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Terms modified by Primary Data Selected AbstractsMortuary Rituals in Japan: The Hegemony of Tradition and the Motivations of IndividualsETHOS, Issue 3 2006Yohko Tsuji Despite rapid social change, traditional mortuary rituals persist in contemporary Japan, and most Japanese ascribe their continuous compliance with tradition to cultural hegemony. In this article, I explore various other motivational forces behind their actions and illustrates how external pressures and individuals' internal motivations are intricately intertwined to generate human behavior. To do so, I consider the social and personal significance of Japanese funerals, examining rituals not only as an embodiment of sociocultural order but also as a culturally prescribed means to legitimize individuals' actions and define their identity. I also demonstrate the multiplicity and fluidity of cultural discourse and the malleability of tradition as well as individuals' active roles in perpetuating and altering mortuary tradition. Primary data were gathered from participant-observation research in Japan since 1988. [funerals, gift exchange, culture and the individual, motivations, identity, Japan] [source] An evidence-based specialist breast nurse role in practice: a multicentre implementation studyEUROPEAN JOURNAL OF CANCER CARE, Issue 1 2003National breast cancer centre's specialist breast nurse project team The objective of this study was to examine the feasibility, implementation, acceptability and impact of an evidence-based specialist breast care nurse (SBN) model of care in Australia. Primary data were collected from four diverse Australian breast cancer treatment centres over a 12-month period. The design was a multicentre demonstration project. Information about the provision of care and patient needs was collected through prospective logs. Structured interviews were conducted with women who received the SBN intervention (N = 167) and with a control group of women treated prior to the intervention period (N = 133). Health professionals (N = 47) were interviewed about their experience of the SBN. Almost all women had contact with an SBN at five scheduled consultations and 67% of women in the intervention group requested at least one additional consultation with the SBN. Women in the intervention group were more likely to receive hospital fact sheets and to be told about and participate in clinical trials. Ninety-eight per cent of women reported that the availability of an SBN would affect their choice of hospital, with 48% indicating that they would recommend only a hospital with a SBN available. Health professionals reported that SBNs improved continuity of care, information and support for the women, and resulted in more appropriate referrals and use of the time of other members of the team. In conclusion, the SBN model is feasible and acceptable within diverse Australian treatment centres; there is evidence that some aspects of care were improved by the SBN. [source] High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strainsGENES, BRAIN AND BEHAVIOR, Issue 2 2010V. M. Philip Genetic reference populations, particularly the BXD recombinant inbred (BXD RI) strains derived from C57BL/6J and DBA/2J mice, are a valuable resource for the discovery of the bio-molecular substrates and genetic drivers responsible for trait variation and covariation. This approach can be profitably applied in the analysis of susceptibility and mechanisms of drug and alcohol use disorders for which many predisposing behaviors may predict the occurrence and manifestation of increased preference for these substances. Many of these traits are modeled by common mouse behavioral assays, facilitating the detection of patterns and sources of genetic coregulation of predisposing phenotypes and substance consumption. Members of the Tennessee Mouse Genome Consortium (TMGC) have obtained phenotype data from over 250 measures related to multiple behavioral assays across several batteries: response to, and withdrawal from cocaine, 3,4-methylenedioxymethamphetamine; "ecstasy" (MDMA), morphine and alcohol; novelty seeking; behavioral despair and related neurological phenomena; pain sensitivity; stress sensitivity; anxiety; hyperactivity and sleep/wake cycles. All traits have been measured in both sexes in approximately 70 strains of the recently expanded panel of BXD RI strains. Sex differences and heritability estimates were obtained for each trait, and a comparison of early (N = 32) and recent (N = 37) BXD RI lines was performed. Primary data are publicly available for heritability, sex difference and genetic analyses using the MouseTrack database, and are also available in GeneNetwork.org for quantitative trait locus (QTL) detection and genetic analysis of gene expression. Together with the results of related studies, these data form a public resource for integrative systems genetic analysis of neurobehavioral traits. [source] Comparing Safety Climate between Two Populations of Hospitals in the United StatesHEALTH SERVICES RESEARCH, Issue 5p1 2009Sara J. Singer Objective. To compare safety climate between diverse U.S. hospitals and Veterans Health Administration (VA) hospitals, and to explore the factors influencing climate in each setting. Data Sources. Primary data from surveys of hospital personnel; secondary data from the American Hospital Association's 2004 Annual Survey of Hospitals. Study Design. Cross-sectional study of 69 U.S. and 30 VA hospitals. Data Collection. For each sample, hierarchical linear models used safety-climate scores as the dependent variable and respondent and facility characteristics as independent variables. Regression-based Oaxaca,Blinder decomposition examined differences in effects of model characteristics on safety climate between the U.S. and VA samples. Principal Findings. The range in safety climate among U.S. and VA hospitals overlapped substantially. Characteristics