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Possible Consequences (possible + consequence)
Selected AbstractsSpeaking Foreign Languages in the United States: Correlates, Trends, and Possible ConsequencesMODERN LANGUAGE JOURNAL, Issue 4 2006JOHN P. ROBINSON With President George W. Bush's unprecedented call in January 2006 to expand the foreign language capacity of the United States, it has become clear that languages other than English (LOE) are of great interest to public policy in the United States. Yet the language capacity of the United States remains poorly documented. The 2000 General Social Survey (GSS) included new questions concerning the languages spoken by 1,398 respondents. Although about one quarter (26%) of respondents to this GSS sample claimed they could speak another language, only 10% overall said they could speak it very well. Those respondents who speak a foreign language were typically aged 25,44, graduate school educated, self-identified as being of a race other than White, and living in large metropolitan cities and on the coasts. Spanish (50%), French (15%), and German (9%) were the most common languages spoken by the survey respondents. Whereas 67% of respondents who learned the language at home as a child said they could speak it very well, only 10% of those who learned it in school or elsewhere did speak it very well. As expected, LOE speakers gave significantly more responses revealing support of LOE and policies favorable to immigration, with LOE-home speakers being more positive about these issues than LOE speakers who learned the language at school. These findings can help to inform national policy debates concerning how best to address the language needs of the United States. [source] Integrity Tests and the Five-Factor Model of Personality: A Review and Empirical Test of Two Alternative PositionsINTERNATIONAL JOURNAL OF SELECTION AND ASSESSMENT, Issue 2 2006Bernd Marcus The psychological meaning of integrity test scores has been explored predominantly in relation to the five-factor model of personality (FFM). Two alternative positions on this topic can be identified in the literature which state, respectively, that integrity tests measure (a) a higher-order factor of personality covering three FFM dimensions or (b) a linear composite of numerous facets from various domains within the FFM. An empirical test of these alternative positions, using structural equation modeling, revealed that the value of both views depended on the type of integrity test examined. With a personality-based integrity test, position (a) had to be refuted, whereas position (b) was strongly supported. There was also more supportive evidence for position (b) with an overt test, but the difference was far less pronounced than for the personality-based measure. Possible consequences for theories on the role of personality in personnel selection are discussed. [source] Population dynamics of the pipistrelle bat: effects of sex, age and winter weather on seasonal survivalJOURNAL OF ANIMAL ECOLOGY, Issue 2 2003Thomas Sendor Summary 1Life-history theory assumes increased mortality at certain stages such as hibernation. However, seasonal variation of survival rates of hibernating mammals has rarely been estimated. In this study, apparent survival of pipistrelle bats (Pipistrellus pipistrellus) hibernating and performing summer swarming at a large hibernaculum (Marburg Castle, Hesse, Germany), was modelled using seasonal (summer/winter) capture,recapture data for the years 1996,2000. The spring survival interval includes the period of arousal at the end of hibernation and therefore validly measures survival associated with hibernation. 2In five summers and four winters, 15 839 bats were captured and released (13 082 individuals) and 3403 recaptures recorded. Analysis was complicated by transience and trap-dependence. Recapture rates varied seasonally and by group. The autumnal survival estimates were negatively biased due to transience effects that could not be taken into account. 3Survival could be modelled using two age-classes, with reduced first-year juvenile survival. The age effect persisted over the first autumn and spring. There was virtually no evidence for sex-specific survival rates; male and female survival were found to be almost equal. In the best-fitting models, survival rates varied over time and differed among sexes and age-classes by a constant amount. Between years, there was only a small variation in spring survival, which could not be explained by winter severity. 4Adult spring survival was surprisingly high, averaging 0·892 (= 0·028). No evidence for increased mortality during hibernation could be found. This contradicted the expectation of reduced over-winter survival due to depleted fat reserves at the end of hibernation. Thus, hibernation does apparently not entail a survival cost for the pipistrelle bat. Rough estimates of annual adult survival averaged 0·799 ( = 0·051), which considerably exceeds previous estimates; annual juvenile survival was estimated at 0·527 ( = 0·095). Hence, previous studies have substantially underestimated pipistrelle bat survival. Possible consequences of these findings for various aspects of life histories are discussed. [source] Possible consequences of the Copenhagen climate change meeting for conservation of animalsANIMAL CONSERVATION, Issue 6 2009N. Pettorelli No abstract is available for this article. [source] Mean electromotive force proportional to mean flow in MILD turbulenceASTRONOMISCHE NACHRICHTEN, Issue 1 2010K.