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Reflecting
Kinds of Reflecting Terms modified by Reflecting Selected AbstractsReflecting on Type 2 Diabetes Prevention: More Questions than Answers!DIABETES OBESITY & METABOLISM, Issue 2007J. Rosenstock Given the enormous public health and economic burden posed by the global epidemic of type 2 diabetes mellitus (T2DM), intervention in the prediabetes stage of disease to prevent progression to T2DM and its vascular complications seems the most sensible approach. Precisely how best to intervene remains the subject of much debate. Prudent lifestyle changes have been shown to significantly reduce the risk of progression in individuals with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). Although lifestyle modifications are notoriously difficult to maintain, there is evidence that intensive intervention results in continued preventive benefit after the stopping of structured counselling. A number of drug therapies, including metformin, acarbose, orlistat and rosiglitazone, have also been proven effective in preventing progression from IFG/IGT, but unresolved issues still remain. Specifically, whether large numbers of individuals with glucose dysregulation who may never progress to T2DM should be exposed to the risk of pharmacological adverse effects is a topic of discussion and debate. Furthermore, there are limited data on the effectiveness of implementing interventions during the prediabetic state to prevent cardiovascular complications that may be hyperglycaemia related. A recent American Diabetes Association (ADA) consensus statement on IFG/IGT recommends lifestyle modification for individuals with IFG or IGT. Of note, the ADA consensus statement introduces the option of adding metformin treatment to lifestyle changes in those individuals who have combined IFG/IGT plus an additional risk factor for progression and who also have some features that increase the likelihood of benefiting from metformin treatment. The dipeptidyl peptidase-4 inhibitors are a new class of oral antidiabetic agents that, in addition to being effective in improving glycaemic control, may exert beneficial effects in preserving ,-cell function. These characteristics, combined with a low risk of hypoglycaemia, weight neutrality and what appears , so far , to be a relatively benign tolerability profile, make these agents intriguing candidates for preventive treatment. [source] Analysing European Integration: Reflecting on the English SchoolJCMS: JOURNAL OF COMMON MARKET STUDIES, Issue 1 2002Thomas Diez The English School of international relations has rarely been used to analyse European integration. But, as we argue in this article, there may be considerable value in adding the English School to the canon of approaches to European integration studies in order to contextualize European integration both historically and internationally. The concepts of international society, world society and empire in particular may be used to reconfigure the current debate about the nature of EU governance and to compare the EU to other regional international systems, as well as to reconceptualize the EU's international role, and in particular the EU's power to influence affairs beyond its formal membership borders. Conversely, analysing the EU with the help of these English School concepts may also help to refine the latter in the current attempts to reinvigorate the English School as a research programme. [source] Safe Houses and Green Architecture: Reflections on the Lessons of the Chemically SensitiveJOURNAL OF ARCHITECTURAL EDUCATION, Issue 4 2000James Wasley Multiple chemical sensitivity (MCS) is a controversial condition involving heightened sensitivities to chemicals and allergens. Retreating to "safe" environments is the best available therapy, making the dwellings of those with MCS compelling studies of healthful design. Safe environments have been offered as exemplars of "green" architecture and have been parodied so as to ridicule environmental concern. In both cases, real lessons are obscured. Reflecting on a study of dwellings built by people with MCS, this essay seeks to clarify the relationship of these unique constructions to ecologically minded architecture as a whole. The dialogue between safe and green points towards their synthesis. [source] Reflecting on Reflexivity: Reflexive Textual Practices in Organization and Management TheoryJOURNAL OF MANAGEMENT STUDIES, Issue 3 2008Mats Alvesson abstract This paper identifies four sets of textual practices that researchers in the field of organization and management theory (OMT) have used in their attempts to be reflexive. We characterize them as multi-perspective, multi-voicing, positioning and destabilizing. We show how each set of practices can help to produce reflexive research, but also how each embodies limitations and paradoxes. Finally, we consider the interplay among these sets of practices to develop ideas for new avenues for reflexive practice by OMT researchers. [source] The