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Recent Work (recent + work)
Terms modified by Recent Work Selected AbstractsRecent Work in Seventeenth-Century Economic ThoughtHISTORY COMPASS (ELECTRONIC), Issue 1 2006Brian Weiser During the Stuart era, theorists, merchants, government officials, and everyday Englishmen and women tried to understand the rapid shifts in their economy. Such inquiry changed perceptions of how the economy worked. This article explores recent scholarship on economic thought in the Stuart era. It begins with Joyce Appleby's seminal book which sees economic events as the prime mover behind shifts in economic theory, and then considers Andrea Finkelstein's recent assertions that scientific and medical discoveries strongly influenced economic thinkers like William Petty and Thomas Mun. The article then examines a series of works that analyze the impact of politics on economic thought, how economic thought inspired literature, the interplay of economic thought and religion, and how those who were not economic literati viewed the economy. [source] Recent Work on TruthANALYTIC PHILOSOPHY, Issue 4 2002Julian Dodd First page of article [source] Recent Work on CausationANALYTIC PHILOSOPHY, Issue 1 2001Article first published online: 17 DEC 200 First page of article [source] Personal Meaning, Self-Representation, and Agency in Some Recent WorksAMERICAN ANTHROPOLOGIST, Issue 1 2001Mark A. Cravalho Inuit Morality Play: The Emotional Education of. Three-Year-Old. Jean L. Briggs. New Haven, CT: Yale University Press, 1998. 275 pp. The Power of Feelings: Personal Meaning in Psychoanalysis, Gender, and Culture. Nancy J. Chodorow. New Haven, CT: Yale University Press, 1999. 320 pp. Identity and Agency in Cultural Worlds. Dorothy Holland. William Lachicotte Jr. Debra Skinner. and Carol Cain. Cambridge, MA: Harvard University Press, 1998. 349 pp. [source] LKB1 and AMP-activated protein kinase control of mTOR signalling and growthACTA PHYSIOLOGICA, Issue 1 2009R. J. Shaw Abstract The AMP-activated serine/threonine protein kinase (AMPK) is a sensor of cellular energy status found in all eukaryotes that is activated under conditions of low intracellular ATP following stresses such as nutrient deprivation or hypoxia. In the past 5 years, work from a large number of laboratories has revealed that one of the major downstream signalling pathways regulated by AMPK is the mammalian target-of-rapamycin [mammalian target of rapamycin (mTOR) pathway]. Interestingly, like AMPK, the mTOR serine/threonine kinase plays key roles not only in growth control and cell proliferation but also in metabolism. Recent work has revealed that across eukaryotes mTOR orthologues are found in two biochemically distinct complexes and only one of those complexes (mTORC1 in mammals) is acutely sensitive to rapamycin and regulated by nutrients and AMPK. Many details of the molecular mechanism by which AMPK inhibits mTORC1 signalling have also been decoded in the past 5 years. AMPK directly phosphorylates at least two proteins to induce rapid suppression of mTORC1 activity, the TSC2 tumour suppressor and the critical mTORC1 binding subunit raptor. Here we explore the molecular connections between AMPK and mTOR signalling pathways and examine the physiological processes in which AMPK regulation of mTOR is critical for growth or metabolic control. The functional conservation of AMPK and TOR in all eukaryotes, and the sequence conservation around the AMPK phosphorylation sites in raptor across all eukaryotes examined suggest that this represents a fundamental cell growth module connecting nutrient status to the cell growth machinery. These findings have broad implications for the control of cell growth by nutrients in a number of cellular and organismal contexts. [source] SIZE OF HOUSEHOLD FIREARM COLLECTIONS: IMPLICATIONS FOR SUBCULTURES AND GENDER,CRIMINOLOGY, Issue 3 2007BRIAN R. WYANT Recent work (Cook and Ludwig, 2003) has linked local firearm density to increased burglary victimization risk. The current work investigates within-household gun density or household firearm collection size. Previous work has suggested two subcultures of gun owners: protection-minded and sport- or hunting-minded. It also has identified gender gaps in reporting any household guns and in the number reported. None of the earlier work, however, has controlled for selection into gun-owning household status. This limitation raises potential questions about earlier findings. The current research controls for selection. If the two subcultures thesis is correct, protection-minded owners should report smaller household firearm collections. The expected