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Regiocontrolled Synthesis (Regiocontroll + synthesis)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

Microwave-Assisted Paal,Knorr Reaction , Three-Step Regiocontrolled Synthesis of Polysubstituted Furans, Pyrroles and Thiophenes

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 24 2005
Giacomo Minetto
Abstract An efficient and highly versatile synthesis of furans, pyrroles and thiophenes is described. Starting from commercially available or easily prepared ,-keto esters, functional homologation provides differently substituted 1,4-diketones that can be transformed, through a microwave-assisted Paal,Knorr condensation, into the corresponding methoxycarbonyl heterocycles. The methoxycarbonyl moiety can be directly transformed into an NH2 group by hydrolysis to carboxylic acid and Curtius rearrangement or into an amide by reaction with a primary amine in the presence of Me3Al. The method is compatible with the presence of a CbzNH group so that the final heterocycle can be inserted into a peptide sequence as a turn inducer. By using this procedure, a collection of more than 60 different tetrasubstitued pyrroles or trisubstituted thiophenes has been prepared. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]

Promiscuous Substrate Binding Explains the Enzymatic Stereo- and Regiocontrolled Synthesis of Enantiopure Hydroxy Ketones and Diols

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2009
Marcela Kurina-Sanz
Abstract Regio- and stereoselective reductions of several diketones to afford enantiopure hydroxy ketones or diols were accomplished using isolated alcohol dehydrogenases (ADHs). Results could be rationalised taking into account different (promiscuous) substrate-binding modes in the active site of the enzyme. Furthermore, interesting natural cyclic diketones were also reduced with high regio- and stereoselectivity. Some of the 1,2- and 1,3-diketones used in this study were reduced by employing a low excess of the hydrogen donor (2-propanol) due to the quasi-irreversibility of these ADH-catalysed processes. Thus, using lower quantities of co-substrate, scale-up could be easily achieved. [source]

ChemInform Abstract: Dimethyldioxirane Oxidation of 2-Silyloxypyrroles: An Efficient Regiocontrolled Synthesis of 5-Hydroxy-3-pyrrolin-2-ones.

CHEMINFORM, Issue 20 2008
John Boukouvalas
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

ChemInform Abstract: New Regiocontrolled Synthesis of Functionalized Pyrroles from 2-Azetidinone-Tethered Allenols.

CHEMINFORM, Issue 20 2008
Benito Alcaide
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Facile Regiocontrolled Synthesis of Trialkyl-Substituted Pyrazines.

CHEMINFORM, Issue 14 2006
Tarek Abou Elmaaty
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

Chemoselective Silylzincation of Functionalized Terminal Alkynes Using Dianion-Type Zincate (SiBNOL-Zn-ate): Regiocontrolled Synthesis of Vinylsilanes.

CHEMINFORM, Issue 3 2005
Shinji Nakamura
No abstract is available for this article. [source]

ChemInform Abstract: Regiocontrolled Synthesis of the Trimeric Quinone Framework of Conocurvone.

CHEMINFORM, Issue 25 2002
Ashkan Emadi
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]