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Presents Challenges (present + challenge)
Selected AbstractsPresent Challenges in the Numerical Modeling of Polymer-forming ProcessesTHE CANADIAN JOURNAL OF CHEMICAL ENGINEERING, Issue 6 2002Michel Vincent Abstract The purpose of the present paper is to present an overview of the main progresses recently made in the numerical modeling of polymer-forming processes and to describe the challenges to overcome in the near future. Examples are presented in different domains, such as die extrusion, injection molding, film processing, reactive extrusion and pipe reinforcement. Cet article a pour but de présenter une vue d'ensemble des principaux progrès réalisés récemment dans la modélisation numérique des procédés de mise en forme des polymères et de décrire les défis à surmonter dans le proche avenir. Des exemples sont présentés dans différents domaines, tels l'extrusion au travers d'une filière, le moulage par injection, la mise en forme des films, l'extrusion réactive et le renforcement des conduites. [source] Assessment in Clinical Psychology: A Perspective on the Past, Present Challenges, and Future ProspectsCLINICAL PSYCHOLOGY: SCIENCE AND PRACTICE, Issue 3 2006James N. Butcher Assessment emerged during the early twentieth century with the development of tests for assessing characteristics such as intelligence, personality, and suitability for employment. The long, interwoven relationship between clinical psychology and assessment began to change during the 1970s when many clinical psychologists became more involved in behavioral therapy and moved away from psychological testing and with the expanding role of managed care in the mental health services. Clinical assessment broadened into forensic, medical, and personnel applications with psychologists expanding professional roles. The status of assessment was reviewed and some challenges were highlighted. The potential for assessment to contribute to the understanding of mental health problems through collaborative cross-cultural study of psychopathology was suggested with the growing development of clinical psychology internationally. [source] Addiction research centres and the nurturing of creativity: The Centre for Addictions Research of British Columbia, CanadaADDICTION, Issue 2 2010Tim Stockwell ABSTRACT The Centre for Addictions Research of British Columbia (CARBC) was established as a multi-campus and multi-disciplinary research centre administered by the University of Victoria (UVic) in late 2003. Its core funding is provided from interest payments on an endowment of CAD$10.55 million. It is supported by a commitment to seven faculty appointments in various departments at UVic. The Centre has two offices, an administration and research office in Victoria and a knowledge exchange unit in Vancouver. The two offices are collaborating on the implementation of CARBC's first 5-year plan which seeks to build capacity in British Columbia for integrated multi-disciplinary research and knowledge exchange in the areas substance use, addictions and harm reduction. Present challenges include losses to the endowment caused by the 2008/2009 economic crisis and difficulties negotiating faculty positions with the university administration. Despite these hurdles, to date each year has seen increased capacity for the Centre in terms of affiliated scientists, funding and staffing as well as output in terms of published reports, electronic resources and impacts on policy and practice. Areas of special research interest include: drug testing in the work-place, epidemiological monitoring, substance use and injury, pricing and taxation policies, privatization of liquor monopolies, polysubstance use, health determinants of indigenous peoples, street-involved youth and other vulnerable populations at risk of substance use problems. Further information about the Centre and its activities can be found on http://www.carbc.ca. [source] Advances in pancreatic islet transplantation in humansDIABETES OBESITY & METABOLISM, Issue 1 2006Sulaiman A. Nanji With recent advances in methods of islet isolation and the introduction of more potent and less diabetogenic immunosuppressive therapies, islet transplantation has progressed from research to clinical reality. Presently, several international centres have demonstrated successful clinical outcomes with high rates of insulin independence after islet transplantation. Ongoing refinements in donor pancreas procurement and processing, developments in islet isolation and purification technology, and advances in novel immunological conditioning and induction therapies have led to the acceptance of islet transplantation as a safe and effective therapy for patients with type 1 diabetes. This review provides a historical perspective of islet transplantation, outlines the recent advances and current clinical outcomes, and addresses the present challenges and future directions in clinical islet transplantation. [source] How Lutherans Read the Bible: A North American and Global ConversationDIALOG, Issue 1 2006By Dennis T. Olson Abstract:, Recent debates and conflicts over the interpretation of the Bible among Lutherans both in the U.S. and in other parts of the world impel us to consider our history in a Lutheran tradition, our present challenges, and