impact is observed in one national survey and is partially replicated in a second. Gender gaps seemed more independent than previously suggested. This study is the first to provide evidence of two partially overlapping subcultures of gun owners even after controlling for selection into gun-owning household status. Practical implications for burglary risk may exist. [source] GENDER, STREETLIFE AND CRIMINAL RETALIATION,CRIMINOLOGY, Issue 4 2004CHRISTOPHER W. MULLINS Recent work in criminology has highlighted the central role of retaliation in shaping criminal violence in America's inner cities. Most of this work, however, has been based on male offenders. It has also failed to consider whether and how gender structures payback in real-life settings and circumstances. In this paper, we analyze in-depth, semi-structured interviews with forty men and twelve women who recently engaged in one or more episodes of retaliatory violence to examine the ways in which gender shapes vengeance. We hope to provide an insider's view of how gender frames the context and dynamics of retaliatory events for both men and women. [source] Dilemmas of Counter-Mapping Community Resources in TanzaniaDEVELOPMENT AND CHANGE, Issue 1 2002Dorothy L. Hodgson Recent work has celebrated the political potential of ,counter-mapping', that is, mapping against dominant power structures, to further seemingly progressive goals. This article briefly reviews the counter-mapping literature, and compares four counter-mapping projects from Maasai areas in Tanzania to explore some potential pitfalls in such efforts. The cases, which involve community-based initiatives led by a church-based NGO, ecotourism companies, the Tanzanian National Parks Authority, and grassroots pastoralist rights advocacy groups, illustrate the broad range of activities grouped under the heading of counter-mapping. They also present a series of political dilemmas that are typical of many counter-mapping efforts: conflicts inherent in conservation efforts involving territorialization, privatization, integration and indigenization; problems associated with the theory and practice of ,community-level' political engagement; the need to combine mapping efforts with broader legal and political strategies; and critical questions involving the agency of ,external' actors such as conservation and development donors, the state and private business interests. [source] Differing strategies for forming the arthropod body plan: Lessons from Dpp, Sog and Delta in the fly Drosophila and spider AchaearaneaDEVELOPMENT GROWTH & DIFFERENTIATION, Issue 4 2008Hiroki Oda In the insect Drosophila embryo, establishment of maternal transcription factor gradients, rather than cell,cell interactions, is fundamental to patterning the embryonic axes. In contrast, in the chelicerate spider embryo, cell,cell interactions are thought to play a crucial role in the development of the embryonic axes. A grafting experiment by Holm using spider eggs resulted in duplication of the embryonic axes, similar to the Spemann's organizer experiment using amphibian eggs. Recent work using the house spider Achaearanea tepidariorum has demonstrated that the homologs of decapentaplegic (dpp), short gastrulation (sog) and Delta, which encode a bone morphogenetic protein (BMP)-type ligand, its antagonist and a Notch ligand, respectively, are required in distinct aspects of axis formation. Achaearanea Dpp appears to function as a symmetry-breaking signal, which could account for Holm's results to some extent. Experimental findings concerning Achaearanea sog and Delta have highlighted differences in the mechanisms underlying ventral and posterior development between Drosophila and Achaearanea. Achaearanea ventral patterning essentially depends on sog function, in contrast to the Drosophila patterning mechanism, which is based on the nuclear gradient of Dorsal. Achaearanea posterior (or opisthosomal) patterning relies on the function of the caudal lobe, which develops from cells surrounding the blastopore through progressive activation of Delta-Notch signaling. In this review, we describe the differing strategies for forming the arthropod body plan in the fly and spider, and provide a perspective towards understanding the relationship between the arthropod and vertebrate body plans. [source] Early requirement for fgf8 function during hindbrain pattern formation in zebrafishDEVELOPMENTAL DYNAMICS, Issue 2 2004Elizabeth L. Wiellette Abstract Fibroblast growth factor (FGF) signaling is required for normal development of the vertebrate brain, including the isthmus and caudal regions of the hindbrain. Recent work in zebrafish