of individuals influenced safety climate consistently across settings. Working in southern and urban facilities corresponded with worse safety climate among VA employees and better safety climate in the U.S. sample. Decomposition results predicted 1.4 percentage points better safety climate in U.S. than in VA hospitals: ,0.77 attributable to sample-characteristic differences and 2.2 due to differential effects of sample characteristics. Conclusions. Results suggest that safety climate is linked more to efforts of individual hospitals than to participation in a nationally integrated system or measured characteristics of workers and facilities. [source] Survey Conditioning in Self-Reported Mental Health Service Use: Randomized Comparison of Alternative Instrument FormatsHEALTH SERVICES RESEARCH, Issue 2 2007Naihua Duan Objective. To test the effect of survey conditioning (whether observed survey responses are affected by previous experience in the same survey or similar surveys) in a survey instrument used to assess mental health service use. Data Sources. Primary data collected in the National Latino and Asian American Study, a cross-sectional household survey of Latinos and Asian Americans residing in the United States. Study Design. Study participants are randomly assigned to a Traditional Instrument with an interleafed format placing service use questions after detailed questions on disorders, or a Modified Instrument with an ensemble format screening for service use near the beginning of the survey. We hypothesize the ensemble format to be less susceptible to survey conditioning than the interleafed format. We compare self-reported mental health services use measures (overall, aggregate categories, and specific categories) between recipients of the two instruments, using 2 × 2 ,2 tests and logistic regressions that control for key covariates. Data Collection. In-person computer-assisted interviews, conducted in respondent's preferred language (English, Spanish, Mandarin Chinese, Tagalog, or Vietnamese). Principal Findings. Higher service use rates are reported with the Modified Instrument than with the Traditional Instrument for all service use measures; odds ratios range from 1.41 to 3.10, all p -values <.001. Results are similar across ethnic groups and insensitive to model specification. Conclusions. Survey conditioning biases downward reported mental health service use when the instrument follows an interleafed format. An ensemble format should be used when it is feasible for measures that are susceptible to survey conditioning. [source] Globalization vs. localization: global food challenges and local solutionsINTERNATIONAL JOURNAL OF CONSUMER STUDIES, Issue 3 2010Quaye Wilhelmina Abstract The objective of this study was to examine the effect of global,local interactions on food production and consumption in Ghana, and identify possible local solutions. Primary data were collected using a combination of quantitative-qualitative methods, which included focus group discussions and one-on-one interviews. Approximately 450 household heads were randomly selected and interviewed between August 2007 and August 2008 in Eastern, Central, Upper East and Northern Regions of Ghana. Findings revealed increasing consumption of foreign rice as opposed to decreasing consumption of local rice and other staples like millet, sorghum and yam because of global,local interactions. However, opportunities exist to re-localize production-consumption patterns through the use of ,glocal foods' like improved ,koose and waakye'. Referencing the situation in Ghana, the study recommends improved production and processing practices backed with appropriate technologies that reflect changing consumption dynamics in order to take full advantage of opportunities created as a result of global,local interactions. [source] A contingency approach to reward strategy in the UK not-for-profit sectorINTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 4 2000Anjali Bakhru The word ,charity' is derived from the Latin word ,caritas', meaning love of other people or beneficence and liberality to those in distress. It is argued, however, that as organisations within the charity or not-for-profit (NFP) sector become more commercial or ,business-like', the greater is the imperative to focus on effectiveness as well as efficiency. In terms of an organisation's reward strategy, it is critical that individual performance is assessed and linked to rewards. The aim of the paper is essentially to examine current approaches to reward strategy in the UK voluntary sector as well as to assess the ,effectiveness' of existing reward strategies, making suggestions as to how a ,best practice' approach could be adopted. Primary data were gathered from organisations within the NFP sector, and it was concluded that the sector needs to question the ,effectiveness' of reward strategies, to link individual performance objectives with its reward strategy, and to move away from pure cost-efficiency considerations to ensure that there is a balance between long-term and short-term objectives. At the same time, a ,best practice' approach for reward strategies within the NFP sector cannot be prescriptive in terms of suggesting ,one best way', but rather a contingency approach is recommended with regard to the selection of the mix of financial and non-financial factors within the reward strategy. Copyright © 2000 Henry Stewart Publications. [source] Study of Gerontological Nursing CurriculumNURSING & HEALTH SCIENCES, Issue 3 2002S.J. Chon The purpose of this study was: (i) to survey the present status of the gerontological nursing course in 3-year diploma programs, baccalaureate degree programs (BSN), and graduate programs in Korea; and (ii) to analyze the contents of the syllabus, credits, clinical practise, and gerontological nursing textbooks used within these programs, so as to provide basic data for developing a standard model for a gerontological