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Potential Problems (potential + problem)
Selected AbstractsNarcissism and Effective Crisis Management: A Review of Potential Problems and PitfallsJOURNAL OF CONTINGENCIES AND CRISIS MANAGEMENT, Issue 4 2007Granville King III In the event of a crisis, effective leadership by senior officials plays a significant role in an organization's attempt to return to a state of normal operation. Effectiveness, however, can be hampered by a leader's behaviour and attitude towards colleagues, and other employees within the organization. This paper explores how narcissism and narcissistic leaders may affect crisis management within an organization. Using the literature from the American Psychiatric Association, crisis management, and leadership, this paper explores how personality disorders associated with narcissism may affect the pre-crisis, crisis, and post-crisis stages of crisis management. The paper concludes by offering suggestions on how to handle narcissistic leaders within an organization, and areas for future research. [source] Using Opaquers under Direct Composite Resin Veneers: An Illustrated Review of the TechniqueJOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY, Issue 6 2003LUÍS ANTÔNIO FELIPPE DDS ABSTRACT In restorative dentistry direct composite resin materials can be used to conservatively resolve many esthetic problems. Opaque resins are often necessary to mask discolorations and/or dark backgrounds when restoring anterior teeth. This article presents a direct composite resin veneer technique using opaquers. Potential problems with the tone of restorations after the use of opaquers are discussed. Advantages, limitations, and the clinical technique are presented. Training, as well as attention to the technique, contributes to an acceptable result. CLINICAL SIGNIFICANCE Resinous opaquers can be used as a valid adjunct to the direct composite resin veneer technique when conservatively restoring dark teeth. [source] Fast analysis in liquid chromatography using small particle size and high pressureJOURNAL OF SEPARATION SCIENCE, JSS, Issue 12 2006Dao T.-T. Abstract In order to enhance chromatographic performances in terms of efficiency and rapidity, LC has recently evolved in the development of short columns packed with small particles (sub-2 ,m) working at high pressures (>400 bar). This approach has been described 30 years ago according to the fundamental chromatographic equations. However, systems and columns compatible with such high pressures have been introduced in the market in 2004 only. Advantages of small particles working at high pressure will be discussed in terms of sensitivity, efficiency, resolution, and analysis time. Potential problems encountered with high pressure in terms of frictional heating and solvent compressibility will also be discussed even if systems working at a maximum pressure of 1000 bar are not influenced by these parameters and give reliable and reproducible results. Several applications will highlight the potential and interest of this new technology. [source] Using botulinum toxin for pelvic indications in womenAUSTRALIAN AND NEW ZEALAND JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Issue 4 2009Archana RAO Background: Botulinum toxin (BoNT) is a potent neurotoxin. Its ability to cause muscle paralysis is increasingly being utilised for the management of a number of conditions of interest to the gynaecologist. Aims: This review aims to give the reader an overview of the use of BoNT for conditions presenting a management challenge for the gynaecologist, such as chronic pelvic pain and idiopathic detrusor overactivity. Methods: The literature was reviewed regarding the use, side-effects and complications of BoNT in the pelvis, focussing on chronic pelvic pain, provoked vestibulodynia, conditions involving the lower gastrointestinal tract and detrusor overactivity. Results: In terms of pain caused by pelvic floor spasm, daily pelvic pain and dyspareunia are the symptoms most likely to be improved by BoNT. Limited data regarding use for provoked vestibulodynia indicate an improvement in pain scores. In the lower gastrointestinal tract, injection into puborectalis has been showed to objectively improve intravaginal pressures, though there are no randomised controlled trials (class I studies) validating its use in this setting. Class I studies demonstrate a role for BoNT in the management of idiopathic detrusor overactivity, though long-term follow-up data are lacking. Potential problems with BoNT injection include toxin reactions, urinary and faecal incontinence, urinary retention and secondary treatment failure due to antibody production. Conclusions: A single class I study supports the use of BoNT for refractory pelvic floor spasm; however, further adequately powered class I studies for this indication and for provoked vestibulodynia are warranted. [source] A dynamic admission control scheme to manage contention on shared computing resourcesCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 2 2009Percival Xavier Abstract A virtual organization is established when physical organizations collaborate to share their computing resources with the aim of serving each other when there is a likelihood of insufficient local resources during peak resource usage periods at any organization. Contention becomes a potential problem when a large number of requests, which can overwhelm the aggregate capacity of shared resources, are submitted from the participating organizations coincidentally at the same period. In particular, when a small number of requests that require large amounts of computing resources are admitted in place of a large number of requests that require less computing resources, the overall system performance, in terms of admission ratio, can deteriorate significantly. Hence, admission control is necessary to reduce resource oversubscription. Because domain-shared computing resources are likely to be combined to form a large-scale system, it is not possible to define a fixed admission policy solely based on the request's CPU and execution time requirements. In this paper, we introduce an admission control framework, based on a pricing model, for a multi-domain-shared computing infrastructure. The