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Post Hoc Comparisons (post + hoc_comparison)
Selected AbstractsThe relationship between bed rest and sitting orthostatic intolerance in adults residing in chronic care facilitiesJOURNAL OF NURSING AND HEALTHCARE OF CHRONIC ILLNE SS: AN INTERNATIONAL INTERDISCIPLINARY JOURNAL, Issue 3 2010Mary T Fox MSc fox mt, sidani s & brooks d (2010) Journal of Nursing and Healthcare of Chronic Illness2, 187,196 The relationship between bed rest and sitting orthostatic intolerance in adults residing in chronic care facilities Aim., To examine the relationship between orthostatic intolerance and bed rest as it was used by/with 65 adults residing in chronic care facilities. Background., The evidence on the relationship between bed rest and orthostatic intolerance has been obtained from aerospace studies conducted in highly controlled laboratory settings, and is regarded as having high internal validity. In the studies, prolonged and continuous bed rest, administered in a horizontal or negative tilt body position, had a major effect on orthostatic intolerance in young adults. However, the applicability of the findings to the conditions of the real world of practice is questionable. Methods., Participants were recruited over the period of April 2005 to August 2006. A naturalistic cohort design was used. The cohorts represented different doses of bed rest that were naturally occurring. Comparisons were made between patients who had no bed rest (comparative dose group, n = 20), two to four days (moderate dose, n = 23) and five to seven days of bed rest (high dose, n = 22) during a one-week monitoring period. Orthostatic intolerance was measured by orthostatic vital signs and a self-report scale. Bed rest dose was measured by the total number of days spent in bed during one week. Results.,Post hoc comparisons, using Bonferroni adjustments, indicated significant differences in adjusted means on self-reported orthostatic intolerance between the comparative and high (CI: ,4·12, ,0·85; p < 0·001), and the moderate and high (CI: 0·35, 3·56, p < 0·01) bed rest dose cohorts. No group differences were found on orthostatic vital signs. Conclusions., A moderate dose of bed rest with intermittent exposure to upright posture may protect against subjective orthostatic intolerance in patients who are unable to tolerate being out of bed every day. Future research may examine the effects of reducing bed rest days on orthostatic intolerance in individuals with high doses of five to seven days of bed rest. [source] Lidocaine/Monoethylglycinexylidide Test, Galactose Elimination Test, and Sorbitol Elimination Test for Metabolic Assessment of Liver Cell BioreactorsARTIFICIAL ORGANS, Issue 6 2010Jörg C. Gerlach Abstract Various metabolic tests were compared for the performance characterization of a liver cell bioreactor as a routine function assessment of cultures in a standby for patient application in clinical studies. Everyday quality assessment (QA) is essential to ensure a continuous level of cellular functional capacity in the development of hepatic progenitor cell expansion systems providing cells for regenerative medicine research; it is also of interest to meet safety requirements in bioartificial extracorporeal liver support systems under clinical evaluation. Quality criteria for the description of bioreactor cultures were developed using primary porcine liver cells as a model. Porcine liver cells isolated by collagenase perfusion with an average of 3 × 109 primary cells were used in 39 bioreactors for culture periods up to 33 days. Measurements of monoethylglycinexylidide synthesis and elimination of lidocaine, galactose elimination, and sorbitol elimination proved to be useful for routine QA of primary liver cell cultures. We demonstrate two methods for dispensing test substances, bolus administration and continuous, steady-state administration. Bolus test data were grouped in Standard, Therapy, Infection/Contamination, and Cell-free control groups. Statistical analyses show significant differences among all groups for every test substance. Post hoc comparisons indicated significant differences between Standard and Cell-free groups for all elimination parameters. For continuous tests, results were categorized according to number of culture days and time-dependent changes were analyzed. Continuous administration enables a better view of culture health and the time dependency of cellular function, whereas bolus administration is more flexible. Both procedures can be used to define cell function. Assessment of cellular function and bioreactor quality can contribute significantly to the quality of experimental or clinical studies in the field of hepatic bioreactor development. [source] Effects of stimulation rates on Cantonese lexical tone perception by cochlear implant users in Hong KongCLINICAL OTOLARYNGOLOGY, Issue 6 2003D.K.K. Au Effects of stimulation rates on Cantonese lexical tone perception by cochlear implant users in Hong Kong High, moderate and low stimulation rates of 1800, 800 and 400 pulse per second (pps)/channel, respectively, were used to test the effects of stimulation rates on the discrimination and identification of Cantonese lexical tones in 11 Chinese post-lingually deafened adults with cochlear implants (CIs). The subjects were implanted with the MED-EL Combi 40+ CI system. They were randomly assigned to each of the stimulation rate conditions according to an ABC design. In both the Cantonese lexical tone perception tests, the subjects reached the highest scores in the high-stimulation-rate condition, and the lowest scores in the low-stimulation-rate condition (P < 0.01). Post hoc comparisons between different stimulation rates did not yield consistent results. This study demonstrated that the