Potent

Distribution by Scientific Domains
Distribution within Medical Sciences

Kinds of Potent

  • highly potent
  • new potent
  • very potent

  • Terms modified by Potent

  • potent activation
  • potent activator
  • potent activity
  • potent agent
  • potent agonist
  • potent allergen
  • potent analgesic
  • potent angiogenic factor
  • potent antagonist
  • potent anti-hiv agent
  • potent anti-inflammatory activity
  • potent anti-inflammatory property
  • potent antibacterial activity
  • potent anticancer drug
  • potent antigen-presenting cell
  • potent antioxidant
  • potent antioxidant activity
  • potent antitumor activity
  • potent antitumor agent
  • potent apc
  • potent biological activity
  • potent bisphosphonate
  • potent blocker
  • potent carcinogen
  • potent competitive inhibitor
  • potent compound
  • potent cytotoxic activity
  • potent cytotoxicity
  • potent effect
  • potent effects
  • potent enhancer
  • potent immunosuppressant
  • potent inducer
  • potent inhibition
  • potent inhibitor
  • potent inhibitory activity
  • potent ligand
  • potent mitogen
  • potent modulator
  • potent neurotoxin
  • potent predictor
  • potent promoter
  • potent regulator
  • potent risk factor
  • potent stimulator
  • potent stimulus
  • potent suppressor
  • potent tool
  • potent toxin
  • potent vasoconstrictor
  • potent vasodilator

  • Selected Abstracts


    Anti-tumor efficacy of the nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-,-D-arabinofuranosyl) cytosine (4,-thio-FAC) in human pancreatic and ovarian tumor xenograft models

    INTERNATIONAL JOURNAL OF CANCER, Issue 6 2005
    Deborah A. Zajchowski
    Abstract 1-(2-Deoxy-2-fluoro-4-thio-,- D -arabinofuranosyl) cytosine (4,-thio-FAC) is a deoxycytidine analog that has been shown previously to have impressive anti-proliferative and cytotoxic effects in vitro and in vivo toward colorectal and gastric tumors. In our present studies, the pharmacokinetic behavior in nude mice and the effectiveness of 4,-thio-FAC against human pancreatic and ovarian tumor growth were assessed in comparison with standard chemotherapeutic agents. Potent in vitro anti-proliferative effects were observed against pancreatic (Capan-1, MIA-PaCa-2, BxPC-3) and ovarian (SK-OV-3, OVCAR-3, ES-2) cancer cell lines with IC50 of 0.01,0.2 ,M. In vivo anti-tumor activity was evaluated in nude mice bearing subcutaneously (s.c.) implanted human pancreatic tumor xenografts or intraperitoneally (i.p.) disseminated human ovarian xenografted tumors. Oral daily administration of 4,-thio-FAC for 8,10 days significantly inhibited the growth of gemcitabine-resistant BxPC-3 pancreatic tumors and induced regression of gemcitabine-refractory Capan-1 tumors. 4,-Thio-FAC was also a highly effective inhibitor of ovarian peritoneal carcinomatosis. In the SK-OV-3 and ES-2 ovarian cancer models, 4,-thio-FAC prolonged survival to a greater extent than that observed with gemcitabine. Furthermore, the superiority of 4,-thio-FAC to carboplatin and paclitaxel was demonstrated in the ES-2 clear cell ovarian carcinoma model. Studies provide evidence that 4,-thio-FAC is a promising new alternative to gemcitabine and other chemotherapeutic drugs in the treatment of a variety of tumor indications, including pancreatic and ovarian carcinoma. © 2004 Wiley-Liss, Inc. [source]


    Identification of Thiazolidinones Spiro-Fused to Indolin-2-ones as Potent and Selective Inhibitors of the Mycobacterium tuberculosis Protein Tyrosine Phosphatase,B,

    ANGEWANDTE CHEMIE, Issue 34 2010
    Viktor
    Das beste aus 40,000: Detaillierte Untersuchungen zur Struktur-Aktivitäts-Beziehung enthüllten Schlüsselstrukturelemente von Indolin-2-on-3-spirothiazolidinonen (siehe Beispiel) und deren für eine starke Inhibierung des pathophysiologisch wichtigen Titelproteins geeignete Konfiguration. [source]


