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Possible Alternatives (possible + alternative)
Selected AbstractsBeating-Heart Valvular Surgery: A Possible Alternative for Patients with Severely Compromised Ventricular FunctionJOURNAL OF CARDIAC SURGERY, Issue 2 2002Richard J. Kaplon M.D. We report a novel approach to myocardial protection in a patient requiring multi-valve surgery who had an ejection fraction of 15%. Warm oxygenated blood was infused continuously both antegrade and retrograde during aortic valve replacement and mitral and tricuspid valve repair. Adequacy of perfusion was confirmed by the absence of electrocardiographic changes. Clinical improvement suggests that this strategy of myocardial protection warrants further investigation. [source] Long-term Management of an Implantable Left Ventricular Assist Device Using Low Molecular Weight Heparin and Antiplatelet Therapy: A Possible Alternative to Oral AnticoagulantsARTIFICIAL ORGANS, Issue 5 2007Bart Meuris Abstract:, Between January 2004 and December 2005, out of 14 patients with decompensated heart failure who were treated with an INCOR left ventricular assist device (Berlin Heart AG, Berlin, Germany), 10 patients were kept on a long-term regime of low molecular weight heparin (LMWH) and antiplatelet therapy. The treatment objective was bridge-to-transplantation. All patients received LMWH in therapeutic doses according to body weight, in combination with daily aspirin 160 mg, clopidogrel 75 mg, and three times dipyridamole 75 mg. Effectiveness of the low molecular weight regime was monitored through measurement of antifactor Xa activity (base and peak levels). Antiplatelet therapy was monitored through weekly platelet function tests. Within this group of 10 patients, six patients successfully received transplants and four patients died, the latest death after 405 days of INCOR support. Causes of death were sepsis, intestinal hemorrhage, acute right ventricular failure, and one major stroke. Long-term management of INCOR assist devices using a combination of LMWH and antiplatelet therapy is feasible. This treatment strategy can serve as an alternative to oral anticoagulants. [source] A new method for scoring additive multi-attribute value models using pairwise rankings of alternativesJOURNAL OF MULTI CRITERIA DECISION ANALYSIS, Issue 3-4 2008Paul Hansen Abstract We present a new method for determining the point values for additive multi-attribute value models with performance categories. The method, which we refer to as PAPRIKA (Potentially All Pairwise RanKings of all possible Alternatives), involves the decision-maker pairwise ranking potentially all undominated pairs of all possible alternatives represented by the value model. The number of pairs to be explicitly ranked is minimized by the method identifying all pairs implicitly ranked as corollaries of the explicitly ranked pairs. We report on simulations of the method's use and show that if the decision-maker explicitly ranks pairs defined on just two criteria at-a-time, the overall ranking of alternatives produced by the value model is very highly correlated with the true ranking. Therefore, for most practical purposes decision-makers are unlikely to need to rank pairs defined on more than two criteria, thereby reducing the elicitation burden. We also describe a successful real-world application involving the scoring of a value model for prioritizing patients for cardiac surgery in New Zealand. We conclude that although the new method entails more judgments than traditional scoring methods, the type of judgment (pairwise rankings of undominated pairs) is arguably simpler and might reasonably be expected to reflect the preferences of decision-makers more accurately. Copyright © 2009 John Wiley & Sons, Ltd. [source] The mental health of female sex workersACTA PSYCHIATRICA SCANDINAVICA, Issue 2 2010W. Rössler Rössler W, Koch U, Lauber C, Hass A-K, Altwegg M, Ajdacic-Gross V, Landolt K. The mental health of female sex workers. Objective:, There is limited information available about the mental health of female sex workers. Therefore, we aimed to make a comprehensive assessment of the mental status of female sex workers over different outdoors and indoors work settings and nationalities. Method:, As the prerequisites of a probability sampling were not given, a quota-sampling strategy was the best possible alternative. Sex workers were contacted at different locations in the city of Zurich. They were interviewed with a computerized version of the World Health Organization Composite International Diagnostic Interview. Additional information was assessed in a structured face-to-face interview. Results:, The 193 interviewed female sex workers displayed high rates of mental disorders. These mental disorders were related to violence and the subjectively perceived burden of sex work. Conclusion:, Sex work is a major public health problem. It has many faces, but ill mental health of sex workers is primarily related to different forms of violence. [source] Skin Tightening Effect Using Fractional Laser Treatment: I. A Randomized Half-Side Pilot Study on Faces of Patients with AcneDERMATOLOGIC