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Real Potential (real + potential)
Selected AbstractsPromoting a Just Education: Dilemmas of rights, freedom and justiceEDUCATIONAL PHILOSOPHY AND THEORY, Issue 6 2007Sharon Todd Abstract This paper identifies and addresses some dilemmas to be faced in promoting educational projects concerned with human rights. Part of the difficulty that human rights education initiatives must cope with is the way in which value has been historically conferred upon particular notions such as freedom and justice. I argue here that a just education must grapple head-on with the conceptual dilemmas that have been inherited and refuse to shy away from the implications of those dilemmas. To do this I address the fundamental fictions upon which rights are based and view those fictions as nonetheless useful for opening up the ethical terms of human rights education. With reference to the work of Arendt, Lyotard and Levinas, I conclude that the real potential of human rights education lies in its capacity to provoke insights that help youth live with ambiguity and dilemma, where freedom, justice, and responsibility cannot be dictated to them, but rather involve tough decisions that must be made in everyday life. [source] ,Can you regain your youth?', the real potential of stem cell technologyEQUINE VETERINARY JOURNAL, Issue 1 2010R. K. W. SMITH No abstract is available for this article. [source] Routine use of Xeomin® in patients previously treated with Botox®: long term resultsEUROPEAN JOURNAL OF NEUROLOGY, Issue 2009D. Dressler Background and purpose:, Based upon large and carefully performed studies Xeomin® was first registered in 2005. However, its real potential can only be assessed, when it is used outside of study design restrictions, in an independent setting, in off-label indications and during continued use. Methods and results:, Two hundred and sixty-three patients (91 with dystonia, 84 with spasticity, 17 with hemifacial spasm and re-innervation synkinesias, 64 with hyperhidrosis, 7 with hypersalivation), who were previously treated with Botox® for at least 1 year under stable conditions, were converted in a blinded fashion to Xeomin® using a 1:1 conversion ratio and identical treatment parameters. Therapeutic outcome and adverse effects were monitored by neurological examination and structuralised interviews. In 223 patients (all except those with axillary hyperhidrosis) Xeomin® was used continuously throughout a 3 year period. Altogether 1050 injection series were performed. Patients with dystonia received 261.5 ± 141.0 MU Botox®/Xeomin®, patients with spasticity 450.5 ± 177.1 MU, patients with hemifacial spasm and reinnervation synkinesias 44.7 ± 19.5 MU and patients with hyperhidrosis 286.9 ± 141.6 MU. The maximum botulinum toxin dose applied was 840 MU. There were no subjective or objective differences between Botox® and Xeomin® treatments with respect to onset latency, maximum and duration of their therapeutic effects and their adverse effect profiles. Long-term use did not reveal additional safety relevant aspects. None of the patients lost therapeutic efficacy during the observation period. Conclusions:, Xeomin® can be used safely in doses of up to 840 MU. Even when applied in high doses it did not produce secondary therapy failure. There were no diffusion differences between Botox® and Xeomin®. Using a conversion ratio of 1:1 Xeomin® and Botox® can easily be exchanged in a continued treatment. [source] Graphene Solution-Gated Field-Effect Transistor Array for Sensing ApplicationsADVANCED FUNCTIONAL MATERIALS, Issue 18 2010Markus Dankerl Abstract Graphene, with its unique combination of physical and electronic properties, holds great promise for biosensor and bioelectronic applications. In this respect, the development of graphene solution-gated field-effect transistor (SGFET) arrays capable of operation in aqueous environments will establish the real potential of graphene in this rapidly emerging field. Here, we report on a facile route for the scalable fabrication of such graphene transistor arrays and provide a comprehensive characterization of their operation in aqueous electrolytes. An on-chip structure for Hall-effect measurements allows the direct determination of charge carrier concentrations and mobilities under electrolyte gate control. The effect of the solution-gate potential on the electronic properties of graphene is explained using a model that considers the microscopic structure of water at the graphene/electrolyte interface. The graphene SGFETs exhibit a high transconductance and correspondingly high sensitivity, together with an effective gate noise as low as tens of ,V. Our study demonstrates that graphene SGFETs, with their facile technology, high transconductance, and low noise promise to far outperform state-of-the-art Si-based devices for biosensor and bioelectronic applications. [source] Never Ending Stories: Recent Trends in the Historiography of Jammu and KashmirHISTORY COMPASS (ELECTRONIC), Issue 2 2007Vernon Hewitt This article reviews recent historiography on Jammu and Kashmir, showing how it has sought to escape an overemphasis on independence and partition, and has sought to relocate itself free of the histories of India and Pakistan. In doing so, it has tried to critique the official Indian and Pakistani sources, question the homogeneity of Kashmiri identity, and interrogate the aims and objectives of leading Kashmiri nationalists, primarily that of Sheikh Abdullah. It has also sought to identify the multiplicity of Kashmiri voices premised on issues of culture and language. Energised by the recent violence and turmoil within Indian administered