Home About us Contact
|
Home About us Contact | ||
|
|
||
Recent Increase (recent + increase)
Selected AbstractsInvestigative Visual Analysis of Global TerrorismCOMPUTER GRAPHICS FORUM, Issue 3 2008Xiaoyu Wang Abstract Recent increases in terrorist activity around the world have made analyzing and understanding such activities more critical than ever. With the help of organizations such as the National Center for the Study of Terrorism and Responses to Terrorism (START), we now have detailed historical information on each terrorist event around the world since 1970. However, due to the size and complexity of the data, identifying terrorists' patterns and trends has been difficult. To better enable investigators in understanding terrorist activities, we propose a visual analytical system that focuses on depicting one of the most fundamental concepts in investigative analysis, the five W's (who, what, where, when, and why). Views in our system are highly correlated, and each represents one of the W's. With this approach, an investigator can interactively explore terrorist activities efficiently and discover reasons of attacks (why) by identifying patterns temporally (when), geo-spatially (where), between multiple terrorist groups (who), and across different methods or modes of attacks (what). By coupling a global perspective with the details gleaned from asking these five questions, the system allows analysts to think both tactically and strategically. [source] Recent Changes in the Workforce and Practice of Dermatologic SurgeryDERMATOLOGIC SURGERY, Issue 3 2009EMILY P. TIERNEY MD BACKGROUND The increasing number of American College of Mohs Surgery (ACMS) fellowship positions over the last decade has resulted in a greater number of fellowship-trained surgeons in dermatologic surgery. METHODS Mohs micrographic fellowship-trained surgeons (MMFTSs) and non-Mohs fellowship-trained surgeons performing Mohs micrographic surgery (NMMFTSs) were compared using the American Academy of Dermatology Practice Profile Survey (2002/05). An analysis of recent Mohs fellowship classes was also performed. RESULTS In 2005, there was an equivalent proportion of MMFTSs and NMMFTSs in the workforce (ratio MMFTS:NMMFTS=0.9) but, in 2005, there was a shift in the youngest age cohort (29,39) to a greater proportion of MMFTSs (MMFTS:NMMFTS=1.55). In 2005, the youngest MMFTSs (29,39) were more likely to be female (47.1%) than of MMFTSs overall (24%). MMFTSs were 5 times as likely to be in full-time academic positions and performed 2 to 3 times as many Mohs cases per week as NMMFTSs. CONCLUSIONS Consistent with demographic shifts in dermatology, differences have emerged in the demographics, surgical volumes, and settings of MMFTSs and NMMFTSs. Recent increases in the ACMS fellowship positions have resulted in a greater proportion of MMFTSs among younger dermatologic surgeons. It will be important to follow how this increase in fellowship trainees affects the dermatologic surgery workforce. [source] Private Pension Arrangements and Retirement in Britain,FISCAL STUDIES, Issue 1 2005James Banks Abstract This paper looks at the policy debate surrounding private pensions and retirement patterns in the UK. Recent increases in longevity have led not only to increased pressures in public pensions but also to corresponding increases in the importance of private pensions in the UK and changes in the way in which they are structured. We consider the economic implications of these changes, and in particular the increased importance of defined contribution plans. In addition, we discuss the prospects for future trends in retirement ages. [source] Business Management Reform in the Department of Defense in Anticipation of Declining BudgetsPUBLIC BUDGETING AND FINANCE, Issue 3 2007DOUGLAS A. BROOK Business management reform efforts have been part of the U.S. Defense Department agenda for decades. Current reform efforts have explicitly established the goal of generating, harvesting, and reinvesting savings from business management reform to buy more capital items; that is, they have focused on a measurable reallocation from operating and support costs to investment within a given budget top line. Recent increases in the defense top line, largely related to the war on terrorism, are not likely to persist; in addition, an examination of the factors affecting the top line suggests that a decline in the near term is likely. An examination of current and past defense management reforms suggests that efficiency-seeking business management reforms are not likely to generate sufficient resources to cover a budget decline. Instead, management reform should be sustained for reasons of stewardship and accountability. [source] FROM CRISIS TO CUMULATIVE EFFECTS: FOOD SECURITY CHALLENGES IN ALASKAANNALS OF ANTHROPOLOGICAL PRACTICE, Issue 1 2009David V. Fazzino Recent increases in the price of fuel in rural Alaska, coupled with high prices of grocery store foods and decreased efficacy of hunting and fishing have led to a food crisis in many regions of rural Alaska. In the summer of 2008 it was predicted that these events would lead to an upswing in the number of individuals migrating to urban areas of Alaska, putting additional stress on the already dwindling resources of food assistance providers. Through discussions with food assistance providers in Fairbanks, Alaska, a research program was designed to assess how well recent migrants were able to meet their food needs. In total 39 individuals were