performance of the admission control framework is evaluated under different scenarios that contribute to the overall degree of competition for shared resources. The results are presented and analyzed in this paper. Copyright © 2008 John Wiley & Sons, Ltd. [source] Evaluation of the rodent micronucleus assay by a 28-day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS),Mammalian Mutagenicity Study Group (MMS)ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 2 2001Shuichi Hamada Abstract To examine whether micronucleus tests can be incorporated into general toxicology assays, we performed micronucleus tests applying the treatment protocols typically used in such assays. In this 13th Collaborative Study of the CSGMT, both rats and mice were tested, although rats were used in the majority of the studies. Fifteen mutagens were tested in rats, mainly by oral (p.o.) administration. Micronucleus induction was evaluated 2, 3, and 4 days, and 1, 2, 3, and 28 days after the beginning of the treatment in the peripheral blood, and at 28 days in the bone marrow. Of the 15 chemicals that induced micronuclei in rats in short-term assays, two chemicals (1,2-dimethylhydrazine·2HCl and mitomycin C) were negative in all our experiments, possibly because of insufficient dose levels. The remaining 13 were positive within the estimated dose range of a general toxicology assay, suggesting the possibility of integrating the micronucleus assay into general toxicology assays. Three patterns were observed in micronucleus induction during the period of repeated treatment: (1) gradual increases in micronucleus frequency with sequential doses, (2) a peak at 3,5 days followed by gradual decreases in micronucleus frequency with sequential doses, and (3) a rapid increase in micronucleus frequency followed by a plateau. We evaluated factors that might have been involved in those patterns, such as the spleen function, target organ exposure, extramedullary hematopoiesis, hypothermia, and hypoxia. Another factor we considered was dosage. Because the dosages employed in a general toxicity assay are usually lower than those used in short-term micronucleus assays, this discrepancy was considered the greatest potential problem for integrating the micronucleus assay into general toxicology assays. Our results indicate that the integration of the micronucleus assay into a 28-day toxicological assay is feasible. To serve this purpose, blood samples collected 4 days after the beginning of treatment and blood and bone marrow samples collected at autopsy should be examined. Furthermore, although it is recognized that mice may be suitable for performing independent micronucleus assays, we propose that rats can provide biologically important and relevant information regarding potential chemical mutagens that can be evaluated under conditions used in the conduct of general toxicology studies. Environ. Mol. Mutagen. 37:93,110, 2001 © 2001 Wiley-Liss, Inc. [source] Boundary element simulation of DC stray currents in oil industry due to cathodic protection interferenceEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 5 2007I. A. Metwally Abstract This paper presents a 3D theoretical simulation and analysis of DC stray current corrosion (SCC) in oil fields that could contribute to oil leak and finally oil deferment of electric submersible pump (ESP) systems. Application of the boundary element analysis system (BEASY) allowed cathodic protection (CP) interference to be assessed in terms of the normal current density, which is directly proportional to the corrosion rate, rather than using the qualitative approach of measuring the potential shift of the soil. Different real structures consisting of pipelines and/or well casings with different arrangements and interference conditions are simulated. The results reveal that the application of impressed current cathodic protection (ICCP) systems creates DC SCC on other nearby unprotected structures. This is an inherent potential problem with the application of such systems which dominates with decreasing soil conductivity, and/or increasing the anode current density and its proximity to the protected structures. On the contrary, SCC can be reduced by using multi-groundbed anodes. Copyright © 2006 John Wiley & Sons, Ltd. [source] Low bone mineral density in children and adolescents with inflammatory bowel disease: A population-based study from Western SwedenINFLAMMATORY BOWEL DISEASES, Issue 12 2009Susanne Schmidt MD Abstract Background: Low bone mineral density (BMD) has been recognized as a potential problem in children with inflammatory bowel disease (IBD). The aim of the study was to investigate BMD in Swedish children and adolescents with IBD and to evaluate possible factors affecting BMD. Methods: To evaluate BMD, all patients (n = 144) underwent a dual-energy X-ray absorptiometry (DXA) of the whole body and the spine. BMD values were expressed as Z-scores using normative pediatric data from Lunar (GE Medical Systems). Results: In this population-based study, the lowest BMD values were found in the lumbar spine. The entire IBD group showed significantly lower BMD Z-scores of the lumbar spine (L2,L4) in comparison to healthy references (,0.8 standard deviation [SD], range ,5.9 to 3.7 SD, P < 0.001). Decreased BMD with a Z-score < ,1 SD occurred in 46.7% of the individuals with Crohn's disease (CD) and in 47.0% of those with ulcerative colitis (UC). Low BMD with a Z-score , ,2 SD was present in 26.7% of the patients with CD and in 24.1% of the UC patients. In a multiple regression model with BMD lumbar spine as the depending variable, possible factors associated with lower BMD were male gender, low body mass index (BMI), and treatment with azathioprine. Conclusions: Low BMD is prevalent in Swedish pediatric patients with IBD. Possible risk factors for lower BMD are male gender, low BMI, and treatment with azathioprine, as a probable marker of disease course severity. (Inflamm Bowel Dis 2009) [source] Predicting Business Failures in Canada,ACCOUNTING PERSPECTIVES, Issue 2 2007J. Efrim Boritz ABSTRACT Empirical researchers and practitioners frequently use the bankruptcy prediction models developed by Altman (1968) and Ohlson (1980). This poses a potential problem for practitioners in