has identified a requirement for the combination of fgf3 and fgf8 functions in specification of rhombomeres 5 and 6 (r5, r6), when evaluated at mid- and late somitogenesis stages. However, when examined earlier in development, during early somitogenesis stages, FGF8 alone is required to initiate r5 and r6 development. Both a mutation in fgf8 and injection of fgf8 -targeted antisense morpholino-modified oligonucleotides result in suppression of genes normally expressed in r5 and r6 by the one- to two-somite stage. This expression recovers by the six-somite stage, and we propose that this recovery is a response to activation of fgf3 and to delayed accumulation of fgf8. These data demonstrate an early, nonredundant requirement for fgf8 function in hindbrain patterning. Developmental Dynamics 229:393,399, 2004. © 2004 Wiley-Liss, Inc. [source] The emergence of a novel representation from action: evidence from preschoolersDEVELOPMENTAL SCIENCE, Issue 2 2010Rebecca Boncoddo Recent work in embodied cognition has proposed that representations and actions are inextricably linked. The current study examines a developmental account of this relationship. Specifically, we propose that children's actions are foundational for novel representations. Thirty-two preschoolers, aged 3.4 to 5.7 years, were asked to solve a set of simple gear-system problems. Participants' motions and verbalizations were coded to establish the strategies they used. The preschoolers initially solved the problems by simulating the turning and pushing of the gears. Subsequently, most participants discovered a new representation of the problems: the turning direction of the gears alternates. Results show that the number of actions that embodied alternation information, during their simulation of the system, predicted the later emergence of the higher-order representation (i.e. that the gears alternate turning direction). Thus, it appears that the preschoolers discovered a new representation based on their own actions. These results are consistent with the developmental embodiment hypothesis: actions are central to the emergence of new representations. [source] Desert pavement dynamics: numerical modeling and field-based calibrationEARTH SURFACE PROCESSES AND LANDFORMS, Issue 13 2007Jon D. Pelletier Abstract Desert pavements are widely used as a relative surface-dating tool because they are progressively better developed on surfaces ranging from thousands to hundreds of thousands of years in age. Recent work, however, has highlighted the dynamic nature of pavements and undermined their use as surface-age indicators. Quade (2001) proposed that latest Pleistocene vegetation advances destroyed all Mojave Desert pavements above 400 m elevation, making all such pavements Holocene in age. In an effort to reconcile young-pavement evidence with their widespread use as Pleistocene surface-age indicators, we developed a numerical model based on the classic conceptual model in which pavements co-evolve with their underlying eolian epipedons over millennial timescales. In this co-evolutionary process, fine-grained eolian deposition and Av -horizon development within the eolian epipedon promotes surface clast motion and pavement development, enhancing the eolian-sediment-trapping ability of the pavement in a positive feedback. Model results illustrate the multi-scale nature of pavement dynamics: pavements may require tens of thousands of years to fully develop from a newly abandoned alluvial surface, but may heal over timescales of decades to centuries if a mature eolian epipedon is present. As such, there is no inconsistency between rapid pavement healing and a Pleistocene age for the underlying alluvial surface. To calibrate the model, we conducted surficial geologic mapping and pavement-sedimentological analysis on two desert piedmonts. Our study areas include both proximal and distal fan environments, illustrating the role of parent-material texture in controlling the mode of pavement formation. Using available geochronology, our work provides a rigorous calibration of pavement formation rates in our study areas and provides evidence supporting the use of pavements as local relative surface-age indicators over Holocene to late Pleistocene timescales. Copyright © 2007 John Wiley & Sons, Ltd. [source] Tributaries influence recruitment of fish in large riversECOLOGY OF FRESHWATER FISH, Issue 4 2009B. M. Pracheil Abstract,,, Recent work demonstrates that tributary inputs are important community reorganisation points for river biota; however, no studies have examined the long-term effects of tributary inputs on fish population dynamics. This study examines