interviewed in November and December 2008, using face-to-face, semistructured interviews. This article discusses a smaller subset of the overall interviews, namely the responses of Natives who currently live in Fairbanks, Alaska. Further, this article informs understandings of "crisis" in the global sense, highlighting the importance of placing "crises" into the larger context of cumulative effects which are long-term and differentially distributed, rather than treating them as discrete and individually mitigatable events. [source] Congenital Left Ventricular Splint in an Adult Patient with Unrepaired Anomalous Left Coronary Artery from the Pulmonary ArteryCONGENITAL HEART DISEASE, Issue 4 2007Adam M. Sabbath MD ABSTRACT A 24-year-old woman presented with a recent increase in dyspnea on exertion and development of presyncope. The patient stated that she has reproducible episodes of dizziness and near fainting when she climbs a flight of stairs and activity is limited to a slow gait. [source] Uganda: No More Pro-poor Growth?DEVELOPMENT POLICY REVIEW, Issue 1 2005Robert Kappel This article explores changing growth regimes in Uganda, from pro-poor growth in the 1990s to growth without poverty reduction, actually even with a slight increase in poverty, after 2000. Not surprisingly, it finds that good agricultural performance is the key determinant of direct pro-poor growth in the 1990s, while lower agricultural growth is the root cause of the recent increase in poverty. At the same time, after 2000 low agricultural growth appears to have induced important employment shifts out of agriculture, which have dampened the increase in poverty. The article also assesses the indirect form of pro-poor growth by analysing the incidence of public spending and the tax system, and finds that indirect pro-poor growth has been achieved to only a limited extent. [source] Long-term succession in a Danish temperate deciduous forestECOGRAPHY, Issue 2 2005Richard H. W. Bradshaw Forest successional trajectories covering the last 2000 yr from a mixed deciduous forest in Denmark show a gradual shift in dominance from Tilia cordata to Fagus sylvatica and a recent increase in total forest basal area since direct management ceased in 1948. The successions are reconstructed by combining a fifty-year record of direct tree observations with local pollen diagrams from Draved Forest, Denmark. Five of the seven successions record a heathland phase of Viking Age dating from 830 AD. The anthropogenic influence is considerable throughout the period of study even though Draved contains some of the most pristine forest stands in Denmark. Anthropogenic influence including felling masks the underlying natural dynamics, with the least disturbed sites showing the smallest compositional change. Some effects of former management, such as loss of Tilia cordata dominance, are irreversible. Artificial disturbance, particularly drainage, has accelerated and amplified the shift towards Fagus dominance that would have occurred on a smaller scale and at a slower rate in the absence of human intervention. [source] Gender differences in genetic damage induced by the tobacco-specific nitrosamine NNK and the influence of the Thr241Met polymorphism in the XRCC3 geneENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 1 2005Courtney E. Hill Abstract The rapid increase in adenocarcinoma of the lung and mortality amongst women strongly suggests that gender differences exist in sensitivity to certain tobacco carcinogens. In the current study, we performed the mutagen-sensitivity assay, with the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), to test the hypothesis that women are more sensitive to the genotoxic effects of NNK than men. Chromosome aberration (CA) frequencies in peripheral blood lymphocytes (PBLs) from 99 patients were evaluated before and after in vitro exposure to NNK. Because the Thr241Met polymorphism in the DNA-repair gene XRCC3 is associated with increased risk of tobacco-related cancers, especially among women, we also tested the hypothesis that individuals who inherit the homozygous variant 241Met allele are more sensitive to the genotoxic effects of NNK. CA frequency was significantly higher 1 hr after NNK treatment in women, compared with men (P = 0.02). When smoking and gender were considered together, a significant interaction was observed. PBLs from female smokers had significantly higher frequencies of NNK-induced CA, compared with female nonsmokers 1 hr after treatment (P = 0.02). We observed no overall effect of the Thr241Met polymorphism on NNK-induced CA in men, women, smokers, or nonsmokers. Overall, our data indicate that women are more sensitive to the genotoxic effects of NNK than men. Because in past years smoking among women has increased, and in view of the close correlation between NNK exposure and adenocarcinoma of the lung, our data provide a plausible explanation for the recent increase in the incidence of this cancer among women. Environ. Mol. Mutagen., 2005. © 2005 Wiley-Liss, Inc. [source] Lake depth rather than fish planktivory determines cladoceran community structure in Faroese lakes , evidence from contemporary data and sedimentsFRESHWATER BIOLOGY, Issue 11 2006SUSANNE LILDAL AMSINCK Summary 1. This study describes the environmental conditions and cladoceran community structure of 29 Faroese lakes with special focus on elucidating the impact of fish planktivory. In addition, long-term changes in biological structure of the Faroese Lake Heygsvatn are investigated. 