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Potential Drawbacks (potential + drawback)
Selected AbstractsOptimal design and optimal control of structures undergoing finite rotations and elastic deformationsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 14 2004A. Ibrahimbegovic Abstract In this work, we deal with the optimal design and optimal control of structures undergoing large rotations and large elastic deformations. In other words, we show how to find the corresponding initial configuration through optimal design or the corresponding set of multiple load parameters through optimal control, in order to recover a desired deformed configuration or some desirable features of the deformed configuration as specified more precisely by the objective or cost function. The model problem chosen to illustrate the proposed optimal design and optimal control methodologies is the one of geometrically exact beam. First, we present a non-standard formulation of the optimal design and optimal control problems, relying on the method of Lagrange multipliers in order to make the mechanics state variables independent from either design or control variables and thus provide the most general basis for developing the best possible solution procedure. Two different solution procedures are then explored, one based on the diffuse approximation of response function and gradient method and the other one based on genetic algorithm. A number of numerical examples are given in order to illustrate both the advantages and potential drawbacks of each of the presented procedures. Copyright © 2004 John Wiley & Sons, Ltd. [source] E-learning: emerging uses, empirical results and future directionsINTERNATIONAL JOURNAL OF TRAINING AND DEVELOPMENT, Issue 4 2003Elizabeth T. Welsh The use of network technology to deliver training is the latest trend in the training and development industry and has been heralded as the ,e-learning revolution.' In an effort to separate hype from reality, this paper reviews practitioner and research literature on e-learning, incorporating unpublished information from interviews with managers and consultants directly involved in e-learning initiatives. Specific attention is given to why organizations use e-learning, what the potential drawbacks to e-learning are, what we know from research about e-learning and what the future of e-learning may hold. [source] Masked intervention effects: Analytic methods for addressing low dosage of interventionNEW DIRECTIONS FOR EVALUATION, Issue 110 2006John E. Lochman This chapter describes potential drawbacks of using intent-to-treat (ITT) analyses to examine intervention effects and presents several additional analytic methods as alternatives to ITT. [source] Combination treatment of insulin with oral hypoglycaemic agents in patients with type 2 diabetes mellitusPRACTICAL DIABETES INTERNATIONAL (INCORPORATING CARDIABETES), Issue 8 2004AN Dixon MRCP (UK) Clinical Research FellowArticle first published online: 7 DEC 200 Abstract The recently published guidelines from the National Institute for Clinical Excellence (NICE) on the management of blood glucose in type 2 diabetes and the NICE guidelines on the use of the long-acting insulin analogue, glargine, have brought to the fore the use of combination therapy of insulin with oral hypoglycaemic agents (OHAs). The NICE guidelines recommend that when a patient with type 2 diabetes is failing to achieve satisfactory glycaemic control with OHAs alone, insulin should be initiated in combination with OHAs. However, evidence for this approach is less than robust and combination treatment of OHAs with insulin remains a controversial area. This article presents the evidence for different insulin regimens in patients who have secondary failure to OHAs, including combination therapy with basal insulin. The evidence and potential drawbacks of such regimens are discussed. Copyright © 2004 John Wiley & Sons, Ltd. [source] Viewing apoptosis through a ,TUNEL'THE JOURNAL OF PATHOLOGY, Issue 3 2001J. A. Walker Abstract Apoptosis has an important role in carcinogenesis and cancer treatment. The end result of this complex pathway is the formation of apoptotic bodies. These can be difficult to quantify accurately, but quantitation is important if we wish to study this process. Several techniques are available which can help. ,TUNEL' is discussed, with its potential drawbacks, and newer antibody techniques, such as M30 and caspase 3, are then reviewed. Copyright © 2001 John Wiley & Sons, Ltd. [source] Market Orientation and R&D Effectiveness in High-Technology Firms: An Empirical Investigation in the Biotechnology Industry,THE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 3 2010Luigi M. De Luca There seems to be lack of consensus among informed scholars about the importance a of market orientation for high-technology firms. This paper gives a comprehensive review of existing empirical studies on the relationship between market orientation and innovation performance and pinpoints two limitations in this research stream that might be at the origin of such controversy. First, extant research often overlooked key innovation outcomes for high-technology firms, such as those related to research and development (R&D) performance. Second, organizational conditions that can ensure an optimal integration of market knowledge in the innovation process have been less analyzed in the case of these firms. Against this background, the present study contributes to the literature by providing a test of the effect of market orientation on R&D effectiveness and the moderating role of knowledge integration in this