of the pile and the part through which air is outgoing. The lowest temperature in the pile was observed at the bottom, where it did not exceed 50°C against 66°C in the two other areas. There were no significant differences between the three areas in terms of micro-organism survival. Infectious enteroviruses were inactivated rapidly and were not found after the first turning whereas some genomes were detected until after the third turning. Escherichia coli and enterococci presented a similar survival rate and their number decreased by 4 log10 whereas Salmonella decayed at a greater rate than L. monocytogenes. The numbers of C. perfringens decreased gradually to reach a final concentration in the mature compost of about 102 CFU g,1 dry matter (d.m.), which was similar to that of the faecal indicators. Conclusions:, The hygienic effect of sludge composting in mixture with straw results in a significant reduction of enteric micro-organisms, the concentration of the faecal indicators in the final product being <64 most probable number g,1 d.m. The concentrations of Salmonella, enteroviruses and viable nematode eggs in the final product were not detectable which is in accordance with the French legislation. Significance and Impact of the Study:, The results which pointed out the different behaviour of the test micro-organisms reflect the difficulty to propose a relevant indicator of hygienization. Otherwise, they show that composting is an efficient means for hygienization of sludge of rural wastewater treatment, where the straw is available close to their place of production. [source] Granular cell tumors of the esophagus: report of five cases and review of diagnostic and therapeutic techniquesDISEASES OF THE ESOPHAGUS, Issue 5 2007L. De Rezende SUMMARY., Granular cell tumors (GCT) of the esophagus are stromal lesions originating from the Schwann cells of the submucosal neuronal plexus. Although they are very infrequent, they constitute the second largest cause of non-epithelial tumors in the esophagus after leiomyomas. These tumors are generally benign, although a certain number of malignant, aggressive cases have been reported. Diagnosis requires that this possibility be ruled out before deciding on which course of therapeutic action to take as well as familiarization with the relevant indicators. GCT linked synchronically or metachronically to other malignant neoplasias of the esophagus have also been described, but the actual extent of this association is uncertain. This report describes five cases of GCT recently diagnosed as incidental findings following endoscopic exploration. All of these were benign and were treated conservatively. The article discusses new aspects relating to the diagnosis of these lesions and the role carried out by endoscopic ultrasonography in their characterization, both at preliminary diagnosis and monitoring levels. No standard therapeutic guidelines exist for the management of GCT, but endoscopic treatment without invading the muscularis propria layer would be used for symptomatic patients, creating histopathological doubts requiring research on the entire organ. Endoscopic therapeutic techniques are analyzed (resection with forceps or diathermy handles, yttrium-aluminum-garnet laser ablation, alcohol injection) in esophageal GCT, which have overtaken surgery in most cases due to their efficiency, greater safety and fewer complications. [source] The two pillars of the European Central BankECONOMIC POLICY, Issue 40 2004Stefan Gerlach SUMMARY The Pillars of The ECB I interpret the European Central Bank's two-pillar strategy by proposing an empirical model for inflation that distinguishes between the short- and long-run components of inflation. The latter component depends on an exponentially weighted moving average of past monetary growth and the former on the output gap. Estimates for the 1971,2003 period suggest that money can be combined with other indicators to form the ,broadly based assessment of the outlook for future price developments' that constitutes the ECB's second pillar. However, the analysis does not suggest that money should be treated differently from other indicators. While money is a useful policy indicator, all relevant indicators should be assessed in an integrated manner, and a separate pillar focused on monetary aggregates does not appear necessary. ,Stefan Gerlach [source] Oil product consumption in OPEC Member Countries: a comparison of trends and structuresOPEC ENERGY REVIEW, Issue 2 2001Atmane Dahmani The purpose of the present work is to analyse oil product consumption trends within OPEC's 11 Member Countries and to compare the consumption structures within and between the countries. The study examines consumption structures by product (gasoline, kerosene, distillates, residuals and others) and the most relevant indicators of economic growth