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Potential Way (potential + way)
Selected AbstractsInitial Margin Requirements, Volatility, and the Individual Investor: Insights from JapanFINANCIAL REVIEW, Issue 1 2002Kenneth A. Kim Initial margin requirements represent: (1) a cost impediment to the wealth constrained investor and (2) a potential way of mitigating excessive volatility. However, prior empirical research finds that margins are not an effective tool in reducing volatility. We consider the possibility that margins primarily affect certain stocks and investors. Specifically, we test whether margins affect individuals who, as a group, we believe to be the investors most affected when margin requirements change. Our initial empirical tests, however, do not support this contention. [source] Social Capital, Networks, and Community Environments in Bangkok, ThailandGROWTH AND CHANGE, Issue 4 2002Amrita Daniere This paper considers the case of Bangkok where, as in many Asian cities, the expansion of urban areas has outpaced the ability of public entities to manage and provide basic services. One potential way to improve the capacity of neighborhoods to assist in provision or improvement in environmental services is to enhance the positive contributions provided by local social networks and social capital. A conceptual framework is presented to explore the role of social networks in environmental management in polluted urban environments. This is followed by a brief description of the methodology and survey instrument used to collect information from a sample of community households in Bangkok and an analysis of the results from this survey regarding environmental practices, community action, and social networks. Some of the results suggest that increasing the number of social interactions that residents of a community experience is associated with increased community participation as, apparently, is increasing knowledge about what happens to waste or waste water after it leaves the community. Local public education efforts that focus on useful knowledge about environmental impacts may well be an effective way to encourage community participation. [source] Content Validation of Parental Role Conflict in the Neonatal Intensive Care UnitINTERNATIONAL JOURNAL OF NURSING TERMINOLOGIES AND CLASSIFICATION, Issue 1 2006Elenice Valentim Carmona MN PURPOSE.,To validate the content of the nursing diagnosis parental role conflict made by neonatal intensive care (NICU) nurses and researchers in the field and to identify the related major and minor defining characteristics. METHOD.,Fehring's Diagnostic Content Validation model using 59 neonatal specialists. FINDINGS.,Nineteen defining characteristics were validated for use in NICUs: four were considered major and 15 as minor. There was no correlation between nurse profiles and defining characteristic scores. CONCLUSIONS.,In this study, parental role conflict was validated for use in neonatal units but defining characteristics must be described in a clearer and more objective manner. NURSING IMPLICATIONS.,Validation studies in different healthcare settings are required so that the specificities of each clientele are met. NANDA diagnoses must be tested and validated at neonatal units, because this setting has developed few studies and their use in practice is a potential way to improve nursing care. [source] From Policy to Polity: Can the EU's Special Relations with its ,Neighbourhood' be Decentred?JCMS: JOURNAL OF COMMON MARKET STUDIES, Issue 3 2010DIMITAR BECHEV The article investigates the institutional and policy choices regarding the EU's relations with the countries and regions covered by the European Neighbourhood Policy (ENP). It juxtaposes the notion of special relationship inaugurated by the Lisbon Treaty to three models for organizing relations with proximate countries: pre-accession, the European Economic Area (EEA) and association. The convergence-access paradigm is found to be the basic pillar of the EU approach. The article brings in a series of dilemmas concerning the design and the implementation of the ENP as well as perceptions from selected partner countries. As a potential way to manage tensions and dilemmas inherent in the EU strategy, the article proposes an altogether novel dimension: decentred integration geared towards polity-building that could partially delink convergence and access. The last section maps out four scenarios for the future directions of the ENP that cover the whole continuum from piecemeal enhancement of the policy to the creation of a European Partnership Area underpinned by a new tier of institutions. [source] Integrating diversity and fostering interdependence: Ecological lessons learned about refugee participation in multiethnic communitiesJOURNAL OF COMMUNITY PSYCHOLOGY, Issue 4 2002Jessica R. Goodkind Communities in the United States are becoming increasingly diverse, in part, because of the continual resettlement of refugees and immigrants from around the world. The promotion of refugees' well-being and