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Selected AbstractsForaging for Work and Age-Based Polyethism: The Roles of Age and Previous Experience on Task Choice in AntsETHOLOGY, Issue 11 2004Frederic Tripet In social insects, colonies commonly show temporal polyethism in worker behavior, such that a worker follows a predictable pattern of changes between tasks as it ages. This pattern usually leads from workers first doing a safe task like brood care, to ending their lives doing the most dangerous tasks like foraging. Two mechanisms could potentially underlie this pattern: (1) age-based task allocation, where the aging process itself predisposes workers to switch to more dangerous tasks; and (2) foraging for work, where ants switch to tasks that need doing from tasks which have too many associated workers. We tested the relative influence of these mechanisms by establishing nests of Camponotus floridanus with predetermined combinations of workers of known age and previous task specialization. The results supported both mechanisms. Nests composed of entirely brood-tending workers had the oldest workers preferentially switching to foraging. However, in nests initially composed entirely of foragers, the final distribution of tenders and foragers was not different from random task-switching and therefore supportive of foraging for work. Thus, it appears that in C. floridanus there is directionality to the mechanisms of task allocation. Switching to more dangerous tasks is age-influenced, but switching to less dangerous tasks is age-independent. The results also suggest that older workers are more flexible in their task choice behavior. Younger workers are more biased towards choosing within-nest tasks. Finally, there are effects of previous experience that tend to keep ants in familiar tasks. Task allocation based on several mechanisms may balance between: (1) concentrating the most worn workers into the most dangerous tasks; (2) increasing task performance levels; and (3) maintaining behavioral flexibility to respond to demographic perturbations. The degree to which behavior is flexible may correlate to the frequency of such perturbations in a species. [source] Predictors of Perceived Susceptibility to Sport-Related Injury among Competitive Runners: The Role of Previous Experience, Neuroticism, and Passion for RunningAPPLIED PSYCHOLOGY, Issue 4 2009Yannick Stephan Whether individuals take steps to protect themselves against sport-related injury may depend on their perceived susceptibility to injury (Williams-Avery & MacKinnon, 1996). However, little is known about the determinants of perceived susceptibility to sport-related injury. The purpose of the present study is to identify the relations of previous experiences with injury, neuroticism, and passion with perceived susceptibility to sport-related injury among competitive runners. One hundred and seventy competitive runners reported the number of injuries sustained during the last year and completed the neuroticism scale of the NEO-PIR and the Passion Scale. Separate regression analysis revealed that previous experiences with injury, neuroticism, and obsessive passion were significant positive predictors of perceived susceptibility, whereas harmonious passion was significantly and negatively related to perceived susceptibility. When considered simultaneously, previous experiences, neuroticism, and obsessive passion explained unique variance in perceived susceptibility to sport-related injury. This study revealed that perceived susceptibility to sport-related injury is dependent on several distinct variables. Thus, to be effective, injury preventive actions aimed at runners' behaviour modification need to take into account that runners' perceived susceptibility to sport has multiple predictors. L'adoption par les individus de comportements de prévention de la blessure en sport est liée à leur vulnérabilité perçue à celle-ci (Williams-Avery & MacKinnon, 1996). Cependant, aucune étude ne s'est intéressée aux déterminants de cette dimension dans le contexte sportif. L'objectif de cette étude était d'identifier les relations entre les expériences passées avec une ou plusieurs blessures, le névrosisme, et la passion pour l'activité et la vulnérabilité perçue à la blessure chez des coureurs à pied. 170 coureurs compétitifs ont reporté le nombre de blessures contractées lors de la saison précédente, et ont répondu à l'échelle de névrosisme du NEO-PIR, et à l'échelle de passion en sport. Des analyses de régression séparées révèlent une contribution positive des expériences passées avec la blessure, du névrosisme, et de la passion obsessionnelle sur la vulnérabilité perçue, alors que la passion harmonieuse contribue négativement à cette dimension. Une analyse de régression multiple intégrant l'ensemble des prédicteurs révèle un lien significatif et positif entre les expériences passées, le névrosisme, la passion obsessionnelle et la vulnérabilité perçue à la blessure. Cette étude confirme que la perception de vulnérabilité est dépendante de dimensions variées et distinctes. Les actions de prévention de la blessure axées sur les changements de perception de vulnérabilitéà la blessure à des fins de modification des comportements doivent prendre en considération les prédicteurs de cette dimension afin d'être efficaces. [source] Seeking Help a Second Time: Parents'/Caregivers' Characterizations of Previous Experiences With Mental Health Services for Their Children and Perceptions of Barriers to Future UseAMERICAN JOURNAL OF ORTHOPSYCHIATRY, Issue 2 2006Dara Kerkorian PhD This study examines the relationship between urban parents'/caregivers' previous experiences obtaining mental health care for their children and their perceptions of barriers to their children's use of services in the future. Assessments of prior treatment