-H. Rädler Abstract In mean-field magnetohydrodynamics the mean electromotive force due to velocity and magnetic-field fluctuations plays a crucial role. In general it consists of two parts, one independent of and another one proportional to the mean magnetic field. The first part may be nonzero only in the presence of mhd turbulence, maintained, e.g., by small-scale dynamo action. It corresponds to a battery, which lets a mean magnetic field grow from zero to a finite value. The second part, which covers, e.g., the , effect, is important for large-scale dynamos. Only a few examples of the aforementioned first part of the mean electromotive force have been discussed so far. It is shown that a mean electromotive force proportional to the mean fluid velocity, but independent of the mean magnetic field, may occur in an originally homogeneous isotropic mhd turbulence if there are nonzero correlations of velocity and electric current fluctuations or, what is equivalent, of vorticity and magnetic field fluctuations. This goes beyond the Yoshizawa effect, which consists in the occurrence of mean electromotive forces proportional to the mean vorticity or to the angular velocity defining the Coriolis force in a rotating frame and depends on the cross-helicity defined by the velocity and magnetic field fluctuations. Contributions to the mean electromotive force due to inhomogeneity of the turbulence are also considered. Possible consequences of the above findings for the generation of magnetic fields in cosmic bodies are discussed (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] On phenomenology and classification of hoarding: a reviewACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2004T. Maier Objective:, Hoarding is a behavioural abnormity characterized by the excessive collection of poorly useable objects. It is described mainly in association with obsessive,compulsive disorders (OCDs) and in geriatric populations. Yet the literature on the phenomenon is heterogeneous and the notion obviously lacks a consistent definition. This review attempts to describe the psychopathological and clinical spectrum of hoarding and may contribute to clarify its classification. Method:, Systematic review and discussion of the literature on hoarding. Results:, Hoarding is a complex behavioural phenomenon associated with different mental disorders. The psychopathological structure is variously composed of elements of OCDs, impulse-control disorders, and ritualistic behaviour. Severe self-neglect is a possible consequence of hoarding. Conclusion:, Without further specifications the term hoarding is of limited heuristic value and cannot guide therapeutic interventions satisfactorily. The condition needs to be evaluated carefully in every particular case in relation to the aforementioned psychopathological concepts. [source] Hippocampal granule cells opt for early retirementHIPPOCAMPUS, Issue 10 2010C.B. Alme Abstract Increased excitability and plasticity of adult-generated hippocampal granule cells during a critical period suggests that they may "orthogonalize" memories according to time. One version of this "temporal tag" hypothesis suggests that young granule cells are particularly responsive during a specific time period after their genesis, allowing them to play a significant role in sculpting CA3 representations, after which they become much less responsive to any input. An alternative possibility is that the granule cells active during their window of increased plasticity, and excitability become selectively tuned to events that occurred during that time and participate in later reinstatement of those experiences, to the exclusion of other cells. To discriminate between these possibilities, rats were exposed to different environments at different times over many weeks, and cell activation was subsequently assessed during a single session in which all environments were revisited. Dispersing the initial experiences in time did not lead to the increase in total recruitment at reinstatement time predicted by the selective tuning hypothesis. The data indicate that, during a given time frame, only a very small number of granule cells participate in many experiences, with most not participating significantly in any. Based on these and previous data, the small excitable population of granule cells probably correspond to the most recently generated cells. It appears that, rather than contributing to the recollection of long past events, most granule cells, possibly 90,95%, are effectively "retired." If granule cells indeed sculpt CA3 representations (which remains to be shown), then a possible consequence of having a new set of granule cells participate when old memories are reinstated is that new representations of these experiences might be generated in CA3. Whatever the case, the present data may be interpreted to undermine the standard "orthogonalizer" theory of the role of the dentate gyrus in memory. © 2010 Wiley-Liss, Inc. [source] Neurologic Dysfunction in Hypothyroid, Hyperlipidemic Labrador RetrieversJOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 6 2007Christina L. Vitale Background: Hypothyroidism has been associated with a variety of neurologic signs, but the mechanism for this association is not completely understood. Hypothyroidism also is associated with hyperlipidemia that predisposes to atherosclerosis, increased blood viscosity, and thromboembolic events. Objective: The objective is to characterize neurologic signs potentially associated with hyperlipidemia and atherosclerosis in canine hypothyroidism. Animals: This study used dogs referred to North Carolina State University Veterinary Teaching Hospital for evaluation of neurologic signs. Materials and Methods: A retrospective study was conducted in which medical records of dogs with neurologic signs and a diagnosis of hypothyroidism and hyperlipidemia were reviewed. Details of the history, presenting signs, results of routine blood tests, thyroid tests, cerebrospinal fluid (CSF) analysis and diagnostic imaging, and response to therapy were compiled. Results: Three Labrador Retrievers and one Labrador Retriever cross fit the inclusion criteria. All dogs were hypothyroid and severely hyperlipidemic. Neurologic signs included tetraparesis, central and peripheral vestibular signs, facial paralysis, and paraparesis. Two dogs had an acute history and rapid resolution of signs consistent with an infarct, the presence of which was confirmed in 1 of the dogs by magnetic resonance imaging. Two dogs had chronic histories of cranial neuropathies and paraparesis. One of these dogs had evidence of iliac thrombosis and atherosclerosis on ultrasound examination. All dogs improved with thyroid hormone supplementation. Clinical Relevance: Labrador Retrievers may be predisposed to the development of severe hyperlipidemia in association