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Polyherbal Formulation (polyherbal + formulation)
Selected AbstractsHepatoprotective Activity of Polyherbal Formulation (Normeta®) in Oxidative Stress Induced by Alcohol, Polyunsaturated Fatty Acids and Iron in RatsBASIC AND CLINICAL PHARMACOLOGY & TOXICOLOGY, Issue 3 2009Shilpa N. Patere The present study was carried out to evaluate the effects of oral treatment with polyherbal formulation Normeta® (2 ml and 4 ml/kg) on hepatic damage induced by alcohol 10,30% (blood alcohol was maintained at levels between 150 and 350 mg/dl), thermally oxidized oil (polyunsaturated fatty acids) (15% of diet) and carbonyl iron (1.5,2% of diet) for 30 days in rats. In vitro studies with 1, 1-Diphenyl, 2-Picrylhydrazyl (DPPH), Nitric oxide and Ferric chloride (Fe+3 ions) showed that Normeta® possesses antioxidant and metal chelating activity. Alcohol, polyunsaturated fatty acids and iron feeding produced an increase in serum levels of iron, serum glutamate pyruvate transaminase and decrease in serum proteins. It was also associated with elevated lipid peroxidation (thiobarbituric acid reactive substances) and disruption of antioxidant defence mechanism in liver, decreased body weight and increased liver to body weight ratio. Oral administration of Normeta® along with alcohol, polyunsaturated fatty acids and iron decreased the serum iron, serum glutamate pyruvate transaminase levels and increased serum protein levels. The levels of liver thiobarbituric acid reactive substances were decreased and the activities of antioxidant enzymes superoxide dismutase and catalase were increased. Improvement in body weight and liver to body weight ratio was also observed. The effects of Normeta® on physico-metabolic parameters were comparable with silymarin. This indicates that Normeta® has favourable effect in bringing down the severity of hepatotoxicity. [source] Hepatoprotective effect of New Liv,t®, a polyherbal formulation, is mediated through its free radical scavenging activityPHYTOTHERAPY RESEARCH, Issue 5 2004Y. K. Gupta Abstract The effect of New Liv,t®, a polyherbal formulation, was studied on pyrogallol-induced hepatotoxicity in rats. Administration of pyrogallol 100 mg/kg, i.p. caused a signi,cant increase in liver enzymes as well as a signi,cant increase in lipid peroxidation. Simultaneous administration of oral New Liv,t® and pyrogallol prevented these changes in hepatic damage. The results of the study showed that New Liv,t® exerted a hepatoprotective effect against pyrogallol induced liver toxicity, which was mediated through its free radical scavenging property. Copyright © 2004 John Wiley & Sons, Ltd. [source] Protective effect of a polyherbal formulation (Immu-21) against cyclophosphamide-induced mutagenicity in mice,PHYTOTHERAPY RESEARCH, Issue 4 2003G. B. Jena Abstract The object was to evaluate the effects of a polyherbal formulation, Immu-21, against cyclophosphamide (CP)-induced chromosomal aberrations (CA) and micronuclei (MN) in mice. CP alone (40 mg/kg, i.p.) produced classical as well as non-classical chromosomal aberrations in mice, and the incidence of CA was signi,cantly more in the CP treated group when compared with that of the control group. Immu-21, which contains extracts of Ocimum sanctum, Withania somnifera, Emblica officinalis and Tinospora cordifolia, was given at 100 mg/kg, daily, over 7 days, and 30 mg/kg daily over 14 days and inhibited both CP-induced classical and non-classical chromosomal aberrations (,40%,60% of control). A significant increase in MN was also observed in bone marrow erythrocytes of mice treated with CP, and pretreatment with Immu-21 also signi,cantly reduced these. Cytotoxicity was evaluated by estimating the ratio of polychromatic erythrocytes (PCEs) to normochromatic erythrocytes (NCEs). The present results indicate that chronic treatment with Immu-21 prevented CP-induced genotoxicity in mice. Copyright © 2003 John Wiley & Sons, Ltd. [source] | ||||||||||