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Reappraisal
Kinds of Reappraisal Selected AbstractsA REAPPRAISAL OF THE OVERLAP OF VIOLENT OFFENDERS AND VICTIMS,CRIMINOLOGY, Issue 4 2008CHRISTOPHER J. SCHRECK Because research shows a close association between offending and victimization, recent work has argued that theories that account for crime should explain victimization as well. The current study uses a new approach to examine the extent of the overlap between offenders who commit violent crime and victims of violence to determine whether it is worthwhile to pursue separate theories to account for these phenomena. Specifically, we take the statistical approach that Osgood and Schreck (2007) developed for analyzing specialization in violent versus property offending and apply it to analyzing tendencies to gravitate toward violent offending versus victimization. In doing so, we treat the differentiation into victim and offender roles as an individual-level latent variable while controlling for confounding between the likelihood that individuals will take either role in violent acts and their overall numbers of encounters with violence (as either offender or victim). Our purpose is to examine 1) whether significant differentiation can be observed between the tendency to be an offender versus the tendency to be a victim, 2) whether any such differential tendency is stable over time, and 3) if it is possible to predict whether individuals will tend toward violent offending versus victimization. Using two waves of data from the National Longitudinal Study of Adolescent Health to explore these objectives, we find significant and stable levels of differentiation between offenders and victims. Moreover, this differentiation is predictable with explanatory variables. [source] A REAPPRAISAL OF BATEMAN'S CLASSIC STUDY OF INTRASEXUAL SELECTIONEVOLUTION, Issue 11 2007Brian F. Snyder Bateman's (1948) study showing greater variances in number of mates and reproductive success in male than female Drosophila melanogaster is a foundational paper in sexual selection. Here we show for the first time that his methods had flaws, including the elimination of genetic variance, sampling biases, miscalculations of fitness variances, statistical pseudo-replication, and selective presentation of data. We conclude that Bateman's results are unreliable, his conclusions are questionable, and his observed variances are similar to those expected under random mating. Despite our analysis, we do not intend this article as a criticism of Bateman; he accomplished his work without modern computational tools, and his approach was groundbreaking emphasizing the significance of fitness variance for sexual selection. However, this reanalysis has implications for what counts as evidence for sexual selection and we believe that our concerns should be of interest to contemporary students of sexual selection. We call for repetitions of Bateman's study using modern statistical and molecular methods. [source] BARBARIAN PIRACY AND THE SAXON SHORE: A REAPPRAISALOXFORD JOURNAL OF ARCHAEOLOGY, Issue 1 2005A.F. PEARSON Summary. The tradition of Saxon and other Continental piracy is one of the longest standing tenets of Romano-British studies. It may also be one of its greatest myths, which owes more to its considerable antiquarian pedigree than to any firm basis in fact. This paper reassesses Roman military strategy around the British coast, and suggests that the ,Saxon Shore Forts' and other coastal installations played a more significant economic and logistical role than is often appreciated. Moreover, the idea that each monument fulfilled a single, dedicated function is argued to be too simplistic: instead it is proposed that individual forts served in various capacities during their operational lifetime, and quite possibly not those for which they were originally conceived. [source] RUDOLPH OTTO'S IDEA OF THE HOLY: A REAPPRAISALTHE HEYTHROP JOURNAL, Issue 1 2007OWEN WARE This paper explores the ambiguity in Rudolph Otto's discussion of the mysterium tremendum in order to address a broader set of difficulties in The Idea of the Holy (1917). In doing so, I outline two common criticisms of Otto's position. The first attacks Otto for not providing a secure transition from the numinous experience of terror to the holy experience of faith. The second attacks Otto for upholding a kind of theistic dualism, which seemingly puts his thought at odds with mysticism. Rather than reconstruct Otto's argument in favour of theism, I maintain that numinous experience, while still a form of otherness or alterity, is best characterized as the breakdown of subject-object dualism. I further suggest that this breakdown is best understood in non-theistic terms. For examples of the latter, I briefly turn to Jean-Luc Marion's notion of saturated phenomena. [source] THE ECONOMICS OF THE NON-DISTRIBUTION CONSTRAINT: A CRITICAL REAPPRAISALANNALS OF PUBLIC AND COOPERATIVE ECONOMICS, Issue 1 2008Vladislav VALENTINOV ABSTRACT,:,This paper re-examines the non-distribution constraint as a key structural feature of non-profit organization. It argues that its traditional understanding as a trustworthiness-enhancing device is incomplete. This paper shows that the non-distribution constraint is also a reflection of the directly utility-enhancing character of involvement in non-profit firms for their key stakeholders. This