an agenda for future directions. This introductory essay briefly introduces some of the distinctive Lutheran emphases in the use of Scripture, provides an overview of the other essays in this issue of Dialog which are largely focused on the North American context, and then offers a sample of what two Lutheran scholars in places other than the U.S. are thinking about their experiences as Lutherans using the Bible in places like Malaysia and Argentina. [source] Barriers to brand building in UK universities?INTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 1 2007Chris Chapleo Branding in universities has become an increasingly topical issue with practitioners, with some institutions committing substantial financial resources to branding activities. It has, however, received only limited academic investigation, and as the particular characteristics of the sector present challenges for those seeking to build brands, it seems to be timely and appropriate to investigate potential barriers to branding. This exploratory study investigates the opinions of the ,brand guardians' of UK universities,Vice Chancellors, Principals and Rectors,on the barriers to successfully building brands and draws conclusions on their views of the key challenges facing successful branding activity in the sector. Implications for practitioners are also explored. Copyright © 2006 John Wiley & Sons, Ltd. [source] Congenital Diaphragmatic Hernia: Update and ReviewJOURNAL OF OBSTETRIC, GYNECOLOGIC & NEONATAL NURSING, Issue 3 2001Linda J. Juretschke MSN Newborns with congenital diaphragmatic hernia (CDH) present challenges for the neonatal intensive-care nurse. Although CDH has been a known condition for almost 200 years, the treatment strategy for newborns with CDH has changed during the past decade. Despite these improvements, the mortality rate for this condition remains high. An understanding of the anatomical basis and new treatment modalities for this condition will prepare nurses to care for these newborns. [source] Global Connections and Practicing Anthropology in the 21st CenturyANNALS OF ANTHROPOLOGICAL PRACTICE, Issue 1 2006Carole E. Hill This chapt er examines the major themes in the chapters that compromise this volume by discussing how the practice of anthropology across nations and regions of the world is changing as a result of globalization. Several themes are delineated that reflect a unity of purpose and concern about the development and structure of practicing and policy anthropology in the 21st century. Divergent viewpoints among the chapters are also examined. Through comparing and contrasting the major points of the chapters, four major interconnected themes are discussed. They are: 1) local/global transformations: challenge to the traditional; 2) the power of practicing anthropology in local/global contexts; 3) academic and practicing transformations, and 4) the closing gap between colonized and colonizer nations. These themes have important implications for the future of global practice and present challenges to the organization and uses of the products of anthropological inquiry. [source] Strategies for the management of donkey jacks in intensive breeding systemsEQUINE VETERINARY EDUCATION, Issue 12 2009I. F. Canisso Summary Donkeys are bred throughout the world and often play an important role in agriculture. They are also bred to produce mules. Traditionally, jacks are considered challenging to breed in domestic conditions, whether for natural breeding or semen collection using either jennies or mares. The donkey's natural sexual behaviour significantly differs from that of other domestic animals. This presents challenges for in-hand donkey breeding, particularly on mule studs where normally only jacks and mares are kept for breeding. This article describes some of the authors' observations on sexual behaviour in donkeys and practical experience of some of the strategies employed to apply this knowledge to breeding management, in order to improve the success of using donkeys for both natural service and semen collection. [source] Two-dimensional anisotropic Cartesian mesh adaptation for the compressible Euler equationsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS, Issue 11 2004W. A. Keats Abstract Simulating transient compressible flows involving shock waves presents challenges to the CFD practitioner in terms of the mesh quality required to resolve discontinuities and prevent smearing. This paper discusses a novel two-dimensional Cartesian anisotropic mesh adaptation technique implemented for transient compressible flow. This technique, originally developed for laminar incompressible flow, is efficient because it refines and coarsens cells using criteria that consider the solution in each of the cardinal directions separately. In this paper, the method will be applied to compressible flow. The procedure shows promise in its ability to deliver good quality solutions while achieving computational savings. Transient shock wave diffraction over a backward step and shock reflection over a forward step are considered as test cases because they demonstrate that the quality of the solution can be maintained as the mesh is refined and coarsened in time. The data structure is explained in relation to the computational mesh, and the object-oriented design and implementation of the code is presented. Refinement and coarsening algorithms are outlined. Computational savings over uniform and isotropic mesh approaches are shown to be significant. Copyright © 2004 John Wiley & Sons, Ltd. [source] "Congratulations, You Have Been Randomized Into the Control Group!