outcome and aspects of relationships with former providers were linked to endorsements of doubt about the utility of treatment as a potential barrier to the children's use of services in the future and the number of barriers parents endorsed. Implications for urban child mental health service delivery are drawn. [source] Previous experience of spontaneous or elective abortion and risk for posttraumatic stress and depression during subsequent pregnancyDEPRESSION AND ANXIETY, Issue 8 2010Lydia Hamama Abstract Background: Few studies have considered whether elective and/or spontaneous abortion (EAB/SAB) may be risk factors for mental health sequelae in subsequent pregnancy. This paper examines the impact of EAB/SAB on mental health during subsequent pregnancy in a sample of women involved in a larger prospective study of posttraumatic stress disorder (PTSD) across the childbearing year (n=1,581). Methods: Women expecting their first baby completed standardized telephone assessments including demographics, trauma history, PTSD, depression, and pregnancy wantedness, and religiosity. Results: Fourteen percent (n=221) experienced a prior elective abortion (EAB), 13.1% (n=206) experienced a prior spontaneous abortion (SAB), and 1.4% (n=22) experienced both. Of those women who experienced either an EAB or SAB, 13.9% (n=220) appraised the EAB or SAB experience as having been "a hard time" (i.e., potentially traumatic) and 32.6% (n=132) rated it as their index trauma (i.e., their worst or second worst lifetime exposure). Among the subset of 405 women with prior EAB or SAB, the rate of PTSD during the subsequent pregnancy was 12.6% (n,51), the rate of depression was 16.8% (n=68), and 5.4% (n,22) met criteria for both disorders. Conclusions: History of sexual trauma predicted appraising the experience of EAB or SAB as "a hard time." Wanting to be pregnant sooner was predictive of appraising the experience of EAB or SAB as the worst or second worst (index) trauma. EAB or SAB was appraised as less traumatic than sexual or medical trauma exposures and conveyed relatively lower risk for PTSD. The patterns of predictors for depression were similar. Depression and Anxiety, 2010.© 2010 Wiley-Liss, Inc. [source] Previous experience of withdrawal from chronic diazepam ameliorates the aversiveness of precipitated withdrawal and reduces withdrawal-induced c-fos expression in nucleus accumbensEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 4 2000Sarah J. Dunworth Abstract Flumazenil (20 mg/kg, i.p.)-precipitated withdrawal from chronic treatment with diazepam (DZP, 15 mg/kg, s.c. in sesame oil for 21 days) resulted in a decreased seizure threshold to the convulsant, pentylenetetrazole (PTZ), infused into the tail vein; withdrawal from 21-day chronic diazepam treatment, interspersed with two periods of drug withdrawal, resulted in a greater decrease in convulsant threshold. A separate experiment showed that consumption of a sucrose solution immediately prior to precipitated withdrawal resulted in a decreased subsequent consumption of the sucrose solution; no such evidence of a conditioned taste aversion (CTA) was seen in mice given prior experience of withdrawal. Thus, prior experience of withdrawal enhanced the effects of a subsequent precipitated withdrawal in increasing seizure sensitivity, but weakened the ability of this withdrawal to serve as an aversive unconditioned stimulus (US). The weakening of the aversive properties of precipitated withdrawal may reflect habituation to the withdrawal stimulus, and was accompanied by a loss of the ability of withdrawal to induce c-fos expression in the shell of the nucleus accumbens, an area sensitive to both novel, and stressful, as well as rewarding stimuli. [source] ML08 CONDUCTING A REVIEW , THE IMPORTANCE OF PROCESSANZ JOURNAL OF SURGERY, Issue 2007A. F. Merry Reviews of practice tend to arise out of conflict between the person reviewed and the organisation requesting the review, usually after a failure of the two parties to resolve their differences at a lower level. It follows that legal challenges are likely, and this has been borne out by experience. Such challenges will generally be based on alleged failures in process. Furthermore, being reviewed is exceptionally stressful for any doctor and creates serious risks to his or her health and reputation. It is essential that these risks are minimized and that all parties emerge from the review believing that the process has been impartial, professional, confidential and fair. The key is to engage a senior lawyer with appropriate experience and expressly charge him or her (in writing) with the responsibility for process. This lawyer must be independent (the reviewing organisation's own lawyers are not appropriate for this position), directly accountable to the chair of the review panel, and have unrestricted time for this task. He or she should be present at all meetings between the panel and the reviewed doctor and should revise all documents produced by the panel. The panel chair should assign the primary responsibility for reviewing the professional competence of the doctor to other panel members and should focus instead on ,chairing', on process, and on the wider (or ,big picture') issues which surround the review. Previous experience in reviews is essential for this role. [source] A protocol is not enough to implement an enhanced recovery programme for colorectal resection,BRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 2 2007J. Maessen Background: Single-centre studies have suggested that enhanced recovery can be achieved with multimodal perioperative care protocols. This international observational study evaluated the implementation of an enhanced recovery programme in five European centres and examined the determinants affecting recovery and length of hospital