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Selected AbstractsNatural surfactants used in cosmetics: glycolipidsINTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Issue 4 2009N. Lourith Synopsis Cosmetic surfactant performs detergency, wetting, emulsifying, solubilizing, dispersing and foaming effects. Adverse reactions of chemical synthesis surfactant have an effect on environment and humans, particularly severe in long term. Biodegradability, low toxicity and ecological acceptability which are the benefits of naturally derived surfactant that promises cosmetic safety are, therefore, highly on demand. Biosurfactant producible from microorganisms exhibiting potential surface properties suitable for cosmetic applications especially incorporate with their biological activities. Sophorolipids, rhamnolipids and mannosylerythritol lipids are the most widely used glycolipids biosurfactant in cosmetics. Literatures and patents relevant to these three glycolipids reviewed were emphasizing on the cosmetic applications including personal care products presenting the cosmetic efficiency, efficacy and economy benefits of glycolipids biosurfactant. Résumé Les tensioactifs sont utilisés en cosmétique pour leur pouvoir détergent, mouillant, émulsionnant, solubilisant, dispersant ou moussant. Les conséquences graves des surfactants chimiques de synthèse sur l'environnement et sur l'homme agissent particulièrement à long terme. Aussi, la demande de surfactant d'origine naturelle plus biodégradable avec une faible toxicité et une meilleure acceptation écologique est en hausse. Les tensioactifs issus de microorganismes offrent des propriétés de surface convenables pour des applications cosmétiques et en particulier combinés avec leurs activités biologiques. Les sophorolipides, les rhamnolipides et les lipides mannosylérythritol sont les glycolipides tensioactifs les plus largement utilisés en cosmétique. Les applications cosmétiques de ces trois glycolipides sont examinées dans la littérature et les brevets particulièrement pour leurs bénéfices en termes d'efficacité et d'économie. [source] Probiotic characteristics of lactic acid bacteria isolated from kimchiJOURNAL OF APPLIED MICROBIOLOGY, Issue 1 2010J.-H. Chang Abstract Aims:, The present work was aimed at identifying strains of lactic acid bacteria (LAB) from kimchi, with properties suitable for use as starter cultures in yogurt fermentation. Methods and Results:, A total of 2344 LAB strains were obtained from two different sources, one group consisted of commercial LAB strains from kimchi, and the second group consisted of those strains isolated from various types of kimchi. The LAB strains from both groups were screened for resistance to biological barriers (acid and bile salts), and the four most promising strains were selected. Further analysis revealed that KFRI342 of the four selected strains displayed the greatest ability to reduce the growth of the cancer cells, SNU-C4. The in vivo efficacy of strains in quinone reductase induction assay was evaluated, and the extent of DNA strand breakage in individual cells was investigated using the comet assay. Strain KFRI342 was identified as Lactobacillus acidophilus by 16S rRNA sequence analysis, showed protection against tumour initiation and imparted immunostimulation as well as protection against DNA damage. Conclusions:, Strain KFRI342, which showed probiotic characteristics reducing cancer cell growth, could be a suitable starter culture for yogurt fermentation because of its strong acid production and high acid tolerance. Significance and Impact of the Study:, This is the first report to describe a bacterium, isolated from kimchi, Lact. acidophilus KFRI342 which has the probiotic characteristics and the acid tolerance needed for its use as a starter culture in yogurt fermentation. [source] Comparison of Water-Based and Solvent-Based Tape Casting for Preparing Multilayer ZnO VaristorsJOURNAL OF THE AMERICAN CERAMIC SOCIETY, Issue 11 2008Lanyi Wang Water-soluble acrylic was used as the binder of the water-based (aqueous) slurry while polyvinyl butyral was the binder of the solvent-based (nonaqueous) slurry. Both types of slurry exhibited shear thinning properties suitable for tape casting. The casting parameters for them were different when the same thick green sheets were cast. Thermogravimetric analysis was used to find the binder burnout temperatures of the aqueous and nonaqueous green tape. Scanning electron microscopy (SEM) studies revealed that both types of green tapes have smooth defect-free surfaces but the aqueous green tape is denser than the nonaqueous one. The multilayer ZnO varistors prepared by aqueous tape casting display comparable good electrical properties to those prepared by nonaqueous tape casting because both types of ceramic have a uniform, fine grain microstructure with a homogeneous dopant distribution