Assignment

Distribution by Scientific Domains
Distribution within Chemistry

Kinds of Assignment

  • channel assignment
  • chemical shift assignment
  • chromosomal assignment
  • chromosome assignment
  • complete assignment
  • configuration assignment
  • configurational assignment
  • correct assignment
  • full assignment
  • genetic assignment
  • group assignment
  • homework assignment
  • individual assignment
  • international assignment
  • nmr assignment
  • nmr chemical shift assignment
  • nmr signal assignment
  • parentage assignment
  • paternity assignment
  • peak assignment
  • random assignment
  • resonance assignment
  • sequential assignment
  • shift assignment
  • signal assignment
  • spectral assignment
  • stereochemical assignment
  • structural assignment
  • structure assignment
  • task assignment
  • tentative assignment
  • traffic assignment
  • treatment assignment
  • unambiguous assignment
  • vibrational assignment
  • wavelength assignment
  • writing assignment

  • Terms modified by Assignment

  • assignment algorithm
  • assignment algorithms
  • assignment problem
  • assignment procedure
  • assignment test

  • Selected Abstracts


    THE BIG FIVE PERSONALITY CHARACTERISTICS AS PREDICTORS OF EXPATRIATE'S DESIRE TO TERMINATE THE ASSIGNMENT AND SUPERVISOR-RATED PERFORMANCE

    PERSONNEL PSYCHOLOGY, Issue 1 2000
    PAULA M. CALIGIURI
    Applying the evolutionary theory of personality, this study proposed and tested the hypotheses that each of the Big Five personality characteristics (Extroversion, Agreeableness, Conscientiousness, Emotional Stability, and Openness or Intellect) predict two criteria of expatriate success: (a) desire to prematurely terminate the expatriate assignment, and (b) supervisor-rated performance on the expatriate assignment. The participants were 143 expatriate employees (and 94 supervisors) from a U.S.-based information technology company. Results from correlation and regression analyses suggest that Extroversion, Agreeableness, and Emotional Stability are negatively related to whether expatriates desire to terminate their assignment. Conscientiousness is positively related to the supervisor-rated performance on the expatriate assignment. Practical implications for expatriate management (e.g., self-selection) are given. [source]


    A Path-Based Algorithm for the Cross-Nested Logit Stochastic User Equilibrium Traffic Assignment

    COMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 1 2009
    Shlomo Bekhor
    A SUE assignment based on the Cross-Nested Logit (CNL) route choice model is presented. The CNL model can better represent route choice behavior compared to the Multinomial Logit (MNL) model, while keeping a closed form equation. The article uses a specific optimization formulation developed for the CNL model, and develops a path-based algorithm for the solution of the CNL-SUE problem based on adaptation of the disaggregate simplicial decomposition (DSD) method. The article illustrates the algorithmic implementation on a real size network and discusses the trade-offs between MNL-SUE and CNL-SUE assignment. [source]


    Bi-level Programming Formulation and Heuristic Solution Approach for Dynamic Traffic Signal Optimization

    COMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 5 2006
    Dazhi Sun
    Conventional methods of signal timing optimization assume given traffic flow pattern, whereas traffic assignment is performed with the assumption of fixed signal timing. This study develops a bi-level programming formulation and heuristic solution approach (HSA) for dynamic traffic signal optimization in networks with time-dependent demand and stochastic route choice. In the bi-level programming model, the upper level problem represents the decision-making behavior (signal control) of the system manager, while the user travel behavior is represented at the lower level. The HSA consists of a Genetic Algorithm (GA) and a Cell Transmission Simulation (CTS) based Incremental Logit Assignment (ILA) procedure. GA is used to seek the upper level signal control variables. ILA is developed to find user optimal flow pattern at the lower level, and CTS is implemented to propagate traffic and collect real-time traffic information. The performance of the HSA is investigated in numerical applications in a sample network. These applications compare the efficiency and quality of the global optima achieved by Elitist GA and Micro GA. Furthermore, the impact of different frequencies of updating information and different population sizes of GA on system performance is analyzed. [source]