alternative explanation allows one to solve the central puzzle of trustworthiness theory: why doesn't the non-distribution constraint destroy entrepreneurial motivation? Additionally, it helps one to understand the role of the non-distribution constraint in economic theories of non-profit organization that do not rely on trustworthiness theory. Finally, it enables one to logically integrate the different economic theories of non-profit organization. [source] CHOLEDOCHODUODENOSTOMY: REAPPRAISAL IN THE LAPAROSCOPIC ERAANZ JOURNAL OF SURGERY, Issue 6 2008Kamran Khalid Background: With the advent of interventional endoscopic procedures and with growing experience of laparoscopic surgery, the indications for open biliary procedures have become limited. This prospective study reviews the indications of open choledochoduodenostomy for benign biliary diseases and presents the short-term and long-term outcomes of this procedure in the present minimally invasive surgical era. Methods: Side-to-side choledochoduodenostomy was carried out for various benign obstructive pathologies of the biliary tract. The various parameters recorded were the demographic data, indications for surgery, early and late complications and the long-term outcome of the procedure. Results: Results of choledochoduodenostomy on 54 consecutive patients over a 9-year period are presented. The mean age was 49.7 years with a male to female ratio of 1:2.6. Thirty (55.5%) patients presented with obstructive jaundice and 42.6% had cholangitis. Overall hospital morbidity was 13% with zero mortality. After a mean follow up of 7.8 years, 96.3% patients had ,good' or ,fair' and 3.7% experienced ,poor' results. No recurrent disease or biliary malignancy was observed. Conclusion: Open biliary drainage procedures may still be indicated in select patients where the facility or expertise for minimally invasive biliary procedures is not available. Choledochoduodenostomy remains an effective biliary drainage procedure with acceptable morbidity and mortality, especially in the high-risk and elderly population. The procedure should be regarded as an essential in the general surgical knowledge and training. [source] Low-grade urothelial carcinoma: Reappraisal of the cytologic criteria on ThinPrep®DIAGNOSTIC CYTOPATHOLOGY, Issue 3 2003Ph.D., Wei Xin M.D. Abstract The diagnostic criteria for low-grade urothelial lesions that have been described in the past were based on urinary specimens prepared by the cytospin method. Recognizing the recent popularity of the ThinPrep® methodology and the cytologic alterations it introduces to the cellular features, we sought to evaluate the reproducibility of these criteria in ThinPrep urinary samples. One hundred twenty-six ThinPrep urinary specimens with a tissue diagnosis of low-grade urothelial carcinoma (LGUC) and 45 negative controls were evaluated. Three pathologists blindly reviewed the slides separately and the consensus on each feature was used in the study. Logistic regression analysis was used to determine which criteria in combination were most predictive of low-grade urothelial carcinoma. All specimens were evaluated for the following 18 features: nucleus/cytoplasm ratio, irregular nuclear border, cytoplasm homogeneity, cell clusters, high cellularity, prominent nucleoli, granular nuclear chromatin, hyperchromasia, acute inflammation, vesicular chromatin, nuclear molding, nuclear eccentricity, elongated nuclei, necrosis, anisonucleosis, irregular bordered fragments, absent cytoplasmic collar, and peripheral palisading. High nucleus-to-cytoplasm ratio, irregular nuclear borders, and homogeneous cytoplasm (combination sensitivity of 59% and specificity of 100%) were the best predictive features for LGUC. Minor predictive criteria were eccentric nuclei and nuclear molding. ThinPrep provides well preserved, cleaner specimens without significantly altering the morphology. The three key criteria applied in cytospin specimens to diagnose LGUC were reproducible in ThinPrep specimens. Diagn. Cytopathol. 2003;29:125,129. © 2003 Wiley-Liss, Inc. [source] The Quest for Distinction: A Reappraisal of the Rural Labor Process in Kheda District (Gujarat), India,ECONOMIC GEOGRAPHY, Issue 2 2000Vinay Gidwani Abstract: In this article I examine how the rural labor process is constitutive of social identity, particularly status, by harnessing empirical evidence from Kheda District, Gujarat, and other parts of India. Emphasis is on the labor practices of the dominant Lewa Patel caste, and only secondarily on the practices of other caste groups. My central claim is that the labor process is a primary arena in which the quest for social distinction occurs and that the primary source of distinction is the ability to withdraw family labor power from the commoditized labor circuit. In this paper I seek to deepen conventional understandings of the labor process within economic geography, agrarian studies, and mainstream economics. [source] If the Armada Had Landed: A Reappraisal of England's Defences in 1588HISTORY, Issue 311 2008NEIL YOUNGER The defeat of the Spanish Armada in 1588 stands as one of the greatest triumphs of Elizabeth I's reign, but, the success of the navy notwithstanding, received wisdom presents the land defences as woefully inadequate. This article shows that the existing picture of the English preparations is flawed in several ways and that they were better organized, more