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Promising Perspectives (promising + perspective)
Selected AbstractsPrevention and control of biofilm-based medical-device-related infectionsFEMS IMMUNOLOGY & MEDICAL MICROBIOLOGY, Issue 3 2010Iolanda Francolini Abstract Biofilms play a pivotal role in healthcare-associated infections, especially those related to the implant of medical devices, such as intravascular catheters, urinary catheters and orthopaedic implants. This paper reviews the most successful approaches for the control and prevention of these infections as well as promising perspectives for the development of novel devices refractory to microbial adhesion, colonization and biofilm formation. [source] Morphological characterization of GFP stably transfected adult mesenchymal bone marrow stem cellsJOURNAL OF ANATOMY, Issue 1 2006Stefania Raimondo Abstract Increasing attention is being given to the use of adult rather than embryonic stem cells, both for research and for the development of transplantation treatments for human disease. In particular, mesenchymal bone marrow stem cells have been studied extensively because of their ability to self-renew and to give rise to various differentiated cell types, and because of the relative ease with which they can be obtained and cultured. In addition, the possibility of labelling stem cells with green fluorescent protein before transplantation has opened new and promising perspectives for their use in basic research. Because no structural or ultrastructural description of adult mesenchymal stem cells is available in the literature, this paper describes their morphology as revealed by light, confocal and electron microscopy, focusing on cells that are particularly suitable for transplantation studies, i.e. those derived from rat bone marrow transfected with green fluorescent protein. The results provide a basis for experimental studies of the differentiation of these cells in normal and pathological tissues. [source] Sibling cannibalism in dorada under experimental conditions.JOURNAL OF FISH BIOLOGY, Issue 4 2000II. Effect of initial size heterogeneity, light regime on early cannibalism Cannibalism among embryos and larvae of Brycon moorei (Characidae) occurs during daytime and night-time, and persists under permanent darkness. Embryos and larvae of dorada-provisioned with formulated feed over the first week of exogenous feeding did not survive, except for those exerting cannibalism. When offered alternative fish prey [embryos of Prochilodus magdalenae (0·5,0·8 mg) and Oreochromis niloticus (9,10 mg)], 1-day-old embryos of dorada preferred preying on these, thereby reducing early cannibalism. However, this promoted depensatory growth and more intense cannibalism later in the larval stage. Dorada provisioned with Artemia nauplii in excess showed more homogeneous growth and higher survival, most cannibalistic acts being restricted to the first 24 h of exogenous feeding, just after oral teeth were fully developed (21 h after hatching). Provisioning dorada with Artemia nauplii a few hours before their oral teeth were fully developed reduced early cannibalism from 41 to 15%. High proportions of deformed fish caused higher mortality, both directly and indirectly, as they promoted early cannibalism, depensatory growth and more intense cannibalism among larvae. The initial sorting of embryos, based on their occupation of the water column improved survival significantly during the first week of exogenous feeding, up to 52% in progenies containing <10% of deformed fish. Size-grading of larvae and young juveniles over the next 2 weeks reduced cannibalism to 2·6 and 1·9% day,, in the first and second weeks, respectively. These results indicate that cannibalism in dorada can be mitigated efficiently through appropriate rearing procedures, and open promising perspectives for the intensive culture of this fast-growing tropical species. [source] The disposition of free and niosomally encapsulated Rac-flurbiprofen in dairy bovinesJOURNAL OF VETERINARY PHARMACOLOGY & THERAPEUTICS, Issue 1 2010E. O. CONFALONIERI Confalonieri, E. O., Soraci, A. L., Becaluba, M., Denzoin, L., Rodriguez, E., Riccio, B., Tapia, O. The disposition of free and niosomally encapsulated Rac-flurbiprofen in dairy bovines. J. vet. Pharmacol. Therap. 33, 9,14. Pharmacokinetic parameters were established for flurbiprofen (FBP) after intravenous (i.v.) administration (0.5 mg/kg) of niosomal and nonniosomal formulations in dairy cattle. Niosomes of FBP showed a drug loading of 92.0 ± 0.7% and the intravenous administration of the FBP niosomes to dairy cattle did not produce any immunological reaction associated to niosomal components. Niosomal FBP was slowly eliminated from plasma and mean residual time (MRT) and AUC0,t and t 1/2 values were significantly higher than those for non niosomal FBP formulations. The results presented in this study indicate that the long circulation of FBP niosomes offers a potential application for improving the pharmacokinetic parameters of short half-life drugs for clinical use. Niosomes offer new promising perspectives of drug delivery modules in bovine therapeutics. [source] | ||||||||||