    Dynamic Optimal Traffic Assignment and Signal Time Optimization Using Genetic Algorithms

    COMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING, Issue 4 2004
    H. R. Varia
    A simulation-based approach is employed for the case of multiple-origin-multiple-destination traffic flows. The artificial intelligence technique of genetic algorithms (GAs) is used to minimize the overall travel cost in the network with fixed signal timings and optimization of signal timings. The proposed method is applied to the example network and results are discussed. It is concluded that GAs allow the relaxation of many of the assumptions that may be needed to solve the problem analytically by traditional methods. [source]


    Isolation and Structure Determination of Aplidinones A,C from the Mediterranean Ascidian Aplidium conicum: A Successful Regiochemistry Assignment by Quantum Mechanical 13C NMR Chemical Shift Calculations

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 23 2005
    Anna Aiello
    Abstract A chemical investigation of a Mediterranean ascidian, Aplidium conicum, has resulted in the isolation of the new metabolites aplidinone A (1), B (2), and C (3). The structures of aplidinones A,C were determined by interpretation of spectroscopic data, whereas the regiochemistry was determined by the comparison of experimental 13C NMR chemical shifts with those predicted by GIAO shielding calculations. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]


    4- and 4,5-Substituted N -Methoxythiazole-2(3H)-thiones , Preparation,UV/Vis Spectra, and Assignment of Electronic Transitions in Comparison to N -Methoxypyridine-2(1H)-thione Using Time-Dependent Density Functional Theory Calculations

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 5 2005
    Jens Hartung
    Abstract Experimentally observed absorptions in UV/Vis spectra of N -methoxy-4-methylthiazole-2(3H)-thione, N -methoxy-5-(p -methoxyphenyl)-4-methylthiazole-2(3H)-thione, N -methoxypyridine-2(1H)-thione, and selected N -hydroxy derivatives thereof have been assigned to ,,,*-type transitions as dominating character, using the results from ab initio calculations [time-dependent density functional theory (TD)RI-BLYP/TZVPP]. Theory further predicts that electronic excitations in N -methoxythiazole-2(3H)-thiones on one side and N -meth-oxypyridine-2(1H)-thione on the other side differ significantly with respect to character and statistical weight of contributing transitions. These effects originate predominantly from contributions of the endocyclic sulfur atom onto orbital energies and shapes in thiazole-2(3H)-thiones, and may be intensified by substituents such as a p -methoxyphenyl group located in position 5. Since the majority of the calculated spectral differences between thiazole- and pyridinethiones refers to excitations of low intensity, the findings from the present study correlate with two important experimental facts: (i) Apart from minor shifts in the exact spectral location of UV/Vis absorptions, electronic spectra of N -hydroxy- or N -methoxy-substituted pyridine-2(1H)-thiones and thiazole-2(3H)-thiones are surprisingly similar in shape. (ii) N -alkoxypyridine-2(1H)-thiones and N -alkoxythiazole-2(3H)-thiones liberate upon UV/Vis excitation oxygen-centered radicals with a comparable efficiency. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]


    Assignment of the [4Fe-4S] clusters of Ech hydrogenase from Methanosarcina barkeri to individual subunits via the characterization of site-directed mutants