efficient and more willing than has been recognized. The privy council was called upon to deploy limited forces to defend a long coastline against an unpredictable attacker, and the evidence shows that they contrived to maximize the effectiveness of the available resources whilst balancing the calls of military practicality, financial necessity and political constraints. An assessment is also made of the response from the counties, using the mobilization as a test case of the structures put in place by the Elizabethan regime to deal with such an emergency. [source] Reappraisal of endosonography of ampullary tumors: Correlation with transabdominal sonography, CT, and MRIJOURNAL OF CLINICAL ULTRASOUND, Issue 1 2009Chien-Hua Chen MD Abstract Purpose. To reappraise the accuracy of transabdominal sonography (US), CT, MRI, and endosonography (EUS) in the diagnosis and staging of ampullary tumors. Method. We reviewed the medical records and the images of 41 consecutive patients with ampullary tumors. Tumor detection rate and accuracy of TNM (tumor,node,metastasis) staging of malignant tumors were determined. Imaging findings were correlated with histopathologic findings. Results. The detection rates for ampullary tumors were 97.6% for EUS, 81.3% for MRI, 28.6% for CT, and 12.2% for US (p < 0.001 for EUS versus CT; p < 0.001 for EUS versus US; p > 0.05 for EUS versus MRI). The accuracy in T staging for ampullary carcinomas was 72.7% for EUS, 53.8% for MRI, and 26.1% for CT (p < 0.01 for EUS versus CT; p > 0.05 for EUS versus MRI). The accuracy in N staging for ampullary carcinomas was 66.7% for EUS, 76.9% for MRI, and 43.5% for CT with no statistically significant difference between the 3 modalities. The sensitivity in detecting malignant lymph nodes was 46.7% for EUS, 25.0% for MRI, and 0% for CT (p < 0.01 for EUS versus CT; p > 0.05 for EUS versus MRI; p > 0.05 for MRI versus CT). Transpapillary stenting, advanced tumor extension (>T2), large tumor size (>2 cm), tumor differentiation, and endoscopic appearance of tumor growth did not significantly influence EUS accuracy in T or N staging (p > 0.05). Conclusion. EUS was superior to CT and was equivalent to MRI for tumor detection and T and N staging of ampullary tumors. Neither indwelling stents nor tumor size, differentiation, or endoscopic appearance affected the staging accuracy of EUS. © 2008 Wiley Periodicals, Inc. J Clin Ultrasound, 2009 [source] Sinusoidal heart rate pattern: Reappraisal of its definition and clinical significanceJOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (ELECTRONIC), Issue 3 2004Houchang D. Modanlou Abstract Objectives: To address the clinical significance of sinusoidal heart rate (SHR) pattern and review its occurrence, define its characteristics, and explain its physiopathology. Background: In 1972, Manseau et al. and Kubli et al. described an undulating wave form alternating with a flat or smooth baseline fetal heart rate (FHR) in severely affected, Rh-sensitized and dying fetuses. This FHR pattern was called ,sinusoidal' because of its sine waveform. Subsequently, Modanlou et al. described SHR pattern associated with fetal to maternal hemorrhage causing severe fetal anemia and hydrops fetalis. Both Manseau et al. and Kubli et al. stated that this particular FHR pattern, whatever its pathogenesis, was an extremely significant finding that implied severe fetal jeopardy and impending fetal death. Undulating FHR pattern: Undulating FHR pattern may be due to the following: (1) true SHR pattern; (2) drugs; (3) pre-mortem FHR pattern; (4) pseudo-SHR pattern; and (5) equivocal FHR patterns. Fetal conditions associated with SHR pattern: SHR pattern has been reported with the following fetal conditions: (1) severe fetal anemia of several etiologies; (2) effects of drugs, particularly narcotics; (3) fetal asphyxia/hypoxia; (4) fetal infection; (5) fetal cardiac anomalies; (6) fetal sleep cycles; and (7) sucking and rhythmic movements of fetal mouth. Definition of true SHR pattern: Modanlou and Freeman proposed the following definition for the interpretation of true SHR pattern: (a) stable baseline FHR of 120,160 bpm; (b) amplitude of 5,15 bpm, rarely greater; (c) frequency of 2,5 cycles per minute; (d) fixed or flat short-term variability; (e) oscillation of the sinusoidal wave from above and below a baseline; and (f) no areas of normal FHR variability or reactivity. Physiopathology: Since its early recognition, the physiopathology of SHR became a matter of debate. Murata et al. noted a rise of arginine vasopressin levels in the blood of posthemorrhagic/anemic fetal lamb. Further works by the same authors revealed that with chemical or surgical vagotomy, arginine vasopressin infusion produced SHR pattern, thus providing the role of autonomic nervous system dysfunction combined with the increase in arginine vasopressin as the etiology. Conclusion: SHR is a rare occurrence. A true SHR is an ominous sign of fetal jeopardy needing immediate intervention. The correct diagnosis of true SHR pattern should also include fetal biophysical profile and the absence of drugs such as narcotics. [source] Of Sharks and Pilot-Fish: Melville's Prophetic Art and the Dream of (French) America A Reprise and ReappraisalLEVIATHAN, Issue 2 2004JEAN-FRANÇOIS LEROUX [source] Microvascularly augmented transverse rectus abdominis myocutaneous flap for breast reconstruction,Reappraisal of its value