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Recent Considerations (recent + consideration)

Distribution by Scientific Domains

Humanities and Social Sciences	50%

Selected Abstracts

Current guidelines applicable for the approval of topically applied dermatological drugs in the EU

FUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 5 2004
Myrjam Dorothea Straube
Abstract Dermatologicals as well as other medicinal products are submitted to the rules governing medicinal products in the European Union (EU) (Directive 2001/83/EC). With appreciation of the EU enlargement those regulatories deserve a recent consideration with special regard to the peculiarities of external dermatological therapy, recently passed novel and future guidelines. As regards the criteria for authorization of a medicinal product it is set out in Regulation (EEC) 2309/93 Article 11(1) that a marketing authorization shall be refused if it appears that the quality, the safety or efficacy of the medicinal product have not been adequately or sufficiently demonstrated by the applicant. Article 26(1) of Council Directive 2001/83/EC is worded a little differently but the criteria are the same irrespective of the procedure for the marketing authorization. For the final evaluation of the benefit/risk profile of a topically applied dermatological medicinal product not only the active agent but the whole galenic formulation as well has to be taken into account as the extent of penetration of the active compound might be influenced by changing the non-active substances. Furthermore the vehicle itself , independent of the active agent , influence the dermatological disorder, often in dependence on the stage of the dermatopathy. With special concern to safety/tolerability the (photo)toxic and (photo)allergic potential of the dermatological drug have to be taken into consideration too. In case of total body therapy in children the differing percutaneous resorption due to another body surface/body weight relation deserves special concern. The following review gives a survey of the current most important EU-guidelines for the evaluation of the benefit/risk profile of topically applied dermatological medicinal drugs and an outlook on further developments. As systemically applied dermatological medicinal products are assessed like other systemically applied drugs they are not treated in the following contribution. [source]

Annual Banned-Substance Review

DRUG TESTING AND ANALYSIS, Issue 4 2010
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The annual update of the list of prohibited substances and doping methods as issued by the World Anti-Doping Agency (WADA) allows the implementation of most recent considerations of performance manipulation and emerging therapeutics into human sports doping control programmes. The annual banned-substance review for human doping controls critically summarizes recent innovations in analytical approaches that support the efforts of convicting cheating athletes by improved or newly established methods that focus on known as well as newly outlawed substances and doping methods. In the current review, literature published between October 2008 and September 2009 reporting on new and/or enhanced procedures and techniques for doping analysis, as well as aspects relevant to the doping control arena, was considered to complement the 2009 annual banned-substance review. Copyright © 2010 John Wiley & Sons, Ltd. [source]

Place, Landscape, and Environment: Anthropological Archaeology in 2009

AMERICAN ANTHROPOLOGIST, Issue 2 2010
Christopher Rodning
ABSTRACT, Topics of current interest to anthropological archaeologists include the relationships between people and place, interactions between people and past environments, and responses by past societies to changes in the natural environment. In this article, I focus on recent considerations of past landscapes and the built environment. This research concentrates on such topics as architecture, the utilization of different environmental zones, and transitions from foraging to farming, one of the long-standing topics of interest to anthropological archaeology. Recent archaeological research also emphasizes climate change and warfare, topics that have relevance to current events and conditions in the modern world. [source]

Contexts of interpretation: assessing immigrant reception in Richmond, Canada

THE CANADIAN GEOGRAPHER/LE GEOGRAPHE CANADIEN, Issue 4 2001
JOHN ROSE
This article examines the responses of established residents to contemporary physical and social changes in Richmond, British Columbia, a Vancouver suburb that has received a considerable number of ethnic-Chinese immigrants over the past decade. In the metropolitan Vancouver context, recent considerations of immigrant reception at the neighbourhood level have focused on the critical reactions of ,white', European-origin residents in upper-middle class areas to local immigrant settlement and housing stock transformations. These studies have given rise to conflicting interpretations of the relationship between immigration and neighbourhood landscape change, the motivations behind resident protest and, in particular, the definition of their responses as racist. Drawing from extended interviews with fifty-four long-term Richmond residents, I attempt to provide a broader account of immigrant reception as a supplement to works that have revolved around housing issues and ,white' resistance. I also critique the way that the term racism has been used to describe resident reactions to immigration-related changes, calling for researchers to be more reflexive and explicit in their application of the concept. [source]