    Lipophilic Pyridinium Bisphosphonates: Potent ,, T Cell Stimulators,

    ANGEWANDTE CHEMIE, Issue 6 2010
    Yonghui Zhang Dr.
    Mit langen Alkylketten versehene, lipophile Pyridiniumbisphosphonate (siehe Bild: P,rot, N,blau, C,orange, H,grau) stimulieren humane ,,-T-Zellen, die den V,2V,2-T-Zellrezeptor exprimieren. Ihre Wirkung ist stärker als diejenige von Zoledronat, das gegen Brust- und Prostatakrebs aktiv ist. Die lipophilen Bisphosphonate binden nur schwach in Knochen, sodass Nebenwirkungen, wie sie sonst bei der klinischen Verwendung von Bisphosphonaten auftreten, weniger wahrscheinlich sind. [source]


    Design and Synthesis of Highly Potent and Plasma-Stable Dimeric Inhibitors of the PSD-95,NMDA Receptor Interaction,

    ANGEWANDTE CHEMIE, Issue 51 2009
    Anders Bach Dr.
    Im Doppel: Die Dimerisierung monomerer Peptidliganden für die PDZ-Domänen des Proteins PSD-95 (postsynaptische Dichte,95) liefert leistungsfähige Inhibitoren von Protein-Protein-Wechselwirkungen, die in Blutplasma stabil sind. Durch Optimierung der Länge des Polyethylenglycol-Linkers gelangt man zu Inhibitoren der PDZ1-2-Domäne (siehe Bild) mit bislang unerreichter Affinität. [source]


    Thirdhand Smoke Identified as Potent, Enduring Carcinogen

    CA: A CANCER JOURNAL FOR CLINICIANS, Issue 4 2010
    John Henry Dreyfuss
    No abstract is available for this article. [source]


    Exploring QSAR for Substituted 2-Sulfonyl-Phenyl-Indol Derivatives as Potent and Selective COX-2 Inhibitors Using Different Chemometrics Tools

    CHEMICAL BIOLOGY & DRUG DESIGN, Issue 6 2008
    Mehdi Khoshneviszadeh
    Selective inhibition of cyclooxygenase-2 inhibitors is an important strategy in designing of potent anti-inflammatory compounds with significantly reduced side effects. The present quantitative structure,activity relationship study, attempts to explore the structural and physicochemical requirements of 2-sulfonyl,phenyl,indol derivatives (n = 30) for COX-2 inhibitory activity using chemical, topological, geometrical, and quantum descriptors. Some statistical techniques like stepwise regression, multiple linear regression with factor analysis as the data preprocessing (FA-MLR), principal component regression analysis, and genetic algorithms partial least squares analysis were applied to derive the quantitative structure,activity relationship models. The generated equations were statistically validated using cross-validation and external test set. The quality of equations obtained from stepwise multiple linear regression, FA-MLR, principal component regression analysis and PLS were in the acceptable statistical range. The best multiple linear regression equation obtained from factor analysis (FA-MLR) as the preprocessing step could predict 77.5% of the variance of the cyclooxygenase-2 inhibitory activity whereas that derived from genetic algorithms partial least squares could predict 84.2% of variances. The results of quantitative structure,activity relationship models suggested the importance of lipophilicity, electronegativity, molecular area and steric parameters on the cyclooxygenase-2 inhibitory activity. [source]


    ChemInform Abstract: An Efficient Asymmetric Synthesis of the Potent ,-Blocker ICI-118,551 Allows the Determination of Enantiomer Dependency on Biological Activity.

    CHEMINFORM, Issue 43 2010
    James R. Baker
    Abstract A highly efficient asymmetric synthesis of the title compound is developed. [source]


    ChemInform Abstract: Discovery of 5-Substituted 2-Amino-4-chloro-8-( (4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7,8-dihydropteridin-6 (5H)-ones as Potent and Selective Hsp90 Inhibitors.

    CHEMINFORM, Issue 40 2009
    Xiaoyuan Li
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


    ChemInform Abstract: Discovery of Novel Acetanilide Derivatives as Potent and Selective ,3-Adrenergic Receptor Agonists.

    CHEMINFORM, Issue 36 2009
    Tatsuya Maruyama
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


    ChemInform Abstract: Potent and Selective Inhibitors of Helicobacter pylori glutamate Racemase (MurI): Pyridodiazepine Amines.