inhibitory effect of a chewing task on a human jaw reflexMUSCLE AND NERVE, Issue 6 2010Pauline Maillou BDS Abstract This study was undertaken to investigate whether an inhibitory jaw reflex could be modulated by experimentally controlled conditions that mimicked symptoms of temporomandibular disorders. Reflecting on previous work, we anticipated that these conditions might suppress the reflex. Electromyographic recordings were made from a masseter muscle in 18 subjects, while electrical stimuli were applied to the upper lip. An inhibitory reflex wave (mean latency 47 ms) was identified and quantified. Immediately following an accelerated chewing task, which in most cases produced muscle fatigue and/or pain, the size of the reflex wave decreased significantly by about 30%. The suppression of inhibitory jaw reflexes by fatigue and pain may result in positive feedback, which may contribute to the symptoms of temporomandibular disorders. Future studies of temporomandibular disorder sufferers will help to determine whether such reflex changes reflect the underlying etiology and/or are a result of the temporomandibular disorder itself. Muscle Nerve, 2010 [source] Understanding Barriers to Peace: Reflecting on Israeli,Palestinian Economic NegotiationsNEGOTIATION JOURNAL, Issue 3 2004Bari Bar-Zion Drawing on relevant negotiations literature, this article describes some of the main barriers in the negotiation process between Israel and the Palestinian Authority as experienced by the author between the years 1998,2000. The analysis of these barriers is viewed through a prism of one case study: the negotiations regarding the economic component of the Wye River Memorandum. By subjecting that two-year negotiation process to a reflective analysis, this article not only attempts to shed light on the case presented, but also to help identify a wider range of barriers and behaviors that characterize the ongoing negotiations between Israel and the Palestinian Authority. [source] Toward a more perfect union: Reflecting on trends and issues for enhancing the academic performance of minority transfer studentsNEW DIRECTIONS FOR COMMUNITY COLLEGES, Issue 114 2001Wynetta Y. LeeArticle first published online: 4 APR 200 This chapter discusses policy issues pertaining to minority transfer students and presents a conceptual model for enhancing and facilitating minority transfers. [source] Reflecting on Pain ControlACADEMIC EMERGENCY MEDICINE, Issue 12 2009James M. Stephen MD No abstract is available for this article. [source] In Reply: Reflecting on Definite Control of Probable PainACADEMIC EMERGENCY MEDICINE, Issue 12 2009Boris D. Veysman MD No abstract is available for this article. [source] Dilemmas of development in Oceania: the political economy of the Tongan agro-export sectorTHE GEOGRAPHICAL JOURNAL, Issue 4 2001Donovan Storey This article critically engages with the recent diffusion of the orthodox development model in Oceania and highlights some evolving dilemmas. In particular, it explores the social, economic and ecological tensions arising from economic reforms that are exacerbating the fragility of already vulnerable nation-states and communities. In order to illustrate its arguments, a case study of the impacts of agro-export growth in Tonga is presented. Attention is drawn to the socially inequitable and ecologically unsustainable outcomes of rapid growth in this sector. In analyzing the political economy of the squash pumpkin sector, the authors point to the important role that culture plays in mediating and conditioning development outcomes. Reflecting on the Tongan case, it is argued that to better understand the implications of orthodox developmental reform in the region, research must seek to more explicitly incorporate distributional and ethical analysis. [source] The European Commission's Guidance on Article 102TFEU: From Inferno to Paradiso?THE MODERN LAW REVIEW, Issue 4 2010Article first published online: 8 JUL 2010, nar Akman The European Commission has for the first time issued a document expressing its official position on the enforcement of Article 102TFEU which prohibits the abuse of a dominant position on the Common Market. The Commission Guidance on enforcement priorities in applying Article 102TFEU to exclusionary abuses (adopted in December 2008) has ended a review of about four years. Given the increased enforcement of Article 102TFEU at the European level and the fact that many national provisions in the EU on unilateral conduct are modelled after Article 102TFEU, how the Commission intends to enforce Article 102TFEU is crucial for the application of competition law and the undertakings subject to it under European and/or national laws. The review period was preceded by severe criticisms of the Commission's approach to Article 102TFEU for protecting competitors instead of competition and for being insufficiently grounded in modern economic thinking. At the heart of the review and the discussions surrounding it lay the question of the objective of Article 