through clinical outcome assessment and intraoperative blood gas analysisMICROSURGERY, Issue 8 2008Jing-Wei Lee M.D. Our experience with 73 transverse rectus abdominis myocutaneous (TRAM) flap transfers was reviewed to see the variance in the incidence of complications among three groups of patients undergoing different types of surgical techniques. The TRAM flap was transferred as a free flap in 26 patients, a unipedicled flap in 25 patients, and a microvascularly augmented pedicled flap in 22 patients. Our data demonstrated that the incidence of partial flap loss and fat necrosis in the microvascularly augmented group was significantly lower than that in the unipedicled flap group (P < 0.01), and also lower than that in the free flap group with a statistically marginal significance (P = 0.055). Supplemental surgery is less often required in the microvascularly augmented group than in the conventional TRAM group (P = 0.002). Substantial increase in venous O2 concentration (P = 0.03), O2 saturation level (P = 0.007), and pH value (P = 0.002) was noticed following supercharge, and this very fact testifies to the perfusion-promoting effect of the microvascular augmentation maneuver. © 2008 Wiley-Liss, Inc. Microsurgery, 2008. [source] REVIEW ARTICLE: Tolerance Mechanisms in Pregnancy: A Reappraisal of the Role of Class I Paternal MHC Antigens,AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Issue 2 2010David A. Clark Citation Clark DA, Chaouat G, Wong K, Gorczynski RM, Kinsky R. Tolerance mechanisms in pregnancy: a reappraisal of the role of class I paternal MHC antigens. Am J Reprod Immunol 2010; 63: 93,103 Problem, Allogeneic pregnancies have a survival advantage over syngeneic pregnancies, and paternal Class I MHC antigens have been implicated. In humans, HLA-C and HLA-G and E are expressed by subpopulations of fetal trophoblast. In mice, Qa-2, a Class Ib antigen, and classical H-2K antigens have been described. However, the mechanism of prevention of embryo demise in utero has not been critically assessed, and a number of conflicting ideas have not been addressed. The ,, T-cell receptor recognizes peptide bound to the groove in Class I MHC, and peptides have profound effects on the interaction of KIR receptors on T and NK cells with Class I MHC. Methods, Data on prevention of pregnancy loss (abortion) in poly IC-treated mice were reviewed along with information about prevention of losses in the abortion-prone CBA × DBA/2 model. This information was combined with data on paternal antigen expression at different times in pregnancy when key events determining outcome are thought to transpire, and role of tolerance signaling molecules such as CD200. Current data on models supporting a role for ,true' uterine NK cells (TuNKs) versus blood NK cells in the uterus (BuNKs) and role of MHC,KIR interaction were reviewed along with incompatible data in the literature. Results, Whilst paternal Class I MHC appears important, there is an important role for paternal non-MHC minor antigens (small peptides) that bind to the antigen-presenting groove of Class I MHC. BuNKs along with CD8+ T cells and Treg cells appear more important than TuNKs where the role of the latter appears primarily to promote angiogenesis. When during pregnancy the maternal immune system cells are first exposed to paternal Class I + peptide is uncertain, but at the time of implantation, if not earlier, seems likely. Conclusion, Suppression of pregnancy loss by paternal/embryo Class I MHC depends on the presence of paternal peptides. This greatly complicates existing models of Class I,KIR interactions in feto-maternal tolerance or rejection. It is important to consider all the data when devising explanatory models. [source] Evidence for Yeast Autophagy during Simulation of Sparkling Wine Aging: A Reappraisal of the Mechanism of Yeast Autolysis in WineBIOTECHNOLOGY PROGRESS, Issue 2 2005Eduardo Cebollero Yeast autolysis is the source of several molecules responsible for the quality of wines aged in contact with yeast cells. However, the mechanisms of yeast autolysis during wine aging are not completely understood. All descriptions of yeast autolysis in enological conditions emphasize the disturbance of cell organization as the starting event in the internal digestion of the cell, while no reference to autophagy is found in wine-related literature. By using yeast mutants defective in the autophagic or the Cvt pathways we have demonstrated that autophagy does take place in wine production conditions. This finding has implications for the genetic improvement of yeasts for accelerated autolysis. [source] Employee Financial Participation and Productivity: An Empirical ReappraisalBRITISH JOURNAL OF INDUSTRIAL RELATIONS, Issue 1 2006Andrew M. Robinson Avner Ben-Ner and Derek Jones cast doubt on the notion of a simple causal link between financial participation (FP) and productivity, and consequently on the validity of much of the empirical literature that has sought to quantify this relationship. This paper is an attempt to investigate this proposition. Our empirical reappraisal revealed that the route through which employee share ownership and profit-sharing schemes achieve these gains is quite separate and more involved than either the theory or prior empirical research suggests. This is particularly evident by extending the complementarities thesis beyond purely participatory bundles to