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Primary Means (primary + mean)
Selected AbstractsDefending Byzantine Spain: frontiers and diplomacyEARLY MEDIEVAL EUROPE, Issue 3 2010Jamie Wood The centrality of the Reconquista in the historiography of medieval Spain has meant that there has been little examination of the evidence for interaction on and across political boundaries in pre-Islamic Spain. This article re-examines existing theories about the defence of the Byzantine province of Spania that had been established by Justinian in the 550s and was taken by the Visigoths in 625. The two existing and opposing models for the extent, defence, and , therefore , the importance of the province to the empire do not explain the evidence convincingly. Rather, a fluid zone of interaction was established in which diplomacy and ,propaganda' was the primary means by which opposition was articulated. [source] Behavioural responses of a south-east Australian floodplain fish community to gradual hypoxiaFRESHWATER BIOLOGY, Issue 3 2007DALE G. MCNEIL Summary 1. Hypoxic conditions occur frequently during hot, dry summers in the small lentic waterbodies (billabongs) that occur on the floodplains of the Murray-Darling River system of Australia. Behavioural responses to progressive hypoxia were examined for the native and introduced floodplain fish of the Ovens River, an unregulated tributary of the Murray River in south-east Australia. 2. Given the high frequency of hypoxic episodes in billabongs on the Ovens River floodplain, it was hypothesised that all species would exhibit behaviours that would confer a degree of hypoxia-tolerance. Specifically, it was hypothesised that as hypoxia progressed, gill ventilation rates (GVRs) would increase and aquatic surface respiration (ASR) would become increasingly frequent. Fish were subjected to rapid, progressive hypoxia from normoxia to anoxia in open tanks. 3. All tested species exhibited behaviours consistent with their use of potentially hypoxic habitats. As hypoxia progressed, GVRs increased and all species, with the exception of oriental weatherloach, began to switch increasingly to ASR with 90% of individuals using ASR at various oxygen concentrations below 1.0 mg O2 L,1. Australian smelt, redfin perch and flat-headed galaxias were the first three species to rise to ASR, with 10% of individuals using ASR by 2.55, 2.29 and 2.21 mg O2 L,1 respectively. Goldfish and common carp were the last two species to rise to ASR, with 10% of individuals using ASR by 0.84 and 0.75 mg O2 L,1 respectively. In contrast to other species, oriental weatherloach largely ceased gill ventilation and used air-gulping as their primary means of respiration during severe hypoxia and anoxia. 4. Australian smelt, redfin perch and flat-headed galaxias were unable to maintain ASR under severe hypoxia, and began exhibiting erratic movements, termed terminal avoidance behaviour, and loss of equilibrium. All other species continued to use ASR through severe hypoxia and into anoxia. Following a rise to ASR, GVRs either remained steady or decreased slightly indicating partial or significant relief from hypoxic stress for these hypoxia-tolerant species. 5. Behavioural responses to progressive hypoxia amongst the fish species of the Ovens River floodplain indicate a generally high level of tolerance to periodic hypoxia. However, species-specific variation in hypoxia-tolerance may have implications for community structure of billabong fish communities following hypoxic events. [source] The role of nutrients in modulating diseaseJOURNAL OF SMALL ANIMAL PRACTICE, Issue 6 2008D. L. Chan The role of nutrition in the management of diseases has often centred on correcting apparent nutrient deficiencies or meeting estimated nutritional requirements of patients. Nutrition has traditionally been considered a supportive measure akin to fluid therapy and rarely it has been considered a primary means of ameliorating diseases. Recently, however, further understanding of the underlying mechanisms of various disease processes and how certain nutrients possess pharmacological properties have fuelled an interest in exploring how nutritional therapies themselves could modify the behaviour of various conditions. Nutrients such as omega-3 fatty acids, antioxidants and certain amino acids such as arginine and glutamine have all been demonstrated to have at least the potential to modulate diseases. Developments in the area of critical care nutrition have been particularly exciting as nutritional therapies utilising a combination of approaches have been shown to positively impact outcome beyond simply proving substrate for synthesis and energy. Application of certain nutrients for the modulation of diseases in veterinary patients is still in early stages, but apparent successes have already been demonstrated, and future studies are warranted to establish optimal approaches. This review describes the rationale of many of these approaches and discusses findings both in human beings and in animals, which may guide future therapy. [source] Bayesian change-point analysis for atomic force microscopy and soft material indentationJOURNAL OF THE ROYAL STATISTICAL SOCIETY: SERIES C (APPLIED STATISTICS), Issue 4 2010Daniel Rudoy Summary., Material indentation studies, in which a probe is brought into controlled physical contact with an experimental sample, have long been a primary means by which scientists characterize the mechanical properties of materials. More recently, the advent of atomic force microscopy, which operates on the same fundamental principle, has in turn revolutionized the nanoscale analysis of soft biomaterials such as cells and tissues. The paper addresses the inferential problems that are associated with material indentation and atomic force microscopy, through a framework for the change-point analysis of pre-contact and post-contact