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Plakortis Simplex (Plakorti + simplex)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

Iodinated Indole Alkaloids From Plakortis simplex , New Plakohypaphorines and an Evaluation of Their Antihistamine Activity

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 15 2004
Francesca Borrelli
Abstract Three new iodinated tryptophan derivatives, plakohypaphorines D,F (4,6), have been isolated from the Caribbean sponge Plakortis simplex. Their structures have been determined by applying spectroscopic methods and microwave-assisted selective dehalogenation. Compound 5 is the first naturally occurring triiodinated indole, while compound 6 is a unique metabolite because it possesses both chlorine and iodine atoms on the indole nucleus. We have evaluated the antihistamine activity of the whole series of plakohypaphorines A,F, but only the diiodinated analogues proved to be active: they display a specific antagonism of the noncompetitive type. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) [source]

Reactivity-based One-pot Synthesis of Immunosuppressive Glycolipids from the Caribbean Sponge Plakortis simplex

CHINESE JOURNAL OF CHEMISTRY, Issue 11 2009
Guokai Lü
Abstract The first synthesis of three natural glycolipid simplexides 1a,1c, which were isolated from the marine sponge Plakortis simplex and claimed to inhibit T cell proliferation, has been concisely accomplished by a reactivity-based one-pot synthetic strategy under the use of p -toluenethioglycoside (STol) donors. [source]