    FEBS JOURNAL, Issue 18 2005
    Lucia Forzi
    Ech hydrogenase from Methanosarcina barkeri is a member of a distinct group of membrane-bound [NiFe] hydrogenases with sequence similarity to energy-conserving NADH:quinone oxidoreductase (complex I). The sequence of the enzyme predicts the binding of three [4Fe-4S] clusters, one by subunit EchC and two by subunit EchF. Previous studies had shown that two of these clusters could be fully reduced under 105 Pa of H2 at pH 7 giving rise to two distinct S½ electron paramagnetic resonance (EPR) signals, designated as the g = 1.89 and the g = 1.92 signal. Redox titrations at different pH values demonstrated that these two clusters had a pH-dependent midpoint potential indicating a function in ion pumping. To assign these signals to the subunits of the enzyme a set of M. barkeri mutants was generated in which seven of eight conserved cysteine residues in EchF were individually replaced by serine. EPR spectra recorded from the isolated mutant enzymes revealed a strong reduction or complete loss of the g = 1.92 signal whereas the g = 1.89 signal was still detectable as the major EPR signal in five mutant enzymes. It is concluded that the cluster giving rise to the g = 1.89 signal is the proximal cluster located in EchC and that the g = 1.92 signal results from one of the clusters of subunit EchF. The pH-dependence of these two [4Fe-4S] clusters suggests that they simultaneously mediate electron and proton transfer and thus could be an essential part of the proton-translocating machinery. [source]


    Assignment of a single disulfide bridge in rat liver methionine adenosyltransferase

    FEBS JOURNAL, Issue 1 2000
    María L. Martínez-Chantar
    Rat liver methionine adenosyltransferase incorporated 8 mol of N -ethylmaleimide per mol of subunit upon denaturation in the presence of 8 m urea, whereas 10 such groups were labelled when dithiothreitol was also included. This observation prompted a re-examination of the state of the thiol groups, which was carried out using peptide mapping, amino acid analysis and N-terminal sequencing. The results obtained revealed a disulfide bridge between Cys35 and Cys61. This disulfide did not appear to be conserved because cysteines homologous to residue 61 do not exist in methionine adenosyltransferases of other origins, therefore suggesting its importance for the differential aspects of the liver-specific enzyme. [source]


    The United Nations Convention on the Assignment of Receivables in International Trade: insolvency aspects

    INTERNATIONAL INSOLVENCY REVIEW, Issue 3 2004
    Spiros V. Bazinas
    Breaking new ground, the UN Convention on the Assignment of Receivables in International Trade refers all priority conflicts with respect to receivables to the law of single and easily determinable jurisdiction, and one that is most likely going to be the insolvency jurisdiction, namely to the law of the assignor's place of business or, in the case of places of business in more than one State, the assignor's central administration. In the case of an insolvency proceeding in another jurisdiction, the mandatory rules of that juridiction displace any priority rule of the law of the assignor's location only if that priority rule is manifestly contrary to the public policy of that jurisdiction. In such a case, the balance of the priority rules of the law of the assignor's location prevails over the priority rules of the insolvency jurisdiction with the exception of rules relating to preferential rights. In any case, the Convention ensures that priority rules do not interfere with basic insolvency rights, such as those relating to stays, avoidance actions and to the performance of contracts or maintenance of the estate. Copyright © 2004 John Wiley & Sons, Ltd. [source]


    The chemiionization reactions Ce + O and Ce + O2: Assignment of the observed chemielectron bands

    INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Issue 10 2009
    Tanya K. Todorova
    Abstract Multiconfigurational quantum chemical methods (CASSCF/CASPT2) have been used to study the chemiionization reactions Ce + O , CeO+ + e, and Ce + O2 , CeO + e,. Selected spectroscopic constants for CeOn and CeO (n = 1, 2), as well as reaction enthalpies of the chemiionization reactions of interest, have been computed and compared with experimental values. In contrast to the lanthanum case, for both Ce + O2(X3,) and Ce + O2( a1,g), the Ce + O2 , CeO + e, reaction is shown to be exothermic, and thus, contributes to the experimental chemielectron spectra. The apparent discrepancy between the computed reaction enthalpies and the high kinetic energy offset values measured in the chemielectron spectra is rationalized by arguing that chemielectrons are produced mainly via two sequential reactions (Ce + O2 , CeO + O, followed by Ce + O , CeO+ + e,) as in the case of lanthanum. For Ce + O2 (a1,g), a chemielectron band with higher kinetic energy than that recorded for Ce + O2( X3,) is obtained. This is attributed to production of O( 1D) from the reaction Ce + O2( a1,g) , CeO + O( 1D), followed by chemiionization via the reaction Ce + O( 1D) , CeO+ + e,. Accurate potential energy curves for the ground and a number of excited states of CeO and CeO+ have been computed, and a mechanism for the chemiionization reactions investigated experimentally was proposed. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2009 [source]