Canada and researchers working with Canadian data because the Altman and Ohlson models were developed using U.S. data. We compare Canadian bankruptcy prediction models developed by Springate (1978), Altman and Levallee (1980), and Legault and Véronneau (1986) against the Altman and Ohlson models using recent data to determine the robustness of all models over time and the applicability of the Altman and Ohlson models to the Canadian environment. Our results indicate that the models developed by Springate (1978) and Legault and Véronneau (1986) yield similar results to the Ohlson (1980) model while being simpler and requiring less data. The Altman (1968) and Altman and Levallee (1980) models generally have lower performance than the other models. All models have stronger performance with the original coefficients than with re-estimated coefficients. Our results regarding the Altman and Ohlson models are consistent with Begley, Ming, and Watts (1996), who found that the original version of the Ohlson model is superior to the Altman model and is robust over time. Les chercheurs empiriques et les praticiens ont souvent recours aux modèles de prédiction des faillites élaborés par Altman (1968) et Ohlson (1980). Or, le fait que ces auteurs aient utilisé des données des États-Unis dans l'élaboration de leurs modèles soulève un problème particulier pour les praticiens canadiens et les chercheurs qui traitent des données canadiennes. Les auteurs comparent les modèles canadiens de prédiction des faillites mis au point par Springate (1978), Altman et Levallée (1980) et Legault et Véronneau (1986) aux modèles proposés par Altman et Ohlson, en se servant de données récentes pour évaluer la robustesse de tous ces modèles dans le temps et l'applicabilité des modèles d'Altman et Ohlson au contexte canadien. L'analyse révèle que les modèles de Springate (1978) et de Legault et Véronneau (1986) produisent des résultats similaires à ceux du modèle d'Ohlson (1980), bien qu'ils soient plus simples et exigent moins de données. De façon générale, les modèles d'Altman (1968) et d'Altman et Levallee (1980) sont moins performants que les autres modèles. Tous les modèles sont plus efficaces lorsqu'ils font usage des coefficients initiaux que lorsqu'ils sont appliqués à de nouvelles estimations des coefficients. Les résultats obtenus en ce qui a trait aux modèles d'Altman et d'Ohlson corroborent ceux de Begley, Ming et Watts (1996) qui constatent que la version initiale du modèle d'Ohlson est supérieure au modèle d'Altman et résiste au passage du temps. [source] Decision making using time-dependent knowledge: knowledge augmentation using qualitative reasoningINTELLIGENT SYSTEMS IN ACCOUNTING, FINANCE & MANAGEMENT, Issue 1 2001Song Jin Yu In this paper we propose a method to enhance the performance of knowledge-based decision-support systems, knowledge of which is volatile and incomplete by nature in a dynamically changing situation, by providing meta-knowledge augmented by the Qualitative Reasoning (QR) approach. The proposed system intends to overcome the potential problem of completeness of the knowledge base. Using the deep meta-knowledge incorporated into the QR module, along with the knowledge we gain from applying inductive learning, we then identify the ongoing process and amplify the effects of each pending process to the attribute values. In doing so, we apply the QR models to enhance or reveal the patterns which are otherwise less obvious. The enhanced patterns can eventually be used to improve the classification of the data samples. The success factor hinges on the completeness of the QR process knowledge base. With enough processes taking place, the influences of each process will lead prediction in a direction that can reflect more of the current trend. The preliminary results are successful and shed light on the smooth introduction of Qualitative Reasoning to the business domain from the physical laboratory application. © 2001 John Wiley & Sons, Ltd. [source] Surface wavelets: a multiresolution signal processing tool for 3D computational modellingINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 3 2001Kevin Amaratunga Abstract In this paper, we provide an introduction to wavelet representations for complex surfaces (surface wavelets), with the goal of demonstrating their potential for 3D scientific and engineering computing applications. Surface wavelets were originally developed for representing geometric objects in a multiresolution format in computer graphics. These wavelets share all of the major advantages of conventional wavelets, in that they provide an analysis tool for studying data, functions and operators at different scales. However, unlike conventional wavelets, which are restricted to uniform grids, surface wavelets have the power to perform signal processing operations on complex meshes, such as those encountered in finite element modelling. This motivates the study of surface wavelets as an efficient representation for the modelling and simulation of physical processes. We show how surface wavelets can be applied to partial differential equations, stated either in integral form or in differential form. We analyse and implement the wavelet approach for a model 3D potential problem using a surface wavelet basis with linear interpolating properties. We show both theoretically and experimentally that an O(h) convergence rate, hn being the mesh size, can be obtained by retaining only O((logN) 7/2N) entries in the discrete operator matrix, where N is the number of unknowns. The principles described here may also be extended to volumetric discretizations. Copyright © 2001 John Wiley & Sons, Ltd. [source] Consumer preferences and fungal and mycotoxin contamination of dried cassava products from GhanaINTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 1 2001Peter W. Wareing Summary Members of one hundred and twenty five households from 19 villages producing dried cassava products were interviewed in Ghana. Kokonte was the most important cassava product in 19% of the households processing it. Most kokonte was produced between January and March. Mould growth during processing or storage was a problem during June and July, which is part of the rainy season. Most producers and market traders preferred