with hypothyroidism. One possible consequence of severe hyperlipidemia is the development of neurologic signs due to atherosclerosis and thromboembolic events. [source] Ethnic migration between area groups in England and WalesAREA, Issue 4 2009James Raymer Minority ethnic populations in England and Wales have been increasing steadily as a share of the total population since the 1991 Census. In this paper, we are interested in how internal migration has changed as a possible consequence. Our analysis focuses on the movements between 12 area groups, as defined by the Office for National Statistics, and addresses the following three research questions: (1) how has internal migration in England and Wales evolved from 1991 to 2004; (2) what are the main differences in the movements between the White (majority) population and the ethnic minority population; and (3) how do migration patterns differ when ethnicity, education and employment statuses are considered together? The data come from the 1991 to 2004 National Health Service Central Registers, the 1999,2004 patient registers and the 2001 Census. We find strong stability in the migration patterns of the total population over time. However, large differences appear when the flows are disaggregated by ethnicity and further by education and employment. Education level is an important factor influencing the migration patterns for the White population, whereas employment status is a much more important factor for the ethnic minority population. [source] Regulation of early response genes in pancreatic acinar cells: external calcium and nuclear calcium signalling aspectsACTA PHYSIOLOGICA, Issue 1 2009N. Fedirko Abstract Nuclear calcium signalling has been an important topic of investigation for many years and some aspects have been the subject of debate. Our data from isolated nuclei suggest that the nuclear pore complexes (NPCs) are open even after depletion of the Ca2+ store in the nuclear envelope (NE). The NE contains ryanodine receptors (RyRs) and Ins(1,4,5)P3 receptors [Ins(1,4,5)P3Rs], most likely on both sides of the NE and these can be activated separately and independently: the RyRs by either NAADP or cADPR, and the Ins(1,4,5)P3Rs by Ins(1,4,5)P3. We have also investigated the possible consequences of nuclear calcium signals: the role of Ca2+ in the regulation of immediate early genes (IEG): c-fos, c-myc and c-jun in pancreatic acinar cells. Stimulation with Ca2+ -mobilizing agonists induced significant increases in levels of expression. Cholecystokinin (CCK) (10 nm) evoked a substantial rise in the expression levels, highly dependent on external Ca2+: the IEG expression level was lowest in Ca2+ -free solution, increased at the physiological level of 1 mm [Ca2+]o and was maximal at 10 mm [Ca2+]o, i.e.: 102 ± 22% and 163 ± 15% for c-fos; c-myc ,73 ± 13% and 106 ± 24%; c-jun ,49 ± 8% and 59 ± 9% at 1 and 10 mm of extracellular Ca2+ respectively. A low CCK concentration (10 pm) induced a small increase in expression. We conclude that extracellular Ca2+ together with nuclear Ca2+ signals induced by CCK play important roles in the induction of IEG expression. [source] Consequences of forest fires on the hydrogeological response of mountain catchments: a case study of the Riale Buffaga, Ticino, SwitzerlandEARTH SURFACE PROCESSES AND LANDFORMS, Issue 2 2003Marco Conedera Abstract The debris flow of 28 August 1997 which occurred in the Riale Buffaga, a torrent channel in the territory of the village of Ronco s./Ascona (Ticino, Switzerland), has been simulated with a good degree of reliability due to the existence of morphologic surveys of the torrent channel preceding the flood event and the presence of a rain gauge that registered the rainfall event at a resolution of 10 minutes. With these data it is possible to conduct a quantitative analysis of the effect of a forest fire on the hydrogeological response of a given catchment. In the case at hand, a 10-year rainfall event caused a 100- to 200-year flood event. This result clearly quantifies the possible consequences of a forest fire in terms of territorial safety. Copyright © 2003 John Wiley & Sons, Ltd. [source] Developmental aspects of distal limb conformation in the horse: the potential consequences of uneven feet in foalsEQUINE VETERINARY JOURNAL, Issue 7 2006A. M. KROEKENSTOEL Summary Reasons for performing study: Distal limb conformation is generally accepted to be an important item with respect to performance and soundness in mature horses, but little is known about the developmental aspects. Objectives: To gain insight into the development of distal limb conformation and to assess the possible consequences of uneven feet in foals. Methods: Conformation of the distal front limbs of 23 Warmblood foals was scored visually and measured using radiographs, at ages 27 and 55 weeks. At the same ages, pressure measurements were made under both front feet. Results: At both ages the hoof-pastern axis was broken-backwards on radiographs, but only occasionally recognised as such, when scored by eye. Over time, the hoof angle decreased, while both the angles of the dorsal and solar surfaces of the distal phalanx (P3) increased and the parallelism between hoof wall and P3 improved. The foals with uneven feet at age 27 weeks showed a significant difference in distal limb loading that persisted until age 55 weeks. Conclusions: The alignment of the distal limb in the sagittal plane increased in a 6 month period. Visual assessment was not sensitive enough to appreciate this. The growth processes in the distal limb could not compensate for existing unevenness and ensuing asymmetrical limb loading. Potential relevance: Foals have a different conformation of the distal limb from mature horses, which should be taken into account when interpreting radiographs. Unevenness of the feet resulted in asymmetrical loading of the proximal and distal interphalangeal joint, which might lead to increased susceptibility to overload injuries and decreased performance at mature age. [source] Lactate has the potential to promote hydrogen sulphide formation in the human colonFEMS MICROBIOLOGY LETTERS, Issue 2 2009Perrine Marquet Abstract High concentrations