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Rat Paw Oedema (rat + paw_oedema)
Selected Abstracts,-Monoisostearyl glyceryl ether enhances percutaneous penetration of indometacin in-vivoJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 12 2002Atsushi Suzuki ABSTRACT Molecules that reversibly remove the barrier resistance of skin enhance penetration. ,-Monoisostearyl glyceryl ether (GE-IS) is a novel compound that can be used as a non-ionic surfactant and increases percutaneous penetration of indometacin in rat abdominal skin in-vitro. The present study investigated GE-IS-induced enhancement of indometacin penetration in-vivo. When 1% GE-IS in propylene glycol was applied to rat abdominal skin, serum and muscle concentrations of indometacin increased markedly. Anti-inflammatory activities of test solutions containing both indometacin and GE-IS were investigated in experimental models of acute and chronic inflammation. Application of indometacin with GE-IS to the skin produced greater inhibitory effects on carrageenan-induced rat paw oedema, UV-induced erythema in guinea-pigs, and adjuvant arthritis in rats, compared with application of indometacin alone. The results suggest that GE-IS enhances penetration in-vivo and improves the anti-inflammatory effects of indometacin in animal models. Thus, GE-IS might contribute to the development of cosmetic or medical formulations to improve transfer of bioactive substances to hypodermal sites. [source] Pharmacological studies on Indian black tea (leaf variety) in acute and chronic inflammatory conditionsPHYTOTHERAPY RESEARCH, Issue 6 2008Dilip K. Roy Abstract Infusions of Indian black tea (BTI), when administered orally, produced significant inhibition of rat paw oedema, induced with carrageenin (pre and post treatment) and arachidonic acid. BTI was also found to inhibit peritoneal capillary permeability and caused a marked reduction of lipopolysaccharide induced PGE2 generation. In these models, the observed antioedema effect was similar to that of BW755C (a dual inhibitor of cyclooxygenase and 5-lipoxygenase enzymes). BTI was found to scavenge superoxide and hydroxyl radicals, and also protected rat erythrocytes from the damaging effects of hydrogen peroxide. In chronic studies, BTI inhibited granuloma formation along with the reduction of both lipid peroxidation and hydroxyproline content (in the granuloma tissue). Significant antiarthritic activity was observed with regular administration of BTI in the Freund's adjuvant induced model of arthritis. Chronic treatment with BTI (in arthritic rats) resulted in a decrease of paw diameter and tissue lipid peroxidation, along with a restoration of GSH, catalase and superoxide dismutase levels. Copyright © 2008 John Wiley & Sons, Ltd. [source] Effect of aqueous extract of Tragia involucrata Linn. on acute and subacute inflammationPHYTOTHERAPY RESEARCH, Issue 4 2006Ramar Perumal Samy Abstract Antiinflammatory activity of aqueous extract of Tragia involucrata was tested on carrageenan-induced hind paw oedema and cotton pellet granuloma models in albino rats. In the subacute model, cotton pellet granuloma was produced by implantation of 10 mg sterile cotton in the axilla under ether anaesthesia. The animals were administered an aqueous extract at various concentrations of 50, 100, 200, 300 and 400 mg/kg. Phenyl butazone (80 mg/kg) was used as a standard drug. The paw diameter was measured at different time intervals and the dry granuloma weight was taken after the treatment. The aqueous leaf extract (400 mg/kg) showed the maximum inhibition (84.23%) of oedema at the end of 3 h following carrageenin-induced rat paw oedema. In subacute inflammation, the extract showed 76.25% reduction in granuloma weight. The results prove that the aqueous leaf extract showed highest antiinflammatory activity in acute and subacute inflammation and also support the usage of traditional claims. Copyright © 2006 John Wiley & Sons, Ltd. [source] Antiinflammatory investigation of some species of MikaniaPHYTOTHERAPY RESEARCH, Issue 6 2002E. S. Suyenaga Abstract Mikania laevigata Schultz Bip. ex Baker, M. involucrata Hook. et Arn. and M. hirsutissima DC. (Asteraceae), commonly occurring in the southern Brazilian State of Rio Grande do Sul, were submitted to biological tests to evaluate their potential antiinflammatory activity. Decoctions from the leaves and stems were analysed by the induced rat paw oedema and pleurisy models. The animals were treated orally with different decoction doses. In the induced rat paw oedema test, the animals treated with leaf decoctions from M. laevigata (200,mg/,kg) and M. involucrata (50,mg/,kg) presented an oedema inhibition of 81.56% and 81.67%, respectively, 3,h after the administration of the phlogistic agent. Leaf decoctions from M. hirsutissima (400,mg/,kg) did not show such an activity. Stem decoctions displayed lower antiinflammatory activity when compared with the same doses and response time of the leaf decoctions for all analysed species. In the pleurisy assay, leaf decoctions from M. laevigata (400,mg/,kg) and M. involucrata (200,mg/,kg) inhibited leukocyte migration to the pleural exudate by 28.26% and 54.35%, respectively. Copyright © 2002 John Wiley & Sons, Ltd. [source] Pharmacological properties of the methanol extract from Mentha suaveolens Ehrh.PHYTOTHERAPY RESEARCH, Issue S1 2002Lucrecia Moreno Abstract The present study analyses the pharmacological activity in in vivo and in vitro models of the methanol extract obtained from the leaves and steams of Menta suaveolens Ehrh. This extract lacked toxicity, but exhibited a central nervous system depressant action; an analgesic effect in models of chemical and mechanical stimulation suggesting the induction of a peripheral analgesic response. The extract also exhibited an antiinflammatory action inhibiting the rat paw oedema induced by carrageenin. Moreover, the in vitro studies showed a significant diminution in the contractile effects induced by histamine, serotonin and acetylcholine. Copyright © 2002 John Wiley & Sons, Ltd. [source] | ||||||||||