non-mouldy kokonte, although many (59%) would consume a mouldy product. There was a price premium for non-mouldy kokonte. The most commonly isolated fungi were yeasts and Cladosporium spp. (44 out of 49 samples). Other fungi isolated included Aspergillus spp. (20 samples); Penicillium spp. (15 samples) and Fusarium spp. (30 samples). Sterigmatocystin was detected in 10 samples at 0.17,1.67 mg kg,1; patulin in 4 samples at 0.55,0.85 mg kg,1; cyclopiazonic acid in 4 samples at 0.08,0.72 mg kg,1; penicillic acid in 5 samples at 0.06,0.23 mg kg,1 and tenuazonic acid in 3 samples at 0.02,0.34 mg kg,1. Mycotoxin contamination of mouldy kokonte was a potential problem; there is therefore the need to improve kokonte processing to avoid mould growth. [source] Randomization in psychiatric intervention research in the general practice settingINTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH, Issue 3 2000CM Van Der Feltz-Cornelis Faculty of Medicine Abstract Most studies of psychiatric interventions in general practice settings conform only in part to the requirements of randomization, placebo control and blinding as formulated by the Cochrane Collaboration. It is possible, nonetheless, to develop experimental research designs that are sufficiently near to this standard. These must deal with certain methodological issues specific to psychiatric research. This article discusses scientific standards of psychiatric research with special consideration of interventions in general practice settings. These issues are accompanied by concrete examples and suggestions on how to confront the problems. In psychiatric intervention research, equivalence studies with single-blind outcome assessment, a tested and ethically justified method, are generally used in place of placebo-controlled studies. The article also examines randomization procedures in greater depth. Randomization can be applied across trial subjects or across doctors' practices. Practical consequences of randomizing across subjects, and specific implementations of it such as crossover and pre-post designs in general practice settings, are clarified. Overall, a research design using randomization across doctors' practices is judged preferable to one that randomizes across trial subjects. One potential problem is that the control group may become too small, especially when considerable effects are expected from the intervention being studied. One might consider making the control condition smaller in the first place, or, if indicated on ethical grounds, performing an intermediate analysis and then breaking off the study as soon as a statistically significant effect has been demonstrated. Multilevel statistical techniques offer new opportunities for analysis within such designs. Copyright © 2000 Whurr Publishers Ltd. [source] AAA architecture for mobile IPv6 based on WLANINTERNATIONAL JOURNAL OF NETWORK MANAGEMENT, Issue 5 2004R. C. Wang Mobility support for Internet devices is quite important for consumer electronics. The number of the hand-held devices is growing quickly. However, there are not enough IP addresses for the number of the rapidly growing devices in the All-IP generation. Internet Protocol version 6 (IPv6) was therefore adopted to solve these problems. Our purposed structure is based on IEEE 802.11. However, IEEE 802.11 has a serious security drawback. Further, from the Internet Service Providers' point of view, accounting is a potential problem. A mechanism combining Mobile IPv6 and AAA based on IEEE 802.11 to overcome these problems is essential. Both Internet Protocol version 4 (IPv4) and IPv6 support IP security (IPsec) when data packets are exchanged across the IP network. IPsec operates at the IP layer. It can support system authentication and authorization, However, it lacks a system accounting function. Therefore ISPs cannot establish correct billing for their services. This is the reason why we chose to combine the wireless network and AAA functions. In this paper, the AAA mechanism is used to protect security, with the architecture having authentication, authorization, and accounting functions. We will discuss the benefits of AAA and state the reason why we choose to combine AAA with the mobility architecture.,Copyright © 2004 John Wiley & Sons, Ltd. [source] Description of a clinical technique for tooth extraction in the cleft lip and palate areaINTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY, Issue 2 2001G.S. Dalben Cleft lip and palate are relatively common congenital malformations, which may require specialist paedodontic treatment. In this article, the case of a 9-year-old boy with bilateral complete cleft lip and palate is presented. He attended the Hospital for Rehabilitation of Craniofacial Anomalies (HRAC) for routine examination, during which the presence of pre-canine supernumeraries bilaterally in the cleft area was seen. The extraction of these dental elements was justified by extensive carious lesions and because they represented a potential problem during secondary palatoplasty. The precautions needed in tooth extraction in patients with cleft lip and palate are described, together with illustrations of the clinical procedure. [source] Impact of Elaboration on Responding to Situational Judgment Test ItemsINTERNATIONAL JOURNAL OF SELECTION AND ASSESSMENT, Issue 4 2008Filip Lievens Although faking has been identified as a potential problem in situational judgment tests (SJTs), no studies have investigated proactive approaches for controlling faking in SJTs. Therefore, this study examined the impact of elaboration on responding to SJT items. Elaboration was operationalized as reason-giving. Two hundred and forty-seven master students were assigned to either an honest or a fake condition, and to a non-elaboration or an elaboration condition. Results showed that elaboration decreased the effect of faking for items with high familiarity. Elaboration on familiar items also decreased the percentage of fakers in the top of the distribution. Next, participants in the elaboration condition rated the SJT significantly higher in terms of allowing them to present themselves more realistically and to demonstrate their knowledge, skills, and abilities. Finally, there were no significant differences in participants' satisfaction