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Rheumatoid Disease (rheumatoid + disease)
Selected AbstractsSpread of spinal block in patients with rheumatoid arthritisACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 1 2010K. A. LEINO Background: In clinical practice, we noticed a greater than expected spread of sensory spinal block in patients with rheumatoid arthritis. We decided to test this impression and compared the spread of standard spinal anaesthesia in rheumatoid and non-rheumatoid control patients. Methods: Spinal anaesthesia with 3.4 ml (17 mg) of plain bupivacaine was administered to 50 patients with seropositive rheumatioid arthritis and to 50 non-rheumatoid control patients. The protocol was standardised for all patients. All the patients were undergoing lower limb surgery and the rheumatoid patients were operated on due to their rheumatoid disease. The spread of sensory block was recorded 30 min from the dural puncture using a pin prick test and a cold ice-filled container. The impact of body mass index (BMI), height and age on the spread were analysed. Results: The spread of sensory block was greater in patients with rheumatoid arthritis (15.6±3.1 dermatomes) than in non-rheumatoid patients (14.1±3.3 dermatomes) (P<0.05). Increasing BMI was related to cephalad spread of block in the rheumatoid group (P<0.05), but not in the control group. Conclusion: The mean spread of sensory block 30 min after the injection of plain bupivacaine was 1.5 segments cephalad in patients with rheumatoid arthritis than in those without this disease. BMI might be a patient-related factor contributing to the extent of the block in rheumatoid patients. These findings should be considered when performing a spinal block in rheumatoid patients. [source] Early Prosthetic Valve Failure in a Patient with Rheumatoid ArthritisJOURNAL OF CARDIAC SURGERY, Issue 1 2009Sanjay Asopa M.R.C.S. Most patients do not require cardiac surgical intervention unless they develop complications such as significant valvular regurgitation. Patients with RA often require orthopedic operations and therefore a bioprosthetic valve replacement is normally advocated to avoid problems related to anticoagulation. We report a case of a 64-year-old woman with seropositive RA who had undergone bioprosthetic aortic valve replacement three years previously. She re-presented with early prosthetic valve failure due to accelerated degeneration and calcification. This was treated successfully with redo replacement with a mechanical prosthesis. Here, we discuss our experience and debate the various valve choices available that should be considered in patients with rheumatoid disease. [source] Systemic disorders in patients with periodontal diseaseJOURNAL OF CLINICAL PERIODONTOLOGY, Issue 4 2003Maria Lagervall Abstract Background, aims: Over the past 10 years several studies have been published pointing towards a relationship between periodontal disease and various systemic disorders or diseases. The purpose of this retrospective study was to investigate the occurrence of self-reported systemic disorders in patients referred to a specialist clinic for periodontal treatment and to explore possible relationships between general health and periodontal disease severity in this population. Material and Methods: Data were collected from the dental records and the health questionnaires of 1006 subjects. Stepwise multiple linear regression analyses were adopted to calculate correlations between systemic disorders as independent variables and number of remaining teeth and the relative frequency of periodontal pockets of 5 mm or more, respectively, as the dependent variable. Results: The number of remaining teeth was significantly and positively correlated to the presence of cardiovascular disease, diabetes and rheumatoid disease after adjustment for age, sex and smoking. The relative frequency of diseased sites, however, was not significantly correlated to any one of the investigated systemic health disorders. Conclusion: No significant associations between investigated systemic disorders and periodontal disease severity were found if the relative frequency of deep periodontal pockets was used as the clinical parameter for periodontal disease severity. However, cardiovascular disease, diabetes and rheumatoid disease were found to be significantly correlated to number of lost teeth, which may represent one aspect of periodontal health. This result held true in nonsmokers only. Zusammenfassung Hintergrund: Während der letzten 10 Jahre wurden zahlreiche Studien publiziert, die auf einen Zusammenhang zwischen Parodontitis und verschiedenen systemischen Störungen und Erkrankungen hinweisen. Zielsetzung: Feststellung der Häufigkeit von selbst angegebenen systemischen Erkrankungen bei Patienten, die an eine parodontologische Spezialklinik zur Parodontitistherapie überwiesen worden waren, in einer retrospektiven Studie und Untersuchung möglicher Zusammenhänge zwischen allgemeiner Gesundheit und dem Schweregrad parodontaler Erkrankungen in dieser Bevölkerungsgruppe. Material und Methoden: Die Daten wurden aus den Behandlungsakten und Gesundheitsfragebögen von 1006 Personen gewonnen. Eine schrittweise multiple lineare Regressionsanalyse wurde verwendet, um Korrelationen zwischen systemischen Erkrankungen als unabhängigen Variablen und der Zahl verbliebener Zähne bzw. der relativen Häufigkeit parodontaler Taschen 5 mm als abhängigen Variablen zu berechnen. Ergebnisse: Nach Korrektur für Alter, Geschlecht und Rauchen war die Zahl verbliebener Zähne signifikant positiv mit Herz-Kreislauf-Erkrankungen, Diabetes und rheumatischen Erkrankungen korreliert. Die relative Häufigkeit erkrankter Stellen war allerdings mit keiner der untersuchten systemischen Erkrankungen korreliert. Schlussfolgerung: Wenn die relative Häufigkeit tiefer parodontaler Taschen als Maß für den Schweregrad parodontaler Erkrankung gewählt