maximum stimulation rate of 1800 pps/channel could be an ,optimal' stimulation rate and an informed choice of parameter for the benefit of Cantonese-speaking CI users in lexical tone perception. [source] The quest for logia psyche in business leadership: An empirical study of cognitive moral development in construction industry dyadsJOURNAL OF LEADERSHIP STUDIES, Issue 4 2010James N. Reischl This research study examines the ageless human debate of the body versus the soul, testing leadership in the industry of building constructors. Based on Kohlbergian theory of cognitive moral development, the multidisciplinary literature review advances the proposition that moral development proceeds in waves of egoism, leading to altruism that is couched in power,"the apple of the eye." The results from respondents of the Iowa Architects Institute of America (n = 93) indicated that, despite their higher education and aesthetic interests, the sample of architects ranked low on moral maturity level compared to the average of the Defining Issues Test data bank as a whole. Principled scores were 36.4 for architects and 39.1 for the data bank. This research also compared the moral maturity of intra-industry groups in marketing dyads consisting of architects, contractors, and suppliers using analysis of variance. Again, it was expected that architects with higher education and aesthetic interests would rank highest. Findings of post hoc comparisons revealed no significant difference in moral maturity level between architects and contractors engrossed in the same power paradigm (p = 1.00), yet a significant difference existed between architects and suppliers (p = 0.024). This implication is consistent with the teleological ethical pattern that is prevalent in research studies of salespeople. [source] WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence: Analysis of Demographic, Behavioral, Physiologic, and Drinking Variables That Contribute to Dependence and Seeking TreatmentALCOHOLISM, Issue 7 2002Jason Glanz Background Discussions between the World Health Organization (WHO) and the International Society on Biomedical Research on Alcoholism (ISBRA) identified the need for a multiple-center international study on state and trait markers of alcohol abuse and alcohol dependence. The reasoning behind the generation of such a project included the need to understand the alcohol use characteristics of diverse populations and the performance of biological markers of alcohol use in a variety of settings throughout the world. A second major reason for initiating this study was to collect DNA for well-structured and stratified association studies between genetic markers and/or "candidate" genes and behavioral/physiological phenotypes of importance to predisposition to alcohol dependence. Methods An extensive interview instrument was developed with leadership from the U.S. National Institute on Alcohol Abuse and Alcoholism (NIAAA). The instrument was translated from English to Finnish, French, German, Japanese, and Portuguese (Brazilian). One thousand eight hundred sixty-three subjects were recruited at five clinical centers (Montreal, Canada; Helsinki, Finland; Sapporo, Japan; São Paulo, Brazil; and Sydney, Australia). The subjects responded to the structured interview and provided blood and urine samples for biochemical analysis. This article focuses on the demographic characteristics of the study subjects, their drinking habits, alcohol-dependence characteristics, comorbid psychiatric and other drug variables, and predictors for seeking treatment for alcohol dependence. Multiple logistic regression models were constructed and used to explore variables that contribute to various levels of alcohol consumption, to a diagnosis of alcohol dependence, and to seeking treatment for alcohol dependence. ANOVA with post hoc comparisons, ,2, and Pearson moment calculations were used as necessary to assess additional relationships between variables. Results A number of factors previously noted in disparate studies were confirmed in our analysis. Men consumed more alcohol than women, Asians consumed less alcohol than whites or Blacks, alcohol-dependent subjects consumed more alcohol than nondependent subjects, alcohol consumption increased with age, and an increased level of education (university or postgraduate education) reduced the percentage of such individuals in the category designated as heavy drinkers (>210 g alcohol/week) and in the group who were currently in treatment for dependence. However, our analysis allowed for much more detailed comparisons; for example, although men drank more than women on a g/day basis, the differences were less pronounced on g/kg/day basis, and alcohol-dependent women drank equal amounts of alcohol as alcohol-dependent men on a g/kg/day basis. Antisocial personality characteristics or reports of trouble sleeping when an individual stops drinking were associated with higher alcohol intake. The most important of the tested factors that contributed to a DSM-IV diagnosis of dependence, however, was the report of anxiety if an individual stopped drinking. In terms of the various criteria within the DSM-IV criteria for alcohol dependence, no one criterion seemed to be prominent for individuals who sought alcohol dependence treatment, but the higher the number of criteria met by the individual, the higher was the probability that he or she would be in treatment. Conclusions This initial report is the beginning of the "data mining" of this rich data set. The cross-national/cross-cultural aspects of this study allowed for multiple comparisons of variables across several ethnic/racial groups and allowed for assessment of biochemical markers for alcohol intake and predisposition to alcohol dependence in diverse settings. [source] | ||||||||||