102TFEU. Some, including the Directorate General for Competition claimed the objective to be ,consumer welfare', whereas some argued that ,consumer welfare' cannot be adopted as the objective at the expense of the protection of the competitive process. This article critically reviews the Commission Guidance, with an eye to assessing the ultimate objective of and the test of harm under Article 102TFEU. After discussing whether the Guidance indeed sets priorities, it examines the general approach of the Guidance to exclusionary conduct. It points out that despite there being some welcome novelties in the Guidance, there are also suggestions therein whose legitimacy and legality are questionable. Reflecting on the Guidance as a soft-law instrument, the article argues that although regarding the objective of Article 102TFEU, the Commission's apparent tendency towards ,consumer welfare' is not unlawful, the reform of Article 102TFEU to bring it more in line with modern economic and legal thinking seems to be far from complete. [source] Reflecting on The Limits to Capital, 20 Years On ,ANTIPODE, Issue 3 2004Ray Hudson First page of article [source] Statistical Tests Based on New Composite Hypotheses in Clinical Trials Reflecting the Relative Clinical Importance of Multiple Endpoints QuantitativelyBIOMETRICAL JOURNAL, Issue 5 2009Masako Nishikawa Abstract In clinical trials, several endpoints (EPs) are often evaluated to compare treatments in some therapeutic area. Suppose that there are two EPs in a clinical trial. We propose a new set of composite hypotheses for continuous variables, taking the relative clinical importance of the EPs into account. The main hypotheses were formulated to show that a treatment is so superior to the control treatment, which is not necessarily a placebo, in one EP, that the possible non-inferiority of the treatment by at most a certain value in the other EP can be compensated sufficiently, taking the clinical point of view into account. The maximum non-inferiority margin of one EP might not be a biologically unimportant difference in exchange for much superiority of the other EP. This formulation leads to a new composite EP and a very simple test statistic. The intersection-union principle was employed to derive the proposed test. [source] Splice-isoform specific immunolocalization of neuronal nitric oxide synthase in mouse and rat brain reveals that the PDZ-complex-building nNOS, ,-finger is largely exposed to antibodiesDEVELOPMENTAL NEUROBIOLOGY, Issue 4 2007Kristina Langnaese Abstract Knock out mice deficient for the splice-isoform ,, of neuronal nitric oxide synthase (nNOS,,) display residual nitric oxide synthase activity and immunosignal. To attribute this signal to the two minor neuronal nitric oxide synthase splice variants, ,, and ,,, we generated isoform-specific anti-peptide antibodies against the nNOS,, specific ,,-finger motif involved in PDZ domain scaffolding and the nNOS,, specific N-terminus. The nNOS,, ,,-finger-specific antibody clearly recognized the 160-kDa band of recombinant nNOS,, on Western blots. Using immunocytochemistry, this antibody displayed, in rats and wild-type mice, a labeling pattern similar to but not identical with that obtained using a commercial pan-nNOS antibody. This similarity indicates that the majority of immunocytochemically detectable nNOS is not likely to be complexed with PDZ-domain proteins via the ,,-finger motif. This conclusion was confirmed by the inhibition of PSD-95/nNOS interaction by the nNOS,, ,,-finger antibody in pull-down assays. By contrast, nNOS,, ,,-finger labeling was clearly reduced in hippocampal and cortical neuropil areas enriched in NMDA receptor complex containing spine synapses. In nNOS,, knock out mice, nNOS,, was not detectable, whereas the pan-nNOS antibody showed a distinct labeling of cell bodies throughout the brain, most likely reflecting ,,/,,-isoforms in these cells. The nNOS,, antibody clearly detected bacterial expressed nNOS,, fusion protein and nNOS,, in overexpressing HEK cells by Western blotting. Immunocytochemically, individual cell bodies in striatum, cerebral cortex, and in some brain stem nuclei were labeled in knock out but not in wild-type mice, indicating an upregulation of nNOS,, in nNOS,, deficient animals. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007 [source] Disgust sensitivity predicts the insula and pallidal response to pictures of disgusting foodsEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 11 2007Andrew J. Calder Abstract The anterior insula has been implicated in coding disgust from facial, pictorial and olfactory cues, and in the experience of this emotion. Personality research has shown considerable variation in individuals' trait propensity to experience disgust (,disgust sensitivity'). Our study explored the neural expression of this trait, and demonstrates that individual variation in disgust sensitivity is significantly correlated with participants' ventroanterior insular response to viewing pictures of disgusting, but