SURGERY, Issue 1 2010TERUKI DAINICHI MD BACKGROUND Fractional laser resurfacing is a new procedure for skin rejuvenation. OBJECTIVE To assess the skin remodeling effect of fractional laser treatment. METHODS Twelve Asian patients with acne were irradiated using a fractional 1,540-nm erbium glass laser on a random half of the face twice with a 4-week interval. RESULTS The faces were contoured on the treated side of most patients. Statistical analyses of the facial images showed that the skin tightening effect was significant 4 weeks after the first and second irradiation (p<.001 after both treatments). CONCLUSION These results suggest that fractional laser resurfacing is a possible alternative to nonsurgical skin tightening of the face. The authors have indicated no significant interest with commercial supporters. [source] Biopsy of the posterior interosseous nerve: a low morbidity method for assessment of peripheral nerve disordersDIABETIC MEDICINE, Issue 1 2009N. O. B. Thomsen Abstract Aims The sural nerve is the commonest peripheral nerve biopsied to help in the diagnosis of peripheral neuropathy of unknown cause. However, associated complications limit its use. The aim was, as an alternative, to asses biopsy of the terminal branch of the posterior interosseous nerve (PIN) in the forearm. Methods PIN pathology was morphometrically quantified in 10 male patients with Type 2 diabetes and compared with six PIN biopsy specimens taken post mortem from male cadavers with no history of neuropathy or trauma. Results The PIN biopsy procedure provides a long (approximately 3 cm) mono- or bifascicular nerve biopsy with generous epineurial tissue and adjacent vessels. Our results show a significantly lower myelinated fibre density in subjects with diabetes [5782 (3332,9060)/mm2] compared with autopsy control material [9256 (6593,12 935)/mm2, P < 0.007]. No postoperative discomfort or complications were encountered. Conclusions A reduction in myelinated fibre density has previously been shown to be a clinically meaningful measure of neuropathy in diabetic patients. We demonstrate similar findings using the PIN biopsy. The PIN biopsy procedure fulfils the criteria for nerve biopsy and was well tolerated by the patients. It may be a possible alternative to sural nerve biopsy to allow for diagnosis of neuropathy. [source] Media framing and social movement mobilization: German peace protest against INF missiles, the Gulf War, and NATO peace enforcement in BosniaEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 1 2002Alice Holmes Cooper How does media framing of issues affect social movement mobilization? This relationship is examined in light of the striking variation in levels of German peace protest against INF missiles, the Gulf War and the NATO peace-keeping mission to Bosnia. I argue that this variation in mobilization capacity can be explained in part by the degree of congruence between media framing and movement framing of the issues involved. Congruence between the two framings facilitates movement mobilization, whereas divergence hinders it. I compare the relative congruence between movement framing and media framing in Die Tageszeitung and Der Spiegel coverage of the three issues. I also evaluate possible alternative or complementary explanations, including public opinion, ,normalization' and elite cues, and political opportunity structure. [source] Feature-space clustering for fMRI meta-analysis,HUMAN BRAIN MAPPING, Issue 3 2001Cyril Goutte Abstract Clustering functional magnetic resonance imaging (fMRI) time series has emerged in recent years as a possible alternative to parametric modeling approaches. Most of the work so far has been concerned with clustering raw time series. In this contribution we investigate the applicability of a clustering method applied to features extracted from the data. This approach is extremely versatile and encompasses previously published results [Goutte et al., 1999] as special cases. A typical application is in data reduction: as the increase in temporal resolution of fMRI experiments routinely yields fMRI sequences containing several hundreds of images, it is sometimes necessary to invoke feature extraction to reduce the dimensionality of the data space. A second interesting application is in the meta-analysis of fMRI experiment, where features are obtained from a possibly large number of single-voxel analyses. In particular this allows the checking of the differences and agreements between different methods of analysis. Both approaches are illustrated on a fMRI data set involving visual stimulation, and we show that the feature space clustering approach yields nontrivial results and, in particular, shows interesting differences between individual voxel analysis performed with traditional methods. Hum. Brain Mapping 13:165,183, 2001. © 2001 Wiley-Liss, Inc. [source] Gonadal maturation in the blackspot seabream Pagellus bogaraveo: a comparison between a farmed and a wild broodstockJOURNAL OF FISH BIOLOGY, Issue 2004V. Micale The blackspot seabream Pagellus bogaraveo(Brünnich, 1768) has been regarded as a possible alternative to traditionally cultured Mediterranean species