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Propylene Glycol Solution (propylene + glycol_solution)
Selected AbstractsInfluence of administration vehicles and drug formulations on the pharmacokinetic profile of lamotrigine in ratsFUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 5 2002M. M. Castel-Branco Abstract Given that administration vehicles and drug formulations can affect drug bioavailability, their influence on the pharmacokinetic profile of lamotrigine (LTG), a new-generation anti-epileptic drug, was studied in rats. Three different formulations administered intraperitoneally at a dose of 10 mg/kg were used: (1) LTG suspended in a 0.25% methylcelulose solution, (2) LTG dissolved in a 50% propylene glycol solution, and (3) LTG isethionate dissolved in distilled water. Plasma and brain homogenate levels were determined in order to evaluate vehicle-dependent drug absorption. The results demonstrated rapid absorption of LTG when it was administered as an aqueous solution, in contrast to a slower and more erratic absorption after the injection of either the lipophilic solution or the suspension. A plasma peak was achieved 15 min post-dose with the aqueous solution, with a brain peak being achieved 15 min later, while with the other formulations both plasma and brain homogenate peaks were reached 2 h after LTG administration. This study suggests that LTG isethionate dissolved in distilled water is the most suitable formulation for successful LTG pharmacokinetic studies in rats. [source] Application of pressure-controlled colon delivery capsule to oral administration of glycyrrhizin in dogsJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 4 2001Nobuhito Shibata A colon delivery system has been used to improve the bioavailability of glycyrrhizin, a glycoside of glycyrrhetic acid. The bioavailability of glycyrrhizin is low when administered in conventional oral galenic dosage forms because glycyrrhizin is enzymatically hydrolysed both in the stomach and in the intestine. It was reasoned that if large amounts of glycyrrhizin were directly delivered to the colon, enzymatic activity should be reduced due to saturation so that intact glycyrrhizin could be absorbed into the systemic circulation. Based on this assumption, pressure-controlled colon delivery capsules (PCDCs) were used as a colon delivery system. Eight types of glycyrrhizin solution were prepared and were introduced into PCDCs. After oral administration of the test PCDCs to beagle dogs, blood samples were obtained over 24 h and plasma glycyrrhizin concentrations were measured by an HPLC method. With PCDCs containing aqueous glycyrrhizin and propylene glycol solutions, plasma glycyrrhizin levels were extremely low and the bioavailabilities of glycyrrhizin were 0.6% and 0.4%, respectively. When Labrasol was added to both types of glycyrrhizin solution, the bioavailability was improved to 4.6 % for aqueous solution and 3.8% for propylene glycol solution. When a surfactant, Polysorbate 80, was added in combination with Labrasol, synergistic effects were not obtained. Furthermore, dose-dependent effects of Polysorbate 80 were not obtained. Labrasol, which is a component of self-emulsifying drug delivery systems (SEDDS), has been shown to strongly improve the bioavailability of glycyrrhizin from the colon. [source] Experimental investigation on chemical sensor based on a multimode fiber Bragg gratingMICROWAVE AND OPTICAL TECHNOLOGY LETTERS, Issue 9 2006Xinzhu Sang Abstract A chemical sensor based on a Bragg grating in the multimode fiber has been demonstrated experimentally. Experimental results indicate that the reflection peak of high-order mode P2 exhibits a much higher concentration sensitivity of the chemical solution than the reflection peak P1 of the high-order mode. The sensor has been used to measure the concentrations of propylene glycol solutions and sugar solutions, which could detect 0.05% and 0.04% concentration change for them with the wavelength interrogation module of 1-pm resolution. © 2006 Wiley Periodicals, Inc. Microwave Opt Technol Lett 48: 1739,1741, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.21761 [source] | ||||||||||