of sulphide are toxic for the gut epithelium and may contribute to bowel disease. Lactate is a favoured cosubstrate for the sulphate-reducing colonic bacterium Desulfovibrio piger, as shown here by the stimulation of sulphide formation by D. piger DSM749 by lactate in the presence of sulphate. Sulphide formation by D. piger was also stimulated in cocultures with the lactate-producing bacterium Bifidobacterium adolescentis L2-32. Other lactate-utilizing bacteria such as the butyrate-producing species Eubacterium hallii and Anaerostipes caccae are, however, expected to be in competition with the sulphate-reducing bacteria (SRB) for the lactate formed in the human colon. Strains of E. hallii and A. caccae produced 65% and 96% less butyrate from lactate, respectively, in a coculture with D. piger DSM749 than in a pure culture. In triculture experiments involving B. adolescentis L2-32, up to 50% inhibition of butyrate formation by E. hallii and A. caccae was observed in the presence of D. piger DSM749. On the other hand, sulphide formation by D. piger was unaffected by E. hallii or A. caccae in these cocultures and tricultures. These experiments strongly suggest that lactate can stimulate sulphide formation by SRB present in the colon, with possible consequences for conditions such as colitis. [source] Bacterial metabolism in small temperate streams under contemporary and future climatesFRESHWATER BIOLOGY, Issue 12 2007KAJ SAND-JENSEN Summary 1. We examined the detailed temperature dependence (0,40 °C) of bacterial metabolism associated with fine sediment particles from three Danish lowland streams to test if temperature dependence varied between sites, seasons and quality of organic matter and to evaluate possible consequences of global warming. 2. A modified Arrhenius model with reversible denaturation at high temperatures could account for the temperature dependence of bacterial metabolism and the beginning of saturation above 35 °C and it was superior to the unmodified Arrhenius model. Both models overestimated respiration rates at very low temperatures (<5 °C), whereas Ratkowsky's model , the square root of respiration , provided an excellent linear fit between 0 and 30 °C. 3. There were no indications of differences in temperature dependence among samples dominated by slowly or easily degradable organic substrates. Optimum temperature, apparent minimum temperature, Q10 -values for 0,40 °C and activation energies of bacterial respiration were independent of season, stream site and degradability of organic matter. 4. Q10 -values of bacterial respiration declined significantly with temperature (e.g. 3.31 for 5,15 °C and 1.43 for 25,35 °C) and were independent of site and season. Q10 -values of bacterial production behaved similarly, but were significantly lower than Q10 -values of respiration implying that bacterial growth efficiency declined with temperature. 5. A regional warming scenario for 2071,2100 (IPCC A2) predicted that mean annual temperatures will increase by 3.5 °C in the air and 2.2,4.3 °C in the streams compared with the control scenario for 1961,1990. Temperature is expected to rise more in cool groundwater-fed forest springs than in open, summer-warm streams. Mean annual bacterial respiration is estimated to increase by 26,63% and production by 18,41% among streams assuming that established metabolism,temperature relationships and organic substrate availability remain the same. To improve predictions of future ecosystem behaviour, we further require coupled models of temperature, hydrology, organic production and decomposition. [source] Differences in temperature, organic carbon and oxygen consumption among lowland streamsFRESHWATER BIOLOGY, Issue 12 2005KAJ SAND-JENSEN Summary 1. Temperature, organic carbon and oxygen consumption were measured over a year at 13 sites in four lowlands streams within the same region in North Zealand, Denmark with the objectives of determining: (i) spatial and seasonal differences between open streams, forest streams and streams with or without lakes, (ii) factors influencing the temperature dependence of oxygen consumption rate, (iii) consequences of higher temperature and organic content in lake outlets on oxygen consumption rate, and (iv) possible consequences of forecasted global warming on degradation of organic matter. 2. High concentrations of easily degradable dissolved (DOC) and particulate organic carbon (POC) were found in open streams downstream of plankton-rich lakes, while high concentrations of recalcitrant DOC were found in a forest brook draining a forest swamp. Concentrations of predominantly recalcitrant POC and DOC were low in a groundwater-fed forest spring. Overall, DOC concentration was two to 18 times higher than POC concentrations. 3. Oxygen consumption rate at 20 °C was higher during summer than winter, higher in open than shaded streams and higher in lake outlets than inlets. Rate was closely related to concentrations of chlorophyll and POC but not to DOC. The ratio of oxygen consumption rate to total organic concentrations (DOC + POC), serving as a measure of organic degradability, was highest downstream of lakes, intermediate in open streams and lowest in forest streams. 4. Temperature coefficients describing the exponential increase of oxygen consumption rate between 4 and 20 °C averaged 0.121 °C,1 (Q10 of 3.35) in 70 measurements and showed no significant variations between seasons and stream sites or correlations with ambient temperature and organic content. 5. Oxygen consumption rate was enhanced downstream of lakes during summer because of higher temperature and, more significantly, greater concentrations of degradable organic carbon. Oxygen consumption rates were up to seven times higher in the stream with three impoundments than in a neighbouring unshaded stream and 21 times higher than in the groundwater-fed forest spring. 