Potent

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Anti-tumor efficacy of the nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-,-D-arabinofuranosyl) cytosine (4,-thio-FAC) in human pancreatic and ovarian tumor xenograft models

Identification of Thiazolidinones Spiro-Fused to Indolin-2-ones as Potent and Selective Inhibitors of the Mycobacterium tuberculosis Protein Tyrosine Phosphatase,B,

Lipophilic Pyridinium Bisphosphonates: Potent ,, T Cell Stimulators,

Design and Synthesis of Highly Potent and Plasma-Stable Dimeric Inhibitors of the PSD-95,NMDA Receptor Interaction,

Thirdhand Smoke Identified as Potent, Enduring Carcinogen

Exploring QSAR for Substituted 2-Sulfonyl-Phenyl-Indol Derivatives as Potent and Selective COX-2 Inhibitors Using Different Chemometrics Tools

ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent ,-Blocker ICI-118,551 Allows the Determination of Enantiomer Dependency on Biological Activity.

ChemInform Abstract: Discovery of 5-Substituted 2-Amino-4-chloro-8-( (4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6 (5H)-ones as Potent and Selective Hsp90 Inhibitors.

ChemInform Abstract: Discovery of Novel Acetanilide Derivatives as Potent and Selective ,3-Adrenergic Receptor Agonists.

ChemInform Abstract: Potent and Selective Inhibitors of Helicobacter pylori glutamate Racemase (MurI): Pyridodiazepine Amines.

ChemInform Abstract: Discovery of Potent, Selective Sulfonylfuran Urea Endothelial Lipase Inhibitors.

ChemInform Abstract: Chlorahololides C,F: A New Class of Potent and Selective Potassium Channel Blockers from Chloranthus holostegius.

ChemInform Abstract: The Discovery of GSK221149A: A Potent and Selective Oxytocin Antagonist.

Potent, Selective, and Orally Active Adenosine A2A Receptor Antagonists: Arylpiperazine Derivatives of Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.

Identification of a Novel 3,5-Disubstituted Pyridine as a Potent, Selective, and Orally Active Inhibitor of Akt1 Kinase.

Synthesis of Pyrazoles and Isoxazoles as Potent ,v,3 Receptor Antagonists.

Hit-to-Lead Studies: The Discovery of Potent, Orally Bioavailable Thiazolopyrimidine CXCR2 Receptor Antagonists.

Discovery of a Substituted 8-Arylquinoline Series of PDE4 Inhibitors: Structure,Activity Relationship, Optimization, and Identification of a Highly Potent, Well Tolerated, PDE4 Inhibitor.

2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine Analogues: Highly Potent, Orally Active, Adenosine A2A Antagonists.

Structure-Based Design of Potent and Selective Inhibitors of Collagenase-3 (MMP-13).

3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: A Novel Class of Potent, Selective Cyclooxygenase-2 (COX-2) Inhibitors.

Design and Synthesis of 1-(4-Benzoylphenyl)imidazole Derivatives as New Potent 20-HETE Synthase Inhibitors.

Potent and Selective Proline Derived Dipeptidyl Peptidase IV Inhibitors.

Discovery of Potent and Orally Bioavailable N,N,-Diarylurea Antagonists for the CXCR2 Chemokine Receptor.

Imidazo[1,2-b]pyridazines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors.

(S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo [1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide Is a Potent and Efficacious KCNQ2 Opener which Inhibits Induced Hyperexcitability of Rat Hippocampal Neurons.

Potent and Selective Inhibitors of Bacterial Methionyl tRNA Synthetase Derived from an Oxazolone,Dipeptide Scaffold

Quinolines as Extremely Potent and Selective PDE5 Inhibitors as Potential Agents for Treatment of Erectile Dysfunction.

Synthesis of Cinnamic Acids and Related Isosteres as Potent and Selective ,v,3 Receptor Antagonists.

Design, Synthesis and Biological Activity of Novel Dimethyl-{2-[6-substituted-indol-1-yl]-ethyl}-amine as Potent, Selective, and Orally-Bioavailable 5-HT1D Agonists.