stay. Methods: Four hundred and twenty-five consecutive patients undergoing elective open colorectal resection above the peritoneal reflection between January 2001 and January 2004 were enrolled in a protocol that defined multiple perioperative care elements. One centre had been developing multimodal perioperative care for 10 years, whereas the other four had previously undertaken traditional care. Results: The case mix was similar between centres. Protocol compliance before and during the surgical procedure was high, but it was low in the immediate postoperative phase. Patients fulfilled predetermined recovery criteria a median of 3 days after operation but were actually discharged a median of 5 days after surgery. Delay in discharge and the development of major complications prolonged length of stay. Previous experience with fast-track surgery was associated with a shorter hospital stay. Conclusion: Functional recovery in 3 days after colorectal resection could be achieved in daily practice. A protocol is not enough to enable discharge of patients on the day of functional recovery; more experience and better organization of care may be required. Copyright © 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. [source] Magnetic Resonances in ECR-Heated Plasmas of the TJ-II HeliacCONTRIBUTIONS TO PLASMA PHYSICS, Issue 6-7 2010D. López-Bruna Abstract Low order rational values of the rotational transform ,magnetic resonances, for brevity, can be present inside ECR,heated plasmas of the TJ-II Heliac, in low magnetic shear conditions, without causing damage to confinement. Moreover, in agreement with previous experience in the TJ-II, the resonances seem to benefit confinement and are associated to changes in the radial electric field, at least in the density gradient region. These results encourage considering magnetic resonances as possible external actuators on confinement in stellarator/heliotron devices (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Dewetted growth of CdTe in microgravity (STS-95)CRYSTAL RESEARCH AND TECHNOLOGY, Issue 6 2004M. Fiederle Abstract Two CdTe crystals had been grown in microgravity during the STS-95 mission. The growth configuration was dedicated to obtain dewetting of the crystals and to achieve high quality material. Background for the performed experiments was based on the theory of the dewetting and previous experience. The after flight characterization of the crystals has demonstrated existance of the dewetting areas of the crystals and their improved quality regarding the earth grown reference sample. The samples had been characterized by EDAX, Synchrotron X-ray topography, Photoluminescence and Optical and IR microscopy. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Neuropharmacological basis of combining antidepressantsACTA PSYCHIATRICA SCANDINAVICA, Issue 2005J. de la Gándara Objective:, To review the neuropharmacological basis of antidepressant combination therapy. Method:, Literature searches and other relevant material were obtained and reviewed. Results:, The overall clinical aim of combining antidepressants is to increase the efficacy whilst minimizing the side effects. Although such prescriptions are frequently based on the previous experience and knowledge, a sound neuropharmacological basis to support these combinations is desirable. When combining antidepressants, it is important to combine mechanisms of action, rather than simply one drug with another, and to aim for synergistic effects. The possibilities of combining mechanisms of action should also be exploited to the full if necessary, and the potential exists for combining two independent actions that have synergistic effects on the serotonergic, noradrenergic and even the dopaminergic systems. Conclusion:, Unfortunately, there are still, as yet, insufficient data to categorically justify choosing one or other combination based only on the neuropharmacological evidence. [source] Do past experience and competitive ability influence foraging strategies of parasitoids under interspecific competition?ECOLOGICAL ENTOMOLOGY, Issue 6 2008CECILE LE LANN Abstract 1.,In solitary parasitoids, several species can exploit the same host patch and competition could potentially be a strong selective agent as only one individual can emerge from a host. In cereal crops, Aphidius rhopalosiphi and A. ervi share the grain aphid Sitobion avenae as host. 2.,The present work studied foraging strategies of both species on patches already exploited by the other species. The study analysed larval competition in multi-parasitised hosts and compared the foraging behaviour of females with and without previous experience. 3.,It was found that A. ervi wins larval competition three times more often than A. rhopalosiphi. Both species spent less time on patches exploited by a heterospecific than on unexploited ones. When they foraged on heterospecifically exploited patches, experienced females induced less mortality in aphids than inexperienced ones. 4.,Although A. rhopalosiphi is a specialist on cereal aphids and is the most abundant species due to its early appearance in the season, S. avenae is still a profitable host for A. ervi, because: (i) A. rhopalosiphi leaves patches partially exploited, (ii) A. ervi wins larval competition in three out of four multi-parasitised hosts, and (iii) A. ervi is only slightly deterred by the cornicular secretions of the host and can thus easily parasitise hosts. [source] Predation risk allocation or direct vigilance response in the predator interaction between perch (Perca fluviatilis L.) and pike (Esox lucius L.)