6. A regional climate model has calculated a dramatic 4,5 °C rise in air temperature over Denmark by 2070,2100. If this is realised, unshaded streams are estimated to become 2,3 °C warmer in summer and winter and 5,7 °C warmer in spring and, thereby, increase oxygen consumption rates at ambient temperature by 30,40% and 80,130%, respectively. Faster consumption of organic matter and dissolved oxygen downstream of point sources should increase the likelihood of oxygen stress of the stream biota and lead to the export of less organic matter but more mineralised nutrients to the coastal waters. [source] A Postmodern Reply to Perez ZagorinHISTORY AND THEORY, Issue 2 2000Keith Jenkins This article engages with the arguments forwarded by Perez Zagorin against the possible consequences of postmodernism for history as it is currently conceived of particularly in its "proper" professional/academic form ("History, the Referent, and Narrative: Reflections on Postmodernism Now,"History and Theory 38 [1999], 1-24). In an overtly positioned response which issues from a close reading of Zagorin's text, I argue that his all-too-typical misunderstandings of postmodernism need to be "corrected",not, however, to make postmodernism less of a threat to "history as we have known it," or to facilitate the assimilation of its useful elements while exorcising its "extremes." My "corrections" instead forward the claim that, understood positively and integrated into those conditions of postmodernity which postmodernism variously articulates at the level of theory, such theory signals the possible "end of history," not only in its metanarrative styles (which are already becoming increasingly implausible) but also in that particular and peculiar professional genre Zagorin takes as equivalent to history per se. And I want to argue that if this theory is understood in ways which choose not to give up (as Derrida urges us not to give up) the "discourse of emancipation" after the failure of its first attempt in the "experiment of modernity," then this ending can be considered "a good thing." [source] The Dilemma of "Authentic Self" Ideology in Contemporary JapanINTERNATIONAL JOURNAL OF JAPANESE SOCIOLOGY, Issue 1 2001Michiko Maekawa This paper examines dilemmas inherent in the pursuit of the modern ideology of "authentic self", which first emerged in the 1960s and is now widespread in contemporary cultures. The ideology is exemplified, in a religious scene, as "self-transformative" religions wherein seekers seek to transform themselves spiritually in order to realize their authentic, or "sacred" selves. Through an examination of Aum Shinrikyo, which began as a typical "self-transformative" religion but later transformed into a destructive cult, I will explain the intrinsic moral imperatives of the ideology of "authenticity". This study of Aum explores the introverted lifestyle and extreme desocialization, which resulted in obsession with the central guru, being legitimated by the ideology. This search for "authenticity" resulted in the members cutting themselves off from the reality of the world. The final analysis suggests that possible consequences of the endless pursuit of the "authentic self" are a "vacuum" self and a loss of empathy with other people. The ontological conditions created by this bring about potential destructiveness, either internal or external. [source] Porosity of human mandibular condylar boneJOURNAL OF ANATOMY, Issue 3 2007G. A. P. Renders Abstract Quantification of porosity and degree of mineralization of bone facilitates a better understanding of the possible effects of adaptive bone remodelling and the possible consequences for its mechanical properties. The present study set out first to give a three-dimensional description of the cortical canalicular network in the human mandibular condyle, in order to obtain more information about the principal directions of stresses and strains during loading. Our second aim was to determine whether the amount of remodelling was larger in the trabecular bone than in cortical bone of the condyle and to establish whether the variation in the amount of remodelling was related to the surface area of the cortical canals and trabeculae. We hypothesized that there were differences in porosity and orientation of cortical canals between various cortical regions. In addition, as greater cortical and trabecular porosities are likely to coincide with a greater surface area of cortical canals and trabeculae available for osteoblastic and osteoclastic activity, we hypothesized that this surface area would be inversely proportional to the degree of mineralization of cortical and trabecular bone, respectively. Micro-computed tomography was used to quantify porosity and mineralization in cortical and trabecular bone of ten human mandibular condyles. The cortical canals in the subchondral cortex of the condyle were orientated in the mediolateral direction, and in the anterior and posterior cortex in the superoinferior direction. Cortical porosity (average 3.5%) did not differ significantly between the cortical regions. It correlated significantly with the diameter and number of cortical canals, but not with cortical degree of mineralization. In trabecular bone (average porosity 79.3%) there was a significant negative correlation between surface area of the trabeculae and degree of mineralization; such a correlation was not found between the surface area of the cortical canals and the degree of mineralization of cortical bone. No relationship between trabecular and cortical porosity, nor between trabecular degree of mineralization and cortical degree of mineralization was found, suggesting that adaptive remodelling is independent and different between trabecular and cortical bone. We conclude (1) that the principal directions of stresses and strains are presumably directed mediolaterally in the subchondral cortex and superoinferiorly in the anterior and posterior cortex, (2) that the amount of remodelling is larger in the trabecular than in the cortical bone of the mandibular condyle; in trabecular bone variation in the amount of remodelling is related to the available surface area of the trabeculae. [source] Review on the effects of exposure to spilled oils on human healthJOURNAL OF APPLIED TOXICOLOGY, Issue 4 2010Francisco Aguilera Abstract Harmful effects of oil spills on diverse flora and fauna species have been extensively studied. Nevertheless, only a few studies have been compiled in the literature dealing with the repercussions