such as seabream and seabass, due to its high market value and good adaptation to captivity. Broodstock establishment and management represent the first step towards reliable production of eggs and fry, which is required to develop aquaculture of this new species. Two different broodstocks were tested for gonadal maturation and spawning, one constituting of wild fish caught as juveniles and reared in tanks until sexual maturity (4 years), and one assembled from wild adult fish caught during or just before the reproductive season. All fish were maintained under the same rearing conditions and fed the same diet. Gonadal stripping and biopsies were performed weekly to monitor maturation in both males and females. Ovarian samples were staged for maturity on the basis of follicular diameter and migration of germinal vesicle. Sperm samples were tested for density (number of spermatozoa ml,1) and motility. The fish reared in captivity reached ovarian maturity during the breeding season of the wild stock. Eggs were obtained by stripping from both farmed and wild specimens, but appeared degenerated as a result of being retained too long in the ovarian cavity due to the absence of spontaneous spawning. Spermiation was prolonged in the farmed fish, but appeared to be blocked in the wild breeders after first sampling. However, the sperm was very viscous and the motile spermatozoa did not exceed 10%. [source] KINETICS OF ACRYLAMIDE FORMATION DURING TRADITIONAL AND VACUUM FRYING OF POTATO CHIPSJOURNAL OF FOOD PROCESS ENGINEERING, Issue 5 2005CLAUDIA GRANDA ABSTRACT Acrylamide is considered a carcinogen in animals and a possible carcinogen in humans. It has been found in starch-rich foods cooked at high temperatures. Vacuum frying (10 Torr) was investigated as a possible alternative to reduce acrylamide formation in potato chips. The cultivar Atlantic was used to determine the kinetics of acrylamide formation during traditional and vacuum frying at different temperatures. There was a 94% decrease in acrylamide content when potatoes were fried to the same final moisture content (1.5% ± 0.3% w.b.) under vacuum compared to those fried under atmospheric conditions. Acrylamide accumulation under vacuum frying was modeled using first-order kinetics (during traditional frying, the logistic kinetic model was used). The behavior of the kinetics of acrylamide content in potato chips fried under the two processes was different mainly because of the different temperatures used. During traditional frying, higher temperatures are used (150 to 180C) and acrylamide after some time is produced but starts degrading, producing a constant level of acrylamide content at longer times. During vacuum frying (10 Torr), acrylamide increased exponentially (but at lower levels) for all frying times. [source] Mandibular Morphology as an Indicator of Human Subadult Age: Interlandmark Approaches,JOURNAL OF FORENSIC SCIENCES, Issue 5 2007Daniel Franklin Ph.D. Abstract:, The dentition is widely recognized as the set of developmental markers that appear to show the least variability against chronological age; these markers are thus widely used in forensic anthropological investigations. As a possible alternative, we investigate here the potential of mandibular morphology as a developmental marker for estimating age at death in subadults. The sample analyzed comprises 79 known age and sex subadult individuals of South African Bantu and African American origin. Linear measurements of ramus height were obtained from the mathematical conversion of three-dimensional landmark data. A series of regression analyses were then performed to predict age by using the measurement of ramus height; results were cross-validated using a jackknife procedure. Our results show that ramus height can be used to predict age in the subadult skeleton with accuracy, closely approaching that of standards based on the dentition (standard error rates are between ±1.1 years and ±2.4 years). [source] Successful treatment with enoximone for severe poisoning with atenolol and verapamil: a case reportACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 6 2004C. Sandroni Combined poisoning with calcium channel blockers (CCBs) and beta-blockers is usually associated with severe hypotension and heart failure. Due to the block of the beta receptors, treatment with adrenergic agonists, even at high doses, can be insufficient, and beta-independent inotropes, such as glucagon, may be required. Phosphodiesterase III (PDEIII) inhibitors represent a possible alternative to glucagon in these cases as they have an inotropic effect which is not mediated by a beta receptor. [source] Role of proton MR for the study of muscle lipid metabolism,NMR IN BIOMEDICINE, Issue 7 2006Chris Boesch Abstract 1H-MR spectroscopy (MRS) of intramyocellular lipids (IMCL) became particularly important when it was recognized that IMCL levels are related to insulin sensitivity. While this relation is rather complex and depends on the training status of the subjects, various other influences such as exercise and diet also influence IMCL concentrations. This may open insight into many metabolic interactions; however, it also