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Regioselective Reduction (regioselective + reduction)

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Chemistry100%

Selected Abstracts

Highly Chemo- and Regioselective Reduction of Aromatic Nitro Compounds Catalyzed by Recyclable Copper(II) as well as Cobalt(II) Phthalocyanines

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2010
Upendra Sharma
Abstract Copper/cobalt phthalocyanines were established for the first time as catalysts for the very efficient chemo- and regioselective reduction of aromatic nitro compounds to generate the corresponding amines. The selective reduction of nitro compounds was observed in the presence of a large range of functional groups such as aldehyde, keto, acid, amide, ester, halogen, lactone, nitrile and heterocyclic functional groups. Furthermore, the present method was found to be highly regioselective towards the reduction of aromatic dinitro compounds in a short time with high yields. In most of the cases the conversion and selectivity were >99% as monitored by GC-MS. The reduction mechanism was elucidated by UV-vis and electrospray ionization quadrupole time-of-flight tandem mass spectrometry. [source]

Regioselective Reduction of 5-Substituted 2-Alkylidene-4-oxothiazolidines by Metal Hydrides.

CHEMINFORM, Issue 38 2004
Rade Markovic
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

ChemInform Abstract: Regioselective Reduction of N-Alkyl-3-sulfonyl Glutarimides.

CHEMINFORM, Issue 33 2002
4-Dihydro-3-tosylpyridin-2-ones., Synthesis of
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Stereoselective Synthesis of Three Isomers of tert -Butyl 5-Hydroxy-4-methyl-3-oxohexanoate through Alcohol Dehydrogenase-Catalyzed Dynamic Kinetic Resolution

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 1-2 2009
Steffen Lüdeke
Abstract Regioselective reduction of the 5-keto group of tert -butyl 4-methyl-3,5-dioxohexanoate (1) leads to a stereodiad of tert -butyl 5-hydroxy-4-methyl-3-oxohexanoate (2). Alcohol dehydrogenases from Lactobacillus brevis (LBADH), Rhodococcus sp. (RS 1-ADH) and Saccharomyces cerevisiae (YGL157w) reduce 1 under dynamic kinetic resolution conditions, thereby establishing two chiral carbons with a single reduction step. While it had been shown previously that LBADH reduction of 1 stereoselectively leads to syn -(4S,5R)- 2, alcohol dehydrogenase-mediated dynamic kinetic resolution now allows easy access to syn -(4R,5S)- 2 (RS 1-ADH; 97.6% ee, syn:anti=92:8, 66% conversion, 37% isolated yield) and anti -(4S,5S)- 2 (YGL157w; 90% ee, anti:syn=93:7, 64% conversion, 42% isolated yield), as well. Thus three out of four possible stereoisomers were formed selectively upon reduction of 1. [source]

Highly Chemo- and Regioselective Reduction of Aromatic Nitro Compounds Catalyzed by Recyclable Copper(II) as well as Cobalt(II) Phthalocyanines

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2010
Upendra Sharma
Abstract Copper/cobalt phthalocyanines were established for the first time as catalysts for the very efficient chemo- and regioselective reduction of aromatic nitro compounds to generate the corresponding amines. The selective reduction of nitro compounds was observed in the presence of a large range of functional groups such as aldehyde, keto, acid, amide, ester, halogen, lactone, nitrile and heterocyclic functional groups. Furthermore, the present method was found to be highly regioselective towards the reduction of aromatic dinitro compounds in a short time with high yields. In most of the cases the conversion and selectivity were >99% as monitored by GC-MS. The reduction mechanism was elucidated by UV-vis and electrospray ionization quadrupole time-of-flight tandem mass spectrometry. [source]