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Real Concern (real + concern)

Distribution by Scientific Domains

Medical Sciences	40%

Selected Abstracts

Recurrence of autoimmune liver disease after liver transplantation: A systematic review

LIVER TRANSPLANTATION, Issue 12 2006
Manjushree Gautam
Recurrence of autoimmune liver disease in allografts has long been a topic of debate. We conducted a systematic review of the literature to examine the reported incidence of recurrence after liver transplantation of primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH). The MEDLINE, EMBASE, and Cochrane electronic databases were used to identify articles. The inclusion criteria used were articles on patients with at least 90 days of posttransplantation follow-up, histologic criteria for diagnosis of PBC and AIH recurrence, radiologic or histologic criteria or both for diagnosis of PSC recurrence, and exclusion of other causes of liver disease causing similar histologic findings. Incidence in individual studies was combined to calculate the overall recurrence. Risk factors were analyzed whenever crude data were available. Funnel plots were used to assess publication bias. Out of 90 articles identified, 43 met criteria for systematic review (PBC, 16; PSC, 14; AIH, 13). The calculated weighted recurrence rate was 18% for PBC, 11% for PSC, and 22% for AIH. No difference was found in PBC and AIH recurrence by type of primary immunosuppression. There were not enough data to assess this issue in PSC studies. There was evidence of publication bias among PSC and AIH studies but not among PBC studies. In conclusion, recurrence of autoimmune liver disease after liver transplantation appears to be a real concern. As these patients are followed long-term, recurrence of disease may become the primary cause of morbidity. Liver Transpl 12:1813-1824, 2006. © 2006 AASLD. [source]

Comparative proteomic analysis of human mesenchymal and embryonic stem cells: Towards the definition of a mesenchymal stem cell proteomic signature

PROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS, Issue 2 2009
Stephane Roche
Abstract Mesenchymal stem cells (MSC) are adult multipotential progenitors which have a high potential in regenerative medicine. They can be isolated from different tissues throughout the body and their homogeneity in terms of phenotype and differentiation capacities is a real concern. To address this issue, we conducted a 2-DE gel analysis of mesenchymal stem cells isolated from bone marrow (BM), adipose tissue, synovial membrane and umbilical vein wall. We confirmed that BM and adipose tissue derived cells were very similar, which argue for their interchangeable use for cell therapy. We also compared human mesenchymal to embryonic stem cells and showed that umbilical vein wall stem cells, a neo-natal cell type, were closer to BM cells than to embryonic stem cells. Based on these proteomic data, we could propose a panel of proteins which were the basis for the definition of a mesenchymal stem cell proteomic signature. [source]

The Australian grocery industry: a competition perspective,

AUSTRALIAN JOURNAL OF AGRICULTURAL & RESOURCE ECONOMICS, Issue 1 2006
Rhonda L. Smith
This article discusses whether at a theoretical level the large and growing role of the vertically integrated supermarket chains raises a buyer-power concern because of potential harm to other retailers, suppliers, and/or consumers. Even if this is possible, whether it is a real concern depends on whether provision exists to constrain the exercise of that power through market responses, such as entry, or through regulatory provisions, such as those contained in the Trade Practices Act. [source]

Salmonella enterica serotype Virchow: epidemiology, resistance patterns and molecular characterisation of an invasive Salmonella serotype in Israel

CLINICAL MICROBIOLOGY AND INFECTION, Issue 10 2006
M. Weinberger
Abstract This study outlines the unique epidemiology of Salmonella enterica serotype Virchow in Israel. Between 1997 and 2002, the overall incidence of non-typhoid Salmonella enterica (NTS) decreased from 69.3 to 53.3 infections/100 000 population, but the incidence of S. Virchow increased (from 7.2 to 9.1 infections/100 000). Since 2000, S. Virchow has become the second-ranking NTS isolate, accounting for 17% and 27% of all stool and blood NTS isolates, respectively. Infants aged <,1 year had the highest incidence of isolation from stools (92.8/100 000). The incidence of isolation from blood was highest for infants aged <1 year (4.4/100 000). Only 6% of isolates were susceptible to all ten antibiotic agents tested; 34% were resistant to one agent, 54% to one to three agents, and 40% to four to six agents. A high proportion of the tested isolates were resistant to nalidixic acid (89%), streptomycin (56%), tetracycline (43%), trimethoprim,sulphamethoxazole (38%) and chloramphenicol (28%), but none to ciprofloxacin or ceftriaxone. Pulsed-field gel electrophoresis revealed two closely related clusters, each containing a predominant pulsotype. Coupled with its invasive propensity, the increasing incidence of highly resistant S. Virchow in Israel is of real concern. Future research should focus on the sources of S. Virchow in the food chain in order to institute effective control measures. [source]

Tagging the tags, Process, observations and analysis of conversations in metatagging at an ASIST interactive poster session

PROCEEDINGS OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE & TECHNOLOGY (ELECTRONIC), Issue 1 2007
Jennifer E. Graham
Results from a 2006 ASIST poster session on tagger's motivations are presented. Researcher's conducted short conversations with conference participants as they viewed the researchers' poster and tagged its contents. Using a content analysis method, researchers' conversations with participants were analyzed. Content analysis revealed six broad themes or "clusters" of interest: 1) General, 2) Observations, 3) Specific Uses/Suggestions, 4) Curricular, 5) Concerns and 6) Opportunities/Potentials. Within those clusters various specific points were ranked by frequency of occurrence. Overall findings indicate the ASIST community is interested in seeing what happens with this phenomenon, but voiced very real concerns about the longevity of tagging, specific uses in scholarly environments, and the effect it will have on annotation, bibliographic, and subject analysis. [source]