embrace firm-specific and organizational variables. Our analysis also addressed recent calls to aid the interpretation of the observed effects of FP by creating a link between the use and operation of FP and its impact on productivity. [source] Script-driven imagery of self-injurious behavior in patients with borderline personality disorder: a pilot FMRI studyACTA PSYCHIATRICA SCANDINAVICA, Issue 1 2010A. Kraus Objective:, Self-injurious behavior (SIB) is one of the most distinctive features of borderline personality disorder (BPD) and related to impulsivity and emotional dysregulation. Method:, Female patients with BPD (n = 11) and healthy controls (n = 10) underwent functional magnetic resonance imaging while listening to a standardized script describing an act of self-injury. Experimental sections of the script were contrasted to the neutral baseline section and group-specific brain activities were compared. Results:, While imagining the reactions to a situation triggering SIB, patients with BPD showed significantly less activation in the orbitofrontal cortex compared with controls. Furthermore, only patients with BPD showed increased activity in the dorsolateral prefrontal cortex during this section and a decrease in the mid-cingulate while imagining the self-injurious act itself. Conclusion:, This pattern of activation preliminary suggests an association with diminished emotion regulation, impulse control as well as with response selection and reappraisal during the imagination of SIB. [source] Quantum Theory and the Resurrection of JesusDIALOG, Issue 3 2004By Anders S. Tune Abstract:, Ever since the time of Hume it has been a truism that the worldview of empirical science, and Christian assertion of the resurrection of Jesus, are antithetical to each other. Yet post-Newtonian science, and especially quantum theory, suggests the need for a reappraisal of this truism. This reappraisal will first examine the implications of the indeterminism of the quantum world, to consider the physical possibility of Jesus' resurrection. Second, an appraisal of the historical evidence will suggest the likelihood of Jesus' resurrection. Finally, I will consider some implications of all this for contemporary Christian thought. [source] Critical reappraisal of current surveillance strategies for Barrett's esophagus: analysis of a large German Barrett's databaseDISEASES OF THE ESOPHAGUS, Issue 8 2008B. H. A. Von Rahden SUMMARY Endoscopic surveillance is recommended for patients with Barrett's esophagus (BE). Based on a large database, gathered from predominantly community-based practices in Germany, we aimed to investigate the time-course of malignant progression and apply these findings to current clinical practice. Data of 1438 patients with BE from a large German BE database were analyzed. Patients with at least one follow-up endoscopy/biopsy were included. Detection of ,malignant Barrett' (either high-grade intra-epithelial neoplasia or invasive adenocarcinoma) was considered as study end-point. Of 1438 patients with BE, 57 patients had low-grade intra-epithelial neoplasia (LG-IN) on initial biopsy and 1381 exhibited non-neoplastic BE. ,Malignant Barrett' was detected in 28 cases (1.9%) during a median follow-up period of 24 months (1,255), accounting for an incidence of 0.95% per patient year of follow-up. The frequency of ,malignant Barrett' was significantly higher (P < 0.001, ,2 -test) in the LG-IN group (n = 11, 19.3%) compared with the non-neoplastic BE group (n = 17, 1.2%). In the non-neoplastic BE group, ,malignant Barrett' was predominantly found during re-endoscopy within the first year of follow-up (12 of 17; 70.6%), in contrast to the LG-IN group, in which ,malignant Barrett' was observed predominantly after a time exceeding 12 months (8 of 11, 72.7%; P = 0.05, Fisher's exact test). Initial endoscopic evaluations seem to play the most crucial role in managing BE. After 1 year of follow-up, endoscopic surveillance should be focused on patients with LG-IN. In patients with repeatedly proven non-neoplastic BE, elongation of the follow-up intervals to the upper limit of current guidelines, that is, 5 years, might be justified. [source] A morphological reappraisal of Tubifex blanchardi Vejdovský, 1891 (Clitellata: Tubificidae)ACTA ZOOLOGICA, Issue 2 2009Roberto Marotta Abstract Tubifex blanchardi Vejdovský, 1891 is a freshwater tubificid, often living in sympatry with Tubifex tubifex (Müller 1774). Although considered from its discovery as a species on its own, its biological status is debated. During the early seventies T. blanchardi was reduced to a mere form of T. tubifex, as a particular case of polymorphism in chaetal pattern. Using classical histological techniques, microdissections of portions of the male genital apparatus and phalloidin staining of dissected copulatory organs we investigated 163 mixed individuals of T. blanchardi and T. tubifex belonging to sympatric populations from the Lambro River (Milan, Northern Italy). The internal morphology of T. blanchardi is described for the first time. Our results show that T. tubifex and T. blanchardi differ in several characters concerning both their external and internal morphology, and in the fine organization of their copulatory organs. Several independent character sets support the separation of T. blanchardi from T. tubifex, suggesting that it is an independent species. This study also supports