    CHEMINFORM, Issue 26 2009
    Bolin Geng
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


    ChemInform Abstract: Discovery of Potent, Selective Sulfonylfuran Urea Endothelial Lipase Inhibitors.

    CHEMINFORM, Issue 20 2009
    Krista B. Goodman
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


    ChemInform Abstract: Chlorahololides C,F: A New Class of Potent and Selective Potassium Channel Blockers from Chloranthus holostegius.

    CHEMINFORM, Issue 37 2008
    Sheng-Ping Yang
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


    ChemInform Abstract: The Discovery of GSK221149A: A Potent and Selective Oxytocin Antagonist.

    CHEMINFORM, Issue 26 2008
    John Liddle
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]


    Potent, Selective, and Orally Active Adenosine A2A Receptor Antagonists: Arylpiperazine Derivatives of Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.

    CHEMINFORM, Issue 29 2007
    Bernard R. Neustadt
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    Identification of a Novel 3,5-Disubstituted Pyridine as a Potent, Selective, and Orally Active Inhibitor of Akt1 Kinase.

    CHEMINFORM, Issue 42 2006
    Sheela A. Thomas
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    Synthesis of Pyrazoles and Isoxazoles as Potent ,v,3 Receptor Antagonists.

    CHEMINFORM, Issue 37 2006
    Thomas D. Penning
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    Hit-to-Lead Studies: The Discovery of Potent, Orally Bioavailable Thiazolopyrimidine CXCR2 Receptor Antagonists.

    CHEMINFORM, Issue 21 2006
    Andrew Baxter
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    Discovery of a Substituted 8-Arylquinoline Series of PDE4 Inhibitors: Structure,Activity Relationship, Optimization, and Identification of a Highly Potent, Well Tolerated, PDE4 Inhibitor.

    CHEMINFORM, Issue 9 2006
    Dwight Macdonald
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]


    2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine Analogues: Highly Potent, Orally Active, Adenosine A2A Antagonists.

    CHEMINFORM, Issue 4 2006
    Part 1.
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    Structure-Based Design of Potent and Selective Inhibitors of Collagenase-3 (MMP-13).

    CHEMINFORM, Issue 26 2005
    Soong-Hoon Kim
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: A Novel Class of Potent, Selective Cyclooxygenase-2 (COX-2) Inhibitors.

    CHEMINFORM, Issue 16 2005
    Ramani R. Ranatunge
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    Design and Synthesis of 1-(4-Benzoylphenyl)imidazole Derivatives as New Potent 20-HETE Synthase Inhibitors.

    CHEMINFORM, Issue 9 2005
    Toshio Nakamura
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    Potent and Selective Proline Derived Dipeptidyl Peptidase IV Inhibitors.

    CHEMINFORM, Issue 5 2005
    Scott D. Edmondson
    No abstract is available for this article. [source]


    Discovery of Potent and Orally Bioavailable N,N,-Diarylurea Antagonists for the CXCR2 Chemokine Receptor.

    CHEMINFORM, Issue 48 2004
    Qi Jin
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    Imidazo[1,2-b]pyridazines: A Potent and Selective Class of Cyclin-Dependent Kinase Inhibitors.

    CHEMINFORM, Issue 35 2004
    Andrew P. Thomas
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    (S)-N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2H-benzo [1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide Is a Potent and Efficacious KCNQ2 Opener which Inhibits Induced Hyperexcitability of Rat Hippocampal Neurons.

    CHEMINFORM, Issue 31 2004
    Yong-Jin Wu
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    Potent and Selective Inhibitors of Bacterial Methionyl tRNA Synthetase Derived from an Oxazolone,Dipeptide Scaffold

    CHEMINFORM, Issue 31 2004
    Manish Tandon
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    Quinolines as Extremely Potent and Selective PDE5 Inhibitors as Potential Agents for Treatment of Erectile Dysfunction.

    CHEMINFORM, Issue 30 2004
    Yingzhi Bi
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    Synthesis of Cinnamic Acids and Related Isosteres as Potent and Selective ,v,3 Receptor Antagonists.

    CHEMINFORM, Issue 29 2004
    Thomas D. Penning
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]


    Design, Synthesis and Biological Activity of Novel Dimethyl-{2-[6-substituted-indol-1-yl]-ethyl}-amine as Potent, Selective, and Orally-Bioavailable 5-HT1D Agonists.

    CHEMINFORM, Issue 12 2004
    Methvin Isaac
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]