of oil exposure on human health; most of them have focused on acute effects and psychological symptoms. The objective of this work was to gather all these studies and to analyze the possible consequences of this kind of complex exposure in the different aspects of human health. Studies found on this topic were related to the disasters of the Exxon Valdez, Braer, Sea Empress, Nakhodka, Erika, Prestige and Tasman Spirit oil tankers. The majority of them were cross-sectional; many did not include control groups. Acute effects were evaluated taking into account vegetative-nervous symptoms, skin and mucous irritations, and also psychological effects. Genotoxic damage and endocrine alterations were assessed only in individuals exposed to oil from Prestige. The results of the reviewed articles clearly support the need for biomonitoring human populations exposed to spilled oils, especially those individuals involved in the cleanup, in order to evaluate not only the possible immediate consequences for their health but also the medium- and long-term effects, and the effectiveness of the protective devices used. Copyright © 2010 John Wiley & Sons, Ltd. [source] A comparison of different pre-treatment procedures for reducing heteroscedasticity and other irrelevant features in data prior to modelling of benthic count profilesJOURNAL OF CHEMOMETRICS, Issue 7-9 2007Geir Rune Flåten Abstract Challenges related to quantifying environmental disturbance biologically from benthic count profiles by using the Community Disturbance Index (CDI) approach are assessed. A pre-treatment framework incorporating removal of irrelevant features, scaling and converting transformations is proposed. Within this framework the characteristics of benthic count data are discussed and possible consequences for the CDI calculations are shown. It is established that the benthic count data need to be corrected for heteroscedasticity while scaling is found to be unnecessary for the CDI calculations. Copyright © 2007 John Wiley & Sons, Ltd. [source] Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged ratsAGING CELL, Issue 5 2010Brigitte Potier Summary This study aims to determine whether the regulation of extracellular glutamate is altered during aging and its possible consequences on synaptic transmission and plasticity. A decrease in the expression of the glial glutamate transporters GLAST and GLT-1 and reduced glutamate uptake occur in the aged (24,27 months) Sprague,Dawley rat hippocampus. Glutamatergic excitatory postsynaptic potentials recorded extracellularly in ex vivo hippocampal slices from adult (3,5 months) and aged rats are depressed by DL-TBOA, an inhibitor of glutamate transporter activity, in an N -Methyl- d- Aspartate (NMDA)-receptor-dependent manner. In aged but not in young rats, part of the depressing effect of DL-TBOA also involves metabotropic glutamate receptor (mGluRs) activation as it is significantly reduced by the specific mGluR antagonist d-methyl-4-carboxy-phenylglycine (MCPG). The paired-pulse facilitation ratio, a functional index of glutamate release, is reduced by MCPG in aged slices to a level comparable to that in young rats both under control conditions and after being enhanced by DL-TBOA. These results suggest that the age-associated glutamate uptake deficiency favors presynaptic mGluR activation that lowers glutamate release. In parallel, 2 Hz-induced long-term depression is significantly decreased in aged animals and is fully restored by MCPG. All these data indicate a facilitated activation of extrasynaptic NMDAR and mGluRs in aged rats, possibly because of an altered distribution of glutamate in the extrasynaptic space. This in turn affects synaptic transmission and plasticity within the aged hippocampal CA1 network. [source] Frequency of under- and overfeeding in mechanically ventilated ICU patients: causes and possible consequencesJOURNAL OF HUMAN NUTRITION & DIETETICS, Issue 1 2006C. Reid Abstract Introduction, In critically ill patients enteral nutrition (EN) is frequently associated with underfeeding and intolerance, whilst parenteral nutrition (PN) has been associated with a greater risk of infectious complications and overfeeding. Materials and methods The adequacy of nutritional support provided to critically ill patients was prospectively recorded and compared with estimated requirements. The incidence of, and practices contributing to, under- (<80% of energy requirements) and overfeeding (>110% of energy requirements) were identified. Results, Overall patients received approximately 81% and 76% of prescribed energy and protein intakes respectively. Underfeeding occurred on 50.3% of days. Reasons for patients failing to achieve adequate intakes included, fasting for airway management procedures (21%) and gastrointestinal intolerance (14%). Overfeeding, although less common (18.6% of days), was more likely to occur in patients with a tracheostomy requiring prolonged mechanical ventilation (>16 days). The combination of oral and nasogastric feeding or use of nutrient-dense feeds were most frequently associated with overfeeding. Discussion, The overall adequacy of nutritional intakes in the present study was similar to those reported elsewhere. However, the incidence of overfeeding was greater than anticipated and occurred in patients already experiencing delayed weaning from mechanical ventilation. [source] Saccharomyces cerevisiae biodiversity in spontaneous commercial fermentations of grape musts with ,adequate' and ,inadequate' assimilable-nitrogen contentLETTERS IN APPLIED MICROBIOLOGY, Issue 1 2003L. Granchi Abstract Aim: To evaluate whether intraspecific diversity of Saccharomyces cerevisiae in wine fermentations is affected by initial assimilable-nitrogen content. Methods and Results:Saccharomyces cerevisiae isolates from two spontaneous commercial wine fermentations started with adequate and inadequate nitrogen amounts were characterized by mitochondrial DNA restriction analysis. Several strains occurred in each fermentation, two strains, but not the same ones, being predominant at frequencies of about 30%. No significant differences were detected by comparing the biodiversity indices of the two fermentations. Cluster