integration depends upon how our communities value diversity and provide opportunities for meaningful involvement. However, refugees often face challenges to such involvement. An ecological perspective suggests that it is important to consider not only the characteristics of individuals but also to examine the extent to which particular settings are able to facilitate the participation of community members. The purpose of this study was to understand the participation experiences of 54 Hmong refugees living in multiethnic housing developments. Interviews revealed that while Hmong residents valued participation highly, most were excluded from meaningful avenues of participation because of multiple barriers, including language differences, time constraints, and discrimination. No supports to address these barriers existed in their communities. It is important to understand and build individuals' capacities to participate and communities' capacities to promote involvement, integrate diversity, and foster interdependence. Participation is fundamental to the process of enabling refugees to become an integral part of their new communities and is a potential way for them to regain a sense of control over their lives and the decisions that affect them. © 2002 Wiley Periodicals, Inc. [source] Redox-induced configuration conversion for thioacetamide dimer can function as a molecular switchJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 14 2010Haiying Liu Abstract The electronic switching properties of thioacetamide dimer (TAD) were investigated using the nonequilibrium Green's function method combined with density functional theory for design of a novel molecular switch. The H-bonded TAD can be converted upon hole-trapping to a three-electron (3e)-bonded configuration with a S,S linkage which could provide a more favorable channel for charge transfer than the before. The redox-induced configuration conversion between the H-bonded and the 3e-bonded TADs could govern the charge migration through the molecular junction with a considerable difference in conduction currents. The calculated I,V characteristic curves of two configurations exhibit a switching behavior with an On-Off ratio in a range of about 4.3,7.6 within the applied voltages. Clearly, this hypothetical scheme provides a potential way to explore the novel conformation-dependent molecular switch. © 2010 Wiley Periodicals, Inc. J Comput Chem 2010 [source] Detection of Malingered PTSD: An Overview of Clinical, Psychometric, and Physiological Assessment: Where Do We Stand?JOURNAL OF FORENSIC SCIENCES, Issue 3 2007Ryan C. W. Hall M.D. ABSTRACT: Posttraumatic stress disorder (PTSD) is a condition that can be easily malingered for secondary gain. For this reason, it is important for physicians to understand the phenomenology of true PTSD and indicators that suggest an individual is malingering. This paper reviews the prevalence of PTSD for both the general population and for specific events, such as rape and terrorism, to familiarize evaluators with the frequency of its occurrence. The diagnostic criteria for PTSD, as well as potential ambiguities in the criteria, such as what constitutes an exposure to a traumatic event, are reviewed. Identified risk factors are reviewed as a potential way to help differentiate true cases of PTSD from malingered cases. The question of symptom overreporting as a feature of the disease versus a sign of malingering is discussed. We then examine how the clinician can use the clinical interview (e.g., SIRS, CAPS), psychometric testing, and the patient's physiological responses to detect malingering. Particular attention is paid to research on the MMPI and the subscales of infrequency (F), infrequency-psychopathology (Fp), and infrequency-posttraumatic stress disorder (Fptsd). Research and questions regarding the accuracy of self-report questionnaires, specifically the Mississippi Scale (MSS) and the Personality Assessment Inventory (PAI), are examined. Validity, usability, and cutoff values for other psychometric tests, checklists, and physiological tests are discussed. The review includes a case, which shows how an individual used symptom checklist information to malinger PTSD and the inconsistencies in his story that the evaluator detected. We conclude with a discussion regarding future diagnostic criteria and suggestions for research, including a systematic multifaceted approach to identify malingering. [source] Success and safety in the biological control of environmental weeds in New ZealandAUSTRAL ECOLOGY, Issue 5 2000SIMON V. FOWLER Abstract Biological control, using specialist insect herbivores and plant pathogens, can be a self-sustaining, cost-effective and low-risk tool for the management of environmental weeds. Agents have been recorded attacking non-target plants in New Zealand and elsewhere, but the effects are usually minor and/or transitory. It seems probable that only two cases, worldwide, will result in significant damage to non-target plants (representing 0.5% of the nearly 400 insect, mite, or fungal