not appetizing or bland, foods. Similar correlations were also seen in the pallidum and orofacial regions of motor and somatosensory cortices. Our results also accord with comparative research showing an anterior to posterior gradient in the rat pallidum reflecting increased ,liking' of foods [Smith, K. S. and Berridge, K. C. (2005) J. Neurosci., 25, 849,8637]. [source] Congruence between social values and implicit motives: effects on life satisfaction across three culturesEUROPEAN JOURNAL OF PERSONALITY, Issue 4 2006Jan Hofer This study examines the relationship between implicit motives for intimacy-affiliation and power, explicit value orientations, and life satisfaction. The Satisfaction With Life Scale, the Schwartz Value Survey, and a bias-free TAT-type picture-story-test were administered to 319 adult participants in Cameroon, Costa Rica, and Germany. The stories were coded for motive imagery reflecting needs for intimacy-affiliation and power. Based on motives associated with the domain intimacy-affiliation, the results revealed that an alignment of implicit motives and self-attributed values is associated with an enhanced life satisfaction across cultures. In contrast, no such relationship could be found for motives and values associated with the domain of power. Copyright © 2006 John Wiley & Sons, Ltd. [source] Experiencing the Production of SoundsEUROPEAN JOURNAL OF PHILOSOPHY, Issue 2 2001Matthew Nudds It is often supposed that our experience of sounds is as of things distinct from the material world of sight and touch: reflecting on the character of our auditory experience might seem to confirm that. This paper describes the features of our auditory experience that can lead one to think of sounds in this way. It then describes a way we can experience sounds as being part of the material world. Since this is a kind of experience that essentially involves more than one sense, the paper ends by drawing some conclusions about how we should think about the senses. [source] SHARED AND UNIQUE FEATURES OF DIVERSIFICATION IN GREATER ANTILLEAN ANOLIS ECOMORPHSEVOLUTION, Issue 2 2006R. Brian Langerhans Abstract Examples of convergent evolution suggest that natural selection can often produce predictable evolutionary outcomes. However, unique histories among species can lead to divergent evolution regardless of their shared selective pressures,and some contend that such historical contingencies produce the dominant features of evolution. A classic example of convergent evolution is the set of Anolis lizard ecomorphs of the Greater Antilles. On each of four islands, anole species partition the structural habitat into at least four categories, exhibiting similar morphologies within each category. We assessed the relative importance of shared selection due to habitat similarity, unique island histories, and unique effects of similar habitats on different islands in the generation of morphological variation in anole ecomorphs. We found that shared features of diversification across habitats were of greatest importance, but island effects on morphology (reflecting either island effects per se or phylogenetic relationships) and unique aspects of habitat diversification on different islands were also important. There were three distinct cases of island-specific habitat diversification, and only one was confounded by phylogenetic relatedness. The other two unique aspects were not related to shared ancestry but might reflect as-yet-unmeasured environmental differences between islands in habitat characteristics. Quantifying the relative importance of shared and unique responses to similar selective regimes provides a more complete understanding of phenotypic diversification, even in this much-studied system [source] CONSTANCY OF THE G MATRIX IN ECOLOGICAL TIMEEVOLUTION, Issue 6 2004Mats BjÖrklund Abstract The constancy of the genetic variance-covariance matrix (G matrix) across environments and populations has been discussed and tested empirically over the years but no consensus has so far been reached. In this paper, I present a model in which morphological traits develop hierarchically, and individuals differ in their resource allocation and acquisition patterns. If the variance in resource acquisition is many times larger than the variance in resource allocation then strong genetic correlations are expected, and with almost isometric relations among traits. As the variation in resource acquisition decreases below a certain threshold, the correlations decrease overall and the relations among traits become a function of the allocation patterns, and in particular reflecting the basal division of allocation. A strong bottleneck can break a pattern of strong genetic correlation, but this effect diminishes rapidly with increasing bottleneck size. This model helps to understand why some populations change their genetic correlations in different environments, whereas others do not, since the key factor is the relation between the variances in resource acquisition and allocation. If