during the period 1980,98. The analysis shows that, during this period, most countries increased their consumption of gasoline, kerosene and distillates, which are light and medium products. However, the consumption of heavy products, such as residuals, was diversified within the considered countries. The structural change analysis, which relates to the similarities in the oil product consumption structures of Member Countries, was carried out by using sub-groups for the periods in which consumption structures are similar. This grouping seems to be the result of the influence of important factors on oil consumption, mainly oil product domestic prices, refinery capacity and configuration, the demographic factor and social unrest. Further steps in the study refer to some practical aspects regarding observed homogeneity in the grouping of oil consumption patterns. [source] Charismatic Leadership and Objective Performance IndicatorsAPPLIED PSYCHOLOGY, Issue 4 2009Jens Rowold Recent empirical and theoretical work has advanced our understanding of charismatic leadership in organisations. Despite this progress, only a few studies have tested the hypothesis that charismatic leadership might be related to objective, organisationally relevant indicators. In order to address this research gap, the present study tested whether charismatic leadership was related to followers' absenteeism, their training and development activities, as well as branch-level profit. Charismatic leadership was defined according to Conger and Kanungo's (1998) theory. It could be demonstrated that facets of charismatic leadership were negatively related to followers' absenteeism, but positively related to their training and development activity. Moreover, charismatic leadership showed a positive relationship to profit. In sum, the results contribute to theory and practice of charismatic leadership. Un travail empirique et théorique récent a fait progresser notre compréhension du leadership charismatique dans les organisations. Malgré ce progrès, seules quelques études ont testé l'hypothèse selon laquelle un leadership charismatique serait liéà des facteurs objectifs et pertinents pour l'organisation. Pour une compréhension plus approfondie des effets du leadership chatismatique, la présente étude teste si ce style de leadership est lié aux suiveurs, à l'absentéisme, aux activités de formation et de développement ainsi qu'aux bénéfices au niveau de la branche. Le leadership charismatique est défini en accord avec la théorie de Conger et Kanungo (1998). On a pu démontrer que les facettes du leadership charismatique sont liées négativement aux suiveurs, à l'absentéisme et positivement à l'activité de formation et de dévelpppement. En outre, le leadership charismatique montre une relation positive au profit. En somme, les résultats contribuent à la théorie et à la pratique du leadership charismatique. [source] Pragmatic indicators for remote Aboriginal maternal and infant health care: why it matters and where to startAUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, Issue 2010Malinda Steenkamp Abstract Objective: There are challenges in delivering maternal and infant health (MIH) care to remote Northern Territory (NT) communities. These include fragmented care with birthing in regional hospitals resulting in cultural and geographical dislocation for Aboriginal women. Many NT initiatives are aimed at improving care. Indicators for evaluating these for remote Aboriginal mothers and infants need to be clearer. We reviewed existing indicators to inform a set of pragmatic indicators for reporting improvement in remote MIH care. Methods: Scientific databases and grey literature (organisational websites and Google Scholar) were searched using the terms ,Aboriginal/maternal/infant/remote health/monitoring performance'. Key stakeholders identified omitted indicators sets. Relevant sets were reviewed and organised by indicator type, stage of patient journey, topic and theme. Results: Forty-two indicators sets were found. Seven focused on Aboriginal health, 23 on reproductive/maternal health, eight on child/infant health and four on other aspects, e.g. remote health. We identified more than 1,000 individual indicators. Of these, 656 were relevant for our purpose and were subsequently organised into 300 topics and 16 themes for antenatal, birth and postpartum, and infant care by indicator type. Conclusion: There are many measures for monitoring health care delivery to mothers and infants. Few are framed around remote MIH services, despite poorer health outcomes of remote mothers and infants and the specific challenges with providing care in this setting. Establishing relevant indicators is vital to support relevant data collection and the development of appropriate policy for remote Aboriginal maternal and infant care. [source] | ||||||||||||||||