(?)": Issues to Consider When Recruiting Schools for Matched-Pair Randomized Control Trials of Prevention ProgramsJOURNAL OF SCHOOL HEALTH, Issue 3 2008Peter Ji PhD ABSTRACT Background:, Recruiting schools into a matched-pair randomized control trial (MP-RCT) to evaluate the efficacy of a school-level prevention program presents challenges for researchers. We considered which of 2 procedures would be most effective for recruiting schools into the study and assigning them to conditions. In 1 procedure (recruit and match/randomize), we would recruit schools and match them prior to randomization, and in the other (match/randomize and recruitment), we would match schools and randomize them prior to recruitment. Method:, We considered how each procedure impacted the randomization process and our ability to recruit schools into the study. After implementing the selected procedure, the equivalence of both treatment and control group schools and the participating and nonparticipating schools on school demographic variables was evaluated. Results:, We decided on the recruit and match/randomize procedure because we thought it would provide the opportunity to build rapport with the schools and prepare them for the randomization process, thereby increasing the likelihood that they would accept their randomly assigned conditions. Neither the treatment and control group schools nor the participating and nonparticipating schools exhibited statistically significant differences from each other on any of the school demographic variables. Conclusions:, Recruitment of schools prior to matching and randomization in an MP-RCT may facilitate the recruitment of schools and thus enhance both the statistical power and the representativeness of study findings. Future research would benefit from the consideration of a broader range of variables (eg, readiness to implement a comprehensive prevention program) both in matching schools and in evaluating their representativeness to nonparticipating schools. [source] An analysis of trust among globally distributed work teams in an organizational settingKNOWLEDGE AND PROCESS MANAGEMENT: THE JOURNAL OF CORPORATE TRANSFORMATION, Issue 3 2007Sue Newell Regardless of whether a project team is located in the same workplace or distributed around the world, trust remains an important element deemed necessary to facilitate knowledge sharing and collaborative work. At the same time, distribution across sites presents challenges to trust building that are not present among co-located teams. A further complicating factor in trust building among distributed teams is national culture. As we demonstrate, the impact of nationality can be increased when organizations put the distributed sites in a competitive frame. Using the Newell and Swan threefold typology of trust, this paper analyzes trust among IT work teams whose members are located at sites that are distributed in the United States, Ireland, and India. Our case analysis confirms the problematic nature of trust building among globally distributed teams. Specifically, we found that due to situational factors and socio-psychological dynamics an ,Us versus Them' attitude prevails among the distributed sites. This paper concludes that the traditional approaches used by organizations to address the challenges of global collaboration are insufficient and that trust building in an organizational setting requires project managers to actively work on relationship management to minimize the impact of an inter-group perspective. Copyright © 2007 John Wiley & Sons, Ltd. [source] Advances in proteomics data analysis and display using an accurate mass and time tag approachMASS SPECTROMETRY REVIEWS, Issue 3 2006Jennifer S.D. Zimmer Abstract Proteomics has recently demonstrated utility for increasing the understanding of cellular processes on the molecular level as a component of systems biology approaches and for identifying potential biomarkers of various disease states. The large amount of data generated by utilizing high efficiency (e.g., chromatographic) separations coupled with high mass accuracy mass spectrometry for high-throughput proteomics analyses presents challenges related to data processing, analysis, and display. This review focuses on recent advances in nanoLC-FTICR-MS-based proteomics approaches and the accompanying data processing tools that have been developed to display and interpret the large volumes of data being produced. © 2006 Wiley Periodicals, Inc., Mass Spec Rev 25:450,482, 2006 [source] Strategically Managing Negotiation Linkage DynamicsNEGOTIATION AND CONFLICT MANAGEMENT RESEARCH, Issue 1 2010Larry Crump Abstract Negotiation linkage (the way in which one negotiation influences the process or outcome of another) presents challenges that are complex and real. Based on field research, this qualitative study examines four linked-bilateral trade treaty negotiations conducted by Australia, Chile, the European Union, Singapore, and the United States to establish theoretical understanding about