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Rectal Tumors (rectal + tumor)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

Laparoscopic sphincter-preserving surgery for low rectal tumor using prolapsing technique

ASIAN JOURNAL OF ENDOSCOPIC SURGERY, Issue 1 2010
M.H. Zheng
Abstract Introduction: With this study, we aimed to assess the feasibility and outcome of laparoscopy-assisted low anterior resection with a prolapsing technique for low rectal tumors. Materials and Methods: We studied surgical techniques, recovery status, complications, oncological clearance and the results of short-term follow-up in 15 patients who had received laparoscopy-assisted low anterior resection with a prolapsing technique for low rectal tumors between October 2005 and January 2008. Results: None of the cases was converted to open surgery. The mean operation time was 185 min (150,232 min), and the mean blood loss was 75 ml (25,105 ml). The mean time for passage of flatus, duration of urinary drainage, and postoperative hospital stay were 3 d (1,4 d), 6 d (5,10 d) and 11 d (7,20 d), respectively. The total amount of lymph nodes harvested was 15 (9,21), and the mean distal margin from the tumor was 2.5 cm (1.0,3.9 cm). No major complications were observed. The mean follow-up time was 13 months (4,27 months). Neither local recurrence nor metastasis was observed. Acceptable anal function results were obtained in most patients. Discussion: Laparoscopy-assisted low anterior resection with a prolapsing technique can be successfully performed. [source]

The predictive value of apoptosis protease-activating factor 1 in rectal tumors treated with preoperative, high-dose-rate brachytherapy

CANCER, Issue 2 2006
Inti Zlobec M.Sc.
Abstract BACKGROUND The objective of this study was to assess the value of apoptosis protease-activating factor 1 (APAF-1) as a predictive marker of response in rectal tumors treated with preoperative, high-dose-rate endorectal brachytherapy. METHODS Immunohistochemistry for APAF-1 was performed on 94 rectal tumor biopsy specimens from patients who were treated on a preoperative, high-dose-rate brachytherapy protocol. Tumors were considered positive when > 10% of tumor cells were immunoreactive. The association between APAF-1 expression and tumor response was made using the chi-square test. RESULTS Forty-four tumors (43%) were positive for APAF-1. Thirty tumors had complete pathologic tumor regression after preoperative radiotherapy. Of these, 18 tumors were positive for APAF-1. A partial response occurred in 35 tumors. Eighteen tumors (51%) were positive for the protein. Only 8 of 29 nonresponsive tumors (28%) were immunoreactive for APAF-1. A significant association was found between complete tumor regression and positive APAF-1 status (P = 0.018). APAF-1 expression in partially responsive tumors was significantly greater than in nonresponsive tumors (P = 0.03). CONCLUSIONS APAF-1 expression in pretreatment rectal tumor biopsy specimens may be useful as a predictive marker of response to preoperative radiotherapy in patients with rectal carcinoma. Cancer 2006. © 2005 American Cancer Society. [source]