nursing curriculum. Primary data were collected from all the nursing programs in Korea, from November 2000 to February 2001, by way of mail and fax. Data on the detailed contents of the gerontological nursing curriculum were collected from those programs that had a gerontological nursing course. The results of the study revealed that 36 diploma programs (58%), 40 BSN (80%), and 17 graduate programs (63%) offered gerontological nursing courses. The credits of the gerontological nursing course offered, by program, were found to be: one credit (10 diploma programs, eight BSN programs), two credits (22 diploma programs, 29 BSN programs) and three credits (one BSN program). The gerontological nursing courses were found to be taught mostly by adult health nursing professors. The contents of gerontological nursing curricula were analyzed by comparison with the core curriculum of NGNA. The majority of the nursing schools were found to include the following: gerontological nursing in general; theory of aging; aging processes; care plan options; and common health problems. Legal/ethical issues; evaluation; regulatory and reimbursement issues; education issues; nursing research in gerontology; and environment issues of older adults were not covered in most of the programs. Differences were noted between ADN, BSN, and graduate school curricula. However, similar curriculum contents were found among the undergraduate programs, suggesting that these curricula used gerontological nursing textbooks as references. [source] Site-directed PEGylations of Thymosin , 1 Analogs and Evaluation of Their ImmunoactivityCHINESE JOURNAL OF CHEMISTRY, Issue 4 2009Jiankun QIE Abstract PEGylation is an effective way to improve the pharmacokinetic profiles of pharmaceutical proteins or peptides. But the relatively large and long PEG chains would be likely to shelter the active site of a small peptide because of its small size, compared with a protein. Therefore, the positions and numbers of PEGylation are crucial for the bioactivity of a PEGylated peptide. To elucidate the relationship between the PEGylated positions and bioactivity of a peptide drug, site-specific PEGylations were performed on Zadaxin (Thymosin , 1, T,1), which is a pharmaceutical peptide with an , -helix region, a , -turn region, and random coils. Site-specific mono-PEGylations of T,1 in different conformational regions were realized through introducing one cysteine residue into the desired positions of the peptide, followed by a coupling reaction with a thiol-attached maleimide-PEG reagent. Primary data from IFN- , production of splenocytes induced by Con A showed that the influence of PEGylation on Zadaxin was position-dependent, and mostly, positive effects were observed after PEGylation, which indicated that the position of PEGylation is important for maintaining the bioactivity of a peptide. [source] The Cost-Effectiveness of Independent Housing for the Chronically Mentally Ill: Do Housing and Neighborhood Features Matter?HEALTH SERVICES RESEARCH, Issue 5 2004Joseph Harkness Objective. To determine the effects of housing and neighborhood features on residential instability and the costs of mental health services for individuals with chronic mental illness (CMI). Data Sources. Medicaid and service provider data on the mental health service utilization of 670 individuals with CMI between 1988 and 1993 were combined with primary data on housing attributes and costs, as well as census data on neighborhood characteristics. Study participants were living in independent housing units developed under the Robert Wood Johnson Foundation Program on Chronic Mental Illness in four of nine demonstration cities between 1988 and 1993. Study Design. Participants were assigned on a first-come, first-served basis to housing units as they became available for occupancy after renovation by the housing providers. Multivariate statistical models are used to examine the relationship between features of the residential environment and three outcomes that were measured during the participant's occupancy in a study property: residential instability, community-based service costs, and hospital-based service costs. To assess cost-effectiveness, the mental health care cost savings associated with some residential features are compared with the cost of providing housing with these features. Data Collection/Extraction Methods. Health service utilization data were obtained from Medicaid and from state and local departments of mental health. Non-mental-health services, substance abuse services, and pharmaceuticals were screened out. Principal Findings. Study participants living in newer and properly maintained buildings had lower mental health care costs and residential instability. Buildings with a richer set of amenity features, neighborhoods with no outward signs of physical deterioration, and neighborhoods with newer housing stock were also associated with reduced mental health care costs. Study participants were more residentially stable in buildings with fewer units and where a greater proportion of tenants were other individuals with CMI. Mental health care costs and residential instability tend to be reduced in neighborhoods with many nonresidential land uses and a higher proportion of renters. Mixed-race neighborhoods are associated with reduced probability of mental health hospitalization, but they also are associated with much higher hospitalization costs if hospitalized. The degree of income mixing in the neighborhood has no effect. Conclusions. Several of the key findings are consistent with theoretical expectations that higher-quality housing and neighborhoods lead to better mental health outcomes among individuals with CMI. The mental health care cost savings associated with these favorable features far outweigh the costs of developing and operating properties with them. Support for the hypothesis that "diverse-disorganized" neighborhoods are more accepting of