    Titration and Assignment of Residues that Regulate the Enantioselectivity of Phenylacetone Monooxygenase

    ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 8-9 2007
    Francesca Zambianchi
    Abstract Phenylacetone monooxygense (PAMO) from Thermobifida fusca was employed for the asymmetric oxidation of thioanisole (sulfooxidation) and of racemic 2-phenylpropionaldehyde (Baeyer,Villiger oxidation). A pH dependence of enantioselectivity was observed in both cases. Two different residues, with pKa values of 7.8±0.2 and 9.2±0.2, appeared to be responsible for the pH effects on PAMO enantioselectivity. The protonation of Arg337 and the FAD:C4a-hydroperoxide/FAD:C4a-peroxide equilibrium were identified as the major factors responsible for the fine-tuning of PAMO enantioselectivity in Baeyer,Villiger oxidation and sulfooxidation, respectively. [source]


    Community organization and species richness of ants (Hymenoptera/Formicidae) in Mongolia along an ecological gradient from steppe to Gobi desert

    JOURNAL OF BIOGEOGRAPHY, Issue 12 2003
    Martin Pfeiffer
    Abstract Aim, Ants (Hymenoptera/Formicidae) have strong influences on ecosystems especially in arid regions. However, little is known about ants of the vast steppe and desert regions of Central Asia. Here we provide the first comprehensive study of ant communities in Mongolia, conducted along a north-to-south gradient in climate. We examined ants' distribution patterns, assessed the impact of climatic parameters on community structure and species diversity and investigated the influence of the corresponding communities of plants. Location, Mongolia (Central Asia). Methods, We observed 31,956 ants at seed baits at 11 study sites along a transect from steppe to Gobi desert for which we attained meteorological data (mean yearly precipitation: 197 to 84 mm). Extra sampling was conducted at sugar and protein baits and by the inspection of different microhabitats. Vegetation patterns of each plot were recorded. Statistical evaluation comprised ordination and correlation. Results, We observed 15 species of ants at seed baits. Three faunal complexes of ants could be distinguished by detrended correspondence analysis (DCA): (1) in steppe baits were dominated by Formica - and Myrmica -species, (2) in semi desert we found mostly species of Tetramorium, Myrmica, Proformica, Plagiolepis, and Leptothorax, and (3) in desert Cataglyphis aenescens and Messor aciculatus dominated, and Lasius was exclusively found there. Another 11 rare ant species were sampled by hand and at sugar baits. Altogether five ant species were new to the Mongolian fauna: Cardiocondyla koshewnikovi, Myrmica koreana, Myrmica pisarskii, Polyergus nigerrimus, and Proformica kaszabi. Assignment of taxa to functional groups showed that in steppe cold climate specialists dominated, in semi desert we found mainly opportunists, and in desert hot climate specialists. Several functional groups know from arid zones in other parts of the world were missing. In desert certain species were highly dominant. First DCA scores of ant- and plant-communities were highly correlated with each other and with climatic parameters. While plant species diversity was positively correlated with increasing northern latitude, ant diversity and ant species richness were not correlated with latitude and responded neither to precipitation, nor to any other climatic parameter. Semi desert was a transition zone between steppe and desert, with high species richness. Ant genus composition of the ecotone overlapped with both other regions. However, beta diversity between pairs of plots within this zone was low, indicating a small-scale mosaic pattern. Main conclusions, The ant communities in the Mongolian steppe and desert zones were strongly influenced by low temperatures and differed in many aspects from the ant fauna in other arid ecosystems, especially in terms of species richness, diversity of feeding guilds, and richness of functional groups. [source]