wurde, ließ sich keine Assoziation zwischen den untersuchten systemischen Erkrankungen und dem Parodontitisschweregrad zeigen. Allerdings waren Herz-Kreislauf-Erkrankungen, Diabetes und rheumatischen Erkrankungen signifikant mit der Zahl verlorener Zähne korreliert, die einen Aspekt parodontaler Gesundheit repräsentieren. Dieses Ergebnis ergab sich aber nur für Nichtraucher. Résumé Références et buts: Au cours des 10 dernières années, plusieurs études ont été publiées pour souligner une relation entre la maladie parodontale et diverses désordres ou maladies systémiques. Cette étude rétrospective se propose de rechercher l'apparition de désordres systémiques racontés par des patients adressés à une clinique spécialisée pour traitement parodontal et d'explorer de possibles relations entre la santé générale et la sévérité de la maladie parodontale dans cette population. Matériel et Méthodes: Les données furent récoltées des dossiers dentaires et des interrogatoires médicaux de 1006 sujets. Une analyse de régression multiple linéaire échelonnée a été utilisée pour calculer les corrélations entre les désordres systémiques en tant que variables indépendantes et le nombre de dents restantes et la fréquence relative de poches parodontales d'au moins 5mm, respectivement, comme variable dépendante. Résultats: le nombre de dents restantes était significativement et positivement corréléà la présence de maladies cardiovasculaires, de diabète et de maladie rhumatoïde après ajustement pour l'âge, le sexe, et le tabagisme. La relative fréquence de sites malades, cependant, n'était corrélée à aucun des désordres systémiques étudiés. Conclusion: Aucune association significative entre les désordres systémiques étudiés et la sévérité de la maladie parodontale ne fut trouvée lorsque la fréquence relative de poches parodontales profondes était utilisée comme paramètre clinique pour définir la sévérité de la maladie parodontale. Cependant, une maladie cardio-vasculaire, le diabète, une maladie rhumatoïde sont corrélées significativement au nombre de dents perdues qui peut être représentatif d'un aspect de santé parodontale. Ces résultats n'étaient valables que chez les non fumeurs. [source] Discoid Lupus Erythematosus in Children: Clinical, Histopathologic, and Follow-Up Features in 27 CasesPEDIATRIC DERMATOLOGY, Issue 2 2003Celia Moises-Alfaro, M.D. During a mean follow-up period of 36 months, seven patients (26%) developed systemic lupus erythematosus (SLE). Four of these patients were less than 10 years of age. No correlation was found between localized and disseminated lesions and evolution to SLE. Three of four patients with a positive family history for rheumatoid disease developed SLE (p < 0.05). Hyperpigmentation was significantly more frequent (p < 0.04) in children less than 10 years of age. There was a female predominance of 5:1 among patients less than 10 years of age. Our findings suggest that onset of DLE prior to 10 years of age does not indicate a greater risk of developing SLE. The occurrence of localized or disseminated lesions does not seem to influence the outcome. [source] Calycopterin, an immunoinhibitory compound from the extract of Dracocephalum kotschyiPHYTOTHERAPY RESEARCH, Issue 9 2008Najme Faham Abstract Medicinal plants have been widely investigated for their various effects. Dracocephalum kotschyi Boiss (Labiatae) is used in Iranian traditional medicine for the treatment of rheumatoid diseases. The inhibitory effect of D. kotschyi on the lectin-induced cellular immune response has been demonstrated previously. In this study, mitogen-treated lymphocytes were exposed to the extract of D. kotschyi and analysed for the induction of apoptosis using flow cytometry and gel electrophoresis. The data obtained indicated a dose-dependent increase of cells in the sub-G1 phase of cell cycle. Study of internucleosomal DNA fragmentation showed a typical DNA laddering in agarose gels. A bioactivity-guided fractionation assay to find the active components responsible for the inhibitory effect of D. kotschyi on mitogen-induced lymphocyte proliferation led to the isolation of calycopterin from the ethyl acetate extract of D. kotschyi. Its structure was identified by spectroscopic methods including 1H-NMR, 13C-NMR, MS and UV spectra. Calycopterin inhibited lymphocyte proliferation in a dose-dependent manner with an IC50 value of 1.7 µg/mL. In conclusion, the results of this study suggest that D. kotschyi extract has the capacity to induce apoptosis in the lymphocytes and that isolated calycopterin is responsible for the inhibitory effect of D. kotschyi on lymphocyte proliferation. Copyright © 2008 John Wiley & Sons, Ltd. [source] Cytomics, the human cytome project and systems biology: top-down resolution of the molecular biocomplexity of organisms by single cell analysisCELL PROLIFERATION, Issue 4 2005G. ValetArticle first published online: 11 AUG 200 In addition, differential molecular cell phenotypes between diseased and healthy cells provide molecular data patterns for (i) predictive medicine by cytomics or for (ii) drug discovery purposes using reverse engineering of the data patterns by biomedical cell systems biology. Molecular pathways can be explored in this way including the detection of suitable target molecules, without detailed a priori knowledge of specific disease mechanisms. This is useful during the analysis of complex diseases such as infections, allergies, rheumatoid diseases, diabetes or malignancies. The top-down approach reaching from single cell heterogeneity in cell systems and tissues down to the molecular level seems suitable for a human cytome project to systematically explore the molecular biocomplexity of human organisms. The analysis of already existing data from scientific studies or routine diagnostic procedures will be of immediate value in clinical medicine, for example as personalized therapy by cytomics. [source] | ||||||||||