individuals with CMI and, hence, associated with better mental health outcomes, is mixed. [source] Mythico-History, Social Memory, and Praxis: Anthropological Approaches and DirectionsHISTORY COMPASS (ELECTRONIC), Issue 3 2009Susan Rasmussen This article explores the interface and tension between myth, history, and memory, in relation to ideology and praxis of identity. There is a critical overview of anthropological and other approaches in the humanities and social sciences to ,mythico-history' and social memory, their mutual influences, and current debates and directions in this literature. In particular, emphasis is upon the uses of oral narratives in historiography and social context in the constructions of personal and collective identities of difference, for example, ethnicity and gender in ,narratives of nation' and ,myths of matriliny' and their connections to social practice, drawing on secondary cross-cultural data and primary data from this anthropologist's research in Tuareg (Kel Tamajaq) communities of northern Niger and Mali. [source] Strategic stakeholder orientations and performance consequences,a case of private nonprofit performing arts in the USINTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 1 2010Jasper Hsieh This paper borrows a market orientation perspective in considering how organizations behave toward stakeholders and the implications on performance in the institutional performing arts environment. To investigate the relationship between stakeholder orientations and organizational performance, both interviews and a survey instrument were used. Using nonprofit performing arts organizations in three metropolitan areas of Northwestern US as a sample frame, primary data was collected from leading directors of these organizations. The results generally indicate a positive relationship between stakeholder orientation and organizational performance. Complex relationships between dimensions of stakeholder orientation and performance consequences were also observed. Copyright © 2009 John Wiley & Sons, Ltd. [source] Barriers to implementing e-learning: a Kuwaiti case studyINTERNATIONAL JOURNAL OF TRAINING AND DEVELOPMENT, Issue 1 2008Ghadah Essa Ali The paper reports on a research project that encompasses two key objectives: (1) finding out about the barriers affecting or preventing e-learning from being adopted by companies as an integral part of their workforce's training and learning processes and (2) establishing a comparison between the barriers and the e-learning implementation models found in Kuwait and in the practice of Western companies. The practices from Western countries are used as a benchmark for the Kuwaiti experience. The collection of the primary data was carried out through the use of semi-structured questionnaires with human resources managers as well as IT managers in charge of the e-learning of 11 of the largest companies in Kuwait. The research results show that the key implementation barriers in Kuwait are (1) lack of management support; (2) language barriers; (3) IT problems; and (4) workload and lack of time. From these, two are common to Western countries (technology and time). The remaining two (management support and language barriers) are specific to Kuwait. Regarding the comparison between the two implementation models, the key finding was that the usual e-learning development cycle (plan,design,integrate,improve) was not followed in Kuwait. The planning, designing and improving stages were largely ignored, with the emphasis resting almost completely on integrating the e-learning tools and processes in the rest of the organization. This finding was found to be in line with barrier number one , lack of management support. The key lesson learned from this research is that the problem of e-learning implementation in Kuwait is not so much one of knowing what the barriers are but one of knowing what the appropriate management processes should be for companies to achieve business success. The paper also provides recommendations for an e-learning development plan to fit the current business environment in Kuwait. [source] Vertical integration and cost behavior in poultry industry in Ogun and Oyo States of NigeriaAGRIBUSINESS : AN INTERNATIONAL JOURNAL, Issue 1 2009Olasunkanmi M. Bamiro In this article, the influence of vertical integration on cost behavior in poultry farming in southwestern Nigeria is examined. The study was based on primary data obtained in cross-section survey of 211 randomly selected poultry farms in the study area. An average farmer in the sample was 44 years old; 85% were males and 72% had tertiary education. An average poultry farm in the sample had 4,342 birds, about half of which were laying birds. A set of cost and revenue share equations estimated by Zellner's seemingly unrelated regression (SUR) method revealed that vertical integration (measured in proxy by value-added sales ratio) is feed and veterinary service using, labor saving, and output augmenting. However, the scale effect of vertical integration was found to be higher in layers production than what obtains in broilers and cock/cockerel productions. [EconLit citations: Q120, D240, R340]. © 2009 Wiley Periodicals, Inc. [source] Feasibility and cost-effectiveness of using magnification chromoendoscopy and pepsinogen serum levels for the follow-up of patients with atrophic chronic gastritis and intestinal metaplasiaJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 10 2007Mário Dinis-Ribeiro Abstract Background:, The follow-up of patients with atrophic chronic gastritis or intestinal metaplasia may lead to early diagnosis of gastric cancer. However, to-date no cost-effective model has been proposed. Improved endoscopic examination using magnification chromoendoscopy together with non-invasive functional assessment with pepsinogen serum levels are accurate in the diagnosis of intestinal metaplasia (extension) and minute dysplastic lesions. The aim of