species used in classical weed biocontrol). Both of these cases were predictable from host range testing. Negative indirect, or ,downstream', ecological effects from specific weed biocontrol agents are difficult to predict and measure. They are probably insignificant compared to the impacts of the invasive plants that the agents are introduced to control. However, it is necessary to balance the risks associated with any introduction against the environmental benefits from controlling a weed to a predicted level. Recent analyses suggest that success rates are better than generally perceived. For New Zealand programmes, where enough time has lapsed to allow assessment, we calculate a full/partial success rate of 83%. Many of the costs associated with environmental weeds are difficult to quantify. Detailed risk assessment will make biological control programmes more expensive and time-consuming, so that reliance on non-biological management methods for environmental weeds may actually increase. The costs of biocontrol programmes against some New Zealand weeds can be kept down by using research already carried out in Australia and other countries, and the process is reciprocal. Developing international consortia of sponsors is also a potential way to fund programmes against weeds shared by several countries. [source] Direct use of vegetable oil and animal fat as alternative fuel in internal combustion engineBIOFUELS, BIOPRODUCTS AND BIOREFINING, Issue 2 2008Pinaki Mondal Abstract Gradual depletion of world petroleum reserves and the impact of environmental pollution of increasing exhaust emissions lead to the search for a suitable alternative fuels for diesel engines. The substitution of conventional fuels (gasoline, diesel) by renewable biofuels is considered a potential way to reduce pollution and to support the sustainable development of a country. Direct use of vegetable oil and animal fat is a promising alternative to solve these problems. An exhaustive review of the experiments in this area, carried out by several researchers in last three decades, is presented here. Different problems associated with the direct use of vegetable oil and animal fat and potential solutions from both public and private sectors are discussed. Some engine manufacturers have started to launch full-warranty engines with vegetable oil as fuel. It is expected that the competitive engine market will witness more intense research, resulting in the launch of more vegetable-oil engines with full warranties. The steep rise in food prices in recent years is concerning policy-makers and has raised the old ,food vs fuel' debate. It has been concluded that vegetable oil can probably only substitute small to medium portions of petroleum-based fuel due to future severe land-usage competition from food sector. This calls for intense research initiatives into the production of suitable fuel from non-edible vegetable oil, grown in wasteland. In this regard, genetic engineering may prove to be extremely effective in developing ,designer fuel'. © 2008 Society of Chemical Industry and John Wiley & Sons, Ltd [source] Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxelINTERNATIONAL JOURNAL OF CANCER, Issue 11 2009Lysann Sauer Abstract It has recently been shown that docetaxel chemotherapy is effective in prolonging life in patients with prostate cancer (PCa). We have investigated potential ways of increasing the effectiveness of chemotherapy in this disease. We have previously reported that sphingosine kinase 1 (SphK1) inhibition is a key step in docetaxel-induced apoptosis in the PC-3 PCa cell line and that pharmacologicalSphK1 inhibition is chemosensitizing in the docetaxel-resistant PCa LNCaP cell line. In this study we have addressed the mechanism of docetaxel-induced apoptosis of PC-3 cells and identified SphK1-dependent and -independent components. We have shown that SphK1 inhibition by docetaxel is a two-step process involving an initial loss of enzyme activity followed by a decrease in SphK1 gene expression. Using hormoneresistant PC-3 and DU145 PCa cells we have demonstrated that both pharmacological and siRNA-mediated SphK1 inhibition leads to a four-fold decrease in the docetaxel IC50 dose. This work points out to potential ways of increasing the effectiveness of chemotherapy for PCa by SphK1 inhibition. © 2009 UICC [source] Potential roles of melatonin and chronotherapy among the new trends in hypertension treatmentJOURNAL OF PINEAL RESEARCH, Issue 2 2009Fedor Simko Abstract:, The number of well-controlled hypertensives is unacceptably low worldwide. Respecting the circadian variation of blood pressure, nontraditional antihypertensives, and treatment in early stages of hypertension are potential ways to improve hypertension therapy. First, prominent variations in circadian rhythm are characteristic for blood pressure. The revolutionary MAPEC (Ambulatory Blood Pressure Monitoring and Cardiovascular Events) study, in 3000 adult hypertensives investigates, whether chronotherapy influences the cardiovascular prognosis beyond blood