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Rat Paw Edema (rat + paw_edema)

Distribution by Scientific Domains

Chemistry	50%

Selected Abstracts

Inhibition of early and late phase allergic reactions by Euphorbia hirta L.

PHYTOTHERAPY RESEARCH, Issue 4 2006
G. D. Singh
Abstract A 95% ethanol extract from whole aerial parts of Euphorbia hirta (EH A001) showed antihistaminic, antiinflammatory and immunosuppressive properties in various animal models. EH A001 inhibited rat peritoneal mast cell degranulation triggered by compound 48/80. It significantly inhibited dextran-induced rat paw edema. EH A001 prevented eosinophil accumulation and eosinophil peroxidase activity and reduced the protein content in bronchoalveolar lavage fluid (BALF) in a ,mild' model of asthma. Moreover, the CD4/CD8 ratio in peripheral blood was suppressed. EH A001 attenuated the release of interleukin-4 (IL-4) and augmented interferon- , (IFN- ,) in ovalbumin-sensitized mouse splenocytes. The results were compared with the effects of known compounds, ketotifen, cetirizine and cyclophosphamide. These findings demonstrated that Euphorbia hirta possessed significant activity to prevent early and late phase allergic reactions. Copyright © 2006 John Wiley & Sons, Ltd. [source]

Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn.

PHYTOTHERAPY RESEARCH, Issue 7 2004
C. Selvam
Abstract The ethyl acetate extract of stem bark of Semecarpus anacardium showing in vivo anti-in,ammatory activity in carrageenan induced rat paw edema assay was investigated in order to identify its active compounds. Chemical investigation of the ethyl acetate extract of S.anacardium afforded 3,4,2,,4,-tetrahydroxychalcone (butein) and 7,3,,4,-trihydroxy,avone. Evaluation of COX-1 inhibitory activity of 3,4,2,,4,-tetrahydroxychalcone and 7,3,,4,-trihydroxy,avone provided the IC50 values of 28.4 and 36.7 µM respectively. Further investigation of these compounds for COX-2 inhibitory activity revealed moderate potency towards this enzyme. Copyright © 2004 John Wiley & Sons, Ltd. [source]

Anti-Inflammatory, Antiproliferative, and Radical-Scavenging Activities of Tolfenamic Acid and Its Metal Complexes

CHEMISTRY & BIODIVERSITY, Issue 6 2009
Dimitra Kovala-Demertzi
Abstract Some new complexes of tolfenamic acid (=2-[(2-methyl-3-chlorophenyl)amino]benzoic acid; Htolf) with potentially interesting biological activities are described. The complexes [Mn(tolf)2(H2O)2], [Co(tolf)2(H2O)2], [Ni(tolf2(H2O)2], [Cu(tolf)2(H2O)]2, and [Zn(tolf)2(H2O)] were prepared by the reaction of tolfenamic acid, a potent anti-inflammatory drug, with metal salts. The radical-scavenging activities of the complexes were evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging assay. Their ability to inhibit soybean lipoxygenase, , -glucuronidase, and trypsin-induced proteolysis was studied. Their inhibitory effects on rat paw edema induced by carrageenin was studied and compared with those of tolfenamic acid. The complex [Zn(tolf)2(H2O)] exhibited the strongest in vivo inhibitory effect at 0.1,mm/kg Body Weight (BW; 93.0±0.9%), superior than the inhibition induced by tolfenamic acid at the same molar dose (76.0±0.9%). Tolfenamic acid and its metal complexes have been evaluated for antiproliferative activity in vitro against the cells of three human cancer cell lines, MCF-7 (breast cancer cell line), T24 (bladder cancer cell line), and A-549 (non-small cell lung carcinoma), and a mouse fibroblast L-929 cell line. The complexes [Mn(tolf)2(H2O)2] and [Cu(tolf)2(H2O)]2 have shown selectivity against T24 cell line. The IC50 values of these two complexes against T24 cancer cell lines are in a micromolar range similar or better to that of the antitumor drug cisplatin. [source]

Multitarget Drugs: Synthesis and Preliminary Pharmacological Characterization of Zileuton Analogues Endowed with Dual 5-LO Inhibitor and NO-Dependent Activities

CHEMMEDCHEM, Issue 9 2010
Donatella Boschi Prof.
Multitarget drugs: The title compounds represent the first class of dual-action drugs with 5-LO inhibition and NO-dependent activities. They block leukotriene B4 production with potencies near that of zileuton and are capable of relaxing rat tracheal rings and rat aorta strips through a NO-mediated mechanism. Some compounds also show anti-inflammatory activity in carrageenan- induced rat paw edema. [source]