a change in environment does not lead to a change in this ratio, no change can be expected, whereas if the ratio is changed substantially then major changes can be expected. This model can also help to understand the constancy of morphological patterns within larger taxa as a function of constancy in resource acquisition patterns over time and environments. When this pattern breaks, for example on islands, larger changes can be expected. [source] Interspecific interference and the functional response of four species of carnivorous stonefliesFRESHWATER BIOLOGY, Issue 9 2003J.M. Elliott Summary 1.,A previous study compared the functional responses to their prey and intraspecific interference in mature larvae of Perlodes microcephalus, Isoperla grammatica, Dinocras cephalotes and Perla bipunctata. The present study extends this work by assessing interspecific interference between pairs of these species in equal numbers (one, two or three larvae per species) to provide total predator densities of two, four or six larvae. Baetis larvae as prey were replaced as they were eaten, and their density per predator was varied between 20 and 200 larvae. 2.,The number of prey eaten by each competing species increased curvilinearly with prey density, the relationship being well described by a Type II model. Of the two constants in the model, handling time varied considerably between species, mean values being shortest for Perlodes, slightly higher for Isoperla, and much higher for Dinocras and Perla. It was not affected significantly either by predator density or the identity of the competing species. 3.,Attack rate also varied between species and decreased with predator density. This decrease was slight for Perlodes, and also for Dinocras and Perla in competition with Isoperla. The decrease in Dinocras and Perla was similar to that for intraspecific interference. 4.,The decrease in attack rate was described by a convex curve for Perlodes with the other three species and for Dinocras/Perla with Isoperla, but by a concave curve (negative power function) for Isoperla competing with the other three species, and for both Dinocras and Perla in competition with Perlodes. Prey consumption also decreased with predator density, the severity of competition with different species reflecting that for attack rate. 5.,A comparison with previous results for intraspecific interference showed that the latter was dominant for Perlodes in all contests and for Dinocras or Perla competing with Isoperla, whilst interspecific interference dominated for Isoperla in all contests and for Dinocras and Perla competing with Perlodes. Both types of interference were applicable to competition between Dinocras and Perla. Isoperla was the least, and Perlodes the most, aggressive of the four species with Dinocras and Perla intermediate. [source] Variable alluvial sandstone architecture within the Lower Old Red Sandstone, southwest WalesGEOLOGICAL JOURNAL, Issue 3-4 2004Brian P. J. Williams Abstract Sandstone bodies within the Lower Old Red Sandstone (ORS) in southern Pembrokeshire exhibit variability in architecture, sediment grade and composition both spatially and temporally. Four architectural styles are observed, namely decimetre- to metre-thick sheets, metre-thick multi-storey amalgamations, inclined-heterolithic units and ribbon geometries. Sandstone bodies in the Freshwater East Formation are sheet-like, heterolithic units several metres thick. An association with lingulids and wave ripples alludes to a marine influence, possibly estuarine tidal flats or storm washovers. Within the Moor Cliffs Formation, the most common sandstone bodies are centimetre- to metre-thick sheets with high width-to-depth ratios. Fine-grained sandstones represent sheet-flood deposition on unconfined, planar surfaces, whereas coarser-grained sandstones constitute distinctive amalgamations of discrete flood events, reflecting either a change in provenance or tectonic influence. Clear incision of coarse-grained, multi-storey units within the Inter-Tuff Moor Cliffs Formation reflects a change in relative sea-level, possibly tectonically induced. The base of the Conigar Pit Sandstone Member (CPSM) is marked by a distinctive, exotic-clast conglomerate defining the base to heterolithic, lateral-accretion bedsets and sandstone sheets. This association defines a significant influx of coarse-grained sediment post-Chapel Point Calcrete formation, an interval of presumed topographic stability across the Anglo-Welsh Basin. This influx must reflect rejuvenation of source regions, with changes in base-level reflecting either eustatic or tectonic influences. Commonly observed in the CPSM are fine-grained, inclined-heterolithic bedsets recording deposition by highly sinuous rivers with flashy discharge. Up-sequence within the CPSM are metre-thick, multi-storey amalgamations of predominatly trough cross-stratified medium- to coarse-grained sandstone. It is likely that these units are genetically related to contemporaneous decimetre-thick sandstone