?ECOLOGY OF FRESHWATER FISH, Issue 3 2005A. Vainikka Abstract , Predation risk allocation hypothesis predicts that a prey's response to predator depends on prey's previous experience on predator. Here we tested whether the group of three perch respond differentially to pike, predator of perch, depending on the timing of high constant (HC) and high unpredictable (HU) risk periods within low constant risk periods in short-term (10 h) experiments, and whether the response is stronger during a HU risk period than during a HC risk period. Perch clearly erected the dorsal fin in response to predation risk treatments (pike odour only, odour and visible pike). Decrease in activity and increase in shoaling behaviour were observed mainly during high risk periods. However, the perch's responses to pike did not differ statistically between periods of various levels of predation risk or depending on the timing of high risk situations within constant low risk periods, and thus, suggesting that perch respond mainly to changes in the current predation risk. Resumen 1. La hipótesis de la asignación de riesgo a la predación predice que la respuesta a un predador depende de la experiencia previa de la presa al predador. En este trabajo analizamos si un grupo de tres individuos de Perca fluviatilis respondían de forma distinta a la presencia de Esox lucius, (un predador común de esta especie) y si éstas dependían del momento en el que se producen periodos de alto riesgo constante y de alto riesgo impredecible, en experimentos de corto plazo (10 horas) de riesgo bajo y constante y si la respuesta era mayor durante perí odos de riesgo impredecible y alto que durante períodos de riesgo constante alto. 2. Claramente P. fluviatilis respondió levantando la aleta dorsal en respuesta a los tratamientos de riesgo a la predación (solamente olor y olor + visibilidad de E. lucius). Una menor actividad y una mayor tendencia a la formación de bancos fueron observados durante períodos de alto riesgo. Sin embargo, las respuesta de P. fluviatilis a E. lucius no difirieron estadísticamente entre períodos de varios niveles de riesgo a la predación o entre aquellos que dependieron del momento en el que se produjeron situaciones de alto riesgo dentro de períodos de bajo riesgo constante. 3. Concluimos que P. fluviatilis puede utilizar señales olfatorias como determinantes de respuestas al riesgo a la predación y responder a aumentos de riesgo, sin excluir la posibilidad de que amenazas repetidas decrezcan la intensidad de la respuesta. Nuestros resultados, obtenidos en experimentos realizados a pequeña escala temporal, no niegan la posibilidad de la P. fluviatilis y otras especies puedan balancear la alimentación con actividades anti-predación, de acuerdo a cambios en el riesgo de predación a lo largo de escalas temporales de varios días. [source] Review article: Inotrope and vasopressor use in the emergency departmentEMERGENCY MEDICINE AUSTRALASIA, Issue 5 2009Ainslie Senz Abstract Shock is a common presentation to the ED, with the incidence of septic shock increasing in Australasia over the last decade. The choice of inotropic agent is likely dependent on previous experience and local practices of the emergency and other critical care departments. The relatively short duration of stay in the ED before transfer leaves little room for evaluating the appropriateness of and response to the agent chosen. Delays in transfer to inpatient facilities means that patients receive advanced critical care within the ED for longer, requiring initiation and titration of vasoactive agents in the ED. This article discusses the general concepts of shock and the indicators for inotrope and vasopressor use, revises the various agents available and reviews the current evidence for their use. [source] Employers' Attitudes to Employment of People with Epilepsy: Still the Same Old Story?EPILEPSIA, Issue 12 2005Ann Jacoby Summary:,Purpose: One area of life quality known to be compromised by having epilepsy is employment, and one factor contributing to the employment problems of people with epilepsy (PWE) is employer attitudes. Much research on this topic is now outdated and given the changing legal, medical, and social contexts in which PWE live, we therefore reexamined employer attitudes in the united Kingdom. Method: A mail survey of a random sample of U.K. companies selected to be representative of the 14 U.K. economic regions and proportional to the number of employees. Findings: The overall response rate was 41% (n = 204). Twenty-six percent of respondents reported having experience of employing PWE. Sixteen percent considered that there were no jobs in their company suitable for PWE; 21% thought employing PWE would be "a major issue." Employers were uniformly of the view that PWE, even when in remission, should disclose their condition to a prospective employer. Seizure severity, frequency, and controllability were all considered important features of epilepsy in the context of employment. Epilepsy created high concern to around half of employers, including the likelihood of it being linked to a work-related accident. Employers were willing to make accommodations for PWE, in particular job sharing, temporary reassignment of duties, and flexible working hours. Attitudes to employment of PWE were influenced by company size and type and previous experience of doing so. Conclusions: We conclude that it is still the same old story for employers' attitudes toward PWE, though happily for PWE, with some room for optimism. [source] Foraging for Work and Age-Based Polyethism: The Roles of Age and Previous Experience on Task Choice in AntsETHOLOGY, Issue 11 2004Frederic Tripet In social insects, colonies commonly show temporal polyethism in worker behavior, such that a worker follows a predictable pattern of changes between tasks as it ages. This pattern usually leads from workers first doing a safe task like brood care, to ending their lives doing the most dangerous tasks like foraging. Two mechanisms could potentially underlie this pattern: (1) age-based task allocation, where