the idea that T. blanchardi and T. bergi (Hrab,, 1935), another species closely related to T. tubifex, are not conspecific. The observed morphological differences between allopatric populations of T. tubifex are discussed. [source] NHS malaise: diagnosis and treatment optionsECONOMIC AFFAIRS, Issue 4 2001Heather Gage The paper questions whether the recent reform package of the NHS will solve its ongoing problems, or whether a more fundamental reappraisal of the system is required. [source] A critical reappraisal of treatment response criteria in systemic mastocytosis and a proposal for revisionsEUROPEAN JOURNAL OF HAEMATOLOGY, Issue 5 2010A. Pardanani Abstract Mast cell disease (MCD) is a hematopoietic stem cell neoplasm that is associated with infiltration of one or more organs with cytologically abnormal mast cells (MC). MCD is frequently but not always associated with a KIT mutation and, in some cases, is associated with clonal expansion of non-MC lineage cells. In adults, there is almost always MC infiltration of the bone marrow, which is a cardinal feature of systemic mastocytosis (SM). While, as members of the wider community of physician scientists, we recognize the contribution of the current consensus treatment response criteria for SM, as individuals with more than average clinical experience in SM, we would like to point out their limitations and engage in a constructive discussion that will hopefully lead to a consideration for revisions. We present here an alternative proposal for treatment response assessments we believe is more objective, reproducible, and importantly, SM-subtype specific, given the recent progress in our understanding of the natural history of this disease. We believe this proposal is timely given the prospects for new clinical trials in SM, and the related regulatory aspects of new drug approval that are currently not adequately addressed. The intent of this exercise is not to undermine the complexity of the disease or previous work by other investigators, but to come up with ideas for response criteria that are more practical and consider meaningful patient outcome. [source] Critical reappraisal of referrals to electromyography and nerve conduction studies,EUROPEAN JOURNAL OF NEUROLOGY, Issue 2 2005S. Podnar A large number of examinees referred to electromyographic (EMG) laboratories do not have symptoms or signs suggestive of a peripheral nervous system disorder, and the aim of the present study was to check this. All examinees evaluated by the author in a ,general' EMG laboratory in the first 4 months of 2002 were included. Data on examinees, referral physicians and diagnoses, clinical symptoms and signs, and electrodiagnostic findings were statistically evaluated. Three hundred examinees, 42% men, were included. A neurological diagnosis was provided in 55% of referrals. Electrodiagnostic abnormalities were found in 45% of examinees. Using multivariate statistics, a positive effect of neurological referral diagnosis, history of paraesthesias and of weakness and sensory loss on examination, and a negative effect of history of pain on pathological electrodiagnostic findings were found. Except 20 patients with carpal tunnel syndrome, no patient with normal clinical examination had abnormal electrodiagnostic findings. Our study confirmed the inappropriateness of referrals to electrodiagnostic examination to screen patients for peripheral nervous disorders. We propose electrodiagnostic examination mainly of patients with unequivocal clinical signs of a peripheral nervous system lesion and of patients with typical symptoms of the carpal tunnel syndrome. [source] Prior pallidotomy reduces and modifies neuronal activity in the subthalamic nucleus of Parkinson's disease patientsEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 2 2008A. Zaidel Abstract Parkinson's disease (PD) patients with prior radio-frequency lesions in the internal segment of the globus pallidus (GPi, pallidotomy), whose symptoms have deteriorated, may be candidates for further invasive treatment such as subthalamic deep brain stimulation (STN DBS). Six patients with prior pallidotomy (five unilaterally; one bilaterally) underwent bilateral STN DBS. The microelectrode recordings (MERs, used intraoperatively for STN verification), ipsilateral and contralateral to pallidotomy, and MERs from 11 matched PD patients who underwent bilateral STN DBS without prior pallidotomy were compared. For each trajectory, average, variance and mean successive difference (MSD, a measure of irregularity) of the root mean square (RMS) of the STN MER were calculated. The RMS in trajectories ipsilateral to pallidotomy showed significant reduction of the mean average and MSD of STN activity when compared with trajectories from patients without prior pallidotomy. The RMS parameters contralateral to pallidotomy tend to lie between those ipsilateral to pallidotomy and those without prior pallidotomy. The average STN power spectral density of oscillatory activity was notably lower ipsilateral to pallidotomy than contralateral, or without prior pallidotomy. The finding that pallidotomy reduces STN activity and changes firing characteristics, in conjunction with the effectiveness of STN DBS despite prior pallidotomy, calls for reappraisal and modification of the current model of the basal ganglia (BG) cortical network. It highlights the critical role of direct projections from