with the SJT across the elaboration and non-elaboration condition. [source] Predicting the distribution of Sasquatch in western North America: anything goes with ecological niche modellingJOURNAL OF BIOGEOGRAPHY, Issue 9 2009J. D. Lozier Abstract The availability of user-friendly software and publicly available biodiversity databases has led to a rapid increase in the use of ecological niche modelling to predict species distributions. A potential source of error in publicly available data that may affect the accuracy of ecological niche models (ENMs), and one that is difficult to correct for, is incorrect (or incomplete) taxonomy. Here we remind researchers of the need for careful evaluation of database records prior to use in modelling, especially when the presence of cryptic species is suspected or many records are based on indirect evidence. To draw attention to this potential problem, we construct ENMs for the North American Sasquatch (i.e. Bigfoot). Specifically, we use a large database of georeferenced putative sightings and footprints for Sasquatch in western North America, demonstrating how convincing environmentally predicted distributions of a taxon's potential range can be generated from questionable site-occurrence data. We compare the distribution of Bigfoot with an ENM for the black bear, Ursus americanus, and suggest that many sightings of this cryptozoid may be cases of mistaken identity. [source] Mid-term Results of the Ross ProcedureJOURNAL OF CARDIAC SURGERY, Issue 4 2001Domenico Paparella M.D. Although the Ross procedure has been performed for over three decades, its role in the management of patients with aortic valve disease is not well established. This study reviews our experience with this operation. From 1990 to 1999, 155 patients underwent the Ross procedure. The mean age of 106 men and 49 women was 35 years. Most patients (85%) had congenital aortic valve disease. The pulmonary autograft was implanted in the subcoronary position in 2 patients, as an aortic root inclusion in 78, and aortic root replacement in 75. The follow-up extended from 9 to 114 months, mean of 45 ± 28 months, and it was complete. All patients have had Doppler echocardiographic studies. There was only one operative and one late death. The survival was 98% at 7 years. The freedom from 3+ or 4+ aortic insufficiency was 86% at 7 years and the freedom from reoperation on the pulmonary autograft was 95% at 7 years. Dilation of the aortic annulus and/or sinotubular junction was the most common cause of aortic insufficiency. One patient required three reoperations on the biological pulmonary valve. Most patients (96%) have no cardiac symptoms. The Ross procedure has provided excellent functional results in most patients, but progressive aortic insufficiency due to dilation of the aortic annulus and/or sinotubular junction is a potential problem in a number of patients. [source] Conservation planning and viability: problems associated with identifying priority sites in Swaziland using species list dataAFRICAN JOURNAL OF ECOLOGY, Issue 3 2010Robert J. Smith Abstract Conservation planning assessments based on species atlas data are known to select planning units containing ecotones because these areas are relatively species-rich. However, this richness is often dependent on the presence of adjoining core habitat, so populations within these ecotones might not be viable. This suggests that atlas data may also fail to distinguish between planning units that are highly transformed by agriculture or urbanization with those from neighbouring untransformed units. These highly transformed units could also be identified as priority sites, based solely on the presence of species that require adjoining habitat patches to persist. This potential problem was investigated using bird and mammal atlas data from Swaziland and a landcover map and found that: (i) there was no correlation between planning unit species richness and proportion of natural landcover for both taxa; (ii) the priority areas that were identified for both birds and mammals were no less transformed than if the units had been chosen at random and (iii) an approach that aimed to meet conservation targets and minimize transformation levels failed to identify more viable priority areas. This third result probably arose because 4.8% of the bird species and 22% of the mammal species were recorded in only one planning unit, reducing the opportunity to choose between units when aiming to represent each species. Therefore, it is suggested that using species lists to design protected area networks at a fine spatial scale may not conserve species effectively unless population viability data are explicitly included in the analysis. Résumé On sait que les évaluations de planifications de la conservation qui se basent sur les données d'atlas des espèces choisissent des unités de planification qui contiennent des écotones parce que ces zones sont relativement riches en espèces. Cependant, cette richesse dépend souvent de la présence proche d'un habitat principal, de sorte que les populations de ces écotones pourraient en fait ne pas être viables. Cela signifie que les données des atlas pourraient aussi ne pas faire la distinction entre les unités de planification qui sont fortement modifiées par l'agriculture ou l'urbanization et celles, voisines, qui ne sont pas modifiées. Des unités profondément modifiées pourraient aussi être identifiées comme sites prioritaires, si l'on se base seulement sur la présence d'espèces qui ont besoin des îlots d'habitats voisins pour subsister. Ce problème potentiel fut étudié en utilisant les données d'atlas sur des oiseaux et des mammifères du Swaziland et une carte de la couverture du terrain, et on a découvert que (i) il n'y avait pas de corrélation entre la richesse en espèces des unités de planification et la proportion de couverture naturelle pour les deux taxons; (ii) les zones prioritaires qui avaient été identifiées pour les oiseaux et pour les mammifères n'étaient pas moins transformées que si les unités avaient été choisies au hasard et (iii) une approche qui visait à atteindre des cibles de conservation et à minimizer le taux de transformation n'avait pas réussi à identifier les zones prioritaires les plus viables. Ce