this study was to assess the feasibility and cost-effectiveness of a follow-up model for patients with atrophic chronic gastritis and intestinal metaplasia based on gastric mucosal status using magnification chromoendoscopy and pepsinogen. Methods:, A cohort of patients with lesions as severe as atrophic chronic gastritis were followed-up according to a standardized protocol using magnification chromoendoscopy with methylene blue and measurement of serum pepsinogen I and II levels. A single node decision tree and Markov chain modeling were used to define cost-effectiveness of this follow-up model versus its absence. Transition rates were considered time-independent and calculated using primary data following cohort data analysis. Costs, quality of life and survival were estimated based on published data and extensive sensitivity analysis was performed. Results:, A total of 100 patients were successfully followed-up over 3 years. Seven cases of dysplasia were diagnosed during follow-up, all among patients with incomplete intestinal metaplasia at baseline, six of whom had extensive (pepsinogen I to II ratio <3) incomplete intestinal metaplasia. For those individuals with atrophic chronic gastritis or complete intestinal metaplasia, a yearly measurement of pepsinogen levels or an endoscopic examination on a 3-yearly basis would cost ,455 per quality-adjusted life year (QALY) gain. Endoscopic examination and pepsinogen serum level measurement on a yearly basis would cost ,1868 per QALY for patients with extensive intestinal metaplasia. Conclusions:, The follow-up of patients with atrophic chronic gastritis or intestinal metaplasia is both feasible and cost-effective if improved accurate endoscopic examination of gastric mucosa together with non-invasive assessment of gastric mucosal status are used to identify individuals at high-risk for development of gastric cancer. [source] Supporting the poor but skilled artisans by making assets available to them: an empirical investigation in rural IndiaJOURNAL OF INTERNATIONAL DEVELOPMENT, Issue 1 2005Arindam Banik Large amounts of investments are made by developing countries in designing and implementing poverty alleviation programmes. Many of such programmes are also targeted at well defined beneficiaries. This paper attempts to analyse if some segments of beneficiaries are more likely to benefit from these programmes vis-ŕ-vis other beneficiaries. From an econometric analysis of primary data collected from the SITRA programme in India it was found that the socially and economically disadvantaged sections of beneficiaries were more likely to have benefited from the programme, under which improved toolkits were provided to poor rural artisans at ninety per cent subsidy. The conclusions have important policy implications as they lead to possible win-win situations as narrower targeting of the same poverty alleviation programme on more disadvantaged sections could achieve higher growth as well as greater reduction of poverty. Copyright © 2005 John Wiley & Sons, Ltd. [source] Investigation of physical and bathymetric characteristics of Lakes Abaya and Chamo, Ethiopia, and their management implicationsLAKES & RESERVOIRS: RESEARCH AND MANAGEMENT, Issue 3 2006Seleshi Bekele Awulachew Abstract The purpose of this study was to investigate the physical parameters of Lakes Abaya and Chamo in the Ethiopian rift lakes system, including such physical characteristics as depth, water resources capacity, hydrology, water balances, and impacts of water use and degradation of their watersheds. These parameters have not previously been studied for these two lakes to any significant extent. This study describes the bathymetry survey undertaken for these two lakes, and the morphometric characteristics derived from it. This study is part of a research project developed to provide further details on such parameters as hydrology, water quality, sediment inflows and deposition, lake hydrodynamics and consumptive water uses. The bathymetric survey was conducted, utilizing a combination of global positioning system (GPS) and echo sounder. To calculate the morphometric characteristics, the background lake map was digitized, and the surveyed primary data were developed as digital values. The digital values were interpolated, generating grids of the elevation surface. The elevation area and elevation volume curves (capacity curves) of the two lakes were developed from the digital values, describing the water resources capacity of the lake water basins. The results of this study increase our understanding of the water resources of these two lakes, as well as provide better understanding of their vulnerability to human activities because of their shallow depths. Immediate application of the results, as a basis for continuation of this study, also is highlighted. [source] The front end of innovation in an era of industry convergence: evidence from nutraceuticals and functional foodsR & D MANAGEMENT, Issue 5 2006Stefanie Bröring Industry convergence, defined as a ,blurring' of boundaries between industries, induced by converging value propositions, technologies and markets, appears to be a pervasive phenomenon leading to the emergence of inter-industry segments. A current example of convergence can be witnessed in the nutraceuticals and functional foods sector, emerging at the boundary between the food and pharmaceutical industries. Not only technologies blur, but there is also a convergence of demand structures: consumers try to satisfy different needs in one transaction. In this context, this paper explores how actors from different industry-specific resource backgrounds can engage in an innovative activity requiring new technological and marketing competences. Given that absorptive capacity is limited by existing competences, this paper asks how organizations with different R&D competences are able to seize opportunities for innovation emerging from convergence. Empirical findings