nearly 40 years of young-of-year (yoy) paddlefish recruitment data to investigate the hypothesis that tributaries influence mainstem fish population dynamics. We generated hydrological variables from daily mean flow data (1965,2007) from an impounded reach of the mainstem Missouri River and from the Niobrara River, a relatively unaltered tributary, using Indicators of Hydrologic Alteration software. Three multiple regression models using natural-log transformed catch per unit effort (log cpue) as the response variable were created using (1) Missouri River-only flow variables, (2) Niobrara River-only flow variables and (3) Missouri River and Niobrara River flow variables. Flow variables from the Niobrara River explain a greater proportion of yoy paddlefish log cpue variability demonstrating that tributaries can positively impact fish population dynamics in altered rivers. [source] Exporting the German Model: The Establishment of a New Automobile Industry Cluster in ShanghaiECONOMIC GEOGRAPHY, Issue 1 2005Heiner Depner Abstract: Recent work has provided evidence that the establishment of new industry clusters cannot be jump-started through policy initiatives alone. This evidence does not imply, however, that the genesis of a new cluster cannot be planned at all. Especially in the context of a developing economy, it seems useful to reinvestigate the relation among economic development, the strategies of multinational firms, and state intervention in this respect. Drawing from the case of the automobile industry and its supplier system in Shanghai in which German firms play an important role, we provide empirical evidence of the evolution of a new cluster that is supported by the state in various forms and characterized by a focal, hierarchically structured production system. We use a multidimensional approach to clusters, which leads to a more nuanced understanding of the evolution and growth of a cluster than that provided by earlier accounts. This approach allows us to distinguish the development of the Shanghai automobile industry cluster along its vertical, horizontal, external, institutional, and power dimensions. We provide evidence that another dimension,"culture",plays an important role, especially in its relation to issues of power and institutions. The role of this dimension is demonstrated in the case of German firms, which tap into the Chinese innovation system. This system is characterized by particular business relations, institutions, norms, and various social practices that are new to German firms. We demonstrate how this difference creates problems in establishing local production and supplier relations and how these problems can be overcome. [source] Electrocatalytic Properties and Sensor Applications of Fullerenes and Carbon NanotubesELECTROANALYSIS, Issue 9 2003Bailure Abstract The electrochemical behavior of fullerene and fullerene derivatives are reviewed with special reference to their catalytic and sensor applications. Recent work on carbon nanotubes, used as catalyst supports in heterogeneous catalysis and sensor development is also presented. An overview of recent progress in the area of fullerene electrochemistry is included. Several cases of electrocatalytic dehalogenation of alkyl halides, assisted by the electrode charge transfer to fullerenes, are discussed. Research work on the electrocatalysis of biomolecules, such as hemin, cytochrome c, DNA, coenzymes, glucose, ascorbic acid, dopamine, etc. have also been considered. Based on the studies of the interaction of fullerenes, fullerene derivatives, and carbon nanotubes with other molecules and biomolecules in particular, the possibilities for the preparation of electrochemical sensors and their application in electroanalytical chemistry are highlighted. [source] Differences between the effects of three plasticity inducing protocols on the organization of the human motor cortexEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2006Karin Rosenkranz Abstract Several experimental protocols induce lasting changes in the excitability of motor cortex. Some involve direct cortical stimulation, others activate the somatosensory system and some combine motor and sensory stimulation. The effects usually are measured as changes in amplitude of the motor-evoked-potential (MEP) or short-interval intracortical inhibition (SICI) elicited by a single or paired pulses of transcranial magnetic stimulation (TMS). Recent work has also tested sensorimotor organization within the motor cortex by recording MEPs and SICI during short periods of vibration applied to single intrinsic hand muscles. Here sensorimotor organization is focal: MEPs increase