2. Present-day species richness and community structure of cladocerans were identified from pelagial snapshot samples and from samples of surface sediment (0,1 cm). Multivariate statistical methods were applied to explore cladoceran species distribution relative to measured environmental variables. For Lake Heygsvatn, lake development was inferred by cladoceran-based paleolimnological investigations of a 14C-dated sediment core covering the last ca 5700 years. 3. The 29 study lakes were overall shallow, small-sized, oligotrophic and dominated by brown trout (Salmo trutta). Cladoceran species richness was overall higher in the surface sediment samples than in the snapshot samples. 4. Fish abundance was found to be of only minor importance in shaping cladoceran community and body size structure, presumably because of predominance of the less efficient zooplanktivore brown trout. 5. Canonical correspondence analysis showed maximum lake depth (Zmax) to be the only significant variable in explaining the sedimentary cladoceran species (18 cladoceran taxa, two pelagic, 16 benthic) distribution. Multivariate regression trees revealed benthic taxa to dominate in lakes with Zmax < 4.8 m and pelagic taxa to dominate when Zmax was > 4.8 m. 6. Predictive models to infer Zmax were developed using variance weighted-averaging procedures. These were subsequently applied to subfossil cladoceran assemblages identified from a 14C-dated sediment core from Lake Heygsvatn and showed inferred Zmax to correspond well to the present-day lake depth. A recent increase in inferred Zmax may, however, be an artefact induced by, for instance, eutrophication. [source] Less frequent body weight gain in elderly type 2 diabetic patients treated with glimepirideGERIATRICS & GERONTOLOGY INTERNATIONAL, Issue 1 2003Kaori Inoue Background: The purpose of the present paper was to study the effect of a new sulfonylurea, glimepiride, which has an extra-pancreatic action that improves insulin resistance, on glycemic control and body weight gain in elderly patients with type 2 diabetes mellitus (DM). Methods: Thirty-seven type 2 diabetic patients being treated with either gliclazide or glibenclamide were switched to glimepiride for 6 months and clinical parameters were compared between elderly (, 65 years old, n = 9) and non-elderly (< 65 years old, n = 28) patients. Results: There was no significant difference between the two groups in baseline characteristics, or in changes in fasting plasma glucose (FPG) and HbA1c. For body weight change, however, none of the elderly patients (0/9) exhibited an increase, but 9 of 28 (32%) non-elderly subjects showed body weight gain (P < 0.05). Conclusions: Body weight gain with glimepiride treatment is less frequent in elderly patients with type 2 DM than in non-elderly patients with the disease. These data together with the recent increase in obese elderly patients with diabetes suggest that glimepiride is recommended for treatment of type 2 diabetes in this age group. [source] Upward range extension of Andean anurans and chytridiomycosis to extreme elevations in response to tropical deglaciationGLOBAL CHANGE BIOLOGY, Issue 1 2007TRACIE A. SEIMON Abstract High-alpine life forms and ecosystems exist at the limits of habitable environments, and thus, are especially sensitive to environmental change. Here we report a recent increase in the elevational limit of anurans following glacial retreat in the tropical Peruvian Andes. Three species have colonized ponds in recently deglaciated terrain at new record elevations for amphibians worldwide (5244,5400 m). Two of these species were also found to be infected with Batrachochytrium dendrobatidis (Bd), an emerging fungal pathogen causally associated with global amphibian declines, including the disappearance of several Latin American species. The presence of this pathogen was associated with elevated mortality rates of at least one species. These results represent the first evidence of upward expansion of anurans to newly available habitat brought about by recent deglaciation. Furthermore, the large increase in the upper limit of known Bd infections, previously reported as 4112 m in Ecuador, to 5348 m in this study, also expands the spatial domain of potential Bd pathogenicity to encompass virtually all high elevation anuran habitats in the tropical Andes. [source] Uncertainties in central England temperature 1878,2003 and some improvements to the maximum and minimum seriesINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 9 2005David Parker Abstract We assess the random and systematic uncertainties affecting the central England temperature (CET) record since 1878 on daily, monthly and annual time scales. The largest contribution to uncertainty in CET on all these time scales arises from areal sampling, followed for annual and monthly CET by thermometer calibration. For the daily series, random thermometer precision and screen errors are the second largest source of uncertainty. Annual CETs are least uncertain, whereas daily CETs are most uncertain. Despite the uncertainties in annual mean CET, the trend of 0.077 °C per decade since 1900 is significant at the 1% level. In an additional investigation, we detect biases in the published series of central England maximum and minimum temperatures, and implement systematic adjustments of up to ±0.2 °C to the values up to 1921 and up to ±0.1 °C to the values since 1980. These adjustments are of opposite sign in maximum and minimum temperature, so