Kashmir, new trends in historiography hold out real potential in offering not just fresh insights but also new and innovative solutions, at some risk of losing sight of the ,political' as an subject open to meaningful generalisation and investigation. [source] Towards using modern data assimilation and weather forecasting methods in solar physicsASTRONOMISCHE NACHRICHTEN, Issue 3-4 2007A. S. BrunArticle first published online: 7 MAR 200 Abstract We discuss how data assimilation and forecasting methods developed in Earth's weather prediction models could be used to improve our capability to anticipate solar dynamical phenomena and assimilate the huge amount of data that new solar satellites, such as SDO or Hinode, will provide in the coming years. We illustrate with some simple examples such as the solar magnetic activity cycle, the eruption of CMEs, the real potential of such methods for solar physics. We believe that we now need to jointly develop solar forecasting models, whose purpose are to assimilate observational data in order to improve our predictability power, with "first principle" solar models, whose purpose is to understand the underpinning physical processes behind the solar dynamics. These two complementary approaches should lead to the development of a solar equivalent of Earth's general circulation model. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Development of a large-scale biocalorimeter to monitor and control bioprocessesBIOTECHNOLOGY & BIOENGINEERING, Issue 2 2002D. Voisard Abstract Calorimetry has shown real potential at bench-scale for chemical and biochemical processes. The aim of this work was therefore to scale-up the system by adaptation of a standard commercially available 300-L pilot-scale bioreactor. To achieve this, all heat flows entering or leaving the bioreactor were identified and the necessary instrumentation implemented to enable on-line monitoring and dynamic heat balance estimation. Providing that the signals are sufficiently precise, such a heat balance would enable calculation of the heat released or taken up during an operational (bio)process. Two electrical Wattmeters were developed, the first for determination of the power consumption by the stirrer motor and the second for determination of the power released by an internal calibration heater. Experiments were designed to optimize the temperature controller of the bioreactor such that it was sufficiently rapid so as to enable the heat accumulation terms to be neglected. Further calibration experiments were designed to correlate the measured stirring power to frictional heat losses of the stirrer into the reaction mass. This allows the quantitative measurement of all background heat flows and the on-line quantitative calculation of the (bio)process power. Three test fermentations were then performed with B. sphaericus 1593M, a spore-forming bacterium pathogenic to mosquitoes. A first batch culture was performed on a complex medium, to enable optimization of the calorimeter system. A second batch culture, on defined medium containing three carbon sources, was used to show the fast, accurate response of the heat signal and the ability to perfectly monitor the different growth phases associated with growth on mixed substrates, in particular when carbon sources became depleted. A maximum heat output of 1100 W was measured at the end of the log-phase. A fed-batch culture on the same defined medium was then carried out with the feed rate controlled as a function of the calorimeter signal. A maximum heat output of 2250 W was measured at the end of the first log-phase. This work demonstrates that real-time quantitative calorimetry is not only possible at pilot-scale, but could be readily applied at even larger scales. The technique requires simple, readily available devices for determination of the few necessary heat flows, making it a robust, cost-effective technique for process development and routine monitoring and control of production processes. © 2002 Wiley Periodicals, Inc. Biotechnol Bioeng 80: 125,138, 2002 [source] The synthetic furanonaphthoquinone induces growth arrest, apoptosis and differentiation in a variety of leukaemias and multiple myeloma cellsBRITISH JOURNAL OF HAEMATOLOGY, Issue 4 2005Julian C. Desmond Summary 2-Methyl-naphtho[2,3- b]furan-4,9-dione (FNQ3), a synthetic analogue of the quinone kigelinone, has demonstrated a real potential for use in the treatment of a variety of solid tumours. Unlike other quinones, such as mitomycin-C and adriamycin, the cytotoxicity of FNQ3 is often 10- to 14-fold more potent towards the tumour cells than their normal counterparts. We report, for the first time, that the drug had activity against a broad spectrum of leukaemias and multiple myeloma cells. It decreased the growth of acute myeloid leukaemia (AML) and multiple myeloma cell lines in a dose-dependent fashion (50% inhibitory concentration ,1·25 ,g/ml against most of the leukaemia cell lines). This dose apparently initiated mitochondrial collapse as measured by depolarisation of the mitochondrial membrane. FNQ3 potentiated the differentiation of HL-60 myeloid cells in the presence of either 1,, 25(OH)2 dihydroxyvitamin D3 [1,,25(OH)2D3] or all- trans -retinoic acid (ATRA). FNQ3 inhibited the proliferation of primary AML cells while inducing apoptosis. Eleven of 14 (79%) AML marrow samples had a prominent decrease in their clonogenic growth when cultured in the presence of the drug. In summary, this drug has growth inhibitory, apoptotic and differentiative effects against myeloid leukaemias and multiple myeloma cells. FNQ3 may represent a new therapeutic approach to these malignancies. [source] | ||||||||||