and SICI decreases in the vibrated muscle, whilst the opposite occurs in neighbouring muscles. In six volunteers we compared the after effects of three protocols that lead to lasting changes in cortical excitability: (i) paired associative stimulation (PAS) between a TMS pulse and an electrical stimulus to the median nerve; (ii) motor practice of rapid thumb abduction; and (iii) sensory input produced by semicontinuous muscle vibration, on MEPs and SICI at rest and on the sensorimotor organization. PAS increased MEP amplitudes, whereas vibration changed sensorimotor organization. Motor practice had a dual effect and increased MEPs as well as affecting sensorimotor organization. The implication is that different protocols target different sets of cortical circuits. We speculate that protocols that involve repeated activation of motor cortical output lead to lasting changes in efficacy of synaptic connections in output circuits, whereas protocols that emphasize sensory inputs affect the strength of sensory inputs to motor circuits. [source] How fatiguing is dispositional suppression?EUROPEAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 2 2007Disentangling the effects of procedural rebound, ego-depletion Recent work has shown that correcting a dispositional inference may lead social observers to over-emphasize the role of dispositional factors in subsequent judgments. This effect has been explained as a procedural rebound following a phase of dispositional suppression. We conducted two experiments to test an alternative explanation in terms of ego-depletion. In Experiment 1, we compared the effects of ego-depletion and dispositional rebound by relying on the attitude attribution paradigm and the cookie paradigm. In Experiment 2, we turned to a difficult math task in order to induce fatigue. We were able to replicate the dispositional rebound and the ego-depletion effects but none of the experiments supported an ego-depletion explanation of post-suppression dispositional rebound. Copyright © 2006 John Wiley & Sons, Ltd. [source] ,And the beat goes on' The cardiac conduction system: the wiring system of the heartEXPERIMENTAL PHYSIOLOGY, Issue 10 2009Mark R. Boyett The cardiac conduction system (CCS), consisting of the sino-atrial node, atrioventricular node and His,Purkinje system, is responsible for the initiation and co-ordination of the heart beat. In the last decade, our understanding of the CCS has been transformed. Immunohistochemistry, used in conjunction with anatomical techniques, has transformed our understanding of its anatomy; arguably, we now understand the position of the sino-atrial node (not the same as in medical textbooks), and our new understanding of the atrioventricular node anatomy means that we can compute its physiological and pathophysiological behaviour. Ion channel expression in the CCS has been shown to be fundamentally different from that in the working myocardium. Dysfunction of the CCS has previously been attributed to fibrosis, but it is now clear that remodelling of ion channels plays an important role in dysfunction during ageing, heart failure and atrial fibrillation. Differences in ion channel expression may even be responsible for the bradycardia in the athlete and differences in heart rate among different species (such as humans and mice). Recent work has highlighted less well-known components of the CCS, including tricuspid, mitral and aortic rings and even a third (retro-aortic) node. These additional tissues do not participate in the initiation and co-ordination of the heart beat and instead they are likely to be the source of various life-threatening arrhythmias. During embryological development, all parts of the CCS have been shown to develop from the primary myocardium of the linear heart tube, partly under the influence of the transcription factor, Tbx3. [source] ,25 Crack opening displacement parameter in cohesive zone models: experiments and simulations in asphalt concreteFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 10 2008S. H. SONG ABSTRACT Recent work with fracture characterization of asphalt concrete has shown that a cohesive zone model (CZM) provides insight into the fracture process of the materials. However, a current approach to estimate fracture energy, i.e., in terms of area of force versus crack mouth opening displacement (CMOD), for asphalt concrete overpredicts its magnitude. Therefore, the ,25 parameter, which was inspired by the ,5 concept of Schwalbe and co-workers, is proposed as an operational definition of a crack tip opening displacement (CTOD). The ,25 measurement is incorporated into an experimental study of validation