the aging process itself predisposes workers to switch to more dangerous tasks; and (2) foraging for work, where ants switch to tasks that need doing from tasks which have too many associated workers. We tested the relative influence of these mechanisms by establishing nests of Camponotus floridanus with predetermined combinations of workers of known age and previous task specialization. The results supported both mechanisms. Nests composed of entirely brood-tending workers had the oldest workers preferentially switching to foraging. However, in nests initially composed entirely of foragers, the final distribution of tenders and foragers was not different from random task-switching and therefore supportive of foraging for work. Thus, it appears that in C. floridanus there is directionality to the mechanisms of task allocation. Switching to more dangerous tasks is age-influenced, but switching to less dangerous tasks is age-independent. The results also suggest that older workers are more flexible in their task choice behavior. Younger workers are more biased towards choosing within-nest tasks. Finally, there are effects of previous experience that tend to keep ants in familiar tasks. Task allocation based on several mechanisms may balance between: (1) concentrating the most worn workers into the most dangerous tasks; (2) increasing task performance levels; and (3) maintaining behavioral flexibility to respond to demographic perturbations. The degree to which behavior is flexible may correlate to the frequency of such perturbations in a species. [source] Parenting Self-Efficacy Among Mothers of School-Age Children: Conceptualization, Measurement, and Correlates,FAMILY RELATIONS, Issue 1 2000Priscilla K. Coleman Relationships among parenting self-efficacy, general self-efficacy, child and maternal characteristics, and parenting satisfaction in 145 mothers of school-aged children were examined. Higher parenting self-efficacy was observed in mothers of less emotional and more sociable children, and among mothers who were better educated, had higher family incomes, and reported more previous experience with children. Higher parenting self-efficacy and several mother and child variables predicted greater satisfaction with parenting. Influences of mothers' experience with children other than their own and maternal education on parenting satisfaction were mediated by parenting self-efficacy. Suggestions concerning the conceptualization and measurement of parenting self-efficacy are provided. [source] Patients' experiences with partial dentures: a qualitative studyGERODONTOLOGY, Issue 4 2005Patricia A. Smith Objective:, The aim of the study was to gain insight into people's experiences of being given and using partial dentures. Methods:, In-depth semi-structured interviews were carried out with 23 people of varied age, social background and denture wearing experience in Tayside, Scotland. Participants were encouraged to discuss how they came to have partial dentures, their day-to-day denture use and their interactions with dentists. The interview data were systematically coded using key theme headings, and summary charts were constructed to facilitate analysis. Results:, The initial decision that a partial denture was needed was generally difficult to accept. People perceived the main benefits of partial dentures to be improved appearance and confidence, but experienced a variety of difficulties with their dentures and often coped with these by only wearing them on social occasions. Participants had not always told their dentists about the difficulties they experienced. Barriers to seeking help with denture problems included financial constraints, previous experience of rushed appointments or poor communication from dentists and a perceived lack of entitlement to help when partial dentures were issued free. Conclusions:, Partial dentures can be difficult to cope with. People experience a range of difficulties in wearing them, not all of which have been discussed with dentists. Informative and supportive communication when partial dentures are first needed, and subsequently, can improve the quality of patients' experiences and may help promote effective use and appropriate help-seeking by partial denture wearers. [source] Survey Conditioning in Self-Reported Mental Health Service Use: Randomized Comparison of Alternative Instrument FormatsHEALTH SERVICES RESEARCH, Issue 2 2007Naihua Duan Objective. To test the effect of survey conditioning (whether observed survey responses are affected by previous experience in the same survey or similar surveys) in a survey instrument used to assess mental health service use. Data Sources. Primary data collected in the National Latino and Asian American Study, a cross-sectional household survey of Latinos and Asian Americans residing in the United States. Study Design. Study participants are randomly assigned to a Traditional Instrument with an interleafed format placing service use questions after detailed questions on disorders, or a Modified Instrument with an ensemble format screening for service use near the beginning of the survey. We hypothesize the ensemble format to be less susceptible to survey conditioning than the interleafed format. We compare self-reported mental health services use measures (overall, aggregate categories, and specific categories) between recipients of the two instruments, using 2 × 2 ,2 tests and logistic regressions that control for key covariates. Data Collection. In-person computer-assisted interviews, conducted in respondent's preferred language (English, Spanish, Mandarin Chinese, Tagalog, or Vietnamese). Principal Findings. Higher service use rates are reported with the Modified Instrument than with the Traditional Instrument for all service use measures; odds ratios range from 1.41 to 3.10, all p -values <.001. Results are similar across ethnic groups and insensitive to model specification. Conclusions. Survey conditioning biases downward reported mental health service use when the instrument follows an interleafed format. An ensemble format should be used when it is feasible for measures that are susceptible to survey conditioning. [source] Benefiting from mistakes: The impact of guided errors on learning, performance, and self-efficacyHUMAN RESOURCE DEVELOPMENT QUARTERLY, Issue 3 2005Steven J. Lorenzet We conducted an experiment using training in a software package for presentations. Ninety undergraduate students with no previous experience received either training that guided them to commit common errors or alternatively training that sought to prevent errors from occurring. From previous research and relevant theory, a typology for manipulating errors is presented. In addition, we offer and test a new way of using errors in training, based on guided errors. Before training, a subject matter expert identified common errors that occur when first learning the software package. Trainees in the guided-errors condition were then guided into and out of mistakes during training. Findings revealed superior performance (accuracy and speed) and self-efficacy associated with using guided errors during training. Study limitations and implications for research and practice are also discussed. [source] Pharmacokinetics of mesalazine pellets in children with inflammatory bowel diseaseINFLAMMATORY BOWEL DISEASES, Issue 5 2004Heleen Wiersma MD Abstract Mesalazine is a first-line drug in pediatric inflammatory bowel disease (IBD), and is customarily used to induce and maintain remission in mild to moderate disease. In children, pharmacokinetic data are scarce, and dosage recommendations are largely extrapolated from studies in adults. Aim of the study was to obtain the pharmacokinetic profile of a new mesalazine pellet formulation in children with ulcerative colitis and Crohn's colitis. A single oral dose of 20 mg/kg mesalazine was administered to 13 patients (age 6,16 years). Serial blood and urine sampling for determination of mesalazine and acetylmesalazine was performed before and during 24 hours following ingestion. Maximum plasma concentration of mesalazine (Cmax) was 1332 ng/mL (geometric mean, geometric coefficient of variation [CV]: 0.57), obtained 3.7 hours (tmax; CV: 0.31) after drug administration. Systemic exposure as determined by area under the plasma concentration-time curve (AUC0,, ) was 8712 ng/ml*h (CV: 0.44). Terminal half-life of elimination of mesalazine was 3.5 hours (t1/2; CV: 1.43). This study presents extensive pharmacokinetic data on mesalazine in children with mild-moderately active ulcerative colitis and Crohn's colitis. In comparison with previous experience in adults, pharmacokinetics of mesalazine administered as pellets appear to be similar in both populations. [source] Use of dry powder inhalers in COPDINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 12 2007D. S. Wilson Summary Introduction:, This was a study of 30 chronic obstructive pulmonary disease (COPD) patients to assess the ease of use and preference of four dry powder inhalers , accuhaler, aerolizer, handihaler, turbohaler , the accuhaler and turbohaler are multidose devices, whereas the aerolizer and handihaler are single dose devices. Method:, None of the subjects had previous experience of dry powder inhalers. The correct technique for each inhaler was divided into 12 steps including one critical step that if not performed would result in no drug delivery. Subjects were shown the correct technique for each inhaler in a random order and were assessed immediately and 1 h later. Each subject was asked to rank the four devices for preference and ease of use, as well as to assess how comfortable it felt to inhale through the device using a visual analogue scale. Results:, The numbers of perfect scores were not significantly different between devices, but the number of fatal errors that would result in no drug delivery was significantly more common in single dose devices (p < 0.01). There were significant differences in the rankings of each device (Friedman test, p < 0.005) with the turbohaler being ranked first most often and the handihaler last. The turbohaler scored highest for comfort of inhalation and the accuhaler lowest, but differences were small. Conclusions:, In COPD patients starting on dry powder inhalers, multidose devices appear to be preferred, have fewer problems and are easier to use effectively. [source] A standardized and reliable method to apply the Global Assessment of Functioning (GAF) scale to psychiatric case recordsINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 2 2000Dr M. Mirandola Abstract The Global Assessment of Functioning (GAF) scale is widely used both in routine clinical practice and in research. However, its reliability has never been assessed when used to rate information in clinical records. The present study focuses on the development of a standardized method (an ongoing modelling process between raters) for establishing desired levels of inter-rater reliability (IRR) in the application of the GAF to psychiatric case records. Fifty-one patients at first-ever contact with mental health services were included in the study. They were selected from a total sample of 662 first-ever patients by using a systematic sampling. Three raters (resident psychiatrists at their third year of training) took part in a 12-hour training programme, during which they were asked to assess the global psychological functioning of patients, taking into account information recorded in case records. The extent of agreement between raters was estimated by applying the ,limits of agreement' method and the ,concordance correlation coefficient'. The training programme