the BG to brain-stem structures and suggests a possible GPi,STN reciprocal positive-feedback mechanism. [source] A Simple Engineering Estimate of the Fatigue Notch Factor of Arbitrary Stress ConcentratorsADVANCED ENGINEERING MATERIALS, Issue 4 2010Hans-Peter Gaenser In fatigue life estimates, the fatigue stress endured at the hot spot is usually higher than what is predicted by the elastic stress concentration factor. Recently, Neuber's and Novozhilov's approaches of introducing an effective stress by averaging the actual stress field over a characteristic microstructural length have experienced a reappraisal. The present contribution aims at complementing these recent proposals by a mathematically simple engineering assessment of arbitrarily shaped notches, resulting in a closed-form expression for the fatigue notch factor. The limits of validity of the solution are discussed. [source] Intended and unintended consequences of internal motivation to behave nonprejudiced: The case of benevolent discrimination,EUROPEAN JOURNAL OF SOCIAL PSYCHOLOGY, Issue 6 2009Jennifer Fehr Internal motivation to behave nonprejudiced reduces prejudice. The present research looks at the impact of internal motivation in a special case of prejudiced behavior, namely benevolent discrimination. It was hypothesized that internal motivation does not reduce, but rather increases benevolent discrimination as long as individuals are not aware of its negative consequences. This is because of the positive intention required to show benevolent discrimination. Once the negative consequences have been made salient, internal motivation will facilitate self-criticism of one's own benevolently discriminating behavior, which will be reflected in a more critical reappraisal of previous benevolently discriminating behavior. The predictions were supported in three studies. Study 1 analyzed the impact of internal motivation on benevolent discrimination. Study 2 and 3 analyzed the effect of internal motivation on the critical reappraisal of one's own benevolently discriminating behavior. The implications for the regulation of benevolent discrimination in the broader context of social discrimination are discussed. Copyright © 2009 John Wiley & Sons, Ltd. [source] Experimental Physiology ,Review Article: Tissue capillary supply , it's quality not quantity that counts!EXPERIMENTAL PHYSIOLOGY, Issue 10 2010Stuart Egginton This article explores how common misunderstandings about the microcirculation , that capillary supply varies directly with O2 demand, that local capillary supply in muscle is determined by fibre type and that it is appropriate to model capillary distribution as either random or in a fixed geometric pattern , arise from quantifying capillarity by simple measures of quantitative extent, rather than the more functionally relevant qualitative distribution. We show that the latter approach reveals exquisite control of angiogenesis that determines the location of new vessels with astonishing accuracy, motivating a reappraisal of the physiological remodelling process and a new approach to computational investigations into peripheral O2 transport. [source] Triassic metasedimentary successions across the boundary between the southern Apennines and the Calabrian Arc (northern Calabria, Italy)GEOLOGICAL JOURNAL, Issue 2 2005A. Iannace Abstract The boundary area between the Apenninic fold-and-thrust belt and the crystalline Calabrian Arc, located around Sangineto in northern Calabria, has been investigated. New geological mapping in the Sant'Agata area has been performed on the Triassic successions traditionally attributed to the metasedimentary San Donato Unit. This, coupled with a reappraisal of the stratigraphy and tectonics of coeval successions present more to the south in the Cetraro Unit, results in a new reconstruction of the Triassic evolution of all the metasedimentary successions found in the region. Four informal stratigraphic units have been distinguished in the S. Agata area. The lowest one (Unit A) consists of well-bedded metalimestones and bioturbated marly limestones that correlate with Ladinian,Carnian carbonates in nearby areas. A second unit (Unit B), never recognized before, contains a complex alternation of dolomites, phyllites and some meta-arenites containing several beds of Cavernoso facies, attributed to the Carnian. They grade upward to platform and platform-margin dolomites of Norian,Rhaetian age (Unit C) that in turn are replaced upward and laterally by a fourth unit (Unit D) consisting of well-bedded, dark dolomites and metalimestones with marly interlayers locally found as resedimented large blocks in slope conglomerates. Unit D correlates with Rhaetian,Liassic beds in nearby areas. Several pieces of evidence of post-metamorphic contractional tectonics, with 140°N and 30°N trends, are found together with evidence of SW-directed extension. The siliciclastic Carnian beds of Unit B are correlated with the phyllites of Cetraro, formerly believed to be Middle Triassic; moreover, it is suggested that in the Cetraro area Unit C is almost totally replaced by Unit D. This demonstrates that the former distinction between the two tectonic units in the whole area has to be discarded. We have made a general palaeoenvironmental reconstruction which progresses laterally, during Ladinian,Carnian times, from (i) a coastal, mixed siliciclastic,carbonate,evaporitic area at