of its usefulness with asphalt concrete, and is utilized to estimate fracture energy. The work presented herein validates the ,25 parameter for asphalt concrete, describes the experimental techniques for utilizing the ,25 parameter, and presents three-dimensional (3D) CZM simulations with a specially tailored cohesive relation. The integration of the ,25 parameter and new cohesive model has provided further insight into the fracture process of asphalt concrete with relatively good agreement between experimental results and numerical simulations. [source] Instantons on D7 brane probes and AdS/CFT with flavourFORTSCHRITTE DER PHYSIK/PROGRESS OF PHYSICS, Issue 5-6 2006R. Apreda Abstract Recent work on adding flavour to the generalized AdS/CFT correspondence is reviewed. In particular, we consider instanton configurations on two coincident D7 brane probes. These are matched to the Higgs branch of the dual field theory. In AdS5 × S5, the instanton generates a flow of the meson spectrum. For non-supersymmetric gravity backgrounds, the Higgs branch is lifted by a potential with non-trivial physical implications. Based on talk given by J. Erdmenger. [source] A prevalence-based association test for case-control studiesGENETIC EPIDEMIOLOGY, Issue 7 2008Kelli K. Ryckman Abstract Genetic association is often determined in case-control studies by the differential distribution of alleles or genotypes. Recent work has demonstrated that association can also be assessed by deviations from the expected distributions of alleles or genotypes. Specifically, multiple methods motivated by the principles of Hardy-Weinberg equilibrium (HWE) have been developed. However, these methods do not take into account many of the assumptions of HWE. Therefore, we have developed a prevalence-based association test (PRAT) as an alternative method for detecting association in case-control studies. This method, also motivated by the principles of HWE, uses an estimated population allele frequency to generate expected genotype frequencies instead of using the case and control frequencies separately. Our method often has greater power, under a wide variety of genetic models, to detect association than genotypic, allelic or Cochran-Armitage trend association tests. Therefore, we propose PRAT as a powerful alternative method of testing for association. Genet. Epidemiol. 2008. © 2008 Wiley-Liss, Inc. [source] The sedimentary records in Mediterranean rockshelters and caves: Archives of environmental changeGEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 4 2001Jamie C. Woodward It is important to develop rigorous methods and robust conceptual models for the interpretation of rockshelter and cave sediment records so that the cultural sequences they contain can be considered in their proper environmental context. Much of what we know about the prehistory of the Mediterranean region and adjacent areas has largely been pieced together from materials excavated from sedimentary sequences in these environments. The rockshelters and caves of the region form important environmental and sedimentary archives. Recent work has begun to consider if the remarkable climatic variability evident in the high resolution lacustrine and ice core records is manifest in the rockshelter and cave sediment records of the area. In this context, the two main characteristics of a rockshelter or cave site which control its usefulness as an archive of environmental change are the temporal resolution of the sedimentary record and the environmental sensitivity of the site. Many rockshelters and caves can be described as either Active Karst Settings (AKS) or Passive Karst Settings (PKS) and site type is an important influence on climatic sensitivity with a direct influence upon the usefulness of the sedimentary sequence as a proxy record of climate change. It is now clear that some sites may preserve detailed paleoclimatic records and the climatic signal may be represented by distinctive suites of micromorphological features, by variations in the input of allogenic sediment, or by fluctuations in the mineral magnetic properties of the fine sediment fraction. It can be argued that data derived from the analysis of bulk coarse-grained samples often lacks the stratigraphic resolution and environmental sensitivity that can be obtained from other approaches. The most favorable sites for detailed paleoclimatic reconstruction appear to be in active karst settings such as Theopetra Cave (Greece) and Pigeon Cave (Morocco) where micromorphological analyses offer insights into the stratigraphic record that are not otherwise obtainable. The temporal resolution of a site can only be