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Reflectance Confocal Microscopy (reflectance + confocal_microscopy)
Selected AbstractsReflectance confocal microscopy of cutaneous tumors: an atlas with clinical, dermoscopic and histological correlationsAUSTRALASIAN JOURNAL OF DERMATOLOGY, Issue 2 2009Catherine E Scarff No abstract is available for this article. [source] Virtual biopsy of the joint tissues using near-infrared, reflectance confocal microscopy.MICROSCOPY RESEARCH AND TECHNIQUE, Issue 10 2006A pilot study Abstract Standard noninvasive imaging techniques applied to joints provide gross morphological features, insufficient for assessing histological detail. On the other hand, biopsying is invasive, time consuming, and may involve unwanted processing artifacts. Near-infrared reflectance confocal microscopy is a technique that allows serial, high-resolution optical sectioning through intact tissues without employing exogenous fluorescent stains. The aim of this work was to evaluate the potential utility of near-infrared reflectance confocal microscopy for providing immediate histological information on meniscus, articular cartilage, epiphyseal plate, bone, muscle, and tendon. Images from near-infrared reflectance confocal microscopy were compared with mirror routine histology sections. Characteristic architectural features were readily visualized in the three dimensions of space. Additionally, the use of experimental contrast agents highlighted the localization of nuclei. Limitations include penetration depth and minor optical artifacts. In conclusion, near-infrared reflectance confocal microscopy is a useful technique for immediate, nondestructive, serial "virtual" sectioning through intact tissues, being thus a potential adjunct to current imaging techniques in orthopedics. Microsc. Res. Tech., 2006. © 2006 Wiley-Liss, Inc. [source] Noninvasive diagnostic tools for nonmelanoma skin cancerBRITISH JOURNAL OF DERMATOLOGY, Issue 2007M. Ulrich Summary Minimally invasive diagnostic tools have received increased attention for diagnosis, screening and management of nonmelanoma skin cancer (NMSC). Several modalities are commercially available, including high frequency ultrasound, optical coherence tomography and confocal microscopy. While systematic clinical analyses are often lacking, recent reports have shown promising results for reflectance confocal microscopy (RCM) for diagnosis of actinic keratoses and basal cell carcinoma. [source] Preliminary evaluation of in vivo reflectance confocal microscopy features of discoid lupus erythematosusBRITISH JOURNAL OF DERMATOLOGY, Issue 6 2007M. Ardig̣ Summary Background, Discoid lupus erythematosus (DLE) can simulate other inflammatory diseases both clinically and histologically. In vivo reflectance confocal microscopy (RCM) is a noninvasive, reproducible imaging technique already reported to be useful in the evaluation of several inflammatory skin conditions such as contact dermatitis, psoriasis and Darier disease. Objectives, The aims of our study were to define RCM features of DLE and to evaluate its feasibility in biopsy site selection. Methods, Discoid lesions were selected for RCM evaluation from 10 patients with an established diagnosis of DLE. Subsequently, a 4-mm punch biopsy of the same areas evaluated with RCM was rendered for histopathological examination. Results, A series of RCM features of DLE was identified and shown to correlate well with histopathological evaluation. Interface changes, as well as epidermal, dermal and adnexal inflammatory cell infiltration, were identified with RCM in a high percentage of the lesions. A limitation of RCM examination besides imaging depth was the inability to distinguish lymphocytes from other white blood cells. Conclusions, The utility of RCM as a diagnostic tool for DLE awaits further evaluation, although it appears to be promising for biopsy site selection. [source] | ||||||||||