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RANTES Promoter Polymorphisms (rante + promoter_polymorphism)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Chemokine RANTES Promoter Polymorphisms in Allergic Rhinitis,

THE LARYNGOSCOPE, Issue 4 2004
Jeong Joong Kim PhD
Abstract Objectives/Hypothesis RANTES is one of the most widely studied of the chemokines linked to allergic diseases. Two polymorphisms of the RANTES promoter region (,403 G/A and ,28 C/G) have been found. The authors investigated whether these RANTES promoter polymorphisms were associated with allergic rhinitis. Study Design Case-control study. Methods Blood samples for genetic analysis were obtained from 151 individuals with allergic rhinitis and from 278 healthy individuals without atopic disease. Polymerase chain reaction,based assays for detection of the ,403 G/A and ,28 C/G polymorphisms of the RANTES gene were used for genotyping. Results The frequencies of both the RANTES ,403A and ,28G alleles were significantly higher in patients with allergic rhinitis than in control subjects (P < .05 for both). Conclusion The study results indicated that the ,403 and ,28 alleles in the RANTES promoter region belong to the predictor gene set for allergic rhinitis and could be used in genomic analysis. [source]

Association of RANTES promoter polymorphism with juvenile rheumatoid arthritis

ARTHRITIS & RHEUMATISM, Issue 4 2009
Tsung-Chieh Yao
Objective We recently reported that RANTES was a key molecule in the pathogenesis of juvenile rheumatoid arthritis (JRA) in a longitudinal cohort. This study was undertaken to investigate genetic associations between the RANTES ,28 C/G and ,403 G/A polymorphisms and JRA in a well-documented cohort of patients who were followed up prospectively. Methods Patients with JRA (n = 107) and healthy children (n = 139) were genotyped through use of a polymerase chain reaction,based assay. Association of the RANTES promoter polymorphisms with results of laboratory tests, clinical variables, outcome after clinical remission, and response to intraarticular triamcinolone injection was evaluated in patients who were followed up for >1 year. Results JRA patients had a significantly higher frequency of the RANTES ,28 G/G genotype, as compared with ethnically matched healthy controls. The RANTES ,28 C/G polymorphism was associated with the duration of clinical remission, with patients carrying the RANTES ,28G allele experiencing only 49% of the duration of remission experienced by patients who were RANTES ,28 C/C homozygous. The RANTES ,28 C/G polymorphism was associated with the duration of clinical response to intraarticular triamcinolone injection, with patients carrying the RANTES ,28G allele showing shorter duration of clinical response. No significant association between the RANTES ,403 G/A polymorphism and JRA was found in this Chinese population. Conclusion Our findings indicate that the RANTES ,28 C/G polymorphism represents a genetic risk factor for JRA. It is noteworthy that this RANTES promoter polymorphism was also associated with an early relapse of disease after clinical remission and a shorter duration of clinical response to intraarticular administration of corticosteroids. [source]

The effects of RANTES/CCR5 promoter polymorphisms on HIV disease progression in HIV-infected Koreans

INTERNATIONAL JOURNAL OF IMMUNOGENETICS, Issue 2 2008
D. H. Jang
Summary Recent studies have reported that two single nucleotide polymorphisms (SNPs) in the RANTES gene promoter region, ,403G/A and ,28C/G, are associated with a slower rate of decline in CD4+ T-cell number, whereas genetic polymorphisms within the CCR5 promoter are linked to acceleration of AIDS progression. In this study, we investigated the distribution of SNPs in the RANTES and CCR5 promoters and the association between these SNPs and HIV-1 disease progression in HIV-infected Koreans. Twenty-seven long-term non-progressors (LTNPs), 29 AIDS patients and 39 HIV-uninfected persons were enrolled in this study. SNPs for the RANTES and CCR5 promoters were determined by polymerase chain reaction,restriction fragment length polymorphism (PCR-RFLP) and a direct sequencing method. In the analysis of RANTES promoter polymorphisms, the genotypic and allelic frequencies of the RANTES ,28G mutation were significantly lower in HIV-infected patients than in HIV-uninfected persons (P = 0.005 and P = 0.001, respectively). The genotypic frequencies of RANTES ,28G and ,403A mutations did not differ significantly between LTNPs and AIDS patients. The frequencies of three CCR5 promoter polymorphisms, designated 59029 G/A, 59353T/C, and 59402G/A, did not differ significantly between HIV-uninfected and HIV-infected patients. However, the allelic frequency of CCR559353C was significantly higher in AIDS patients than in LTNPs (P = 0.003). These results suggest that RANTES-28G and CCR5 59353C mutations might be associated with HIV infection or pathogenesis in the Korean population. [source]

Chemokine RANTES Promoter Polymorphisms in Allergic Rhinitis,

THE LARYNGOSCOPE, Issue 4 2004
Jeong Joong Kim PhD
Abstract Objectives/Hypothesis RANTES is one of the most widely studied of the chemokines linked to allergic diseases. Two polymorphisms of the RANTES promoter region (,403 G/A and ,28 C/G) have been found. The authors investigated whether these RANTES promoter polymorphisms were associated with allergic rhinitis. Study Design Case-control study. Methods Blood samples for genetic analysis were obtained from 151 individuals with allergic rhinitis and from 278 healthy individuals without atopic disease. Polymerase chain reaction,based assays for detection of the ,403 G/A and ,28 C/G polymorphisms of the RANTES gene were used for genotyping. Results The frequencies of both the RANTES ,403A and ,28G alleles were significantly higher in patients with allergic rhinitis than in control subjects (P < .05 for both). Conclusion The study results indicated that the ,403 and ,28 alleles in the RANTES promoter region belong to the predictor gene set for allergic rhinitis and could be used in genomic analysis. [source]

Association of RANTES promoter polymorphism with juvenile rheumatoid arthritis

ARTHRITIS & RHEUMATISM, Issue 4 2009
Tsung-Chieh Yao
Objective We recently reported that RANTES was a key molecule in the pathogenesis of juvenile rheumatoid arthritis (JRA) in a longitudinal cohort. This study was undertaken to investigate genetic associations between the RANTES ,28 C/G and ,403 G/A polymorphisms and JRA in a well-documented cohort of patients who were followed up prospectively. Methods Patients with JRA (n = 107) and healthy children (n = 139) were genotyped through use of a polymerase chain reaction,based assay. Association of the RANTES promoter polymorphisms with results of laboratory tests, clinical variables, outcome after clinical remission, and response to intraarticular triamcinolone injection was evaluated in patients who were followed up for >1 year. Results JRA patients had a significantly higher frequency of the RANTES ,28 G/G genotype, as compared with ethnically matched healthy controls. The RANTES ,28 C/G polymorphism was associated with the duration of clinical remission, with patients carrying the RANTES ,28G allele experiencing only 49% of the duration of remission experienced by patients who were RANTES ,28 C/C homozygous. The RANTES ,28 C/G polymorphism was associated with the duration of clinical response to intraarticular triamcinolone injection, with patients carrying the RANTES ,28G allele showing shorter duration of clinical response. No significant association between the RANTES ,403 G/A polymorphism and JRA was found in this Chinese population. Conclusion Our findings indicate that the RANTES ,28 C/G polymorphism represents a genetic risk factor for JRA. It is noteworthy that this RANTES promoter polymorphism was also associated with an early relapse of disease after clinical remission and a shorter duration of clinical response to intraarticular administration of corticosteroids. [source]