    Novel tetracyclic imidazole derivatives: Synthesis, dynamic NMR study, and anti-inflammatory evaluation

    JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 3 2010
    Renata Rup
    A series of tetracyclic imidazole derivatives 9a,9v and 10a,10h are prepared by multistep route starting from the known tricyclic diketones 2a,2d. Intermediary dibenzooxepin[4,5- d]imidazoles (3a, 3c) and dibenzothiepin[4,5- d]imidazoles (3b, 3d) are N -protected to 4e, 4f and to the isomeric compounds 5a, 5b and 6a, 6b. The isomeric compounds 5 and 6 are separated. Compounds 4, 5, and 6 are formylated at C(2) to afford 7a,7j. In the last steps, aldehyde group is reduced, then alkylated to the two sets of isomeric ,-dimethylaminoalkyl derivatives 9a,9v. N -deprotection of 9i,9v led to the compounds 10a,10h. Assignment of the syn/anti structure to 5a and 6a was supported by 1D selective ROESY NMR spectra, whereas conformational mobility for the selected representatives 8a and 8b is studied by dynamic NMR. Activation energies (energy barriers for interconversion) are determined to be ,11.5 and 16.2 kcal/mol, respectively. A series of derivatives 9 and 10 were tested in vitro for their anti-inflammatory activity. J. Heterocyclic Chem., (2010). [source]


    Does merit pay reward good teachers?

    JOURNAL OF POLICY ANALYSIS AND MANAGEMENT, Issue 3 2004
    Evidence from a randomized experiment
    A common criticism of merit-pay plans is that they fail to systematically target rewards to the most effective teachers. This study presents new evidence on this issue by evaluating data from Tennessee's Career Ladder Evaluation System and the Project STAR class-size experiment. Because the students and teachers participating in the experiment were randomly assigned, inferences about the relative quality of teachers certified by the career ladder should be unbiased. The results indicate that Tennessee's career ladder had mixed success in rewarding teachers who increased student achievement. Assignment to career-ladder teachers increased mathematics scores by roughly 3 percentile points but generally had smaller and statistically insignificant effects on reading scores. © 2004 by the Association for Public Policy Analysis and Management. [source]


    Assignment of the Raman-active modes of the antitumor agent azathioprine by normal-mode calculations

    JOURNAL OF RAMAN SPECTROSCOPY, Issue 10 2001
    Alberto Vivoni
    Azathioprine is a slow-release prodrug of 6-mercaptopurine and an established clinical agent for the treatment of human leukemias and other immunologically mediated diseases. The Raman spectra (1600,600 cm,1) of solid and solution azathiopurine were recorded and are presented along with results from normal-mode calculations. The band assignments were derived from semi-empirical and ab initio molecular orbital calculations. The ab initio calculations were performed with the restricted Hartree,Fock method and the semi-empirical methods utilized the AM1, PM3 and MNDO-d methods. Copyright © 2001 John Wiley & Sons, Ltd. [source]


    Complete assignment of 1H and 13C NMR data of pravastatin derivatives

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 1 2009
    Markus Bacher
    Abstract The complete 1H and 13C NMR data of 27 pravastatin derivatives are presented. Assignment was achieved by use of 1D and 2D NMR experiments (selective 1D NOE, COSY, NOESY, HSQC, HMBC). Copyright © 2008 John Wiley & Sons, Ltd. [source]


    Assignment of 1H and 13C NMR data for diethyl 2- and 8-quinolylmethylphosphonates and their palladium(II) dihalide complexes