pressure reduction per se. Second, melatonin, statins and aliskiren are hopeful drugs for hypertension treatment. Melatonin, through its scavenging and antioxidant effects, preservation of NO availability, sympatholytic effect or specific melatonin receptor activation exerts antihypertensive and anti-remodeling effects and may be useful especially in patients with nondipping nighttime blood pressure pattern or with nocturnal hypertension and in hypertensives with left ventricular hypertrophy (LVH). Owing to its multifunctional physiological actions, this indolamine may offer cardiovascular protection far beyond its hemodynamic benefit. Statins exert several pleiotropic effects through inhibition of small guanosine triphosphate-binding proteins such as Ras and Rho. Remarkably, statins reduce blood pressure in hypertensive patients and more importantly they attenuate LVH. Addition of statins should be considered for high-risk hypertensives, for hypertensives with LVH, and possibly for high-risk prehypertensive patients. The direct renin inhibitor, aliskiren, inhibits catalytic activity of renin molecules in circulation and in the kidney, thus lowering angiotensin II levels. Furthermore, aliskiren by modifying the prorenin conformation may prevent prorenin activation. At present, aliskiren should be considered in hypertensive patients not sufficiently controlled or intolerant to other inhibitors of renin,angiotensin system. Third, TROPHY (Trial of Preventing Hypertension) is the first pharmacological intervention for prehypertensive patients revealing that treatment with angiotensin II type 1 receptor blocker attenuates hypertension development and thus decreases the risk of cardiovascular events. [source] Supplementary prescribing: potential ways to reform hospital psychiatric careJOURNAL OF PSYCHIATRIC & MENTAL HEALTH NURSING, Issue 2 2006A. JONES phd rn The objective of this study was to explore perceptions held by nurses and psychiatrists towards the potential application of supplementary prescribing on acute psychiatric wards. Six focus groups were conducted with 19 nurses and seven psychiatrists who worked on three wards. Two major themes were identified: first, ways in which patients could receive care and treatment through supplementary prescribing and in new forms of partnership and second, ways by which nurses and psychiatrists could be organized to deliver their care through a supplementary prescribing framework. Nurses and psychiatrists were generally positive about the advent of prescribing and offered positive views as to how patient care could be improved and a general willingness for nurses to adapt and work differently. Findings from this exploratory study offer practical solutions to how supplementary prescribing could work on acute psychiatric wards. [source] Personality constructs and measuresPSYCHOLOGY IN THE SCHOOLS, Issue 3 2007Hedwig Teglasi A psychological construct, such as personality, is an abstraction that is not directly seen but inferred through observed regularities in cognitive, affective, and behavioral responses in various settings. Two assumptions give meaning to the idea of construct validity. First, constructs represent real phenomena that exist apart from the potential ways in which they are measured. Second, constructs have a causal relation to their measures (see D. Boorsboom, G.J. Mellenbergh, & J. van Heerden, 2004). According to these twin assumptions, variation in a construct such as personality or intelligence causes individual differences in responses to items on measures; it also accounts for performance in real life settings. An alternative perspective equates a construct with the operation used for its measurement (M. Friedman, 1991) without a presumption of causality. This article elaborates on the implications of different assumptions about measurement, operation-referenced and construct-referenced, for advancing the science and practice of psychology. © 2007 Wiley Periodicals, Inc. Psychol Schs 44: 215,228, 2007. [source] MicroRNAs as Immune Regulators: Implications for TransplantationAMERICAN JOURNAL OF TRANSPLANTATION, Issue 4 2010A. Harris The explosion of genetic information from recent advances in sequencing technologies, bioinformatics and genomics highlights the importance of understanding mechanisms involved in gene expression and regulation. Over the last decade, it has become clear that small ribonucleic acids (RNAs) are a central component of the cellular gene regulatory network. MicroRNAs (miRNAs) are a family of endogenous, small, noncoding single-stranded RNA of ,22 nucleotides in length that act as posttranscriptional gene regulatory elements. MicroRNAs can inhibit de novo protein synthesis by blocking translation through base-pairing with complementary messenger RNA (mRNA) and also suppress translation by promoting degradation of target mRNA. MicroRNAs are intimately involved in a variety of biologic processes including development, hematopoietic cell differentiation, apoptosis and proliferation. To date, over 800 human miRNAs have been