analysis demonstrated that the strain distribution was independent of nitrogen content, the two pairs of closely related dominant strains grouping into clusters at low similarity. Conclusions: The genetic variability of S. cerevisiae in wine fermentations seemed not to depend on the nitrogen availabilty in musts. Significance and Impact of the Study: Nitrogen content did not affect the genetic diversity but may have induced a ,selection effect' on S. cerevisiae strains dominating wine fermentations, with possible consequences on wine properties. [source] The role of the Badger (Meles meles) in rabies epizootiology and the implications for Great BritainMAMMAL REVIEW, Issue 1 2002G. C. Smith ABSTRACT The occurrence of a wildlife rabies epizootic in Britain remains a very unlikely event, but it is important to examine all the possible consequences of such an event. Here, I examine the possible role of the European Badger (Meles meles) in such an epizootic. The population density of Badgers in Britain is much higher than that in Europe, and appears to have increased substantially over the last decade or so. The population parameters and epizootiology of rabies in the Badger are reviewed in comparison with the Fox (Vulpes vulpes) and other species. Mustelids appear to be very susceptible to rabies, with the smaller mustelids becoming aggressive, although Badgers do not appear to show heightened aggression when infected. Badger populations on the continent become severely reduced when rabies arrives in the area, and circumstantial evidence strongly suggests that Badgers can easily transmit the virus. Preliminary models support the idea that the Badger could be a very significant secondary host, especially in the initial rabies outbreak. The population recovery rate of the Badger suggests that it is unlikely to become a primary host, although short-term epizootics in the Badger population are likely. The potential for controlling rabies in the Badger is also examined. [source] Liver carcinogen aflatoxin B1 as an inducer of mitotic recombination in a human cell lineMOLECULAR CARCINOGENESIS, Issue 3 2001Peter Markus Stettler Abstract The mycotoxin aflatoxin B1 (AFB1) is one of the most potent rodent and human liver carcinogens. Upon cytochrome P450,specific metabolism, it induces mutations as well as mitotic recombination events in in vitro systems. We have found that in the lower eukaryote yeast, the recombinagenic activity of AFB1 surpasses its mutagenic activity, and we speculated on possible consequences in terms of the mechanism of liver carcinogenesis. In this study we investigated whether the recombinagenic activity of AFB1 also would be identified in human cells. To address this question, we followed the fate of a heterozygous thymidine kinase (tk) allele in the human lymphoblastoid cell line TK6 upon exposure to AFB1. Individual mutants that had lost tk activity were subjected to loss of heterozygosity analysis of the tk locus and its flanking markers. Fluorescence in situ hybridization analysis on chromosome 17 also was performed. In parallel, a similar analysis was performed on TK6 cells exposed to the alkylating agent N -nitrosomethylurea, a well-known classic point mutagen. Our analysis showed a difference in the molecular mechanism leading to inactivation of the tk allele upon exposure to these two mutagens. In AFB1 -exposed cells the fraction of recombination-derived mutants predominated, whereas in N -nitrosomethylurea,exposed cells the fraction of point mutants was higher. Thus, the recombinagenic activity of AFB1 previously identified in a lower eukaryote also was found in the human cell line TK6. Our data support the hypothesis that mitotic recombination represents a central mechanism of action in AFB1 -induced liver carcinogenesis. © 2001 Wiley-Liss, Inc. [source] Study of the transport properties of a molecular junction as a function of the distance between the leadsPHYSICA STATUS SOLIDI (B) BASIC SOLID STATE PHYSICS, Issue 7 2007Víctor M. García-Suárez Abstract We consider a model of a molecular junction made of BDT (benzene dithiol) molecule trapped between two Au(100) leads. Using the ab initio approach implemented in the SIESTA package we look for the optimal configurations of the molecule as a function of the distance between the leads. We find that for distances long enough the energy of the system is minimized when the molecule is bonded asymmetrically, i.e. chemisorbed to one of the leads, whereas for distances shorter than 12 Å the energy is minimized when the molecule sits in the middle between the leads. We discuss possible consequences of the above findings for the transport properties of the junction. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] The association between pubertal status and sleep duration and quality among a nationally representative sample of U. S. AdolescentsAMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 4 2005Kristen L. Knutson Many hormones play important roles in both pubertal development and sleep regulation. Because of the possible consequences of impaired sleep, including impaired health and cognition, it is important to examine whether an association between pubertal stage and sleep exists. The aim of this analysis is to examine the association between sleep and adolescent growth and developmental stage in a large sample of adolescents ages 12,16 years from a nationally representative longitudinal study. This analysis used the public-use data set of the National Longitudinal Study of Adolescent Health, an extensive survey of health and behavior among adolescents in the United States. The study included two interviews approximately 1 year apart. Pubertal development, sleep variables, and height are self-reported. Pubertal development scores were calculated by summing responses to three questions for each sex. The sleep variables include sleep duration, frequent insomnia (once/week or more), frequently waking tired (once/week or more), and insufficient sleep. The results indicate a sex difference in the association between sleep problems and pubertal development. Among females, there was a significant increase in sleep problems with increasing pubertal development score, but not among males. The negative association between sleep duration and pubertal development score, however, was significant in both males and females. There is no association between sleep duration and height velocity (inches/year) in this sample. The results, which are based on a large sample size, warrant further examination with more objective measures into the association between sleep and growth and development among adolescents. Am. J. Hum. Biol. 17:418,424, 2005.