requires careful planning of studies in order to control all these confounding influences. This review summarizes various historical, methodological, and practical aspects of 1H-MR spectroscopy (MRS) of muscular lipids. That includes a differentiation of bulk magnetic susceptibility effects and residual dipolar coupling that can both be observed in MRS of skeletal muscle, yet affecting different metabolites in a specific way. Fitting of the intra- (IMCL) and extramyocellular (EMCL) signals with complex line shapes and the transformation into absolute concentrations is discussed. Since the determination of IMCL in muscle groups with oblique fiber orientation or in obese subjects is still difficult, potential improvement with high-resolution spectroscopic imaging or at higher field strength is considered. Fat selective imaging is presented as a possible alternative to MRS and the potential of multinuclear MRS is discussed. 1H-MRS of muscle lipids allows non-invasive and repeated studies of muscle metabolism that lead to highly relevant findings in clinics and patho-physiology. Copyright © 2006 John Wiley & Sons, Ltd. [source] Training and public sector reform: an integrated approachPUBLIC ADMINISTRATION & DEVELOPMENT, Issue 4 2001Padraig Healy This article is partly a response to McCourt and Sola (1999), who raised a number of important observations about the role and limitations of training in promoting public sector reform in Tanzania. In particular, their discussion of the relationship between individual and organizational change is referred to. The article outlines a possible alternative to the straight training approach to capacity building, and suggests it as a possible model for the kind of OD intervention mentioned in McCourt and Sola, The author describes a programme of capacity building for rural district councils in Zimbabwe, which tried to avoid the mistakes of earlier public sector training programmes. In discussing ways of integrating human resource development into programmes of capacity building and public sector reform, the article adds to the debate about process and blueprint approaches as discussed in this journal by Cook, (1997), Blunt (1997) and others. The article concludes with an attempt to assess some of the achievements and failures of the training programme after the initial three years. It draws attention to some of the external factors in the programme operating environment which combine with the internal coordination and management aspects, in determining the overall achievement of such a complex programme. Copyright © 2001 John Wiley & Sons, Ltd. [source] Vetulicolians,are they deuterostomes? chordates?BIOESSAYS, Issue 3 2002Thurston C. Lacalli A recent paper by Shu et al.(1) reinterprets the fossil Vetulicola and related forms, all from the Lower Cambrian, as basal deuterostomes, assigning them their own phylum, Vetulicolia. Their conclusion is based on the presence of structures resembling gill slits and a trunk-like region that shows evidence of segmentation. This report summarizes the fossil evidence for their interpretation and evaluates a possible alternative, that vetulicolians may instead be tunicate-like chordates. Implications for our understanding of the nature of the primitive deuterostome (and chordate) body plan are discussed. BioEssays 24:208,211, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10064 [source] Effect of adiponectin on apoptosis: Proapoptosis or antiapoptosis?BIOFACTORS, Issue 3 2010Yiyi Sun Abstract Adiponectin is a protein hormone mainly secreted by adipose tissue that regulates energy homeostasis and glucose and lipid metabolism. Compared with other adipose-derived hormones, adiponectin is very abundant in plasma and is proposed to be a convenient biomarker for many diseases. A large number of in vitro and in vivo studies support the beneficial effects of adiponectin on metabolic syndrome, diabetes, and atherosclerosis. However, the protective actions were challenged occasionally by the controversies in its role in inflammation and in the specific functions of its different conformations. Recently, quite a few reports suggested that the antiapoptotic activity of adiponectin might contribute to its therapeutic potential during ischemia/reperfusion injury in vivo, whereas some studies demonstrated that adiponectin induced apoptosis both in vitro and in vivo. Herein, this review attempts to summarize the present consensus and divergence and to provide possible alternative and/or complementary explanations for this apparent paradox. [source] Enzymatic Synthesis of 3,-Hydroxyacetaminophen Catalyzed by TyrosinaseBIOTECHNOLOGY PROGRESS, Issue 6 2003Edelmira Valero 3,-Hydroxyacetaminophen, a catechol metabolite of N -acetyl- p -aminophenol (acetaminophen) and N -acetyl- m -aminophenol (a structural analogue of acetaminophen and considered as a possible alternative because it is not hepatotoxic), is enzymatically synthesized for the first time using mushroom tyrosinase. Although reported to be weakly hepatotoxic in vivo, this catechol derivative of acetaminophen is not commercially available. This compound was obtained from its monophenolic