based on primary data collected from 54 R&D projects of a nutraceutical cluster show that there are different approaches of front end decision making: while some firms follow existing processes for front end decision making, others leave existing paths and need partners to fill in gaps already identified at the front end of innovation. [source] From Adjuvant Therapy to Breast Cancer Prevention: BCPT and STARTHE BREAST JOURNAL, Issue 3 2001Barbara K. Dunn MD Abstract: The continued widespread prevalence of breast cancer supports placing a high priority on research aimed at its primary prevention, particularly among women who are at increased risk for developing this disease. The suggestion of potential agents for the primary chemoprevention of breast cancer evolved out of the treatment setting. Extensive experience with tamoxifen, a first-generation selective estrogen receptor modulator (SERM) showing efficacy, first, in the treatment of advanced breast cancer and, subsequently, as adjuvant therapy for early stage disease established the safety of this agent. Cumulative data from multiple adjuvant studies documented the efficacy of tamoxifen in reducing second primary breast cancers in the contralateral breast, supporting its potential as a chemopreventive agent for breast cancer. The safety and second primary data on tamoxifen, together with extensive information on its pharmacokinetics, metabolism, and antitumor effects, as well as its potentially beneficial effects on lipid metabolism and osteoporosis, led the National Surgical Adjuvant Breast and Bowel Project (NSABP) to select tamoxifen for testing in the first prospective randomized phase III trial of the efficacy of a chemopreventive agent for preventing breast cancer in women at increased risk of the disease. Accordingly, in 1992 the NSABP started the Breast Cancer Prevention Trial (P-1) in which 13,388 women 35 years of age who were at increased risk of breast cancer according to Gail model risk factors [family history, age, and personal history (i.e., age at first birth, age at menarche, previous breast biopsies)] were randomized to tamoxifen 20 mg/day or placebo for 5 years. Through 69 months of follow-up tamoxifen reduced the risk of invasive breast cancer, primarily estrogen receptor-positive tumors, by 49% (two-sided p < 0.00001). Tamoxifen reduced the risk of noninvasive breast cancer by 50% (two-sided p < 0.002). In addition, tamoxifen reduced fractures of the hip, radius, and spine, but it had no effect on the rate of ischemic heart disease. As previously shown, the rates of endometrial cancer and vascular events increased with tamoxifen. With the P-1 results establishing tamoxifen as the standard of care for the primary chemoprevention of breast cancer in high-risk women, concern over the side effects of tamoxifen has prompted a continuing search for an agent that displays a more desirable efficacy/toxicity profile. Raloxifene, a second-generation SERM approved for the prevention of osteoporosis in postmenopausal women, displays antiestrogenic properties in the breast and possibly the endometrium, and estrogenic effects in the bone and on the lipid profile, suggesting it as a candidate for comparison with the chemopreventive standard, tamoxifen. Raloxifene will be compared to tamoxifen in an equivalency trial, the Study of Tamoxifen and Raloxifene (STAR) NSABP P-2, which began in July 1999 at almost 500 centers in North America. The plan is to randomize 22,000 postmenopausal women 35 years of age at increased risk of breast cancer by Gail criteria to tamoxifen 20 mg/day or raloxifene 60 mg/day for 5 years. Study endpoints include invasive and noninvasive breast cancer, cardiovascular disease, endometrial cancer, bone fractures, and vascular events. [source] No place called home: the causes and social consequences of the UK housing ,bubble'THE BRITISH JOURNAL OF SOCIOLOGY, Issue 2 2010John Bone Abstract This paper examines the key causes and social consequences of the much debated UK ,housing bubble' and its aftermath from a multidimensional sociological approach, as opposed to the economic perspective of many popular discussions. This is a phenomenon that has affected numerous economies in the first decade of the new millennium. The discussion is based on a comprehensive study that includes exhaustive analysis of secondary data, content and debate in the mass media and academia, primary data gathered from the monitoring of weblogs and forums debating housing issues, and case histories of individuals experiencing housing difficulties during this period. This paper is intended to provide a broad overview of the key findings and preliminary analysis of this ongoing study, and is informed by a perspective which considers secure and affordable housing to be an essential foundation of stable and cohesive societies, with its absence contributing to a range of social ills that negatively impact on both individual and collective well being. Overall, it is argued that we must return to viewing decent, affordable housing as an essential social resource, that provides the bedrock of stable individual, family and community life, while recognizing that its increasing treatment as a purely economic asset is a key contributor to our so-called ,broken society'. [source] The Wildlife Picture Index: monitoring top trophic levelsANIMAL CONSERVATION, Issue 4 2010T. G. O'Brien Abstract Although recent biodiversity loss has been compared with cataclysmic mass extinctions, we still possess few indicators that can assess the extent or location of biodiversity loss on a global scale. The Convention on Biological Diversity (CBD) has mandated development of indicators that can meet the needs of monitoring biodiversity by 2010. To date, many indicators rely on unwarranted assumptions, secondary data, expert opinion and retrospective time series. We present a new biodiversity indicator, the Wildlife Picture Index (WPI) that targets medium and