sheets, the latter being ,splay' events marginal to the main channel axis. The interbedding of multi-storey sandstones and fine-grained laterally accreted units reflects changes in provenance, slope and/or climate. Thickness variations within the Lower ORS detail significant thickening of all units northward into the Benton Fault. It seems likely that this thickening reflects variable accommodation space development associated with active growth along this and other WNW,ESE-trending faults, and migration of channel belts toward the footwall. Copyright © 2004 John Wiley & Sons, Ltd. [source] Information and Communications Technology as a General-Purpose Technology: Evidence from US Industry DataGERMAN ECONOMIC REVIEW, Issue 2 2007Susanto Basu Information technology; general-purpose technology; productivity acceleration Abstract. Many people point to information and communications technology (ICT) as the key for understanding the acceleration in productivity in the United States since the mid-1990s. Stories of ICT as a ,general-purpose technology' suggest that measured total factor productivity (TFP) should rise in ICT-using sectors (reflecting either unobserved accumulation of intangible organizational capital; spillovers; or both), but with a long lag. Contemporaneously, however, investments in ICT may be associated with lower TFP as resources are diverted to reorganization and learning. We find that US industry results are consistent with general-purpose technology (GPT) stories: the acceleration after the mid-1990s was broad-based , located primarily in ICT-using industries rather than ICT-producing industries. Furthermore, industry TFP accelerations in the 2000s are positively correlated with (appropriately weighted) industry ICT capital growth in the 1990s. Indeed, as GPT stories would suggest, after controlling for past ICT investment, industry TFP accelerations are negatively correlated with increases in ICT usage in the 2000s. [source] Use of Observations below Detection Limit for Model CalibrationGROUND WATER, Issue 2 2009Michael LeFrancois Censored (nondetect) values occur when chemical concentrations in water samples are near or below the level that can be measured by an analysis method. It is common to either delete or substitute values for nondetect observations for use in model calibration, but this practice can bias the estimated parameter values and the model predictions. A more realistic representation of the system is obtained from the calibration if we include such observations in a manner reflecting that we know only the value is below the detection limit. Consequently, we propose use of the censored-residual approach to including nondetect values as observations for calibration. In this approach, residuals are calculated as the detection limit minus the simulated value when the simulated value exceeds the detection limit, and the residual is assigned a value of zero when the simulated value is below the detection limit. The new censored-residual approach is particularly advantageous when calibrating transport models to low concentration data. [source] Primary Care Quality and Addiction Severity: A Prospective Cohort StudyHEALTH SERVICES RESEARCH, Issue 2 2007Theresa W. Kim Background. Alcohol and drug use disorders are chronic diseases that require ongoing management of physical, psychiatric, and social consequences. While specific addiction-focused interventions in primary care are efficacious, the influence of overall primary care quality (PCQ) on addiction outcomes has not been studied. The aim of this study was to prospectively examine if higher PCQ is associated with lower addiction severity among patients with substance use disorders. Study Population. Subjects with alcohol, cocaine, and/or heroin use disorders who initiated primary care after being discharged from an urban residential detoxification program. Measurements. We used the Primary Care Assessment Survey (PCAS), a well-validated, patient-completed survey that measures defining attributes of primary care named by the Institute of Medicine. Nine summary scales cover two broad areas of PCQ: the patient,physician relationship (communication, interpersonal treatment, thoroughness of the physical exam, whole-person knowledge, preventive counseling, and trust) and structural/organizational features of care (organizational access, financial access, and visit-based continuity). Each of the three addiction outcomes (alcohol addiction severity (ASI-alc), drug addiction severity (ASI-drug), and any drug or heavy alcohol use) were derived from the Addiction Severity Index and assessed 6,18 months after PCAS administration. Separate longitudinal regression models included a single PCAS scale as the main predictor variable as well as variables known to be associated with addiction outcomes. Main Results. Eight of the nine PCAS scales were associated with lower alcohol addiction severity at follow-up (p,.05). Two measures of relationship quality (communication and whole- person knowledge of the