they do not affect mean CET, but they improve the homogeneity of the diurnal temperature range, which then shows little trend before 1980 and a reduced rising trend thereafter. The uncertainties in maximum and minimum temperature make the data inadequate for the task of establishing the magnitude of the recent increase of diurnal range. © Crown Copyright 2005. Reproduced with the permission of Her Majesty's Stationery Office. Published by John Wiley & Sons, Ltd. [source] Reducing the density of breeding gulls influences the pattern of recruitment of immature Atlantic puffins Fratercula arctica to a breeding colonyJOURNAL OF APPLIED ECOLOGY, Issue 3 2003S. K. Finney Summary 1By acting as both competitors and predators, gulls (Larus spp.) are generally considered to reduce significantly the attractiveness of potential breeding sites for other birds. This perceived threat posed by gulls to other breeding birds has led to the implementation of gull control procedures at many seabird colonies. However, the extent to which reducing gull numbers benefits other species has received little rigorous scientific investigation. 2During a gull control programme (1972,89), gull nest density on the Isle of May, south-east Scotland, was reduced by between 30% and 100% in different sections of the island. Following termination of the original programme in 1989, several sections were maintained as gull-free by repeated removal of nests. 3We used data collected over a 23-year period to determine the extent to which the spatial variation in puffin Fratercula arctica recruitment was influenced by changes in the density and spatial distribution of breeding gulls resulting from the control programme. 4The presence of breeding gulls significantly affected the pattern of recruitment of puffins to the colony. Puffin recruitment rate was highest in the sections of the island where gull nest density was low. Gull density explained 21% of the variation in puffin recruitment rate. 5These results suggest that the reduction in the number of breeding gulls substantially increased the attractiveness of areas of the colony as breeding sites for puffins, and is thus likely to have played an important role in the pattern of expansion of the puffin population on the island. 6Synthesis and applications. Following a recent increase in the conservation status of both herring L. argentatus and lesser black-backed gulls L. fuscus, there has been a move to make management decisions more objective. This has highlighted the need for studies such as this, aimed at assessing the impact of gulls and their removal on other breeding birds, to ensure that any future control programmes are both necessary and effective. [source] Why do we need children's participation?JOURNAL OF COMMUNITY & APPLIED SOCIAL PSYCHOLOGY, Issue 6 2001The importance of children's participation in changing the city Abstract After examining the characteristics of the degradation of the urban environment and the costs that this entails for the child's development, in particular as far as play experience and autonomous mobility are concerned, the article goes on to discuss the role of the children's contribution to the promotion of real and consistent change in the city. The reasons underlying the recent increase in the number of experiments of children's participation are examined together with the main characteristics of this strategy as a privileged access to knowledge concerning the needs of our younger citizens and as an innovative resource in solving the city's problems. It is shown how children's participation experiences can lead to the acquisition of a fresh sensitivity and competence by city administrators and technicians. An analysis is made of several proposals made by children in the course of participation experiments followed by the authors in cities in Italy and abroad during 10 year's of activities in the ,The Children's City' project. These proposals confirm the children's capacity to identify the city's problems as they emerge and to propose solutions that are often innovative or useful for all members of the population. Copyright © 2001 John Wiley & Sons, Ltd. [source] Environment and pollinator-mediated selection on parapatric floral races of Mimulus aurantiacusJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 1 2007M. A. STREISFELD Abstract We tested whether selection by pollinators could explain the parapatric distribution of coastal red- and inland yellow-flowered races of Mimulus aurantiacus (Phrymaceae) by examining visitation to natural and experimental populations. As a first step in evaluating whether indirect selection might explain floral divergence, we also tested for local adaptation in early life stages using a reciprocal transplant experiment. Hummingbirds visited flowers of each race at similar rates in natural populations but showed strong (>95%) preference for red flowers in all habitats in experimental arrays. Hawkmoths demonstrated nearly exclusive (>99% of visits) preference for yellow flowers and only visited in inland regions. Strong preferences for alternative floral forms support a direct role for pollinators in floral divergence. Despite these preferences, measures of plant performance across environments showed that red-flowered plants consistently survived better, grew larger and received more overall pollinator visits than yellow-flowered plants. Unmeasured components of fitness may favour the yellow race in inland habitats. Alternatively, we document a marked