Cetraro to (ii) a transitional carbonate shelf where siliciclastic input was only episodic, and finally to (iii) a bioconstructed margin which was later replaced by a steepened margin created by tectonic instability. Starting from the Norian, subsidence shifted toward the former coastal area where an intraplatform, restricted basin developed. The proposed stratigraphy corresponds closely to the Alpujarride units of the Betic Cordillera, Spain. Moreover, it is shown that strong affinities also exist, in terms of the structural framework, with the metamorphic units of Tuscany and Liguria. Copyright © 2005 John Wiley & Sons, Ltd. [source] The preservation of seismic anisotropy in the Earth's mantle during diffusion creepGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 3 2009J. Wheeler SUMMARY Seismic anisotropy in the Earth, particularly in the mantle, is commonly interpreted as the result of solid-state deformation by dislocation creep that induces a lattice preferred orientation (LPO). Diffusion creep operates where stress levels are lower and/or grain sizes smaller. It is often assumed that diffusion creep induces grain rotations that eventually destroy any existing LPO. A new numerical test of this assumption shows that it is not necessarily the case: diffusion creep will create some relative grain rotations, but rotation rates decrease through time. Hence, when microstructural change due to diffusion creep dominates that due to grain growth, defined here as ,type P' behaviour (the converse being ,type O' behaviour), the model indicates that LPO will be weakened but preserved (for a variety of strain paths including both pure and simple shear). One measure of anisotropy is the proportional difference in shear wave velocities for different polarization vectors (AVs). A model olivine microstructure with equant grains and initial maximum AVs of 10.0 percent has this value reduced to 6.7 per cent when ,rotational steady state' is attained. Other models with different initial maximum AVs values exhibit final maximum AVs values more than half the initial values. If the grains are initially elongate by a factor of 2, maximum AVs is reduced just slightly, to 8.5 per cent. Thus, when grain growth plays a subordinate role to the deformation, diffusion creep weakens seismic anisotropy by a factor of less than 2 (using maximum AVs as a measure and olivine as an example). Consequently, the link between seismic anisotropy and deformation mechanism in the mantle requires reappraisal: regions with LPO may comprise material which once deformed by dislocation creep, but is now deforming by diffusion creep in a rotational steady state. [source] Historians and Moral EvaluationsHISTORY AND THEORY, Issue 4 2004RICHARD T. VANN In dem Gebiet der Geschichte liegt die ganze moralische Welt. ,Schiller ABSTRACT The reappearance of the question of moral judgments by historians makes a reappraisal of the issues timely. Almost all that has been written on the subject addresses only the propriety of moral judgments (or morally charged language) in the written texts historians produce. However, historians have to make moral choices when selecting a subject upon which to write; and they make a tacit moral commitment to write and teach honestly. Historians usually dislike making explicit moral evaluations, and have little or no training in how to do so. They can argue it's not their job; they are only finders of fact. Historians holding a determinist view of actions do not think it appropriate to blame people for doing what they couldn't help doing; for those believing there is an overall pattern to history, individual morality is beside the point. Finally, since earlier cultures had values different from ours, it seems unjust to hold them to contemporary standards. This essay modifies or rejects these arguments. Some historians have manifested ambivalence, acknowledging it is difficult or impossible to avoid making moral evaluations (and sometimes appropriate to make them). Ordinary-language philosophers, noting that historiography has no specialized vocabulary, see it as saturated by the values inherent in everyday speech and thought. I argue that the historicist argument about the inevitably time-bound limitation of all values is exaggerated. Historians who believe in the religious grounding of values (like Lord Acton) obviously disagree with it; but even on a secular level, morals are often confused with mores. If historians inevitably make moral evaluations, they should examine what philosophical ethicists,virtue ethicists, deontologists, and consequentialists,have said about how to make them; and even if they find no satisfactory grounding for their own moral attitudes, it is a brute fact that they have them. I end with an argument for "strong evaluations",neither treating them as a troublesome residue in historiography nor, having despaired of finding a solid philosophical ground for moral evaluations, concluding that they are merely matters of taste. I believe historians should embrace the role of moral commentators, but that they should be aware that their evaluations are, like all historical judgments, subject to the criticisms of their colleagues and readers. Historians run little risk of being censorious and self-righteous; the far greater danger is acquiescing in or contributing to moral confusion and timidity. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||