patient) were associated with the largest decreases in ASI-alc (,0.06). More whole-person knowledge, organizational access, and visit-based continuity predicted lower drug addiction severity (ASI-drug: ,0.02). Two PCAS scales (trust and whole-person knowledge of the patient) were associated with lower likelihood of subsequent substance use (adjusted odds ratio, [AOR]=0.76, 95 percent confidence interval [95% CI]=0.60, 0.96 and AOR=0.66, 95 percent CI=0.52, 0.85, respectively). Conclusion. Core features of PCQ, particularly those reflecting the quality of the physician,patient relationship, were associated with positive addiction outcomes. Our findings suggest that the provision of patient-centered, comprehensive care from a primary care clinician may be an important treatment component for substance use disorders. [source] Defining targets in myeloproliferative disorders: reflecting on what is important,HEMATOLOGICAL ONCOLOGY, Issue S1 2009Martin Griesshammer Abstract The current lack of curative options for essential thrombocythaemia (ET) leads to the goal of reducing the risk of potentially life-threatening thrombohaemorrhagic complications with long-term treatment. The setting of relevant treatment targets is an important consideration in this process, allowing the monitoring of disease control. Recent revisions to the World Health Organization (WHO) diagnostic criteria for the chronic MPDs 1 have implications not only for the diagnosis of patients, but also for the management of their disease and the continuing assessment of their progress. The purpose of this article is to discuss recent revisions to the WHO guidelines, and their influence on the setting of treatment targets in patients with ET. Copyright © 2009 John Wiley & Sons, Ltd. [source] HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice,HEPATOLOGY, Issue 3 2005Hanh-Tu Lieu Human hepatocarcinoma-intestine-pancreas/pancreatic-associated protein HIP/PAP is a secreted C-type lectin belonging to group VII, according to Drickamer's classification. HIP/PAP is overexpressed in liver carcinoma; however, its functional role remains unclear. In this study, we demonstrate that HIP/PAP is a paracrine hepatic growth factor promoting both proliferation and viability of liver cells in vivo. First, a low number of implanted hepatocytes deriving from HIP/PAP-transgenic mice (<1:1,000) was sufficient to stimulate overall recipient severe combined immunodeficiency liver regeneration after partial hepatectomy. After a single injection of HIP/PAP protein, the percentages of bromodeoxyuridine-positive nuclei and mitosis were statistically higher than after saline injection, indicating that HIP/PAP acts as a paracrine mitogenic growth factor for the liver. Comparison of the early events posthepatectomy in control and transgenic mice indicated that HIP/PAP accelerates the accumulation/degradation of nuclear phospho,signal transducer activator transcription factor 3 and tumor necrosis factor , level, thus reflecting that HIP/PAP accelerates liver regeneration. Second, we showed that 80% of the HIP/PAP-transgenic mice versus 25% of the control mice were protected against lethal acetaminophen-induced fulminate hepatitis. A single injection of recombinant HIP/PAP induced a similar cytoprotective effect, demonstrating the antiapoptotic effect of HIP/PAP. Comparison of Cu/Zn superoxide dismutase activity and glutathione reductase-like effects in control and transgenic liver mice indicated that HIP/PAP exerts an antioxidant activity and prevents reactive oxygen species-induced mitochondrial damage by acetaminophen overdose. In conclusion, the present data offer new insights into the biological functions of C-type lectins. In addition, HIP/PAP is a promising candidate for the prevention and treatment of liver failure. (HEPATOLOGY 2005;42:618,626.) [source] Elevated prevalence of hepatitis C infection in users of United States veterans medical centers,HEPATOLOGY, Issue 1 2005Jason A. Dominitz Several studies suggest veterans have a higher prevalence of hepatitis C virus infection than nonveterans, possibly because of military exposures. The purpose of this study was to estimate the prevalence of anti,hepatitis C antibody and evaluate factors associated with infection among users of Department of Veterans Affairs medical centers. Using a two-staged cluster sample, 1,288 of 3,863 randomly selected veterans completed a survey and underwent home-based phlebotomy for serological testing. Administrative and clinical data were used to correct the prevalence estimate for nonparticipation. The prevalence of anti,hepatitis C antibody among serology participants was 4.0% (95% CI, 2.6%-5.5%). The estimated prevalence in the population of Veterans Affairs medical center users was 5.4% (95% CI, 3.3%-7.5%) after correction for sociodemographic and clinical differences between participants and nonparticipants. Significant predictors of seropositivity included demographic factors, period of military service (e.g., Vietnam era), prior diagnoses, health