identified, though the biologic function of only a fraction of miRNAs has been elucidated. Here, we discuss how miRNAs are produced, identified and quantitated, and focus on several key miRNAs that govern expression of genes relevant to allograft rejection, tolerance induction and posttransplant infection. Finally, we discuss potential ways in which the miRNA network can be modulated that ultimately may offer new strategies to promote long-term graft survival. [source] Artificial disruption of skin barrier prior to irritant patch testing does not improve test designBRITISH JOURNAL OF DERMATOLOGY, Issue 1 2004K.L. Gebhard Summary Background, Irritant patch testing is often performed as a 24- or 48-h occlusive patch test with low concentrations of sodium lauryl sulphate (SLS). Objectives, The aim of this study was to investigate potential ways to shorten this test procedure and obtain precise test results. Patients and methods, Thirty-six healthy volunteers underwent irritant patch testing with different pretreatments (PT) of the test fields. Occlusive test chambers were applied on the upper back with SLS 0·5%, 1%, 2% and 5% in large Finn Chambers®. The patches were removed after 4 and 24 h, respectively, depending on the concentration used. Test fields were pretreated as follows: PT 0, field without any PT (control); PT 1, prick with lancet; PT 2, prick with test stamp; PT 3, scratch with lancet; PT 4, incision with standardized incision instrument (0·1,0·2 mm depth). Skin reactions were evaluated by transepidermal water loss (TEWL), skin erythema and skin hydration and as well by a visual score (VS) at 4, 24 and 72 h. Results, Our data show an obvious distinction between PT 0,2 and PT 3,4 at all measurement methods. The average TEWL values with PT 3,4 were higher than those with PT 0,2, especially on the 4-h course. This distinction may derive from the shape and size of the skin impairment achieved by PT 3,4, leading to a mechanical barrier disruption. However, SLS may infiltrate directly into deeper skin layers supported by capillarity. Consequently, no or little penetration through the epidermis and interaction with its structures occurs, which is responsible for irritant skin reactions. The SLS dose in the upper skin layers is therefore lower at these PTs. The lower remaining dose of SLS also explains this distinction, especially for the VS. Additionally, there are presumed reactions in deeper layers of the epidermis and dermis at PT 3,4. Conclusions, In summary, all data suggest a different reaction pattern from the classical irritant response. Therefore, application without any PT seems to be best suited for irritancy skin testing, especially for visual assessment. PTs prior to irritant patch testing have been shown to be unjustifiable. [source] Fluid shifts during cardiopulmonary bypass with special reference to the effects of hypothermiaBRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 7 2000J. K. Heltne Background Generalized overhydration, oedema and organ dysfunction occurs in patients undergoing open heart surgery using cardiopulmonary bypass (CPB) and hypothermia. Inflammatory reactions induced by contact between blood and the foreign surfaces of the extracorporeal circuit are commonly held responsible for the disturbances in fluid balance (,capillary leak syndrome'). Using the CPB circuit reservoir as a fluid gauge (measuring continuous extracorporeal blood volume), fluid shifts between the intravascular and the extravascular space, and differences between normothermic and moderately hypothermic CPB, were examined. Methods Piglets were placed on CPB (thoracotomy) under general anaesthesia. In the normothermic group (n = 7) the core temperature was kept at 38°C before and during 2 h on CPB, whereas in the hypothermic group (n = 7) the temperature was lowered to 29°C during bypass. In addition to accurate recording of fluid during operation, the extracorporeal blood volume was kept constant by maintaining a certain blood level in the CPB circuit's reservoir. Acetated Ringer was used as priming solution in the CPB, as maintenance fluid and for adding fluid to the reservoir if necessary. Results Cardiac output, serum electrolytes and arterial blood gases were all similar in the two groups. Haematocrit fell significantly following the start of CPB in both groups. The reservoir fluid level fell markedly in both groups necessitating fluid supplementation. This extra fluid requirement was transient in the normothermic group, but persisted in hypothermic animals. At the end of 2 h of CPB the hypothermic animals had received seven times more extra fluid than the normothermic pigs. Conclusion There were strong indications of a greater fluid extravasation induced by hypothermia. The model described, using the PBC circuit reservoir as a fluid gauge, provides the opportunity for further study of fluid volume shifts, their causes and potential ways to manipulate fluid pathophysiology related to hypothermia and to PBC. © 2000 British Journal of Surgery Society Ltd [source] | |||||||||||||||||||