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 11 2003
    eljko Marini
    Abstract 1H and 13C NMR spectral data for diethyl 2- and 8-quinolylmethylphosphonates (L) and their palladium(II) dihalide complexes, trans -[PdL2X2] (L = 2-dqmp, 8-dqmp; X = Cl, Br), are presented. The NMR analysis was performed on the basis of one- and two-dimensional homo- and heteronuclear experiments including 1H, 13C, APT, 1H,1H COSY, 1H,13C COSY, HMQC and HMBC techniques. Copyright © 2003 John Wiley & Sons, Ltd. [source]


    Case,control study of pleural mesothelioma in workers with social security in Mexico

    AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 3 2010
    Guadalupe Aguilar-Madrid MD
    Abstract Background Environmental and occupational exposure to asbestos in Mexico in the past has been a cause of deaths and health damages. Its magnitude is unknown to date. Our objective was to identify the proportion of cases of malignant pleural mesothelioma (MPM) that can be attributed to and occupational exposure to asbestos. Methods We carried out a case,control study of MPM in 472 workers insured by the Mexican Institute of Social Security, all Valley of Mexico residents, with 119 incident cases and 353 controls. Cases were histologically confirmed. Participants were questioned concerning their occupational history and sociodemographic data. Assignment to one of the four exposures was performed qualitatively by an expert hygienist. Odds ratios (ORs) and attributable risks (ARs) were calculated using a non-conditional logistic regression model. Results A total of 80.6% of cases and 31.5% of controls had occupational exposure to asbestos. ORs were adjusted for age and gender and by exposure category, and exhibited an increase with probability of exposure as follows: 3.7(95% CI 1.3,10.4) for the likely category and 14.3(95% CI 8,26) for the certain category; AR in the group occupationally exposed to asbestos was 83.2%, and the population AR was 44%. Conclusions Our results show that the relationship between industrial uses of all forms of asbestos is generating an increase in mesothelioma-related diseases and deaths among Mexican workers. As a public health policy, Mexico should prohibit the use of asbestos in all production processes with the aim of controlling the epidemic and preventing the occurrence of new cases of MPM. Am. J. Ind. Med. 53:241,251, 2010. © 2009 Wiley-Liss, Inc. [source]


    Assignment of work involving farm tractors to children on North American farms,

    AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 1 2001
    Barbara Marlenga PhD
    Abstract Background Children are at high risk for tractor-related injury. The North American Guidelines for Children's Agricultural Tasks (NAGCAT) provide recommendations for the assignment of tractor work. This analysis describes tractor-related jobs assigned to farm children and compares them to NAGCAT. Methods A descriptive analysis was conducted of baseline data collected by telephone interview during a randomized, controlled trial. Results The study population consisted of 1,138 children who worked on 498 North American farms. A total of 2,389 farm jobs were reported and 456 (19.1%) involved operation of farm tractors. Leading types of tractor jobs were identified. Modest, yet important, percentages of children were assigned tractor work before the minimum ages recommended by NAGCAT. Conclusions Children on farms are involved in tractor work at a young age and some are involved in jobs that they are unlikely to have the developmental abilities to perform. NAGCAT is a new parental resource that can be applied to these work situations. Am. J. Ind. Med. 40:15,22, 2001. © 2001 Wiley-Liss, Inc. [source]


    ORIGINAL RESEARCH,INTERSEX AND GENDER IDENTITY DISORDERS: Gender Assignment and Medical History of Individuals with Different Forms of Intersexuality: Evaluation of Medical Records and the Patients' Perspective