data that is applicable to experiments across a variety of physical scales. A hierarchical Bayesian model is proposed to account for experimentally observed change-point smoothness constraints and measurement error variability, with efficient Monte Carlo methods developed and employed to realize inference via posterior sampling for parameters such as Young's modulus, which is a key quantifier of material stiffness. These results are the first to provide the materials science community with rigorous inference procedures and quantification of uncertainty, via optimized and fully automated high throughput algorithms, implemented as the publicly available software package BayesCP. To demonstrate the consistent accuracy and wide applicability of this approach, results are shown for a variety of data sets from both macromaterials and micromaterials experiments,including silicone, neurons and red blood cells,conducted by the authors and others. [source] Ion channel remodeling in gastrointestinal inflammationNEUROGASTROENTEROLOGY & MOTILITY, Issue 10 2010H. I. Akbarali Abstract Background,Gastrointestinal inflammation significantly affects the electrical excitability of smooth muscle cells. Considerable progress over the last few years have been made to establish the mechanisms by which ion channel function is altered in the setting of gastrointestinal inflammation. Details have begun to emerge on the molecular basis by which ion channel function may be regulated in smooth muscle following inflammation. These include changes in protein and gene expression of the smooth muscle isoform of L-type Ca2+ channels and ATP-sensitive K+ channels. Recent attention has also focused on post-translational modifications as a primary means of altering ion channel function in the absence of changes in protein/gene expression. Protein phosphorylation of serine/theronine or tyrosine residues, cysteine thiol modifications, and tyrosine nitration are potential mechanisms affected by oxidative/nitrosative stress that alter the gating kinetics of ion channels. Collectively, these findings suggest that inflammation results in electrical remodeling of smooth muscle cells in addition to structural remodeling. Purpose,The purpose of this review is to synthesize our current understanding regarding molecular mechanisms that result in altered ion channel function during gastrointestinal inflammation and to address potential areas that can lead to targeted new therapies. [source] An Experiment in Personalist Politics: The Catholic Worker Movement and Nonviolent ActionPEACE & CHANGE, Issue 1 2001Patrick G. Coy The Catholic Worker movement, co-founded by Dorothy Day in 1933, is well known for its hospitality work with the urban poor. Less examined is the Worker movement's steadfast commitment to nonviolent action as its primary means of political engagement. How has the movement managed to sustain this often costly commitment for nearly seventy years? The answer lies in an analysis of five aspects of Catholic Worker life and thought: Biblical earnestness, personalism, solidarity with the poor through hospitality, living in community, and membership turnover. [source] Covenantal and contractual values in marriage: Marital Values Orientation toward Wedlock or Self-actualization (Marital VOWS) ScalePERSONAL RELATIONSHIPS, Issue 3 2005JENNIFER S. RIPLEY Cultural constructions of marriage have developed to form 2 marital values orientations. These marital values can be understood along a continuum from covenantal at 1 pole to contractual at the other pole. Covenantal marital values prioritize individual sacrifice for the marriage to promote marital health, commitment, and vow taking to resolve conflict, the collective dyad as the primary unit of the marriage, and often spiritual intervention as a primary means of restoring order. Contractual marital values prioritize individual self-actualization to promote marital health, negotiation, and mutual agreement to resolve conflict, the individual as the primary unit of the marriage, and clinical and psychological interventions as a primary means of restoring order. The authors developed a 26-item scale to measure contractual and covenantal marital values. In 3 studies examining a total of 786 student and community participants, the factor structure of the scale was evaluated, and convergent and discriminant construct validity, item internal consistency, and 4-week test,retest reliability were examined. [source] Cross-border ,Traffic': Stories of dangerous victims, pure whores and HIV/AIDS in the experiences of mainland female sex workers in Hong KongASIA PACIFIC VIEWPOINT, Issue 1 2005Kevin D. Ming Abstract:,In recent years, dramatically increasing numbers of mainland Chinese women have entered Hong Kong to engage in sexual labour. Public discourses on the threat of HIV/AIDS increasingly locate these women's bodies as sites of danger, colluding with pre-existing imaginations of mainland rural women as ignorant, desperate and deceptive in representing these women's penetration of Hong Kong's border as a primary means of infection of the Hong Kong body. Drawing on state, media and popular representations, and the narratives of female sex workers themselves, this paper examines the interwoven bio-medical, gendered, sexual and cross-border relationships that intersect in the experiences of mainland Chinese sex workers in Hong Kong. I argue that while images of disease and danger have been used to regulate these women's bodies, mainland female sex workers challenge these images by drawing on other popular stereotypes of mainland women as pure, feminine and traditional. Although images of the related but still ,other' figure of the mainland Chinese woman are powerful mechanisms for the regulation of these women's bodies, mainland female sex workers skilfully use inherent tensions in those images in resisting that