the strategic management of negotiation linkage dynamics. Several outcomes are achieved through case analysis. This study (a) introduces "degree of linkage dynamics" (robust, moderate, or modest) as a concept and concludes that it is determined by structural and contextual factors, (b) develops a framework of linked party action, (c) establishes guidance for managing opportunistic behavior in linked negotiations, (d) builds a six-part typology of strategic techniques that can produce tangible gains in linked negotiations, and (e) examines research opportunities to further extend negotiation linkage theory. Research methodology developed in this study serves as a model for investigating negotiation linkage dynamics. [source] Moral knowledge and responsibilities in evaluation implementation: When critical theory and responsive evaluation collideNEW DIRECTIONS FOR EVALUATION, Issue 127 2010Melissa Freeman An external evaluation documented what occurred in an inaugural summer camp to teach high school students how to preserve religious freedom by learning about and acting on the history and current state of church,state separation and other first amendment issues. Camp designers hoped to promote religious diversity values and civic engagement in youth. An analytic vignette grounded in an inductive analysis of observations, interviews, and document collection represents the competing demands of responsive and critical approaches to evaluation. Balancing obligations to promote the social well-being of society with responsibilities to clients and other stakeholders presents challenges that can be met only by identifying priorities with clients in ongoing dialogue. © Wiley Periodicals, Inc., and the American Evaluation Association. [source] Using scanning electron, confocal and optical microscopes to measure microscopic holes in traysPACKAGING TECHNOLOGY AND SCIENCE, Issue 6 2005Laura Bix Abstract Package integrity is of paramount importance to the medical device industry. As healthcare costs soar and integrity testers become more and more sensitive, concern with the question ,what hole size allows microbial penetration into device packages?' is re-ignited. However, producing a consistent and measurable defect in the microcosm presents challenges. Varying techniques are currently employed to produce these defects. Use of an excimer laser is one of the most precise and accurate techniques, and holes ,certified' to be a given size can be purchased at a significant cost. To verify the accuracy and precision of holes drilled with an excimer laser, researchers measured laser-drilled ,exit' and ,entry' holes in glycol-modified polyetheylene terephthalate (PETG) trays using scanning electron microscopy (SEM) and confocal microscopy. This data and the certification data provided by the laser driller were analysed using a mixed-model analysis of variance (ANOVA). Both the effect of measuring technique and hole side (entry vs. exit) were found to be significant. These significant differences have the potential to impact the question that the industry faces with regard to penetration threshold. This suggests that a shift in thinking is needed. Perhaps it would be better if the industry stops thinking about hole size and begins to think in terms of what researchers have referred to as the ,effective hole', which is defined as the volume of gas that will flow through a hole of defined size per unit time. Copyright © 2005 John Wiley & Sons, Ltd. [source] The New Bureaucracies of Virtue or When Form Fails to Follow FunctionPOLAR: POLITICAL AND LEGAL ANTHROPOLOGY REVIEW, Issue 2 2007Charles L. Bosk As the prospective review of research protocols has expanded to include ethnography, researchers have responded with a mixture of bewilderment, irritation, and formal complaint. These responses typically center on how poorly a process modeled on the randomized clinical trial fits the realities of the more dynamic, evolving methods that are used to conduct ethnographic research. However warranted these complaints are, those voicing them have not analyzed adequately the logic in use that allowed the system of review to extend with so little resistance. This paper locates the expansion in the goal displacement that Merton identified as part of bureaucratic organization and identifies the tensions between researchers and administrators as a consequence of an inversion of the normal status hierarchy found in universities. Social scientists need to do more than complain about the regulatory process; they also need to make that apparatus an object for study. Only recently have social scientists taken up the task in earnest. This paper contributes to emerging efforts to understand how prospective review of research protocols presents challenges to ethnographers and how ethnographic proposals do the same for IRBs (Institutional Research Boards). This essay extends three themes that are already prominent in the literature discussing IRBs and ethnography: (1) the separation of bureaucratic regulations,policies,and procedures from the everyday questions of research ethics that are most likely to trouble ethnographers; (2) the goal displacement that occurs when the entire domain of research ethics is reduced to compliance with a set of federal regulations as interpreted by local committees; and (3) the