care use, and lifestyle factors. At least one traditional risk factor (transfusion or intravenous drug use) was reported by 30.2% of all subjects. Among those testing positive for hepatitis C antibody, 78% either had a transfusion or had used injection drugs. Adjusting for injection drug use and nonparticipation, seropositivity was associated with tattoos and incarceration. Military-related exposures were not found to be associated with infection in the adjusted analysis. In conclusion, the prevalence of hepatitis C in these subjects exceeds the estimate from the general US population by more than 2-fold, likely reflecting more exposure to traditional risk factors among these veterans. (HEPATOLOGY 2005;41:88,96.) [source] Electrically Controllable Selective Reflection of Chiral Nematic Liquid Crystal/Chiral Ionic Liquid CompositesADVANCED MATERIALS, Issue 4 2010Wang Hu A chiral nematic liquid crystal/chiral ionic liquid composite with unique electro-optical characteristics is reported. The composite can be switched electrically between three different light states: transparent, scattering, and mirror reflecting (see images). Moreover, the reflection bandwidth can be controlled accurately and reversibly by adjusting the intensity of the electric field applied. [source] FLORENTINE CIVIC HUMANISM AND THE EMERGENCE OF MODERN IDEOLOGYHISTORY AND THEORY, Issue 3 2007HANAN YORAN ABSTRACT This article revisits the question of the modernity of the Renaissance by examining the political language of Florentine civic humanism and by critically analyzing the debate over Hans Baron's interpretation of the movement. It engages two debates that are usually conducted separately: one concerning the originality of civic humanism in comparison to medieval thought, and the other concerning the political and social function of the civic humanists' political republicanism in fifteenth-century Florence. The article's main contention is that humanist political discourse rejected the perception of social and political reality as being part of, or reflecting, a metaphysical and divine order or things, and thus undermined the traditional justifications for political hierarchies and power relations. This created the conditions of possibility for the distinctively modern aspiration for a social and political order based on liberty and equality. It also resulted in the birth of a distinctively modern form of ideology, one that legitimizes the social order by disguising its inequalities and structures of domination. Humanism, like modern political thought generally, thus simultaneously constructs and reflects the dialectic of emancipation and domination so central to modernity itself. [source] Finding Meaning in Memory: A Methodological Critique of Collective Memory StudiesHISTORY AND THEORY, Issue 2 2002Wolf Kansteiner The memory wave in the humanities has contributed to the impressive revival of cultural history, but the success of memory studies has not been accompanied by significant conceptual and methodological advances in the research of collective memory processes. Most studies on memory focus on the representation of specific events within particular chronological, geographical, and media settings without reflecting on the audiences of the representations in question. As a result, the wealth of new insights into past and present historical cultures cannot be linked conclusively to specific social collectives and their historical consciousness. This methodological problem is even enhanced by the metaphorical use of psychological and neurological terminology, which misrepresents the social dynamics of collective memory as an effect and extension of individual, autobiographical memory. Some of these shortcomings can be addressed through the extensive contextualization of specific strategies of representation, which links facts of representation with facts of reception. As a result, the history of collective memory would be recast as a complex process of cultural production and consumption that acknowledges the persistence of cultural traditions as well as the ingenuity of memory makers and the subversive interests of memory consumers. The negotiations among these three different historical agents create the rules of engagement in the competitive arena of memory politics, and the reconstruction of these negotiations helps us distinguish among the abundance of failed collective memory initiatives on the one hand and the few cases of successful collective memory construction on the other. For this purpose, collective memory studies should adopt the methods of communication and media studies, especially with regard to media reception, and continue to use a wide range of interpretive tools from traditional historiography to poststructural approaches. From the perspective of collective memory studies, these two traditions are closely related and mutually beneficial, rather than mutually exclusive, ways of analyzing historical cultures. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||