troisième résultat vient peut-être du fait que 4.8% des espèces d'oiseaux et 22% des espèces de mammifères avaient été rapportés pour une seule unité de planification, ce qui a réduit la possibilité de choisir entre les unités lorsque l'on a cherchéà représenter chaque espèce. C'est pourquoi on attire l'attention sur le fait que l'utilization des listes d'espèces pour concevoir les réseaux d'AP à petite échelle spatiale risque de ne pas préserver efficacement les espèces à moins que les données sur la viabilité de leur population ne soient explicitement incluses dans l'analyzse. [source] Pressure ulcer prevention in intensive care patients: guidelines and practiceJOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 2 2009Eman S. M. Shahin BSc MSc RN PhD Abstract Background, Pressure ulcers are a potential problem in intensive care patients, and their prevention is a major issue in nursing care. This study aims to assess the allocation of preventive measures for patients at risk for pressure ulcers in intensive care and the evidence of applied pressure ulcer preventive measures in intensive care settings in respect to the European Pressure Ulcer Advisory Panel (EPUAP) and Agency for Health Care Policy and Research (AHCPR) guidelines for pressure ulcer prevention. Design, The design of this study was a cross-sectional study (point prevalence). Setting, The study setting was intensive care units. The sample consisted of 169 patients , 60 patients from surgical wards, 59 from interdisciplinary wards and 50 from medical intensive care wards. Results, The study results revealed that pressure reducing devices like mattresses (alternating pressure air, low air loss and foam) are applied for 58 (36.5%) patients, and all of these patients are at risk for pressure ulcer development. Most patients receive more than one nursing intervention, especially patients at risk. Nursing interventions applied are skin inspection, massage with moisture cream, nutrition and mobility (81.8%, 80.5%, 68.6% and 56.6%) respectively. Moreover, all applied pressure ulcer preventive measures in this study are in line with the guidelines of the EPUAP and AHCPR except massage which is applied to 8.8% of all patients. Conclusions, The use of pressure reducing devices and nursing interventions in intensive care patients are in line with international pressure ulcer guidelines. Only massage, which is also being used, should be avoided according to the recommendation of national and international guidelines. [source] Acute retinal necrosis six years after herpes simplex encephalitis: An elusive immune deficit suggested by insufficient test sensitivityJOURNAL OF MEDICAL VIROLOGY, Issue 2 2004W. Preiser Abstract A patient presented with acute retinal necrosis of the left eye. Demonstration of herpes simplex virus (HSV) DNA in the aqueous humour confirmed the diagnosis. Negative results of HSV type-specific antibody tests based on gG antigens suggested a primary HSV infection. However, the patient had a past history of laboratory-confirmed herpes simplex encephalitis 6 years ago. Using antibody tests based on whole viral lysate antigens, he was seropositive from the onset, and immunoblot testing confirmed a lack of anti-gG reactivity. To be able to assess whether this might be related to the apparent inability of his immune system to suppress clinically symptomatic HSV infection, serial samples were tested by an HSV neutralisation test and a whole-blood flow cytometric assay to determine the frequency of HSV-specific CD4 lymphocytes. However, this did not yield evidence of obvious immunodeficiency; the patient reacted similarly to known positive controls by both assays. Although type-specific HSV serological tests based on gG are generally more specific than those based on whole viral lysate antigens, they have a somewhat lower sensitivity, as a certain percentage of HSV-infected individuals do not develop antibodies against gG, and others may suffer a secondary loss of anti-gG reactivity. Thus there is a risk of missing individual infected patients. Unless this potential problem is recognised, serious consequences might possibly result. We therefore urge virologists and clinicians to exercise great care if highly specific antibody assays based on recombinant proteins are employed. J. Med. Virol. 73:250,255, 2004. © 2004 Wiley-Liss, Inc. [source] Child booster seats and lethal seat belt injuryJOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 11 2004RW Byard Abstract: A 7-year-old boy travelling in the rear seat of a sedan car was wearing a lap-shoulder seat belt and sitting on a booster seat. Following a collision the boy ,submarined' under the seat belt sustaining trauma to the anterior aspect of his neck, cardiac arrest and subsequent death from hypoxic-ischaemic encephalopathy. This case demonstrates a potential problem with unsecured older-style booster seats. Movement of a seat in a collision may cause a child to slip under a seat belt and sustain significant neck injuries. Seatbelts for children must be correctly fitted, booster seats or capsules must be securely fastened and manufacturer's recommendations for size and weight limits should be followed. Unfortunately older booster seats may not have attached instructions for installation and use, may not fit later model vehicles, may not conform to current safety recommendations and may have worn webbing. For these reasons their use should be discouraged. [source] Pharmacokinetic aspects of biotechnology productsJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 9 2004Lisa Tang Abstract In recent years, biotechnologically derived peptide and protein-based drugs have developed into mainstream therapeutic agents. Peptide and protein drugs now constitute a substantial portion of the compounds under preclinical and clinical development in the global pharmaceutical industry. Pharmacokinetic and exposure/response evaluations for peptide and protein therapeutics are frequently complicated by their similarity to endogenous peptides and proteins as well as protein nutrients. The first challenge frequently comes from a lack of sophistication in various analytical techniques for the quantification of peptide and protein drugs in biological matrices. However, advancements in