large-sized terrestrial birds and mammals in forested and savannah ecosystems that. The WPI is a composite indicator based on the geometric mean of relative occupancy estimates derived from camera trap sampling at a landscape scale. It has been designed to meet the needs of a CBD indicator while avoiding many of the pitfalls that characterize some CBD indicators. We present an example using 8 years of camera trap data from Bukit Barisan Selatan National Park, Indonesia to show that the WPI is capable of detecting changes in the rate of loss of biodiversity, a key requirement of a CBD indicator. We conclude that the WPI should be effective at monitoring top trophic levels in forest and savannah ecosystems using primary data and can fill the gap in knowledge about trends in tropical biodiversity. [source] Genetic Heterogeneity of IcelandersANNALS OF HUMAN GENETICS, Issue 1 2003E. Árnason Summary Recently statements have been made about a special ,genetic homogeneity' of the Icelanders that are at variance with earlier work on blood groups and allozymes. To validate these claims an extensive reanalysis was undertaken of mtDNA variation by examining primary data from original sources on 26 European populations. The results show that Icelanders are among the most genetically heterogeneous Europeans by the mean number of nucleotide differences as well as by estimates of , parameters of the neutral theory. The distribution of pairwise differences in general has the same shape as European populations and shows no evidence of bottlenecks of numbers in Iceland. The allelic frequency distribution of Iceland is relatively even with a large number of haplotypes at polymorphic frequencies contrasting with other countries. This is a signature of admixture during the founding or history of Iceland. Assumptions of models used to simulate number of haplotypes at sampling saturation for comparing populations are violated to different degrees by various countries. Anomalies identified in data in previous reports on Icelandic mtDNA variation appear to be due to errors in publicly accessible databases. This study demonstrates the importance of basing analyses on primary data so that errors are not propagated. Claims about special genetic homogeneity of Icelanders are not supported by evidence. [source] Progress and challenges in freshwater conservation planningAQUATIC CONSERVATION: MARINE AND FRESHWATER ECOSYSTEMS, Issue 4 2009Jeanne L. Nel Abstract 1.Freshwater ecosystems and their associated biota are among the most endangered in the world. This, combined with escalating human pressure on water resources, demands that urgent measures be taken to conserve freshwater ecosystems and the services they provide. Systematic conservation planning provides a strategic and scientifically defensible framework for doing this. 2.Pioneered in the terrestrial realm, there has been some scepticism associated with the applicability of systematic approaches to freshwater conservation planning. Recent studies, however, indicate that it is possible to apply overarching systematic conservation planning goals to the freshwater realm although the specific methods for achieving these will differ, particularly in relation to the strong connectivity inherent to most freshwater systems. 3.Progress has been made in establishing surrogates that depict freshwater biodiversity and ecological integrity, developing complementarity-based algorithms that incorporate directional connectivity, and designing freshwater conservation area networks that take cognizance of both connectivity and implementation practicalities. 4.Key research priorities include increased impetus on planning for non-riverine freshwater systems; evaluating the effectiveness of freshwater biodiversity surrogates; establishing scientifically defensible conservation targets; developing complementarity-based algorithms that simultaneously consider connectivity issues for both lentic and lotic water bodies; developing integrated conservation plans across freshwater, terrestrial and marine realms; incorporating uncertainty and dynamic threats into freshwater conservation planning; collection and collation of scale-appropriate primary data; and building an evidence-base to support improved implementation of freshwater conservation plans. Copyright © 2008 John Wiley & Sons, Ltd. [source] On the economic interdependence between China and Japan: Challenges and possibilitiesASIA PACIFIC VIEWPOINT, Issue 2 2009Claes G. Alvstam Abstract The paper presents an analysis of the economic relationship between the two most important economies in Asia. Over the last decades, the Chinese and Japanese economies have become more economically interdependent, a development which will, in the long run, impact the countries' political relationship. The paper seeks to answer the question: How can China and Japan gain from the current economic situation, further enhance their relationship and increase their synergies for regional economic development? Data on trade and Foreign Direct Investment are used in combination with primary data from interviews with Japanese and Chinese companies on how they perceive the current business situation and future potential. The result of the data analysis shows that the countries have much to gain from their economic interdependence. The firms see great potential in their respective markets but are concerned about political turbulence. Three possible scenarios for the future economic relationship are presented, including fierce competition on all markets and a leveraging of resources for mutual development between Chinese and Japanese companies. [source] High-fidelity spectroscopy at the highest resolutionsASTRONOMISCHE NACHRICHTEN, Issue 5 2010D. Dravins Abstract High-fidelity spectroscopy presents challenges for both observations and in designing instruments. High-resolution and high-accuracy spectra are required for verifying hydrodynamic stellar atmospheres and for