precursor, acetaminophen, using the enzyme tyrosinase in the presence of an excess of ascorbic acid, thus reducing back the o -quinone product of catalytic activity to the catechol acetaminophen derivative. A mathematical model of the system is proposed, which is also applicable to the tyrosinase-mediated synthesis of any o -diphenolic compound from its corresponding monophenol. This synthesis procedure is continuous, easy to perform and control, and adaptable to a bioreactor with the immobilized enzyme for industrial purposes in a nonpolluting way. [source] The role of indirect radionuclide cystography during the acute phase of pyelonephritis in young womenBJU INTERNATIONAL, Issue 4 2005Jehonathan H. Pinthus Authors from Israel have investigated the use of dynamic renal scans in young female patients with acute pyelonephritis, combined with indirect radionuclide cystography. They found that using these techniques may avoid up to half of the delayed voiding cysto-urethrograms, preventing the related inconvenience and cost. OBJECTIVE To review our experience using dynamic 99mTc-diethylenetriamine penta-acetic acid renal scintigraphy combined with indirect radionuclide cystography (IRC) in the acute phase of pyelonephritis, as a possible alternative to the conventional imaging, as investigating acute pyelonephritis usually includes imaging the upper urinary tract during the acute phase, to exclude obstruction, and delayed voiding cysto-urethrography (VCUG) when underlying vesico-ureteric reflux (VUR) is suspected. PATIENTS AND METHODS Between 1997 and 1999, 47 young women (median age 22 years, range 18,37) were hospitalized for acute pyelonephritis. The combined study was used during the acute phase of the disease, usually within 24 h of hospitalization. The principle of IRC is based on the reappearance of radioactivity in the ureters or kidneys after previously detecting renal clearance of an intravenously injected radioisotope. The increase in radioactivity over the ureters or kidneys indicates VUR. The subsequent follow-up included VCUG, after recovery and at least 6 weeks after discharge. RESULTS Overall, 47 patients had early IRC studies; obstruction of the urinary tract during the acute phase of the disease was excluded in all. In 13 (28%) of the patients early IRC studies showed VUR involving 21 upper tract units. The renal parenchymal scan was impaired in 17 (36%) patients, and six of these 17 also had detectable concomitant reflux on IRC. Overall, 24 IRC studies (51%) were considered positive, showing VUR, renal parenchymal pathology or both; 23 (49%) were normal. Follow-up VCUG was used in 32 patients (68%); only three (9%) detected VUR. All of the patients with VUR on follow-up VCUG had also had an abnormal early IRC study, showing either reflux (two) or findings suggestive of pathological renal parenchyma (one). CONCLUSIONS In addition to the well-established role of renal scintigraphy in excluding obstruction of the collecting system, early IRC is characterized by high sensitivity and accurate negative predictive value for detecting VUR. It can therefore be used to screen adults presenting with acute pyelonephritis for the presence of VUR. Patients with an abnormal IRC require follow-up VCUG after complete recovery, while those with a negative study may be managed expectantly, with no further radiological evaluation. This proposed strategy may avoid up to half of the delayed VCUG studies, preclude the related inconvenience, and substantially reduce the costs. [source] Discourse rights and the Drumcree marches: a reply to O'NeillBRITISH JOURNAL OF POLITICS & INTERNATIONAL RELATIONS, Issue 1 2002Glen Newey In a recent BJPIR article Shane O'Neill uses Habermas' discourse theory of rights to argue that the conflicts over marches in Drumcree can be resolved rationally in the nationalist residents' favour. I question this conclusion via a critique of Habermas' theory. Habermas' apparently unexceptionable requirement that political outcomes win universal acceptability is bought at the cost of vagueness: it fails to specify how acceptability is secured, or how the requirement itself is derived. So it cannot justify the exceptions to equal civil rights which O'Neill wants, such as exceptions to rights of freedom of expression or movement. Unionists can claim that their position respects Habermas' universal acceptability requirement. This exposes the limitations of attempts to impose abstract principles such as Habermas' on real political conflicts. A possible alternative to this is a form of Schmittian decisionism, in which rules either prove indeterminate, or are confronted with exceptional cases that call for executive intervention outside the framework of rules. Sensitivity to political context requires not derogations from rights, but respect for the autonomy of political processes. [source] Graphical user interfaces in an engineering educational environmentCOMPUTER APPLICATIONS IN ENGINEERING EDUCATION, Issue 1 2005Christopher Depcik Abstract Graphical user interfaces (GUIs) are being increasingly used in the classroom to provide users of computer simulations with a friendly and visual approach to specifying all