recent increase in inland hummingbird density that may have caused a change in the selective environment, favouring the eastward advance of red-flowered plants. [source] Mid- to late Holocene relative sea-level change in Poole Harbour, southern EnglandJOURNAL OF QUATERNARY SCIENCE, Issue 3 2001Robin J. Edwards Abstract A foraminiferal transfer function for mean tide level (MTL) is used in combination with AMS radiocarbon dated material to construct a record of relative sea-level (RSL) change from Poole Harbour, southern Britain. These new data, based on multiple cores from duplicate sites, indicate four phases of change during the last 5000 cal. (calendar) yr: (i) rising RSL between ca. 4700 cal. yr BP and ca. 2400 cal. yr BP; (ii) stable to falling RSL from ca. 2400 cal. yr BP until ca. 1200 cal. yr BP; (iii) a brief rise in RSL from ca. 1200 cal. yr BP to ca. 900 cal. yr BP, followed by a period of stability; (iv) a recent increase in the rate of RSL rise from ca. 400,200 cal. yr BP until the present day. In addition, they suggest that the region has experienced long-term crustal subsidence at a rate of 0.5 mm C14 yr,1. Although this can account for the overall rise in MTL observed during the past 2500 yr, it fails to explain the changes in the rate of rise during this period. This implies that the phases of RSL change recorded in the marshes of Poole Harbour reflect tidal range variations or ,eustatic' fluctuations in sea-level. Copyright © 2001 John Wiley & Sons, Ltd. [source] A review of the background, operating parameters and applications of microemulsion liquid chromatography (MELC)JOURNAL OF SEPARATION SCIENCE, JSS, Issue 15 2005A. Marsh Abstract Microemulsions are dispersions of nanometre-sized droplets of an immiscible liquid within another liquid. Droplet formation is facilitated by the addition of surfactants and often also cosurfactants. Microemulsions are classified as either oil-in-water (O/W) (oil droplets such as octane dispersed throughout aqueous buffer) or water-in-oil (W/O) (aqueous droplets in oil such as hexane). Both microemulsion types have been used as mobile phases for separation in microemulsion HPLC (MELC). There has been a recent increase of interest in this area with new applications and developments such as gradient elution and optimisation of methods using experimental design. O/W microemulsions have been employed as eluents for RP-HPLC while W/O microemulsions have been used for normal phase chromatography. Separations can have superior speed and efficiency to conventional HPLC modes while offering a unique selectivity with excellent resolution. The capability for quantitative and stability-indicating analysis has also been demonstrated. Specific advantages include the ability to operate at low UV wavelengths and elimination of the need for an equilibration rinse between gradients. Operational issues associated with the use of MELC have been identified including the need to add salt to the gradient eluent, relatively high back-pressures and increased need for equipment cleaning compared to conventional RP eluent. This report details the different microemulsion types and compositions used and their reported applications. The use of gradient and isocratic elution is described. The effects on separations of varying operating parameters such as temperature, oil type and concentration, surfactant type and concentration, sample solvent, column type, and organic solvent addition will be discussed and illustrated. [source] The invasive red swamp crayfish as a predictor of Eurasian bittern density in the Camargue, FranceJOURNAL OF ZOOLOGY, Issue 1 2007B. Poulin Abstract Few data exist on the relationships between food levels and breeding density of the Eurasian bittern Botaurus stellaris, a vulnerable species of high-priority concern in Europe. Concurrent data were obtained on male bittern density and relative food abundance over a 3-year period in two wetlands totalling 2500 ha of Mediterranean reed marsh enclosing 25% of the French bittern population. Food abundance was estimated by sampling up to 25 hydrological units using a beach seine in early June of 2002, 2003 and 2004. The density of booming males in each hydrological unit was obtained by point counts and acoustic triangulation in May of the same years. The impact of food abundance on male bittern density was assessed by general regression models using a forward stepwise procedure with mosquitofish Gambusia affinis, carp Cyprinus carpio, other fish species, amphibians, red swamp crayfish Procambarus clarkii and other invertebrates as prey groups. Of these, only to crayfish abundance was bittern density related, contributing to 45% of the variance observed. When the impact of water level was taken into account, the relative abundance of crayfish explained 56% of the inter-annual differences in bittern density. Because crayfish are rich in calcium and well adapted to fluctuating hydroperiods alternating with drought intervals, they provide a good food source for the bitterns throughout the breeding season at the study sites. The loss of diversity and degradation reported from macrophyte-dominated marshes following crayfish invasion does not seem to apply to reed-dominated wetlands. It is further suggested that the recent increase in bittern numbers in the Camargue, while other French populations were decreasing, could in part be related to red swamp crayfish abundance. [source] Hypersensitivity reactions to the polysorbate contained in recombinant erythropoietin