relationship, using a sample of Italian biotechnology firms. The study's objectives are addressed in two steps. The first one consists of an in-depth qualitative study based on semistructured interviews in five biotechnology firms. The second step consists of a follow-up survey of 50 biotechnology firms. Results from hierarchical multiple regression analysis show that the different dimensions of a market orientation have diverse effects on R&D effectiveness of high-technology firms: whereas interfunctional coordination has a positive main effect, the effect of customer orientation is moderated by knowledge integration, and competitor orientation has no effect on R&D effectiveness. Post hoc analyses also show two additional results involving a broader set of dependent variables. First, R&D effectiveness mediates the effects of customer orientation and interfunctional coordination on organizational performance. Second, market orientation does not appear to significantly affect R&D efficiency. The present study contributes to current literature in two main respects. First, it adds to previous work on market orientation and innovation by proposing a new dependent variable,R&D effectiveness,which offers a better perspective to understand the impact of market orientation on innovation performance in high-technology contexts. Second, while part of the current debate on the role of market orientation in high-tech markets seems to be polarized by positions that sustain its potential drawbacks or, on the contrary, its advantages, this study's findings on the moderating role of knowledge integration shed light on important contingency factors, such as organizational capabilities. The authors discuss the study's limitations and provide directions for future research. [source] QUADRAPOD MESH FOR POSTERIOR WALL RECONSTRUCTION IN ADULT INGUINAL HERNIASANZ JOURNAL OF SURGERY, Issue 3 2008Shih-Chung Wu Inguinal hernia repairs are the most frequently carried out operations worldwide, and open-mesh herniorrhaphies have gained wide acceptance for advantages of little tension, less pain and lower recurrence rates. Even so, potential drawbacks of original open-mesh repairs exist, and we accordingly make some modifications, suggesting a new ,quadrapod' marlex mesh as an alternative. From July 2002 to March 2004, we carried out 288 consecutive inguinal hernia repairs using quadrapod mesh in 273 patients, all of them were male and aged older than 35 years. Patient demographics, operative parameters, morbidity and outcomes were collected in detail. After surgery, patients were followed up every 6 months at one surgeon's clinic and any major abnormality was recorded. Mean age of the 273 patients was 58.7 years. Twenty-eight patients had recurrent hernias and 15 bilateral hernias. Mean surgical duration was 50.7 min. One patient suffered from major wound infection and needed prolonged hospitalization for parenteral antibiotics. Owing to old age and benign prostatic hyperplasia, 11 patients receiving spinal anaesthesia had temporary postoperative urine retention and needed short-term urinary catheter insertion. Most patients were discharged 1 day following surgery. Acute wound pain generally improved within days, and no patients complained of chronic pain or debility necessitating special interventions. With a mean follow up of 40.7 months, no case of recurrent herniation was detected to date. Open-mesh herniorrhaphy using quadrapod mesh provides a cheap, feasible and effective alternative choice in centres with limited resources. Preliminary results are encouraging, and a formal prospective study may be warranted. [source] Understory vegetation response to mechanical mastication and other fuels treatments in a ponderosa pine forestAPPLIED VEGETATION SCIENCE, Issue 2 2010Jeffrey M. Kane Abstract Questions: What influence does mechanical mastication and other fuel treatments have on: (1) canopy and forest floor response variables that influence understory plant development; (2) initial understory vegetation cover, diversity, and composition; and (3) shrub and non-native species density in a second-growth ponderosa pine forest. Location: Challenge Experimental Forest, northern Sierra Nevada, California, USA. Methods: We compared the effects of mastication only, mastication with supplemental treatments (tilling and prescribed fire), hand removal, and a control on initial understory vegetation response using a randomized complete block experimental design. Each block (n=4) contained all five treatments and understory vegetation was surveyed within 0.04-ha plots for each treatment. Results: While mastication alone and hand removal dramatically reduced the midstory vegetation, these treatments had little effect on understory richness compared with control. Prescribed fire after mastication increased native species richness by 150% (+6.0 species m2) compared with control. However, this also increased non-native species richness (+0.8 species m2) and shrub seedling density (+24.7 stems m2). Mastication followed by tilling resulted in increased non-native forb density (+0.7 stems m2). Conclusions: Mechanical mastication and hand removal treatments aided in reducing midstory fuels but did not increase understory plant diversity. The subsequent treatment of prescribed burning not only further reduced fire hazard, but also exposed mineral soil, which likely promoted native plant diversity. Some potential drawbacks to this treatment include an increase of non-native species and stimulation of shrub seed germination, which could alter ecosystem functions and compromise fire hazard reduction in the long-term. [source] | |||||||||||||