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Potential Biological Activity (potential + biological_activity)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

Synthesis of a Proline-Rich [60]Fullerene Peptide with Potential Biological Activity.

CHEMINFORM, Issue 25 2004
Panagiota Sofou
No abstract is available for this article. [source]

Cobalt-Catalyzed C,N Bond-Forming Reaction between N-Aromatic 2-Chlorides and Secondary Amines

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 27 2009
Gabriel Toma
Abstract Secondary amines react with N-aromatic 2-chlorides in the presence of a catalytic amount of cobalt chloride. When DPPP was added as ligand, the yield was further improved. The N-aromatic-containing tertiary amines formed are interesting due to their potential biological activity. This work represents the first cobalt-catalyzed approach to C,N bond formation involving N-aromatic 2-chlorides and secondary amines having a certain amount of versatility and functional group tolerance.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source]

Application of 3-methylthiopyrido[4,3- e]-1,4,2-dithiazine 1,1-dioxide to the synthesis of novel series of 4H -pyrido[4,3- e]-1,2,4-thiadiazine derivatives with potential biological activity

JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 6 2009
Zdzis, aw Brzozowski
Two series of 4H -pyrido[4,3- e]-1,2,4-thiadiazine derivatives 3,5 and 7,12 were synthesized by the reactions of 3-methylthiopyrido[4,3- e]-1,4,2-dithiazine 1,1-dioxide 1 with 2-or 6-hydrazinoazines and 2-aminophenols or 2-aminothiophenol, respectively. Aminolysis of 8 (R = Me, Y = O) afforded the corresponding 3-(R-amino)-4-(2-hydroxy-5-methylphenyl)-4H -pyrido[4,3- e]-1,2,4-thiadiazine 1,1-dioxides 13,18. The structures of these compounds were confirmed on the basis of elemental analysis, spectral data, and X-ray crystallography. Compounds 3,5, 7,10, 12,15, and 17,18 were screened in vitro for antibacterial activity. Moreover, preliminary in vitro anticancer assay was performed for compounds 3, 7, 10, 11,13, and 17,18 at the National Cancer Institute (Bethesda, MD) at a single dose (10 ,M) in the full NCI 60 cell panel. J. Heterocyclic Chem., (2009). [source]

Hexaquacobalt(II) bis(5-hydroxy-7-methoxy-4-oxo-2-phenyl-4H -chromene-6-sulfonate) tetrahydrate

ACTA CRYSTALLOGRAPHICA SECTION C, Issue 4 2008
Wu-Wu Li
The title compound, [Co(H2O)6](C16H11O7S)2·4H2O, with cobalt(II) at the centre of symmetry, exhibits alternating hydrophilic and hydrophobic regions. Hydrophilic regions are generated by O,H...O hydrogen bonds among sulfonate groups, involving solvent water molecules and coordinated water molecules; ,,, stacking interactions assemble the flavone skeletons into columns which form the hydrophobic regions. A three-dimensional network is built up from an extensive array of hydrogen bonds, ,,, stacking interactions and electrostatic interactions between the cation and anion. As a salt of the sulfonated derivative of naturally occurring tectochrysin (5-hydroxy-7-methoxyflavone), this compound offers enhanced solubility and potential biological activity over the natural product. [source]