difficulties of sense making when ethnographers and IRB administrators or panel members respond each to the other's concerns. [source] BETTER REGULATION IN EUROPE: BETWEEN PUBLIC MANAGEMENT AND REGULATORY REFORMPUBLIC ADMINISTRATION, Issue 3 2009CLAUDIO M. RADAELLI Can the European regulatory state be managed? The European Union (EU) and its member states have looked at better regulation as a possible answer to this difficult question. This emerging public policy presents challenges to scholars of public management and administrative reforms, but also opportunities. In this conceptual article, we start from the problems created by the value-laden discourse used by policy-makers in this area, and provide a definition and a framework that are suitable for empirical/explanatory research. We then show how public administration scholars could usefully bring better regulation into their research agendas. To be more specific, we situate better regulation in the context of the academic debates on the New Public Management, the political control of bureaucracies, evidence-based policy, and the regulatory state in Europe. [source] Tensions and Paradoxes in Electronic Patient Record Research: A Systematic Literature Review Using the Meta-narrative MethodTHE MILBANK QUARTERLY, Issue 4 2009TRISHA GREENHALGH Context: The extensive research literature on electronic patient records (EPRs) presents challenges to systematic reviewers because it covers multiple research traditions with different underlying philosophical assumptions and methodological approaches. Methods: Using the meta-narrative method and searching beyond the Medline-indexed literature, this review used "conflicting" findings to address higher-order questions about how researchers had differently conceptualized and studied the EPR and its implementation. Findings: Twenty-four previous systematic reviews and ninety-four further primary studies were considered. Key tensions in the literature centered on (1) the EPR ("container" or "itinerary"); (2) the EPR user ("information-processer" or "member of socio-technical network"); (3) organizational context ("the setting within which the EPR is implemented" or "the EPR-in-use"); (4) clinical work ("decision making" or "situated practice"); (5) the process of change ("the logic of determinism" or "the logic of opposition"); (6) implementation success ("objectively defined" or "socially negotiated"); and (7) complexity and scale ("the bigger the better" or "small is beautiful"). Conclusions: The findings suggest that EPR use will always require human input to recontextualize knowledge; that even though secondary work (audit, research, billing) may be made more efficient by the EPR, primary clinical work may be made less efficient; that paper may offer a unique degree of ecological flexibility; and that smaller EPR systems may sometimes be more efficient and effective than larger ones. We suggest an agenda for further research. [source] Developing a blueprint for conservation of the endangered longleaf pine ecosystem based on centers of Coastal Plain plant endemismAPPLIED VEGETATION SCIENCE, Issue 1 2006Bruce A. Sorrie Abstract Question: Can the geographic patterning of endemic plant species inform reserve selection in a region of high endemism? Location: The Southeastern Coastal Plain of North America, focusing primarily on the imperiled longleaf pine (Pinus palustris P. Miller) ecosystem. Methods: We documented the high level of plant endemism in the region, and characterized the endemic taxa into distributional subregions. Results: A total of 1630 plant taxa are endemic to the Coastal Plain, a large proportion of which are endemic to phytogeographical subregions within the Coastal Plain, with particularly large numbers of narrow endemics occurring in the East Gulf Coastal Plain and Florida Peninsula. Conclusions: This pattern of local endemism presents challenges in conserving the full biota of the region: a reserve system focusing on few and large conservation areas has theoretical benefits for long-term management and viability, but will fail to capture many local endemics. We propose that the dispersed distribution of endemic species will require a mixture of large core reserves and smaller satellite reserves. [source] Real-time measurement of protein leaching from micro-particulate larval fish feedsAQUACULTURE RESEARCH, Issue 16 2008Peter M Nicklason Abstract The small size and high surface area to volume ratio of larval fish feed presents challenges for nutrient retention in micro-particulate diets. A method for the accurate and rapid measurement of nutrient retention or loss from micro-particulate feed in water is needed to help develop micro-particulate feeds with good nutrient retention characteristics. The present study developed and validated an instrument method using fibre optic technology that measures protein leaching in real time. Larval fish feed particles of different sizes (100,500 ,m) and formulations were measured. Under consistent experimental conditions, a feed could be assayed for the rate of mass loss and the half-life or time of 50% total soluble mass loss. The results closely approximated natural decay models with coefficients of determination (r2) >0.95. The end result is a fast and accurate method to quantify and provide solid reference