and darbepoietin (Case Report)NEPHROLOGY, Issue 3 2005RICHARD H STEELE SUMMARY: The following case reports are of two patients who have developed hypersensitivity reactions to the red cell growth hormones, darbepoietin and erythropoietin. The subsequent skin testing and clinical course suggested that the cause of these reactions was due to the excipient polysorbate 80. This finding might have implications in the recent increase in the incidence of pure red cell aplasia. [source] Checkpoints and pitfalls in the experimental neuropathology of circulatory disturbanceNEUROPATHOLOGY, Issue 1 2003Toshihiko Kuroiwa In neural tissue injury many pathological processes are common to different neurological disorders, including cerebral ischemia. Because ischemia has a fundamentally simple impact on neural tissue, good laboratory modeling can help improve the general understanding of the neuropathological processes involved. Summarized here are some basic principles that should be followed to ensure that cerebral ischemia studies are reproducible and informative: (i) selection of an appropriate model of cerebral ischemia in an appropriate species (although rodents are widely used for genomic studies, the use of larger animals, with brain structures macroscopically similar to those of humans, is appropriate for many studies, e.g. of white matter lesions or the pathophysiology of cerebral edema); (ii) correct maintenance of physiological parameters, including body temperature, systemic blood pressure, and blood gas tensions, under appropriate general anesthesia; (iii) selection of an appropriate method of cerebral blood flow (CBF) monitoring (decisions include whether or not the experiment requires real-time monitoring, in vivo measurement, and CBF mapping); (iv) appropriate timing of drug application in therapeutic studies (many drugs that are effective when given immediately after a short period of ischemi are ineffective in clinical trials, probably because of longer periods of ischemia and delayed drug delivery in clinical settings); and (v) multiparametric evaluation of therapeutic effect (with the recent increase in diagnosis of cases of mild stroke, measurement of mortality and infarct size have proven to be insufficient for the evaluation of therapeutic effect). Use of mild ischemia models and batteries of neurological tests for individual neurological functions, such as motor, somatosensory, and visual function, are becoming important in experimental ischemia research. In histological evaluation, assessment of the extent of both selective neuronal loss and the infarct will become mandatory. Regional analysis of each brain structure and coordination of the results with the apparent neurological dysfunction is a promising approach. [source] Distribution of lymphoid neoplasms in the Republic of Korea: Analysis of 5318 cases according to the World Health Organization classification,AMERICAN JOURNAL OF HEMATOLOGY, Issue 10 2010Sun Och Yoon Compared with the West, the overall incidence of lymphoid neoplasms is lower, and the subtype distribution is distinct in Asia. To comprehensively investigate the subtype distribution with the age and sex factors, and temporal changes of subtype proportions, we re-assessed all patients with lymphoid neoplasms diagnosed at a large oncology service in the Republic of Korea from 1989 to 2008 using the World Health Organization classifications. Of the total 5,318 patients, 66.9% had mature B-cell neoplasms, 12.5% had mature T/natural killer (NK)-cell neoplasms, 16.4% had precursor lymphoblastic leukemia/lymphoma (ALL/LBL), and 4.1% had Hodgkin's lymphoma. The most common subtypes were diffuse large B-cell lymphoma (30.5%), plasma cell myeloma (14.0%), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma; 12.4%), B-cell ALL/LBL (11.3%), Hodgkin's lymphoma (4.1%), peripheral T-cell lymphoma unspecified (4.0%), T-cell ALL/LBL (3.9%), and extranodal NK/T-cell lymphoma of nasal type (3.9%). Most subtypes showed male predominance, with an average M/F ratio of 1.3. Most mature lymphoid neoplasms were diseases of adults (mean age, 53.5 yr), whereas ALL/LBLs were of young individuals (mean age, 20.3 yr). When the relative proportion of subtypes were compared between two decades (1989,1998 vs. 1999,2008), especially MALT lymphoma has increased in proportion, whereas T/NK-cell neoplasms and ALL/LBL have slightly decreased. In summary, the lymphoid neoplasms of Koreans shared some epidemiologic features similar to those of other countries, whereas some subtypes showed distinct features. Although the increase in incidence of lymphoid neoplasms is relatively modest in Korea, recent increase of MALT lymphoma and decrease of T/NK-cell neoplasms and ALL/LBL are interesting findings. Am. J. Hematol., 2010. © 2010 Wiley-Liss, Inc. [source] Methadone Reincarnated: Novel Clinical Applications with Related ConcernsPAIN MEDICINE, Issue 4 2002Scott M. Fishman MD Methadone has numerous advantages as an analgesic, which have supported its recent increase in use. However, methadone also has a pharmacological profile as an opioid that differentiates it from other, better known or more widely used opioids. It also has unusual pharmacodynamics, pharmacokinetics, and metabolism that must be considered for safe use of methadone as an analgesic. This review looks at the history of methadone use as an analgesic and its properties that distinguish it as an unusual, and potentially, unstable opioid. [source] The Sex Ratio Transition in AsiaPOPULATION