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Primate Studies (primate + studies)
Selected AbstractsTolerance and near-tolerance strategies in monkeys and their application to human renal transplantationIMMUNOLOGICAL REVIEWS, Issue 1 2001Stuart J. Knechtle Summary: Studies in non-human primates to evaluate tolerance strategies in organ transplantation have led to innovation in human transplantation. The two strategies we have studied in detail in non-human primates are T-cell depletion by anti-CD3 immunotoxin and co-stimulation blockade. Each of these strategies has been extended into early human trials in renal transplantation. The results of these human and non-human primate studies are summarized. Continued progress in better and safer immunosuppressive methods remains closely linked to research using non-human primates. However, there has not been a one-to-one correspondence between efficacy in the primate and efficacy in humans. Rather, principles can be derived from non-human primate studies that can be extended into human trials with the knowledge that regimens will likely differ in humans compared to non-human primates. [source] Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primatesIMMUNOLOGICAL REVIEWS, Issue 1 2001Sean P. Montgomery Summary: Non-human primate studies of tolerance induction strategies in solid organ transplantation represent a critical bridge between studies in rodents and humans. Our work demonstrates that strategies involving the blockade of co-stimulatory molecules, especially the CD40,CD154 pathway, have great potential for clinical adaptation. While the combination of anti-CD154 antibody with blockade of the CD28 pathway reduced donor antibody production, graft survival was not significantly improved over that achieved with anti-CD154 antibody alone. Moreover, although long courses of steroids seem to interfere with this approach, it may be possible to combine blockade of the CD40,CD154 pathway with other conventional immunosuppressants without sacrificing efficacy. This is a key issue for reducing the risk associated with eventual clinical trials. Work in the non-human primate islet transplant model demonstrates that viable islets can be recovered, isolated and infused in a reliable fashion. It also confirms the efficacy of a steroid sparing approach to immunosuppression for islet transplantation. These data have been expanded to the kidney allograft model, setting the stage for kidney islet transplantation studies. Overall, tolerance induction and islet transplant studies in non-human primates permit the preclinical screening of promising immunomodulatory approaches developed in rodents and reduce the inherent uncertainties associated with adapting new regimens to the clinic. [source] Forest fragmentation and primates' survival status in non-reserved forests of the ,Kampala area', UgandaAFRICAN JOURNAL OF ECOLOGY, Issue 2004D. BarangaArticle first published online: 17 AUG 200 Abstract Previous primate studies have concentrated on the effects of forest disturbance on primate populations residing mainly in natural forest reserves. The present study was conducted in 20 non-reserved forest patches in the ,Kampala area', a forest-savanna-agricultural mosaic, to investigate the effects of forest fragmentation on the distribution and survival status of arboreal primates in the patches. Mpanga Forest Reserve, as the nearest to the forest patches, was used as a control. Primate census data revealed that the black-and-white colobus (Colobus guereza) was restricted in its distribution while redtail monkeys (Cercopithecus ascanius schmidti) were cosmopolitan. There was no significant relationship between forest patch size and red-tail population size, number of groups and group density decreased. Of the trees sampled, 70% were food species while 30% were nonfood species. Basal area of food tree species significantly increased with forest patch size (R2 = 0.5885) but its relationship with red-tail population size and group density (B = ,0.42784, R2 = 0.18305, P >,0.05) was not significant. [source] Effects of reproductive condition and dominance rank on cortisol responsiveness to stress in free-ranging female rhesus macaquesAMERICAN JOURNAL OF PRIMATOLOGY, Issue 7 2010Christy L. Hoffman Abstract The hypothalamic,pituitary,adrenal (HPA) axis modulates individuals' physiological responses to social stress, which is an inevitable aspect of the daily lives of group-living animals. Previous nonhuman primate studies have reported that sex, age, rank, and reproductive condition influence cortisol levels under stressful conditions. In this study we investigated cortisol responses to stress among 70 multiparous, free-ranging female rhesus macaques (Macaca mulatta) on the island of Cayo Santiago, PR. Plasma cortisol samples were collected in two consecutive years under similar conditions. Twenty-two females were sampled both years, and most of those females were lactating in only one of the years. Individual differences in cortisol levels were stable across years, even though reproductive condition changed for most individuals. No relationship was found between age or social rank and cortisol levels. Of the females that changed reproductive conditions, cortisol levels were higher when they were lactating than when they were cycling, and the amount of change in cortisol from cycling to lactating was greatest for low-ranking individuals. Heightened reactivity to stress during lactation may be the result of concerns about infant safety, and such concerns may be higher among low-ranking mothers than among higher ranking mothers. Psychosocial stress and hyperactivation of the HPA axis during lactation can suppress immune function and increase vulnerability to infectious diseases, thus explaining why adult females in the free-ranging rhesus macaque population on Cayo Santiago have a higher probability of mortality during the birth season than during the mating season. Am. J. Primatol. 72:559,565, 2010. © 2009 Wiley-Liss, Inc. [source] The unique value of primate models in translational researchAMERICAN JOURNAL OF PRIMATOLOGY, Issue 9 2009Carol A. Shively Abstract This special issue of AJP is focused on research using nonhuman primates as models to further the understanding of women's health. Nonhuman primates play a unique role in translational science by bridging the gap between basic and clinical investigations. The use of nonhuman primates in biomedical research challenges our resolve to treat all life as sacred. The scientific community has responded by developing ethical guidelines for the care and the use of primates and clarifying the responsibility of investigators to insure the physical and psychological well-being of nonhuman primates used in research. Preclinical investigations often involve the use of animal models. Rodent models have been the mainstay of biomedical science and have provided enormous insight into the workings of many mammalian systems that h ave proved applicable to human biological systems. Rodent models are dissimilar to primates in numerous ways, which may limit the generalizability to human biological systems. These limitations are much less likely in nonhuman primates and in Old World primates, in particular, Macaques are useful models for investigations involving the reproductive system, bioenergetics, obesity and diabetes, cardiovascular health, central nervous system function, cognitive and social behavior, the musculoskeletal system, and diseases of aging. This issue considers primate models of polycystic ovary syndrome; diet effects on glycemic control, breast and endometrium; estrogen, reproductive life stage and atherosclerosis; estrogen and diet effects on inflammation in atherogenesis; the neuroprotective effects of estrogen therapy; social stress and visceral obesity; and sex differences in the role of social status in atherogenesis. Unmet research needs in women's health include the use of diets in nonhuman primate studies that are similar to those consumed by human beings, primate models of natural menopause, dementia, hypertension, colon cancer, and frailty in old age, and dedicated colonies for the study of breast cancer. Am. J. Primatol. 71:715,721, 2009. © 2009 Wiley-Liss, Inc. [source] Histologic Findings from Positive Crossmatch or ABO-Incompatible Renal Allografts: Accomodation or Chronic Allograft Injury?AMERICAN JOURNAL OF TRANSPLANTATION, Issue 8 2006B. Sis In human and primate studies, the presence of circulating antibody and C4d staining is associated with a variety of clinical phenotypes ranging from minimal to fulminant. But even when the clinical findings are minimal the time dependency of some of these phenotypes should invite caution before predicting the risk of future problems in an organ with C4d and circulating donor-specific antibody. See also articles by Haas et al on page 1829, Colvin et al on page 1790, Gloor et al in this issue on page 1841, and the minireview by Soleimani et al in this issue on page 1781. [source] | |||||||||||||