control and in struggling to achieve their own personal and economic goals. [source] The effect of continuous culture on the growth and structure of tissue-engineered cartilageBIOTECHNOLOGY PROGRESS, Issue 2 2009Aasma A. Khan Abstract The use of bioreactors for cartilage tissue engineering has become increasingly important as traditional batch-fed culture is not optimal for in vitro tissue growth. Most tissue engineering bioreactors rely on convection as the primary means to provide mass transfer; however, convective transport can also impart potentially unwanted and/or uncontrollable mechanical stimuli to the cells resident in the construct. The reliance on diffusive transport may not necessarily be ineffectual as previous studies have observed improved cartilaginous tissue growth when the constructs were cultured in elevated volumes of media. In this study, to approximate an infinite reservoir of media, we investigated the effect of continuous culture on cartilaginous tissue growth in vitro. Isolated bovine articular chondrocytes were seeded in high density, 3D culture on MillicellÔ filters. After two weeks of preculture, the constructs were cultivated with or without continuous media flow (5,10 ,L/min) for a period of one week. Tissue engineered cartilage constructs grown under continuous media flow significantly accumulated more collagen and proteoglycans (increased by 50,70%). These changes were similar in magnitude to the reported effect of through-thickness perfusion without the need for large volumetric flow rates (5,10,L/min as opposed to 240,800 ,L/min). Additionally, tissues grown in the reactor displayed some evidence of the stratified morphology of native cartilage as well as containing stores of intracellular glycogen. Future studies will investigate the effect of long-term continuous culture in terms of extracellular matrix accumulation and subsequent changes in mechanical function. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009 [source] Strength in Networks: Employment Rights Organizations and the Problem of Co-OrdinationBRITISH JOURNAL OF INDUSTRIAL RELATIONS, Issue 4 2006Charles Heckscher In recent decades, alternative organizations and movements ,,quasi-unions', have emerged to fill gaps in the US system of representation caused by union decline. We examine the record of quasi-unions and find that although they have sometimes helped workers who lack other means of representation, they have significant limitations and are unlikely to replace unions as the primary means of representation. But networks, consisting of sets of diverse actors including unions and quasi-unions, are more promising. They have already shown power in specific campaigns, but they have yet to do so for more sustained strategies. By looking at analogous cases, we identify institutional bases for sustained networks, including shared information platforms, behavioural norms, common mission and governance mechanisms that go well beyond what now exists in labour alliances and campaigns. There are substantial resistances to these network institutions because of the history of fragmentation and autonomy among both unions and quasi-unions; yet we also identify positive potential for network formation. [source] Agriculture's Likely Role in Meeting Canada's Kyoto Commitments,CANADIAN JOURNAL OF AGRICULTURAL ECONOMICS, Issue 4 2005Alfons Weersink Voluntary adoption of beneficial management practices will be the primary means by which farmers cut net greenhouse gas (GHG) emissions. The offset system will not be a major driver due to (a) the relatively low prices likely to be offered by large final emitters facing an emission cap, (b) discounts applied to those prices for temporary sequestration, (c) the transaction costs and risk premiums associated with signing carbon contracts, and (d) the low elasticity of supply of CO2 abatement. Although Canadian farmers are likely to participate to only a limited extent in the carbon-offset market, many will find it profitable to adopt one or more of the BMPs for reducing net GHG emissions. Canadian agriculture is likely to contribute significantly to net emission reductions by voluntarily sequestering carbon due to the adoption of zero till in the last decade, and possibly by cutting fertilizer levels in the next decade. The contribution will be mainly a response to meeting personal economic objectives rather than being induced by direct incentives through the offset program. L'adoption volontaire de pratiques de gestion bénéfiques (PGB) sera le principal moyen dont les producteurs disposeront pour diminuer les émissions de gaz à effet de serre (GES). Le système de compensation des GES ne constituera pas un facteur de motivation important pour les raisons suivantes: a) les faibles prix qu'offriront probablement les grands émetteurs finaux confrontés à un plafond d'émissions; b) les escomptes appliqués à ces prix pour la séquestration temporaire; c) les coûts de transaction et les primes de risque associés à la conclusion de contrats de réduction des émissions de carbone; d) la faible élasticité de l'offre de réduction du CO2. Bien que la participation des producteurs canadiens au marché de contrepartie de la fixation du carbone sera probablement limitée, de nombreux producteurs trouveront qu'il est rentable d'adopter une ou plusieurs PGB pour réduire l'émission nette de GES. L'apport de l'agriculture canadienne à la réduction nette des émissions sera probablement important compte tenu de la séquestration volontaire du carbone découlant de l'adoption du semis direct au cours de la dernière décennie et de la diminution probable des concentrations de fertilisants au cours de la prochaine décennie. L'apport sera principalement liéà l'atteinte d'objectifs économiques personnels plutôt qu'aux incitatifs directs du programme de contrepartie de la fixation du carbone. [source] | |||||||||||||||||||