AND DEVELOPMENT REVIEW, Issue 3 2009Christophe Z. Guilmoto This article adopts a comparative perspective to review the recent increase in the sex ratio at birth (SRB) across Asia. It first describes and compares the most recent birth statistics in Asia in order to identify commonalities in the gradual rise of SRBs observed from Armenia to South Korea. This comparison provides the basis for identifying specific transition patterns in the changes in SRBs. Their recent rise is then interpreted in a social and historical framework borrowed from fertility decline and based on three preconditions: access to sex-selection technology, preference for male births, and pressure from low fertility. On a broader plane, the process of growing imbalances in the sex composition of the population gives rise to a tragedy of the commons. This article indicates the factors that appear most likely to trigger a turnaround in this transitional demographic situation and to facilitate a return to biologically normal sex ratios in the future. [source] Characterizing the Emerging Population of Prescription Opioid AbusersTHE AMERICAN JOURNAL ON ADDICTIONS, Issue 3 2006Stacey C. Sigmon PhD Despite an alarming recent increase in prescription opioid abuse, the characteristics of prescription opioid abusers remain largely unknown. In this study, the demographic and drug use characteristics of 75 methadone patients (36 prescription opioid and 39 heroin users) were compared using a retrospective chart review. Prescription opioid abusers exhibited a profile of characteristics that may predict favorable treatment response, including less severe opioid use and IV drug use, and greater social stability compared to primary heroin abusers. Despite the limitations inherent in this retrospective chart review, this study provides initial evidence that prescription opioid abusers may have a number of characteristics that predict favorable treatment response. This new information may inform and assist current efforts to develop efficacious treatments for prescription opioid abuse. [source] The Role of Champions in the External Commercialization of Knowledge,THE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 4 2009Ulrich Lichtenthaler Besides applying knowledge in their own products or services, firms may externally commercialize their knowledge assets (e.g., by means of outlicensing). The literature on champions, however, has focused on internal innovation. This gap in prior research is particularly remarkable as the potential for promoting external knowledge exploitation is high. Some pioneering firms realize great benefits, whereas most others experience major managerial difficulties. This paper tests five hypotheses regarding the emergence and impact of champions of external knowledge exploitation with data from 152 firms across industries. The results of the questionnaire-based study demonstrate the relevance of champions of external knowledge exploitation. Championing constitutes an essential success factor and has strongly contributed to the recent increase in external knowledge commercialization. These findings help to explain the discrepancies between the few successful and the majority of unsuccessful firms. Beyond existing insights, the emergence of champions is affected by external determinants in addition to internal determinants. There is an inverted U-shaped relationship between championing and the internal determinants, that is, organizational climate and active strategy. Moreover, there is a negative relationship between championing and market imperfection and an inverted U-shaped relationship between championing and competitive intensity, which both constitute external determinants of championing. In contrast to the traditional understanding, champions tend to emerge in supportive environments, in which internal and external barriers are relatively low. This surprising finding calls for rethinking the role and motivation of champions. [source] Eighteen years of saturation tagging data reveal a significant increase in nesting hawksbill sea turtles (Eretmochelys imbricata) on Long Island, AntiguaANIMAL CONSERVATION, Issue 3 2006J. I. Richardson Abstract Hawksbill sea turtle Eretmochelys imbricata nesting on Long Island, Antigua, West Indies (also known as Jumby Bay) has been monitored since 1987. Although the numbers of nesting females remained relatively constant for the first 11 survey seasons (1987,1997), inclusion of more recent data (1998,2004) in the analysis reveals a statistically significant upward trend. In particular, neophytes have shown a significant upturn in numbers, whereas the remigrant subpopulation has remained stationary. This indicates that recruitment is driving the upward trend in the total number of nesters. Predictive models based on the Poisson distribution suggest that the neophyte subpopulation will continue to grow in size by an average of 10% per annum. Model-based predictions and their limitations are discussed. The Jumby Bay Hawksbill Project, which has monitored and protected nesting hawksbills and their eggs since the project's onset, is one among several factors that may contribute to the recent increase in nesting females. [source] Is the incidence of rheumatoid arthritis rising?: Results from Olmsted County, Minnesota, 1955,2007ARTHRITIS & RHEUMATISM, Issue 6 2010Elena Myasoedova Objective To examine trends in the incidence and prevalence of rheumatoid arthritis (RA) from 1995 to 2007. Methods To augment our preexisting