    THE JOURNAL OF SEXUAL MEDICINE, Issue 4i 2007
    Lisa Brinkmann PhD
    ABSTRACT Introduction., Until now, there are only few studies that focus on the specific treatment experiences of people with intersexuality and evaluate their outcome in terms of psychological, physical, and social well-being. Further, the presentation of the patients' perspective is often neglected in research. Aim., Overview of preliminary results of the Hamburg-Intersex-Study on gender assignment and medical history of adult subjects with intersexuality (disorders of sex development), as well as the patients retrospectively stated thoughts and feelings regarding these interventions. Main Outcome Measures., Medical records from participants of the study were analyzed. The subjective attitudes and evaluation of the treatment measures were assessed with a self-constructed questionnaire. Data on psychological well-being were measured with the Brief Symptom Inventory. Methods., In total, 37 adult participants (mean age 30.6 years) with following diagnosis were included: congenital adrenal hyperplasia, complete and partial androgen insensitivity syndrome, gonadal dysgenesis and disturbances of the androgen biosynthesis, such as 5 alpha reductase deficiency and 17 beta hydroxysteroid deficiency. Results., The majority of participants had (often multiple) genital surgery to correct the appearance of their genitalia and/or to enable sexual functioning. The diagnostic groups differ not only in amount and invasiveness of experienced surgical and medical treatment but also in the subjective and retrospective evaluation of the treatment measures and in the amount of reported psychological distress. Conclusion., Many subjects stated to have experienced the medical procedures and care very negatively, whereby the aspects of secrecy, untruthfulness, and concealment were stated as most difficult and burdening. Brinkmann L, Schuetzmann K, and Richter-Appelt H. Gender assignment and medical history of individuals with different forms of intersexuality: Evaluation of medical records and the patients' perspective. J Sex Med 2007;4:964,980. [source]


    Assignment of the locus for arachnomelia syndrome to bovine chromosome 23 in Simmental cattle

    ANIMAL GENETICS, Issue 6 2009
    J. Buitkamp
    Summary Arachnomelia syndrome is a lethal inherited malformation mainly of the limbs, vertebral column and skull in cattle, which poses a severe impairment to farmers and breeders. Recently, a number of cases of arachnomelia syndrome have occurred in the Simmental breed and some sires with excellent breeding values had been shown to be carriers of the disease. We herein report the genetic mapping of the mutation underlying arachnomelia in cattle. The disease was mapped using a two-stage genome scan. A first round autosomal genome-wide screening using a limited number of cases identified three chromosomal regions with lod-scores > 1. The position of the arachnomelia syndrome locus was identified to be on BTA 23 by genotyping an additional, independent set of animals with markers that provided positive lod-scores in the course of the initial genome-wide screen. Using a denser set of regional microsatellites, the locus could be mapped to a region about 9 cM in length. The most significant linkage signal with arachnomelia syndrome was obtained with marker NRKM-17 (lod-score > 20) using a recessive model. Interestingly, different genes seem to be responsible for the disease in Brown Swiss and Simmental breeds, as arachnomelia syndrome was mapped to a different location in Brown Swiss. The results provide sufficient information for the development of a genetic test system and also allow the identification of positional candidate genes. [source]


    Assignment of 128 genes localized on human chromosome 14q to the IMpRH map

    ANIMAL GENETICS, Issue 4 2009
    T. Shimogiri
    Summary To provide a gene-based comparative map and to examine a porcine genome assembly using bacterial artificial chromosome-based sequence, we have attempted to assign 128 genes localized on human chromosome 14q (HSA14q) to a porcine 7000-rad radiation hybrid (IMpRH) map. This study, together with earlier studies, has demonstrated the following. (i) 126 genes were incorporated into two SSC7 RH linkage groups by CarthaGene analysis. (ii) In the remaining two genes, TOX4 linked to TCRA located in SSC7 by two-point analysis, whereas SIP1 showed no significant linkage with any gene/marker registered in the IMpRH Web Server. (iii) In the two groups, the gene clusters located from 19.9 to 36.5 Mb on HSA14q11.2-q13.3 and from 64.0 to 104.3 Mb on HSA14q23-q32.33 respectively were assigned to SSC7q21-q26. (iv) Comparison of the gene order between the present RH map and the latest porcine sequence assembly revealed some inconsistencies, and a redundant arrangement of 16 genes in the sequence assembly. [source]


    Assignment of BGLAP, BMP2, CHST4, SLC1A3, SLC4A1, SLC9A5 and SLC20A1 to equine chromosomes by FISH and confirmation by RH mapping