resolving intergalactic absorption-line structures in quasars. Even with great photon fluxes from large telescopes with matching spectrometers, precise measurements of line profiles and wavelength positions encounter various physical, observational, and instrumental limits. The analysis may be limited by astrophysical and telluric blends, lack of suitable lines, imprecise laboratory wavelengths, or instrumental imperfections. To some extent, such limits can be pushed by forming averages over many similar spectral lines, thus averaging away small random blends and wavelength errors. In situations where theoretical predictions of lineshapes and shifts can be accurately made (e.g., hydrodynamic models of solar-type stars), the consistency between noisy observations and theoretical predictions may be verified; however this is not feasible for, e.g., the complex of intergalactic metal lines in spectra of distant quasars, where the primary data must come from observations. To more fully resolve lineshapes and interpret wavelength shifts in stars and quasars alike, spectral resolutions on order R = 300 000 or more are required; a level that is becoming (but is not yet) available. A grand challenge remains to design efficient spectrometers with resolutions approaching R = 1 000 000 for the forthcoming generation of extremely large telescopes (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Semiparametric Bayesian Analysis of Nutritional Epidemiology Data in the Presence of Measurement ErrorBIOMETRICS, Issue 2 2010Samiran Sinha Summary:, We propose a semiparametric Bayesian method for handling measurement error in nutritional epidemiological data. Our goal is to estimate nonparametrically the form of association between a disease and exposure variable while the true values of the exposure are never observed. Motivated by nutritional epidemiological data, we consider the setting where a surrogate covariate is recorded in the primary data, and a calibration data set contains information on the surrogate variable and repeated measurements of an unbiased instrumental variable of the true exposure. We develop a flexible Bayesian method where not only is the relationship between the disease and exposure variable treated semiparametrically, but also the relationship between the surrogate and the true exposure is modeled semiparametrically. The two nonparametric functions are modeled simultaneously via B-splines. In addition, we model the distribution of the exposure variable as a Dirichlet process mixture of normal distributions, thus making its modeling essentially nonparametric and placing this work into the context of functional measurement error modeling. We apply our method to the NIH-AARP Diet and Health Study and examine its performance in a simulation study. [source] The Influence of Top Management Teams in the Strategic Orientation and Performance of Small and Medium-sized EnterprisesBRITISH JOURNAL OF MANAGEMENT, Issue 4 2009Alejandro Escribá-Esteve Identifying which factors affect firms' performance is a critical issue in strategic management research. This paper addresses the influence of managerial team over the behaviour and performance of small and medium-sized enterprises (SMEs). By treating top management team (TMT) characteristics as predictors of a firm's strategic orientation, we seek to provide a more complete understanding of how the characteristics of managerial teams shape decision-making processes and SMEs' behaviours in order to successfully compete in low munificent environments. Based on primary data regarding managerial characteristics and firms' behaviours of a sample of 295 SMEs, our results confirm that a firm's strategic orientation plays a mediating role in explaining how TMT characteristics determine SMEs' performance. [source] Interpreting Experimental Data by Using Molecular Simulation Instead of Model BuildingCHEMISTRY - A EUROPEAN JOURNAL, Issue 26 2009Zrinka Gattin Abstract A proper description of the conformational equilibrium of polypeptides or proteins is essential for a correct description of their function. The conformational ensembles from 16 molecular dynamic simulations of two ,- heptapeptides were used to interpret the primary NMR data, which were also compared to a set of NMR model structures (see graphic). One of the most used spectroscopic techniques for resolving the structure of a biomolecule, such as a protein or peptide, is NMR spectroscopy. Because only NMR signal intensities and frequencies are measured in the experiment, a conformational interpretation of the primary data, that is, measured data, is not straightforward, especially for flexible molecules. It is hampered by the occurrence of conformational and/or time-averaging, by insufficient number of experimental data and by insufficient accuracy of experimental data. All three problematic aspects of structure refinement based on NMR nuclear Overhauser effect (NOE) intensities and 3J coupling data are illustrated by using two ,-heptapeptides in methanol as an example. We have performed 16 molecular dynamics (MD) simulations between 20 to 100,ns in length of unrestrained and NOE distance-restrained cases (instantaneous and time-averaged) of two ,-heptapeptides with a central ,-HAla(,-OH) amino acid in methanol at two different temperatures using two different GROMOS force-field parameter sets, 45,A3 and 53,A6. The created conformational ensembles were used to interpret the primary NMR data on these molecules. They also were compared to a set of NMR model structures derived by single-structure refinement in vacuo by using standard techniques. It is shown that the conformational interpretation of measured experimental data can be significantly improved by using unrestrained, instantaneous and time-averaged restrained MD simulations of the peptides by using a thermodynamically calibrated force field and by explicitly including solvent degrees of freedom. [source] | |||||||||||||||||||||||||