© 2005 Wiley-Liss, Inc. [source] Moral reasoning among physical therapists: results of the defining issues testPHYSIOTHERAPY RESEARCH INTERNATIONAL, Issue 2 2010Laura Lee Swisher Abstract Background and Purpose.,Although there is extensive literature in other health care fields about the ability to make ethical judgements (moral reasoning), there is a paucity of research addressing the moral reasoning of practising physical therapists. The purposes of this research were to 1) identify the types of moral reasoning used by practising physical therapists as measured by the Defining Issues Test; 2) identify differences in moral reasoning among physical therapists based on educational background, demographic variables, clinical experience, practice setting or expertise in ethics; and 3) compare the moral reasoning of physical therapists with that of other professional groups.,Methods.,The Defining Issues Test of James Rest was used to evaluate moral reasoning. Five hundred thirty-seven physical therapists responded to a mail survey sent to a random sample of 2,000 American Physical Therapy Association members. Twelve physical therapists with expertise in ethics or professionalism completed the same survey.,Results.,The mean postconventional score for the random sample was 41.93. This score was lower than the mean scores of physicians, nurses, medical students, nursing students and dental students established in previous research. Females, ethics experts and those in academic settings had higher postconventional scores.,Conclusions.,Physical therapists scored lower in postconventional moral reasoning than some other professional groups with similar educational background. Factors that may inhibit or enhance the development of moral reasoning among physical therapists and possible consequences of high or low moral reasoning scores in physical therapy require further research. These findings may raise concerns about the entry-level educational curriculum and professional development opportunities in the area of ethics and moral reasoning. Results of this research may also highlight the challenges of evaluation, scholarship and research in physical therapy ethics. Further research and theory development is needed to address the relationships between moral theory and descriptive or empirical research within physical therapy. Copyright © 2010 John Wiley & Sons, Ltd. [source] The insertion of a full-length Bos taurus LINE element is responsible for a transcriptional deregulation of the Normande Agouti genePIGMENT CELL & MELANOMA RESEARCH, Issue 4 2006Michael Girardot Summary Mammalian pigmentation is controlled by the concerted action of Tyr, Tyrp1 and Dct producing eumelanin and/or pheomelanin in melanocytes. The ratio of these two pigments is determined by the agonist , -melanocyte stimulating hormone and the antagonist Agouti protein acting on the Mc1r. Here we show that the Agouti gene is over-expressed in Normande breed compared with Prim'Holstein breed. The Normande cattle have a characteristic coat color phenotype with a variable presence of black (eumelanin) hair over a red/brown background. We have found a previously undescribed full-length L1-BT element inserted in the 5,-genomic sequence of the Agouti gene in Normande cattle which promotes the over-expression of alternative transcripts. The variable expression of the alternative transcript directed by the long interspersed nuclear element promoter may be the origin of the brindle coat color pattern of the Normande breed. This new bovine Agouti allele isolated in Normande breed has been named Abr. Finally, as ectopic over-expression of Agouti in Ay mice is responsible for the obesity syndrome, we discuss the possible consequences of Abr for meat and milk production in cattle. [source] Breeding behavior and its possible consequences for gene flow in Taraxacum sect.PLANT SPECIES BIOLOGY, Issue 2 2010Erythrosperma (H. Lindb.) Dahlst. Abstract Studies of pollen, seed set and experimental hybridizations were carried out to clarify breeding behavior and gene flow pathways in Taraxacum sect. Erythrosperma. Seeds from hybridization (106 samples), open pollinated (34) and bagged (43) capitula were analyzed for breeding system using a flow,cytometric seed screen. In the section Erythrosperma, diploids are obligate sexuals, mostly allogamous; however, autogamy also occurs (in 28% of unpollinated capitula). Triploids are apomicts with residual sexuality (in 13% of capitula pollinated by pollen of diploids). Pollen of diploids in Taraxacum is usually approximately the same size (regular pollen). In our study, in the section Erythrosperma, many diploids (24%) produced pollen grains of different sizes (irregular pollen) and one plant produced no pollen. The pollen of triploids is either irregular (33%) or the triploids produce no pollen (67%). Consequently, the method of ploidy level assessment on the basis of pollen characteristics is not suitable for Taraxacum sect. Erythrosperma. Low potential for polyploid hybrid formation between diploid maternal plants and polyploid pollen donors, considerable tendency to autogamy and no evidence of the formation of diploid progeny by polyploid maternal plants (facultative apomixis) indicates low intensity of gene flow within Taraxacum sect. Erythrosperma. This, together with a lower population density and spatial isolation of ploidy levels, is expected to result in a lower rate of formation of new apomictic lineages. Thus, Taraxacum sect. Erythrosperma appears evolutionarily more stable and taxonomically less complicated than sect. Ruderalia. The present study supports the agamospecies concept of Taraxacum sect. Erythrosperma. [source] | |||||||||||||||||||||||||||||||||||||