    ANIMAL GENETICS, Issue 5 2005
    D. Müller
    First page of article [source]


    Assignment of the solute carrier family 27 member 1 (SLC27A1) gene to bovine chromosome 7

    ANIMAL GENETICS, Issue 4 2005
    L. Ordovás
    No abstract is available for this article. [source]


    Assignment of the porcine silencing mediator for retinoid and thyroid hormone receptors (NCOR2) to SSC14q21 by radiation hybrid mapping

    ANIMAL GENETICS, Issue 3 2005
    Y. Song
    No abstract is available for this article. [source]


    Assignment of bovine trophinin (TRO) to the q arm of the X chromosome by fluorescence in situ hybridization

    ANIMAL GENETICS, Issue 2 2004
    M. Asai
    No abstract is available for this article. [source]


    Assignment of the horse grey coat colour gene to ECA25 using whole genome scanning

    ANIMAL GENETICS, Issue 5 2002
    J. E. Swinburne
    The dominant grey coat colour gene of horses has been mapped using a whole genome scanning approach. Samples from a large half-sibling pedigree of Thoroughbred horses were utilized in order to map the grey coat colour locus, G. Multiplex groups of microsatellite markers were developed and used to efficiently screen the horse genome at a resolution of approximately 22 cM, based on an estimated map length for the horse genome of 2720 cM. The grey gene was assigned to chromosome 25 (ECA25), one of the smaller acrocentric horse chromosomes. Based on the current state of knowledge of conserved synteny and coat colour genetics in other mammalian species, there are no obvious candidate genes for the grey gene in the region. [source]


    Repeatability of Sleep Apnea Detection in 48-Hour Holter ECG Monitoring

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, Issue 3 2010
    Barbara Uzna, ska M.D.
    Background: There is a significant relationship between obstructive sleep apnea (OSA) and cardiovascular diseases. Reliability of new methods evaluating apnea in Holter ECG monitoring is still the matter of investigators' studies. Methods: In 48-hour Holter ECG monitoring recordings of 63 patients, we assessed repeatability, comparing the results from both sleep periods. Results: We found good repeatability in evaluation of apnea-hypopnea index value. There was moderate agreement in three categories, that is, normal or bordeline or apneic assignment. Assignment to "healthy" (normal and borderline) or apneic subgroup during consecutive sleep periods showed high repeatability. Conclusions: Holter ECG monitoring is a repetitive method of preliminary diagnosis in patients evaluated for sleep apnea syndrome. Ann Noninvasive Electrocardiol 2010;15(3):218,222 [source]


    Moving From Copyright Assignment to Exclusive License to Publish

    ARTIFICIAL ORGANS, Issue 11 2005
    Paul S. Malchesky D. Eng.
    No abstract is available for this article. [source]


    Protocols for the Sequential Solid-State NMR Spectroscopic Assignment of a Uniformly Labeled 25 kDa Protein: HET-s(1-227)

    CHEMBIOCHEM, Issue 11 2010
    Anne Schuetz
    Abstract The sequence-specific resonance assignment of a protein forms the basis for studies of molecular structure and dynamics, as well as to functional assay studies by NMR spectroscopy. Here we present a protocol for the sequential 13C and 15N resonance assignment of uniformly [15N,13C]-labeled proteins, based on a suite of complementary three-dimensional solid-state NMR spectroscopy experiments. It is directed towards the application to proteins with more than about 100 amino acid residues. The assignments rely on a walk along the backbone by using a combination of three experiments that correlate nitrogen and carbon spins, including the well-dispersed C, resonances. Supplementary spectra that correlate further side-chain resonances can be important for identifying the amino acid type, and greatly assist the assignment process. We demonstrate the application of this assignment protocol for a crystalline preparation of the N-terminal globular domain of the HET-s prion, a 227-residue protein. [source]