bioassays and immunoassays,along with a newer generation of mass spectrometry-based techniques,can often provide capabilities for both efficient and reliable detection. Selection of the most appropriate route of administration for biotech drugs requires comprehensive knowledge of their absorption characteristics beyond physicochemical properties, including chemical and metabolic stability at the absorption site, immunoreactivity, passage through biomembranes, and active uptake and exsorption processes. Various distribution properties dictate whether peptide and protein therapeutics can reach optimum target site exposure to exert the intended pharmacological response. This poses a potential problem, especially for large protein drugs, with their typically limited distribution space. Binding phenomena and receptor-mediated cellular uptake may further complicate this issue. Elimination processes,a critical determinant for the drug's systemic exposure,may follow a combination of numerous pathways, including renal and hepatic metabolism routes as well as generalized proteolysis and receptor-mediated endocytosis. Pharmacokinetic/pharmacodynamic (PK/PD) correlations for peptide and protein-based drugs are frequently convoluted by their close interaction with endogenous substances and physiologic regulatory feedback mechanisms. Extensive use of pharmacokinetic and exposure/response concepts in all phases of drug development has in the past been identified as a crucial factor for the success of a scientifically driven, evidence-based, and thus accelerated drug development process. Thus, PK/PD concepts are likely to continue and expand their role as a fundamental factor in the successful development of biotechnologically derived drug products in the future. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:2184,2204, 2004 [source] Car ownership and welfare-to-workJOURNAL OF POLICY ANALYSIS AND MANAGEMENT, Issue 2 2002Paul M. Ong This study examines the role of car ownership in facilitating employment among recipients under the current welfare-to-work law. Because of a potential problem with simultaneity, the analysis uses predicted car ownership constructed from two instrumental variables, insurance premiums and population density for car ownership. The data come from a 1999,2000 survey of TANF recipients in the Los Angeles metropolitan area. The empirical results show a significant independent contribution of car ownership on employment. The presence of an predicted ownership is associated with a 9 percentage point increase in the odds of being employed. Moreover, the results indicate that lowering insurance premiums by $100 can increase the odds of employment by 4 percentage points. © 2002 by the Association for Public Policy Analysis and Management. [source] Meta-analysis: interferon improves outcomes following ablation or resection of hepatocellular carcinomaALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 7 2010A. K. Singal Aliment Pharmacol Ther 2010; 32: 851,858 Summary Background, Hepatocellular carcinoma (HCC) is third most common cause of tumour-related death in the US with hepatitis C virus (HCV) the most common aetiology. Surgical resection and tumour ablation are curative in patients who cannot be transplanted. With native liver having cirrhosis, HCC recurrence is a potential problem. Aim, To perform a systematic review and meta-analysis of studies evaluating efficacy of IFN to prevent HCC recurrence after its curative treatment in HCV-related cirrhosis. Methods, Ten studies (n = 645, 301 treated with IFN) on the use of IFN after resection or ablation of HCV-associated HCC were analysed. Results, Pooled data showed benefit of IFN for HCC prevention with OR (95% CI) of 0.26 (0.15,0.45); P < 0.00001. The proportion of patients surviving at 5 years (n = 505 in 6 studies) was in favour of IFN with OR of 0.31 [(95% CI 0.21,0.46); P < 0.00001]. Data were homogeneous for HCC recurrence (,2 12.05, P = 0.21) and survival (,2 6.93, P = 0.44). The benefit of IFN was stronger with sustained virological response compared with nonresponders for HCC recurrence [0.19 (0.06,0.60); P = 0.005] and survival [0.31 (0.11,0.90); P = 0.03]. Conclusion, Interferon treatment after curative resection or ablation of HCC in HCV-related cirrhotics prevents HCC recurrence and improves survival. [source] LOW-INCOME HOMEOWNERSHIP: DOES IT NECESSARILY MEAN SACRIFICING NEIGHBORHOOD QUALITY TO BUY A HOME?JOURNAL OF URBAN AFFAIRS, Issue 2 2010ANNA M. SANTIAGO ABSTRACT:,Questions have been raised about the wisdom of low-income homeownership policies for many reasons. One potential reason to be skeptical: low-income homebuyers perhaps may be constrained to purchase homes in disadvantaged neighborhoods. This is a potential problem because home purchases in such neighborhoods: (1) may limit appreciation; (2) may reduce quality of life for adults; and (3) may militate against reputed advantages of homeownership for children. Our study examines the neighborhood conditions of a group of 126 low-income homebuyers who purchased their first home with assistance from the Home Ownership Program (HOP) operated by the Denver Housing Authority. Our approach is distinguished by its use of a comprehensive set of objective and subjective indicators measuring the neighborhood quality of pre-move and post-move neighborhoods. Do low-income homebuyers sacrifice neighborhood quality to buy their homes? Our results suggest that the answer to this question is more complex than it might at first appear. On the one hand, HOP homebuyers purchased in a wide variety of city and suburban neighborhoods. Nonetheless, a variety of neighborhood quality indicators suggest that these neighborhoods, on average, were indeed inferior to those of Denver homeowners overall and to those in the same ethnic group. However, our analyses also revealed that their post-move neighborhoods were superior to the ones they lived in prior to homeownership. Moreover, very few HOP destination neighborhoods evinced severe physical, environmental, infrastructural, or socioeconomic problems, as measured by a wide variety of objective indicators or by the homebuyers' own perceptions. Indeed, only 10% of HOP homebuyers perceived that their new neighborhoods were worse than their prior