Home About us Contact
|
Home About us Contact | ||
|
|
||
Primary Cutaneous B-cell Lymphomas (primary + cutaneous_b-cell_lymphoma)
Selected AbstractsPrimary cutaneous B-cell lymphoma (marginal zone) with prominent T-cell component and aberrant dual (T and B) genotype; diagnostic usefulness of laser-capture microdissectionBRITISH JOURNAL OF DERMATOLOGY, Issue 1 2006F. Gallardo Summary The presence of a dominant B- or T-cell clone is an important diagnostic criterion for distinguishing cutaneous lymphomas from lymphoid reactive infiltrates. Rarely, a combined B- and T-cell rearrangement can be detected from a single sample. In such instances, genotypic analysis does not permit differentiation of the coexistence of a T- and B-cell lymphoma from a single clone harbouring a monoclonal rearrangement for both immunoglobulin heavy chain and T-cell receptor genes. We herein report a case of a skin tumour consistent with a dense cutaneous lymphoid infiltrate showing a double prominent B- and T-cell component. A dual B- and T-cell clonality was detected by polymerase chain reaction from whole-tissue DNA sample. Genotypic analysis with DNA, obtained after laser-assisted microdissection from the B-cell population, again showed both T- and B-cell monoclonal rearrangements. Conversely, the microdissected T-cell population did not reveal a clonal pattern. The diagnosis of cutaneous B-cell lymphoma with a dual B- and T-cell genotype was established. This description illustrates the diagnostic usefulness of laser-capture microdissection in cutaneous lymphomas presenting dual genotype. [source] Primary cutaneous B-cell lymphomas: then and nowJOURNAL OF CUTANEOUS PATHOLOGY, Issue 2006Helmut Kerl Most primary cutaneous B-cell lymphomas (pCBCL) were designated as lymphosarcoma, follicular lymphoma, histiocytic lymphoma, reticulum-cell sarcoma or skin reticuloses. Today, pCBCL are classified as a fully recognized and well-defined group of extranodal lymphomas according to the criteria of the World Health Organization,European Organization for Research and Treatment of Cancer classification. Better understanding of the mechanisms of the pathogenesis in pCBCL will hopefully stimulate investigative research and provide further improvement of diagnosis and treatment. [source] Primary cutaneous follicle center lymphoma of the arm with a novel chromosomal translocation t(12;21)(q13;q22): A case reportAMERICAN JOURNAL OF HEMATOLOGY, Issue 6 2006Tomislav M. Jelic Abstract We report a reciprocal translocation between the long arms of chromosomes 12 and 21, t(12;21)(q13;q22), in a patient with primary cutaneous follicle center lymphoma. Follicle center lymphoma of the skin and follicle center cell lymphoma of the lymph node are morphologically and immunophenotypically very similar. However, the clinical behavior and prognosis of these tumors are different due to the molecular basis of these malignancies. Follicle center cell lymphoma of the lymph node is determined by the presence of a unique translocation between chromosomes 14 and 18, t(14;18)(q32;q21), BCL-2-JH gene rearrangement, that is not present in primary cutaneous follicle center lymphomas. Chromosomal translocations in the primary skin lymphomas have not been previously reported. We hope that our discovery of a new translocation t(12:21)(q13q22) will encourage further investigation into the molecular basis of this translocation and other cytogenetic abnormalities in primary cutaneous B-cell lymphomas. Am. J. Hematol. 81:448,453, 2006. © 2006 Wiley-Liss, Inc. [source] | ||||||||||