input parameters and increased configuration flexibility. In this study, the authors first describe a number of software and language options that are available to build GUIs. Subsequently, a comprehensive comparative assessment of possible alternatives is undertaken in the light of a benchmark educational program used in a course on computational fluid dynamics (CFD) at the University of Michigan. For the GUIs presented, their educational value with respect to flexible data entry and post-processing of results has been demonstrated. In addition, the authors offer recommendations for pros and cons of available options in terms of platform independence, ease of programming, facilitation of interaction with students, and flexibility. © 2005 Wiley Periodicals, Inc. Comput Appl Eng Educ 13: 48,59, 2005; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20029 [source] Bivariate distributed lag models for the analysis of temperature-by-pollutant interaction effect on mortalityENVIRONMETRICS, Issue 3 2007Vito M. R. Muggeo Abstract This paper introduces Bivariate Distributed Lags Models (BDLMs) to investigate synergic effect of temperature and airborne particles on mortality. These models seem particulary attractive since they allow to model interactions between such environmental variables accounting for possible delayed effects. A B-spline framework is used to approximate the coefficient surface of the temperature-by-pollutant interaction and possible alternatives are also discussed. A case study of mortality time-series data in Palermo, Italy, is presented to illustrate the model. Copyright © 2007 John Wiley & Sons, Ltd. [source] Alternative fuzzy operations and applications to social sciencesINTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS, Issue 12 2009Antonio Maturo Some humanistic systems find a suitable method of representation of their features in fuzzy numbers. This is due to the properties of fuzzy numbers that are used to describe indeterminateness. The applications of fuzzy numbers to Social Sciences request, in some cases, that the region of indeterminateness, called spreads, in the results of the operations between fuzzy numbers be less than the ones expected by Zadeh's extension principle. Furthermore, it is important to consider operations that save the shapes of fuzzy numbers for reasons of simplicity and clearness of modeling. To this aim, fuzzy operations are dealt with as possible alternatives to the operations induced by the extension principle. An application to Social Sciences is considered. Finally, the need for defining algebraic structures of fuzzy numbers (e.g., to extend to the fuzzy environment the de Finetti's concept of coherent prevision) leads to considerations for operations defined up to equivalence relations. Some fuzzy extensions of the coherent prevision are introduced. © 2009 Wiley Periodicals, Inc. [source] An alternative urban world is possible: a declaration for urban research and actionINTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, Issue 4 2003Action (INURA)Article first published online: 17 DEC 200, International Network for Urban Research At its June 2002 meeting in Paris and Caen, France, the members of the International Network for Urban Research and Action (INURA) collectively agreed on a declaration to express the organization's urbanist agenda. This declaration operates on two levels: one makes five statements conceived in the tradition of earlier (for example situationist) manifestos; the other is a set of concise statements on the state of the globalization process in the era of globalization and neoliberalism. Subsections of the declaration deal with an urban world, a global city, migrant cities, unsustainable urban-natural relations, neoliberalization, attacks on democracy, community vulnerability, the rise of racism, and some thoughts on possible alternatives. The strategic purpose of this declaration was to be an intervention at meetings of the international urban community, for example for the World Social Forum in Porto Alegre in January 2003 and similar regional and local events. The declaration is published here in order to invite debate among other scholars and activists on the issues raised in its theses and statements. Lors de ses rassemblements de juin 2002 à Paris et Caen, les membres de l'INURA (International Network for Urban Research and Action) ont convenu ensemble d'une déclaration visant à exprimer le programme urbanistique du Réseu. Cette déclaration agit à deux niveaux: l'un énonce cinq propositions dans la tradition de manifestes antérieurs (situationnistes, par exemple), l'autre est une série de communications concises sur l'état de la démarche mondialiste à l'ére de la globalisation et du néolibéralisme. Les paragraphes de la déclaration abordent univers urbain, ville planétaire, villes de migrants, relations ville-nature insoutenables à terme, néolibéralisation, attaques contre la démocratie, vulnérabilité des communautés, montée du racisme et quelques réflexions sur les options possibles. Cette déclaration avait pour objectif stratégique une intervention lors de rencontres de la communauté urbaine internationale, comme