data for a feed formulation or particle size. Using this method allows different feeds to be compared and conclusions drawn for relative performance. [source] High-fidelity spectroscopy at the highest resolutionsASTRONOMISCHE NACHRICHTEN, Issue 5 2010D. Dravins Abstract High-fidelity spectroscopy presents challenges for both observations and in designing instruments. High-resolution and high-accuracy spectra are required for verifying hydrodynamic stellar atmospheres and for resolving intergalactic absorption-line structures in quasars. Even with great photon fluxes from large telescopes with matching spectrometers, precise measurements of line profiles and wavelength positions encounter various physical, observational, and instrumental limits. The analysis may be limited by astrophysical and telluric blends, lack of suitable lines, imprecise laboratory wavelengths, or instrumental imperfections. To some extent, such limits can be pushed by forming averages over many similar spectral lines, thus averaging away small random blends and wavelength errors. In situations where theoretical predictions of lineshapes and shifts can be accurately made (e.g., hydrodynamic models of solar-type stars), the consistency between noisy observations and theoretical predictions may be verified; however this is not feasible for, e.g., the complex of intergalactic metal lines in spectra of distant quasars, where the primary data must come from observations. To more fully resolve lineshapes and interpret wavelength shifts in stars and quasars alike, spectral resolutions on order R = 300 000 or more are required; a level that is becoming (but is not yet) available. A grand challenge remains to design efficient spectrometers with resolutions approaching R = 1 000 000 for the forthcoming generation of extremely large telescopes (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Making Choices for Childbirth: A Randomized Controlled Trial of a Decision-aid for Informed Birth after Cesarean,BIRTH, Issue 4 2005Allison Shorten RN ABSTRACT:,Background:Decision-making about mode of birth after a cesarean delivery presents challenges to women and their caregivers and requires a balance of risks and benefits according to individual circumstances. The study objective was to determine whether a decision-aid for women who have experienced previous cesarean birth facilitates informed decision-making about birth options during a subsequent pregnancy. Method:A prospective multicenter randomized controlled trial of 227 pregnant women was conducted within 3 prenatal clinics and 3 private obstetric practices in New South Wales, Australia. Women with 1 previous cesarean section and medically eligible for trial of vaginal birth were recruited at 12 to 18 weeks' gestation; 115 were randomized to the intervention group and 112 to the control group. A decision-aid booklet describing risks and benefits of elective repeat cesarean section and trial of labor was given to intervention group women at 28 weeks' gestation. Main outcome measures included level of knowledge, decisional conflict score, women's preference for mode of birth, and recorded mode of birth. Results:Women who received the decision-aid demonstrated a significantly greater increase in mean knowledge scores than the control group (increasing by 2.17 vs 0.42 points on a 15-point scale)(p < 0.001, 95% CI for difference = 1.15,2.35). The intervention group demonstrated a reduction in decisional conflict score (p < 0.05). The decision-aid did not significantly affect the rate of uptake of trial of labor or elective repeat cesarean section. Preferences expressed at 36 weeks were not consistent with actual birth outcomes for many women. Conclusion:A decision-aid for women facing choices about birth after cesarean section is effective in improving knowledge and reducing decisional conflict. However, little evide nce suggested that this process led to an informed choice. Strategies are required to better equip organizations and practitioners to empower women so that they can translate informed preferences into practice. Further work needs to examine ways to enhance women's power in decision-making within the doctor-patient relationship. (BIRTH 32:4 December 2005) [source] Behavioral and learning problems in schoolchildren related to cognitive test dataACTA PAEDIATRICA, Issue 7 2004FR Volkmar The interface between disorders of learning and development and disorders of behavior presents challenges for researchers and clinicians alike. In the Elk et al. paper, a large group of children were screened for learning and/or behavioral problems. A relatively large number of children screened positive and their IQ scores were analyzed using a cluster analytic approach. Various patterns were identified including lower and higher functioning children. In our commentary, we point out the challenges for diagnosis of mental health problems in both lower and higher functioning children; the potential overlap of problems in learning and social interaction remains an area in need of additional work. Conclusion: There is a complex interaction between developmental status and behavioral difficulty; further research is needed to clarify diagnostic validity and areas where existing diagnostic systems need further refinement. [source] | ||||||||||||||||||||||||||||