indicated using SEM and transmission electron microscopy. [source] Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics (Theranostics),MACROMOLECULAR RAPID COMMUNICATIONS, Issue 2 2010Wei Chen Abstract In this work, we describe the preparation and biomedical functionalities of complex nanoparticle assemblies with magnetoplasmonic properties suitable for simultaneous cancer therapy and diagnostics (theranostics). Most commonly magnetoplasmonic nanostructures are made by careful adaptation of metal reduction protocols which is both tedious and restrictive. Here we apply the strategy of nanoscale assemblies to prepare such systems from individual building blocks. The prepared superstructures are based on magnetic Fe3O4 nanoparticles encapsulated in silica shell representing the magnetic module. The cores are surrounded in a corona-like fashion by gold nanoparticles representing the plasmonic module. As additional functionality they were also coated by poly(ethyleneglycol) chains as a cloaking agent to extend the blood circulation time. The preparation is exceptionally simple and allows one to vary the contribution of each function. Both modules can carry drugs and, in this study, they were loaded with the potential anticancer drug curcumin. A comprehensive set of microscopy, spectroscopy and biochemical methods were applied to characterize both imaging and therapeutic function of the nanoparticle assemblies against leukemia HL-60 cells. High contrast magnetic resonance images and high apoptosis rates demonstrate the success of assembly approach for the preparation of magnetoplasmonic nanoparticles. This technology allows one to easily "dial in" the functionalities in the clinical setting for personalized theranostic regiments. [source] Engineering the catalytic domain of human protein tyrosine phosphatase , for structure-based drug discoveryACTA CRYSTALLOGRAPHICA SECTION D, Issue 12 2006Artem G. Evdokimov Protein tyrosine phosphatases (PTPs) play roles in many biological processes and are considered to be important targets for drug discovery. As inhibitor development has proven challenging, crystal structure-based design will be very helpful to advance inhibitor potency and selectivity. Successful application of protein crystallography to drug discovery heavily relies on high-quality crystal structures of the protein of interest complexed with pharmaceutically interesting ligands. It is very important to be able to produce protein,ligand crystals rapidly and reproducibly for as many ligands as necessary. This study details our efforts to engineer the catalytic domain of human protein tyrosine phosphatase , (HPTP,-CD) with properties suitable for rapid-turnaround crystallography. Structures of apo HPTP,-CD and its complexes with several novel small-molecule inhibitors are presented here for the first time. [source] Cover Picture: Biotechnology Journal 11/2009BIOTECHNOLOGY JOURNAL, Issue 11 2009Article first published online: 13 NOV 200 Cover illustration: Focus on Biochips. The cover image for this Special Issue edited by Hyun Gyu Park shows a simulation of a thin gold film perforated with periodic nanopores. This setup has unique optical properties suitable for detecting thin layers of biomolecules , in this case a suspended lipid bilayer incorporating transmembrane proteins. See the article by Maynard et al. on p. 1542 of this issue (http://dx.doi.org/10.1002/biot.200900195). [source] Soyprotein fibers with high strength and water stability for potential medical applicationsBIOTECHNOLOGY PROGRESS, Issue 6 2009Narendra Reddy Abstract Fibers with mechanical properties and water stability suitable for tissue engineering have been developed from soyproteins. Proteins are biocompatible and biodegradable and are preferred over synthetic polymers for medical applications. Although plant proteins are abundant and inexpensive and can be made into various types of scaffolds, very few attempts have been made to understand the suitability of using plant proteins for medical applications, especially as fibrous substrates for tissue engineering. So far, it has not been able to obtain good quality soyprotein fibers without using toxic crosslinking agents or blending soyprotein with synthetic polymers. In this research, we have developed 100% soyprotein fibers with good strength and water stability without using any external crosslinking agents. The soyprotein fibers have better wet strength than collagen fibers and are conducive to the attachment, growth, and proliferation of mouse fibroblasts. Fibers are better substrates than films for growth and orientation of cells and are therefore preferable for tissue engineering applications. Soyprotein fibers show good potential to be novel biomaterials with properties suitable for tissue engineering and other medical applications. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009 [source] |