au Forum social mondial de Pôrto Alegre en janvier 2003, ou d'événements locaux et régionaux similaires. Elle est publiée ici afin de susciter un débat entre d'autres intellectuels et militants sur les problèmes que posent ses thèses et propositions. [source] The pure parsimony haplotyping problem: overview and computational advancesINTERNATIONAL TRANSACTIONS IN OPERATIONAL RESEARCH, Issue 5 2009Daniele Catanzaro Abstract Haplotyping estimation from aligned single-nucleotide polymorphism fragments has attracted more and more attention in recent years due to its importance in analysis of many fine-scale genetic data. Its application fields range from mapping of complex disease genes to inferring population histories, passing through designing drugs, functional genomics, and pharmacogenetics. The literature proposes a number of estimation criteria to select a set of haplotypes among possible alternatives. Usually, such criteria can be expressed under the form of objective functions, and the sets of haplotypes that optimize them are referred to as optimal. One of the most important estimation criteria is the pure parsimony, which states that the optimal set of haplotypes for a given set of genotypes is that having minimal cardinality. Finding the minimal number of haplotypes necessary to explain a given set of genotypes involves solving an optimization problem, called the pure parsimony haplotyping (PPH) estimation problem, which is notoriously -hard. This article provides an overview of PPH, and discusses the different approaches to solution that occur in the literature. [source] Corporate Portfolio Management RoundtableJOURNAL OF APPLIED CORPORATE FINANCE, Issue 2 2008Article first published online: 16 JUL 200 The dean of a top ten business school, the chair of a large investment management firm, two corporate M&A leaders, a CFO, a leading M&A investment banker, and a corporate finance advisor discuss the following questions: ,What are today's best practices in corporate portfolio management? What roles should be played by boards, senior managers, and business unit leaders? ,What are the typical barriers to successful implementation and how can they be overcome? ,Should portfolio management be linked to financial policies such as decisions on capital structure, dividends, and share repurchase? ,How should all of the above be disclosed to the investor community? After acknowledging the considerable challenges to optimal portfolio management in public companies, the panelists offer suggestions that include: ,Companies should establish an independent group that functions like a "SWAT team" to support portfolio management. Such groups would be given access to (or produce themselves) business-unit level data on economic returns and capital employed, and develop an "outside-in" view of each business's standalone valuation. ,Boards should consider using their annual strategy "off-sites" to explore all possible alternatives for driving share-holder value, including organic growth, divestitures and acquisitions, as well as changes in dividends, share repurchases, and capital structure. ,Performance measurement and compensation frameworks need to be revamped to encourage line managers to think more like investors, not only seeking value-creating growth but also making divestitures at the right time. CEOs and CFOs should take the lead in developing a shared value creation model that clearly articulates how capital will be allocated. [source] Prescription drug samples , does this marketing strategy counteract policies for quality use of medicines?JOURNAL OF CLINICAL PHARMACY & THERAPEUTICS, Issue 4 2003K. E. M. Groves BSc MSc PhD (Cand) Summary Prescription drug samples, as used by the pharmaceutical industry to market their products, are of current interest because of their influence on prescribing, and their potential impact on consumer safety. Very little research has been conducted into the use and misuse of prescription drug samples, and the influence of samples on health policies designed to improve the rational use of medicines. This is a topical issue in the prescription drug debate, with increasing costs and increasing concerns about optimizing use of medicines. This manuscript critically evaluates the research that has been conducted to date about prescription drug samples, discusses the issues raised in the context of traditional marketing theory, and suggests possible alternatives for the future. [source] Measuring the Benefits of Examinee-Selected QuestionsJOURNAL OF EDUCATIONAL MEASUREMENT, Issue 1 2005Nancy L. Allen Allowing students to choose the question(s) that they will answer from among several possible alternatives is often viewed as a mechanism for increasing fairness in certain types of assessments. The fairness of optional topic choice is not a universally accepted fact, however, and various studies have been done to assess this question. We examine an important class of experiments that we call C1-A, "choose one, answer all," designs, and point out an important problem that they face. We suggest two analytical methods that can be used to circumvent this problem. We illustrate our ideas using