ones, and only 8% held pessimistic expectations about their new neighborhoods' quality of life. Finally, we found that Black homebuyers fared less well than their Latino counterparts, on average, in both objective and subjective measures. [source] Pregnancy after liver transplantationLIVER TRANSPLANTATION, Issue 6 2000Vincent T. Armenti The first known posttransplantation pregnancy was in 1958 in a renal transplant recipient who had received a kidney from her identical twin sister. The first known posttransplantation pregnancy in a liver transplant recipient was in 1978. Information available from female kidney transplant recipients helped in the decision making involved in the management of this case, as well as those that followed. Over the last 20 years, issues specific to liver transplantation and pregnancy have been identified. Similar to the kidney transplant recipient population, when prepregnancy recipient graft function is stable and adequate, pregnancy appears to be well tolerated. Also similar to kidney transplant recipients, there has been no evidence of a specific malformation pattern among the children, and although prematurity and low birth weight occur, overall newborn outcomes have been favorable. Pregnancy in the setting of recurrent liver disease, such as recurrent hepatitis C, poses a potential problem among liver transplant recipients, as well as the possible adverse effects of immunosuppression on maternal kidney function. Also of significance, peripartum graft deterioration has more severe consequences in this transplant recipient population. Therefore, pregnancy must be considered carefully in this transplant recipient group. Since 1991, the National Transplantation Pregnancy Registry (NTPR) has studied the safety of pregnancy outcomes in solid-organ transplant recipients. The purpose of this review is to catalog studies in the literature, as well as to present current data from the registry with management guidelines. [source] Submicromolar hydrogen peroxide disrupts the ability of Fur protein to control free-iron levels in Escherichia coliMOLECULAR MICROBIOLOGY, Issue 3 2007Shery Varghese Summary In aerobic environments, mutants of Escherichia coli that lack peroxidase and catalase activities (Hpx,) accumulate submicromolar concentrations of intracellular H2O2. We observed that in defined medium these strains constitutively expressed members of the Fur regulon. Iron-import proteins, which Fur normally represses, were fully induced. H2O2 may antagonize Fur function by oxidizing the Fur:Fe2+ complex and inactivating its repressor function. This is a potential problem, as in iron-rich environments excessive iron uptake would endanger H2O2 -stressed cells by accelerating hydroxyl-radical production through the Fenton reaction. However, the OxyR H2O2 -response system restored Fur repression in iron-replete Luria,Bertani medium by upregulating the synthesis of Fur protein. Indeed, when the OxyR binding site upstream of fur was disrupted, Hpx, mutants failed to repress transporter synthesis, and they exhibited high levels of intracellular free iron. Mutagenesis and bacteriostasis resulted. These defects were eliminated by mutations or chelators that slowed iron import, confirming that dysregulation of iron uptake was the root problem. Thus, aerobic organisms must grapple with a conundrum: how to monitor iron levels in oxidizing environments that might perturb the valence of the analyte. The induction of Fur synthesis by the OxyR response comprises one evolutionary solution to that problem. [source] Labyrinthula terrestris: a new pathogen of cool-season turfgrassesMOLECULAR PLANT PATHOLOGY, Issue 6 2007MARY W. OLSEN ABSTRACT A new disease of turfgrass known as rapid blight is caused by Labyrinthula terrestris, a newly described member of the Labyrinthulids. This unusual group of microorganisms previously has been found in marine systems, and L. terrestris is the only member of the genus Labyrinthula known to be a pathogen of terrestrial plants. Members of this genus are defined by the formation of ectoplasmic networks in which the unicellular somatic cells move or ,glide'. Infections of cool-season turfgrasses occur most commonly when they are irrigated with suboptimal irrigation water with elevated salinity. Disease has been observed in 11 states in the United States and in the United Kingdom. A phylogenetic study indicates that isolates from turfgrass in the United States fall firmly within a clade containing other Labyrinthula spp. and that they came from a common lineage. Its rapid emergence as a turfgrass pathogen may coincide with increased use of relatively high-salinity water or reclaimed water for irrigation. L. terrestris is a potential problem in susceptible turfgrass varieties wherever soil salinity is allowed to accumulate as a result of poor soil structure or suboptimal quality irrigation water is used for irrigation. [source] Robotic port-site and pelvic recurrences after robot-assisted laparoscopic radical hysterectomy for a stage IB1 adenocarcinoma of the cervix with negative lymph nodesTHE INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY, Issue 2 2010Bilal Sert Abstract Background Port-site metastasis (PSM) following minimally invasive surgery for gynaecological cancer has been recognized as a potential problem over the last two decades. Methods A 60 year-old woman with stage Ib1 adenocarcinoma of the cervix was treated with radical hysterectomy, bilateral salpingo-oophorectomy and bilateral pelvic lymph node dissection, using robot-assisted laparoscopy. Results Eighteen months after primary surgery, the patient developed a pelvic recurrence invading both the bladder mucosa and the parametrium. During the routine recurrence work-up, we found an 8 mm robotic port-site metastasis (PSM) on the abdominal computed tomography (CT) scan. Conclusion This is the first case report emphasizing the risk of PSM and early pelvic recurrences in robot-assisted laparoscopic radical hysterectomy and bilateral pelvic lymph node dissection for an early-stage cervical adenocarcinoma patient with negative lymph nodes, histologically examined by immunohistochemical ultrastaging. Copyright © 2010 John Wiley & Sons, Ltd. [source] | ||||||||||||||||||||||||||||||||||||||||||||||