proved to be feasible, easy to administer and acceptable to psychiatrists in training with limited previous experience of using rating scales. Very high levels of concordance (all greater than 0.95) emerged between the three raters. The GAF, completed using information from case records included in the initial assessment form, appeared to be a reliable instrument, even when used by clinical psychiatrists in training. Copyright © 2000 Whurr Publishers Ltd. [source] The oral health of children considered very high risk for infective endocarditisINTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY, Issue 3 2010RICHARD BALMER International Journal of Paediatric Dentistry 2010; 20: 173,178 Background., Children with previous experience of infective endocarditis or with prosthetic heart valve are considered at very high risk for infective endocarditis. Aim., The aim of this study was to compare the dental health of a group of these children with a group of healthy controls and to determine parental awareness of the importance of good oral health. Design., Oral examination was carried out in 28 children with previous infective endocarditis or a prosthetic heart valve to assess oral health. Findings were compared to a healthy control group of 28. Questionnaires were distributed to the parents to assess awareness of oral health. Results., There was no significant difference in DMFT scores of study and control group (2.43 +/- 3.72 and 1.36 +/- 2.5 respectively) or in DMFT scores of study and control group (1.5 +/- 1.73 and 1.15 +/- 1.42 respectively), 36% of the study group had untreated caries. Parental knowledge of the link between oral health and infective endocarditis was excellent. Conclusions., There were no significant differences between the oral health of cardiac children and healthy children although the dmft and DMFT scores of the study group were high. Of concern was the proportion of children with untreated caries in spite of good dental awareness and attendance. [source] Students' travel behaviour: a cross-cultural comparison of UK and ChinaINTERNATIONAL JOURNAL OF TOURISM RESEARCH, Issue 3 2009Feifei Xu Abstract This paper compares the travel behaviour and attitudes of two different nationalities of undergraduate students from the United Kingdom and China. The survey did find some similarities between the two. Both groups enjoyed beach holidays, and placed importance on having fun and relaxing after their studies. Both were motivated to discover somewhere new and both preferred to eat the local food of the destination. In other ways, the two groups showed significant differences. The Chinese students thought it more important to see the famous sights and learn about other cultures and history, while the British were more concerned to have fun, to socialise and enjoy the challenges of outdoor adventure. These differences were found to exist in both male and female groups. The paper discusses the extent to which these differences could be explained by cultural factors as opposed to market factors or the students' previous experience in their travel career. Copyright © 2008 John Wiley & Sons, Ltd. [source] Calming troubled waters: Peacemakers in a sports riotAGGRESSIVE BEHAVIOR, Issue 4 2001Gordon W. Russell Abstract This investigation sought to identify a set of measures predictive of those who would intervene in a crowd disturbance with the intent of restoring order. Male participants (N = 74) completed a battery of social and personality measures. Men who had previously attempted to break up a fight(s), including those who had recently intervened and judged their efforts to have been successful, were most likely to step in. Additionally, peacemakers were subject to the false consensus effect and strongly believed in law and order. A multiple regression analysis yielded a solution that accounted for 40.3% of the variance, with previous experience as a peacemaker and attitudes toward law and order emerging as the best predictors. Aggr. Behav. 27:292,296, 2001. © 2001 Wiley-Liss, Inc. [source] Conditioning of stress in Nile tilapiaJOURNAL OF FISH BIOLOGY, Issue 4 2004P. S. A. Moreira A Pavlovian conditioning paradigm was used to induce a connection between a conditioned stimulus, light (CS), associated with an unconditioned stimulus, confinement (US) in Nile tilapia Oreochromis niloticus, which resulted in a conditioned endocrine response (CR) to the CS alone manifested as an increase in plasma cortisol. Individual isolated Nile tilapia were submitted for 10 days to the conditioning treatment consisting of turning on a light (CS) for 1 min with subsequent 30 min confinement (US). On the 10th day of the experiment, plasma cortisol was not increased when fish were subjected to no handling at all, or only light, or even a daily stressor for the 9 days. On the other hand, at the 10th day cortisol was significantly increased only when light was presented either with or without pairing with the stressor. These results confirmed that the cue, light (CS), was not stressful in itself, but when given as the CS in the absence of the US post conditioning the hypothalamus,pituitary,interrenal axis was activated. Therefore, it was concluded that memory of a previous experience with a stressor can be recalled by a conditioned stimulus and induce stress, which is the first demonstration of a memory-induced stress in fishes. [source] Predator avoidance behaviour in wild and hatchery-reared brown trout: the role of experience and domesticationJOURNAL OF FISH BIOLOGY, Issue 6 2003D. Álvarez Juvenile brown trout Salmo trutta from natural populations reacted to the presence of piscivorous brown trout by increasing the use of refuges. In contrast, second-generation hatchery fish and the offspring of wild fish raised under hatchery conditions were insensitive to predation risk. The diel