the data from Bridgeman et al. (1997). Our reanalysis of these data show: (a) that differential topic difficulty exists in real choice data, (b) that it affects naïve analyses of such data and masks the effects, positive or negative, of examinee choice, (c) that in this study there is a measurable and positive effect of examinee choice that follows predicted patterns in most but not all cases, (d) that the beneficial strength of examinee choice varies from case to case, and (e) that while the benefits of choice in terms of average points scored on the essays are usually positive, there is a substantial amount of variation around these averages and it is not uncommon for "incorrect" choices to be associated with higher test performance. [source] A new method for scoring additive multi-attribute value models using pairwise rankings of alternativesJOURNAL OF MULTI CRITERIA DECISION ANALYSIS, Issue 3-4 2008Paul Hansen Abstract We present a new method for determining the point values for additive multi-attribute value models with performance categories. The method, which we refer to as PAPRIKA (Potentially All Pairwise RanKings of all possible Alternatives), involves the decision-maker pairwise ranking potentially all undominated pairs of all possible alternatives represented by the value model. The number of pairs to be explicitly ranked is minimized by the method identifying all pairs implicitly ranked as corollaries of the explicitly ranked pairs. We report on simulations of the method's use and show that if the decision-maker explicitly ranks pairs defined on just two criteria at-a-time, the overall ranking of alternatives produced by the value model is very highly correlated with the true ranking. Therefore, for most practical purposes decision-makers are unlikely to need to rank pairs defined on more than two criteria, thereby reducing the elicitation burden. We also describe a successful real-world application involving the scoring of a value model for prioritizing patients for cardiac surgery in New Zealand. We conclude that although the new method entails more judgments than traditional scoring methods, the type of judgment (pairwise rankings of undominated pairs) is arguably simpler and might reasonably be expected to reflect the preferences of decision-makers more accurately. Copyright © 2009 John Wiley & Sons, Ltd. [source] Predicting project delivery rates using the Naive,Bayes classifierJOURNAL OF SOFTWARE MAINTENANCE AND EVOLUTION: RESEARCH AND PRACTICE, Issue 3 2002B. Stewart Abstract The importance of accurate estimation of software development effort is well recognized in software engineering. In recent years, machine learning approaches have been studied as possible alternatives to more traditional software cost estimation methods. The objective of this paper is to investigate the utility of the machine learning algorithm known as the Naive,Bayes classifier for estimating software project effort. We present empirical experiments with the Benchmark 6 data set from the International Software Benchmarking Standards Group to estimate project delivery rates and compare the performance of the Naive,Bayes approach to two other machine learning methods,model trees and neural networks. A project delivery rate is defined as the number of effort hours per function point. The approach described is general and can be used to analyse not only software development data but also data on software maintenance and other types of software engineering. The paper demonstrates that the Naive,Bayes classifier has a potential to be used as an alternative machine learning tool for software development effort estimation. Copyright © 2002 John Wiley & Sons, Ltd. [source] A two-stage procedure for comparing hazard rate functionsJOURNAL OF THE ROYAL STATISTICAL SOCIETY: SERIES B (STATISTICAL METHODOLOGY), Issue 1 2008Peihua Qiu Summary., Comparison of two hazard rates is important in applications that are related to times to occurrence of a specific event. Conventional comparison procedures, such as the log-rank, Gehan,Wilcoxon and Peto,Peto tests, are powerful only when the two hazard rates do not cross each other. Because crossing hazard rates are common in practice, several procedures have been proposed in the literature for comparing such rates. However, most of these procedures consider only the alternative hypothesis with crossing hazard rates; many other realistic cases, including those when the two hazard rates run parallel to each other, are excluded from consideration. We propose a two-stage procedure that considers all possible alternatives, including ones with crossing or running parallel hazard rates. To define its significance level and p -value properly, a new procedure for handling the crossing hazard rates problem is suggested, which has the property that its test statistic is asymptotically independent of the test statistic of the log-rank test. We show that the two-stage procedure, with the log-rank test and the suggested procedure for handling the crossing hazard rates problem used in its two stages, performs well in applications in comparing two hazard rates. [source] | ||||||||||||||||||||||||||||||||||