established through a rigorous stratigraphic analysis and a comprehensive dating program. These are fundamental considerations in the study of rockshelter sediment records, especially when attempting to correlate between sites and draw comparisons with other proxy records of environmental change derived from sedimentary environments with rather different characteristics. Rockshelters and caves are part of a wider sediment system, and their investigation must be accompanied by detailed geomorphological, sedimentological, paleoecological, and geochronological studies of the off-site Quaternary record. © 2001 John Wiley & Sons, Inc. [source] Ideas, Interests, and Institutions: Challenging the Property Rights Paradigm in BotswanaGOVERNANCE, Issue 4 2003Amy R. Poteete Recent work in international studies and comparative politics scrutinizes the relative importance of ideas, interests, and institutions as sources of policy change. A growing body of scholarship identifies ideas as the main causal factors, influencing perceived interests as well as perceived policy options. Others contend that policies can best be understood as products of institutions. Neither explanation can account for both policy choice by politicians and the implementation strategies of administrators. In Botswana, the use of professional criteria for hiring and advancement encourages adherence to international professional norms within the bureaucracy, but electoral competition gives politicians more reason to be attentive to local political concerns. The institutions that define relations of authority among actors with different motivations shape the outcomes of policy choice and implementation. Institutions influence the attentiveness of policy-makers to ideas when making decisions, the degree of attention particular policy-makers give to ideas from particular sources, and the degree of acceptance that ideas must achieve to affect policy. Better evaluations of political development can be achieved through attentiveness to the mix of actors involved in policy decisions, the diversity of institutions and ideas that affect their policy preferences, and the relations of authority that shape their relative influence over policy choice and implementation. [source] Fascinating organosulfur functionalities: Polychalcogens as diatomic sulfur sourcesHETEROATOM CHEMISTRY, Issue 5 2007Eli Zysman-Colman Recent work on the chemistry of dialkoxy disulfides is summarized. It includes various aspects of their structure and relationship to the isomeric thionosulfites as well as their use as diatomic sulfur precursors. © 2007 Wiley Periodicals, Inc. 18:449,459, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20341 [source] Sunlight ultraviolet irradiation and BRAF V600 mutagenesis in human melanoma,HUMAN MUTATION, Issue 8 2008Ahmad Besaratinia Abstract The incidence of melanoma, the most lethal form of skin cancer, continues to increase in the Western world. In addition to genetic alterations in high- and low-susceptibility genes identified for melanoma, somatic mutations in BRAF gene occur frequently in human melanoma and are distinctively linked to sun exposure. Of significance is a single hotspot codon, i.e., BRAF V600, wherein up to 92% of all mutations arise. Recent work in our laboratory has demonstrated that solar ultraviolet (UV) irradiation triggers mutagenesis through induction of various DNA lesions, many of which capable of producing similar types of mutations, as those seen in BRAF V600 variants in human melanoma. In this review article, we have discussed application of "DNA damage-targeted mutagenicity" of solar UV-irradiation for determining the mechanistic involvement of sunlight UV in BRAF V600 mutagenesis in human melanoma. We envision that establishing "DNA-damage derived mutagenesis" in this exceptionally unique target gene may resolve the underlying mechanism(s) of melanoma-genesis, thus helping define preventive and therapeutic measures against this malignant disease. Hum Mutat 0, 1,9, 2008. © 2008, Wiley-Liss, Inc. [source] Synovial mast cells: role in acute and chronic arthritisIMMUNOLOGICAL REVIEWS, Issue 1 2007Peter A. Nigrovic Summary:, Mast cells reside in the normal synovium and increase strikingly in number in rheumatoid arthritis and other joint diseases. Given the broad spectrum of activity of this lineage, it has for decades been considered probable that mast cells are involved in the pathophysiology of synovitis. Recent work in murine arthritis has substantiated this suspicion, showing that mast cells can contribute importantly to the initiation of inflammatory arthritis. However, the role of the greatly expanded