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Record Linkage Study (record + linkage_study)
Selected AbstractsPerinatal risk factors and coeliac disease in children and young adults: a record linkage studyALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 2 2009S. E. ROBERTS Summary Background, Little is known about perinatal risk factors and coeliac disease. Aim, To investigate the relationship between perinatal risk factors and subsequent coeliac disease among offspring. Methods, Record linked abstracts of birth registrations, maternity, in-patient and day case records in a defined population of southern England. Results, Using univariate analysis, coeliac disease in the child was associated with maternal coeliac disease (odds ratio = 20.6; 95% CI = 5.04,84.0; based on two cases in both mother and child) and with social class, year of birth, maternal smoking and parity. Multivariate analysis confirmed an increased risk of coeliac disease of 3.79 (95% CI = 1.85,7.79) for classes IV and V compared with I and II, an increased risk of 1.92 (1.06,3.49) for births during 1975,1979 compared with 1970,1974 and an increased risk of 1.80 (1.05,3.09) for ,subsequent' compared with ,first' births. Smoking during pregnancy was no longer associated with coeliac disease. Because numbers were small, maternal coeliac disease was excluded from the multivariate anaylsis. Conclusions, This study shows increased risks of coeliac disease for manual social classes, births during the late 1970s and ,subsequent' births. Overall, perinatal risk factors seem to have a limited role in the aetiology of coeliac disease in children and young adults. [source] Aspirin increases mortality in diabetic patients without cardiovascular disease: a Swedish record linkage study,PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Issue 12 2009Lennart Welin MD Abstract Purpose Aspirin is effective in secondary prevention of cardiovascular disease. The results are less convincing when aspirin is used for primary prevention even in high-risk patients (i.e., patients with diabetes). We therefore analyzed the effect of aspirin on mortality and serious bleeding in diabetic patients with and without cardiovascular disease. Methods We performed a record linkage study of the patient registry of the Västra Götaland region in south-western Sweden, the Swedish mortality register and the Swedish register of dispensed drugs. All diabetic patients (n,=,58,465) from 1 July 2005 to 30 June 2006 were followed up with respect to bleeding until 31 October 2006, and mortality until 31 December 2006. Results When 19 confounding factors (diseases and interventions) were assessed, aspirin significantly increased mortality in diabetic patients without cardiovascular disease from 17% (95% confidence interval; 95%CI, 1,36) at age 50 years to 29% (16,43) at age 85 years. In contrast aspirin tended to decrease mortality among elderly diabetic patients with cardiovascular disease. Theoretical calculations indicated that aspirin caused 107 excess deaths among diabetic patients without cardiovascular disease and prevented 164 deaths among diabetic patients with cardiovascular disease. Aspirin also increased the risk of serious bleeding by 46% (95%CI, 22,75) in diabetic patients without cardiovascular disease but decreased the risk among those with cardiovascular disease. Conclusion Aspirin use in diabetes patients without cardiovascular disease remains controversial and current guidelines should be revised until results from ongoing large randomized controlled trials become available. Copyright © 2009 John Wiley & Sons, Ltd. [source] Women's fertility and mortality in late mid life: A comparison of three contemporary populationsAMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 4 2009Emily Grundy Evolutionary theory suggests a trade-off between reproduction and somatic maintenance implying a negative relationship between parity and longevity, at least in natural fertility populations. In populations in which fertility control is usual, there are also a number of mechanisms that may link reproductive careers and later mortality, but evidence of associations between women's fertility patterns and their later life health has been judged inconclusive due to varying controls for socio-economic characteristics and marital status. Here, we build on three recent studies that followed a common framework to investigate associations between women's parity and timing of first and last birth with mortality in late middle age in three contemporary developed counties, Norway, England and Wales, and the USA. Data were drawn from whole population registers (Norway); a large census-based record linkage study (England and Wales), and a nationally representative survey linked to death records (USA). Results show that teenage childbirth was associated with higher mortality risks in late middle age in all three countries. Risks of death were significantly raised among nulliparous women in Norway and England and Wales, and also raised (although not significantly so) for childless US women. However, although higher parity was associated with a slight mortality disadvantage in England and Wales and the USA, the reverse seemed the case in Norway. These finding suggest that in populations in which fertility control is usual, contextual factors influencing the relative costs and benefits of childbearing may influence associations between fertility histories and later mortality. Am. J. Hum. Biol., 2009. © 2009 Wiley-Liss, Inc. [source] | ||||||||||