pattern of activity also differed between wild and hatchery brown trout. Second-generation hatchery fish were predominantly active during daytime regardless of risk levels. Wild fish, however, showed a shift towards nocturnal activity in the presence of predators. These findings emphasize the potential role of domestication in weakening behavioural defences. They support the idea that the behavioural divergence between wild and domesticated individuals can arise from a process of direct or indirect selection on reduced responsiveness to predation risk, or as a lack of previous experience with predators. [source] Evaluation of intrarenal oxygenation in mice by BOLD MRI on a 3.0T human whole-body scanner,JOURNAL OF MAGNETIC RESONANCE IMAGING, Issue 3 2007Lu-Ping Li PhD Abstract Purpose To extend observations on intra-renal oxygenation with blood oxygen level-dependent (BOLD) MRI in human and rats to mouse kidneys imaged with a human whole-body scanner. Materials and Methods Renal BOLD MRI studies were performed on a 3.0T scanner using a multiple gradient-echo (mGRE) sequence with a custom-designed 2.0-cm surface coil to acquire six T2*-weighted images in mice (N = 8) at an in-plane resolution of 156 × 156 ,m2. BOLD MRI data were obtained before and after administration of furosemide (10 mg/kg intravenously [i.v.]). Results The mean weight of eight mice was 24.6 ± 1.0 g. The baseline renal R2* (mean ± standard error [SE]) was 28.6 ± 2.1 seconds,1 in the renal cortex (CO), 35.4 ± 2.2 in the outer medulla (OM), and 21.2 ± 2.1 seconds,1 in the inner medulla (IM). The BOLD response to furosemide (,R2*) was 4.1 ± 1.4 in the CO, 10.1 ± 2.1 seconds,1 in the OM, and 3.4 ± 0.8 seconds,1 in the IM in mice. Conclusion Intrarenal BOLD MR images with sufficiently high resolution can be obtained on a human whole-body scanner when combined with a small receiver coil to allow studies in mice. Both baseline R2* and ,R2* values following administration of furosemide were consistent with previous experience in humans and rats. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc. [source] An educational evaluation of supervisor and mentor experiences when supporting Primary Care Graduate Mental Health WorkersJOURNAL OF PSYCHIATRIC & MENTAL HEALTH NURSING, Issue 5 2009N. HARRISON ma pgdip cogth pgdip pc couns pgdip ed ba(hons) dpsn rgn rmn This paper reports on the findings of a postal survey used to enhance understanding into the backgrounds, experiences and support offered to supervisors and mentors of Primary Care Graduate Mental Health Workers (PCGMHWs). A postal questionnaire was sent to the total population of supervisors and mentors who had supported PCGMHW students from three universities in the Northwest of England, during the period of their introduction 2004,2006. Most supervisors and mentors had previous experience of supervision and mentorship with other types of students but not PCGMHWs. Data suggest that there were difficulties due limited understanding of the role of PCGMHWs and how it was to be operationalized. Respondents reported staff shortages, time constraints and competing commitments, which limited support available to students. The lack of organizational readiness and infrastructure to support the role was widely reported. However, the role has developed and is generally well received. The implications for future development of the PCGMHW and the preparation and support of supervisors and mentors are discussed. [source] Incidence and Precipitating Factors of Morbidity among Israeli Travelers AbroadJOURNAL OF TRAVEL MEDICINE, Issue 5 2002Lihi Winer Background: During recent years international travel, including visits to the developing world, has become increasingly popular. Many of these travelers suffer from some sort of health problem during their trip or after their return. Travelers clinics that give pretravel immunization and counseling have emerged. This study analyzes the incidence and risk factors for health problems among Israelis traveling abroad. Methods: The study surveyed by telephone 200 people who visited the traveler's clinic at Soroka Medical Center in Beer-Sheva during the years 1998 to 1999. The travelers were questioned after returning from their journey about the type and duration of the trip, compliance with medical advice given in the travel clinic, and health problems during the trip. Results: The mean age was 26.4 ± 9.4 years, 7% went on an organized tour, 23% traveled alone, and 77% traveled with a friend. The mean duration of the trip was 14.7 ± 13.4 weeks. Of the travelers, 70% reported some health impairment. Problems reported most frequently were gastrointestinal tract diseases (43%), respiratory tract diseases (25%), and injuries (10%). Only 4% were admitted to a hospital during their trip. After their return, 19.5% consulted a physician. Comparing the group of travelers who were sick with the rest, a correlation between noncompliance with the keeping of food hygiene and illness was found (p = .008). Additional risk factors for illness were long duration (p < .001), solitary trip (p = .04), and young age (p < .001). Of the people who were advised to take antimalaria chemoprophylaxis, 55% reported regular use of these drugs. Compliance with treatment correlated with older age (p < .001), short duration of stay (p = .01), previous experience, and travel to Africa (p < .001). Conclusions: Most of the travelers to developing countries are young, travel for long periods, and live in basic conditions during their stay abroad. For these reasons travelers are at increased risk for morbidity. High risk travelers should be identified and counseled in order to increase their compliance with the medical advice and immunizations. A screening program for returning travelers should be considered. [source] | ||||||||||||||||||||||||||||||||||||||||