population of synovial mast cells in established arthritis remains unknown. Here we review the current understanding of mast cell function in acute arthritis and consider the potentially important influence of this cell on key processes within the chronically inflamed synovium, including leukocyte recruitment and activation, fibroblast proliferation, angiogenesis, matrix remodeling, and injury to collagen and bone. We also consider recent evidence supporting an immunomodulatory or anti-inflammatory role for mast cells as well as pharmacologic approaches to the mast cell as a therapeutic target in inflammatory arthritis. [source] Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repairIMMUNOLOGICAL REVIEWS, Issue 1 2004Stephanie A. Nick McElhinny Summary:, The nonhomologous end-joining pathway is a major means for repairing double-strand breaks (DSBs) in all mitotic cell types. This repair pathway is also the only efficient means for resolving DSB intermediates in V(D)J recombination, a lymphocyte-specific genome rearrangement required for assembly of antigen receptors. A role for polymerases in end-joining has been well established. They are a major factor in determining the character of repair junctions but, in contrast to ,core' end-joining factors, typically appear to have a subtle impact on the efficiency of end-joining. Recent work implicates several members of the Pol X family in end-joining and suggests surprising complexity in the control of how these different polymerases are employed in this pathway. [source] Primitive immune systems: Are your ways my ways?IMMUNOLOGICAL REVIEWS, Issue 1 2004Baruch Rinkevich Summary:, Although vertebrate immune systems have been commonly conceived as exquisitely developed to combat pervasiveness by pathogens, they are not infallible. The enigmatic expression of histocompatibility in vertebrates, the manifestation of natural chimerism, autoimmunity, malignancy, and other puzzling outcomes hint that immunity did not arise in evolution to fight infections and that this capacity is a late evolutionary appendage, owing its appearance to the redeployment of a system developed for other reasons. Allorecognition in the colonial tunicate Botryllus schlosseri serves here as a platform for a contending paradigm, advocating that immunity has developed as a surveillance machinery against and for purging of nascent selfish cells (stemmed from a kin organism or from transformed cells within the organism of origin). Defense against pathogens (always representing xenogeneic aliens) appeared later, revealing the multiplicity of newly developed phenomena. Allorecognition events characteristic of the Botryllus primitive immune system, such as fusion versus rejection, the morphological resorption with its expressed hierarchy, and the somatic/germ-cell parasitic outcomes, provide clues to the evolutionary basis of allorecognition. Recent work on Botryllus immunity that highlights the cost of littering individuality by somatic variants/allogeneic cells is discussed. [source] Caspases and T lymphocytes: a flip of the coin?IMMUNOLOGICAL REVIEWS, Issue 1 2003Saquib Lakhani Summary:, In this review, we consider the role caspases play in cell death downstream of death receptors and cell intrinsic death mechanisms. In particular, we focus on these mechanisms in antigen-induced cell death, a mechanism which regulates the number of surviving T cells at the end of an immune response. The relative role of the apoptosome as an amplifier rather than an initiator of apoptosis is considered. Several factors that regulate the susceptibility to activation-induced cell death are considered. These factors emanate from the stimulation of the T-cell receptors and include multiple pathways. Recent work has shown that death receptor signaling can play an interesting role in cell proliferation in both humans and animals. These recent findings are discussed in the light of models of death receptor signaling. [source] High-Performance SOFC Cathodes Prepared by InfiltrationADVANCED MATERIALS, Issue 9 2009John M. Vohs Abstract Improved cathodes are required for low-temperature operation of solid-oxide fuel cells (SOFCs). Recent work has shown that electrode fabrication and modification by infiltration of active components into a porous scaffold can result in outstanding electrochemical performance. In this paper we review the literature on this new approach for cathode preparation and discuss the insights that this work has provided for understanding the relationships between the materials properties, electrochemical performance, and electrode stability. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||