inception cohort of patients with RA (1955,1994), we assembled a population-based incidence cohort of individuals ,18 years of age who first fulfilled the American College of Rheumatology 1987 criteria for the classification of RA between January 1, 1995 and December 31, 2007 and a cohort of patients with prevalent RA on January 1, 2005. Incidence and prevalence rates were estimated and were age-and sex-adjusted to the white population in the US in 2000. Trends in incidence rates were examined using Poisson regression methods. Results The 1995,2007 incidence cohort comprised 466 patients (mean age 55.6 years), 69% of whom were female and 66% of whom were rheumatoid factor positive. The overall age- and sex-adjusted annual RA incidence was 40.9/100,000 population. The age-adjusted incidence in women was 53.1/100,000 population (versus 27.7/100,000 population in men). During the period of time from 1995 to 2007, the incidence of RA increased moderately in women (P = 0.02) but not in men (P = 0.74). The increase was similar among all age groups. The overall age- and sex-adjusted prevalence on January 1, 2005 was 0.72% (95% confidence interval [95% CI] 0.66, 0.77), which is an increase when compared with a prevalence of 0.62% (95% CI 0.55, 0.69) in 1995 (P < 0.001). Applying the prevalence on January 1, 2005 to the US population in 2005 showed that an estimated 1.5 million US adults were affected by RA. This is an increase from the previously reported 1.3 million adults with RA in the US. Conclusion The incidence of RA in women appears to have increased during the period of time from 1995 to 2007. The reasons for this recent increase are unknown, but environmental factors may play a role. A corresponding increase in the prevalence of RA was also observed. [source] A Standard Protocol for Liana Censuses,BIOTROPICA, Issue 2 2006Jeffrey J. Gerwing ABSTRACT A recent increase in published studies of lianas has been paralleled by a proliferation of protocols for censusing lianas. This article seeks to increase uniformity in liana inventories by providing specific recommendations for the determination of which taxa to include, the location of diameter measurement points on individual stems, the setting of minimum stem diameter cutoffs, the treatment of multiple-stemmed and rooted clonal groups, and the measurement of noncylindrical stems. Use of more uniform liana censusing protocols may facilitate comparison of independently collected data sets and further our understanding of global patterns in liana abundance, diversity, biomass, and dynamics. RESUMEN El reciente incremento de publicaciones sobre bejucos ha estado acompañado por una proliferación de protocolos para censarlos. Este artículo busca incrementar la uniformidad de los inventarios de lianas dando recomendaciones específicas sobre los taxa que deben incluirse, la ubicación de los puntos de medición del diámetro en tallos individuales, el establecimiento de diámetros mínimos de medición, la forma de tratar a grupos de tallos múltiples y clones arraigados, y la medición de tallos no cilíndricos. El uso de protocolos de medición más uniformes facilitará la comparación de bases de datos colectadas de forma independiente y incrementará nuestro entendimiento de patrones globales de abundancia, diversidad, biomasa y dinámica de lianas. [source] Nutrition and allergic diseaseCLINICAL & EXPERIMENTAL ALLERGY REVIEWS, Issue 5 2006S. Tricon Summary The prevalence of asthma and allergic diseases has increased dramatically over the past few decades with the highest incidence occurring in children. Most asthma and related atopic disorders have their origins in early life. Thus, it is imperative to understand the early life origins of the disease in order to identify targets for prevention and early intervention. Although atopic diseases have genetic determinants, the increased incidence of these diseases has occurred far too rapidly for genetic changes to explain the increase. This, most likely, results from changes in environmental influences acting on a pre-existent genetic susceptibility. One of the environmental changes over the last 20,40 years that could have contributed to the recent increase in atopic diseases is diet. Food allergy is often one of the earliest manifestations of atopy, and sensitization to food is a risk factor for the subsequent appearance of respiratory allergy and asthma. However, studies investigating the effects of dietary restrictions on the prevention of allergy have been disappointing. On the other hand, current data suggests that exclusive breastfeeding should be encouraged for at least 4,6 months in infants at both high and low risk of atopy. Increased risk of asthma has also been observed in low birth weight infants, suggesting that under-nutrition can detrimentally alter foetal development. Epidemiological and immunological studies also suggest that dietary modification or supplementation in the foetal and early life could reduce the development of atopic diseases. The current dietary hypotheses relate to antioxidants, lipids, electrolytes and probiotics. The aims of this report are: (i) to assess the best methods to analyse nutrient intake and nutrient status; (ii) to review the existing epidemiological evidence for an association between dietary intake (nutrients and food) and allergic diseases; and (iii) to define the windows of opportunity for nutritional supplementation to be used as a preventative strategy for asthma and allergy. [source] | |||||||||||||||||||||||||