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Terms modified by Philadelphia Selected AbstractsFine-needle aspiration cytology: Author: Svante R. Orell, Gregory F. Sterrett, and Darrel Whitaker, Churchill Livingstone, Philadelphia, 2005DIAGNOSTIC CYTOPATHOLOGY, Issue 6 2006Rana S. Hoda M.D. No abstract is available for this article. [source] Current Treatment of Myoclonic Astatic Epilepsy: Clinical Experience at the Children's Hospital of PhiladelphiaEPILEPSIA, Issue 9 2007Sudha Kilaru Summary:,Purpose: Myoclonic astatic epilepsy (MAE) is a generalized epilepsy of early childhood. Little is known about the use of newer antiepileptic treatments (AET) in MAE. The purpose of this study was to describe the characteristics, treatment, and outcome of a contemporary MAE cohort exposed to the new generation AET. Methods: Charts of subjects with MAE treated between 1998 and 2005 were reviewed. Results: Twenty-three subjects (19 boys), with a median (range) follow-up of 38 (2, 86) months were identified. Thirty-nine percent had a family history of epilepsy, and 39% had family history of febrile seizures. Age at seizure onset was a median of 36 (12,24) months. Initial EEG was normal in 30%. When seizures ceased, EEG background and epileptiform abnormalities persisted in 17 and 58%, respectively. On average, each subject was exposed to five AET. The most frequently used AET was valproate (83%). Seizure freedom occurred spontaneously in three subjects, with ethosuximide and levetiracetam in one each, valproate and lamotrigine in two each, topiramate in three and the ketogenic diet (KD) in five subjects. By 36 months after seizure onset, 67% achieved seizure freedom. At the last visit, 43% were developmentally normal, 52% had mild, and 5% had moderate cognitive disabilities. Time to seizure freedom did not correlate with cognitive outcome. Conclusions: The new generation of AET may offer significant benefit to children with MAE. The KD was the most effective AET in this series, and perhaps should be considered earlier in treatment. [source] Migrating Partial Seizures in Infancy: Expanding the Phenotype of a Rare Seizure SyndromeEPILEPSIA, Issue 4 2005Eric Marsh Summary:,Purpose: The constellation of early-onset, unprovoked, alternating electroclinical seizures and neurodevelopmental devastation was first described by Coppola et al. We report six new patients and the prospect of a more optimistic developmental outcome. Methods: Retrospective chart reviews were performed on six infants evaluated at the Children's Hospital of Philadelphia (five patients) and at Hershey Medical Center (one patient) who had electroclinically alternating seizures before age 6 months of age. Electroclinical characteristics and long-term follow-up were recorded. Results: All had unprovoked, early-onset (range, 1 day to 3 months; mean, 25 days) intractable electroclinical seizures that alternated between the two hemispheres. Each patient underwent comprehensive brain imaging and neurometabolic workups, which were unrevealing. In all patients, subsequently intractable partial seizures developed and often a progressive decline of head circumference percentile occurred with age. Three demonstrated severe developmental delay and hypotonia. All survived, and 7-year follow-up on one patient was quite favorable. Conclusions: Our patients satisfied the seven major diagnostic criteria first described by Coppola et al. The prognosis of this rare neonatal-onset epilepsy syndrome from the original description and subsequent case reports was very poor, with 28% mortality, and the majority of survivors were profoundly retarded and nonambulatory. Our patient data validate the diagnostic criteria of this syndrome and further quantify a previously described observation of progressive decline of head circumference percentiles with age. Our data also suggest that the prognosis of this syndrome, although poor, is not as uniformly grim as the cases reported previously in the literature. [source] Cocaine Rapid Efficacy Screening Trial (CREST): a paradigm for the controlled evaluation of candidate medications for cocaine dependenceADDICTION, Issue 2005Deborah B. Leiderman ABSTRACT Aim Development of effective medications for the treatment of cocaine dependence remains a major priority for the National Institute on Drug Abuse (NIDA) at the National Institutes of Health. The Cocaine Rapid Efficacy Screening Trial (CREST) paradigm was developed by the Division of Treatment Research and Development (DT R&D) at NIDA with the goal of enhancing pilot clinical trial validity when systematically assessing a range of medications and drug classes for potential utility in treatment of cocaine dependence. Design CREST utilizes a randomized, controlled, parallel group, blinded methodology for comparing one or more marketed medications against a standard, pharmaceutical grade placebo. The trial design is comprised of a flexible 2,4-week screening/baseline period followed by randomization to an 8-week treatment period. Measures Standard measures of outcomes for the CREST included urinary benzoylecgonine (primary metabolite of cocaine), retention, cocaine craving, depression, clinical global impression and HIV-risk behaviors. In order to facilitate comparisons of data from the CREST studies across sites, drug classes and time, standardized procedures, measures and psychosocial counseling were used. Results A total of 19 medications were evaluated in out-patient treatment research clinics in Boston, Cincinnati, Los Angeles, New York and Philadelphia. Conclusions Findings supported decisions to move forward three medications (cabergoline, reserpine, tiagabine) using full-scale, adequately powered, randomized placebo-controlled trial designs. Lessons learned from the CREST experience continue to shape cocaine pharmacotherapy trial design and execution. [source] Gene expression analysis of BCR/ABL1-dependent transcriptional response reveals enrichment for genes involved in negative feedback regulationGENES, CHROMOSOMES AND CANCER, Issue 4 2008Petra Håkansson Philadelphia (Ph) chromosome-positive leukemia is characterized by the BCR/ABL1 fusion protein that affects a wide range of signal transduction pathways. The knowledge about its downstream target genes is, however, still quite limited. To identify novel BCR/ABL1-regulated genes we used global gene expression profiling of several Ph-positive and Ph-negative cell lines treated with imatinib. Following imatinib treatment, the Ph-positive cells showed decreased growth, viability, and reduced phosphorylation of BCR/ABL1 and STAT5. In total, 142 genes were identified as being dependent on BCR/ABL1-mediated signaling, mainly including genes involved in signal transduction, e.g. the JAK/STAT, MAPK, TGFB, and insulin signaling pathways, and in regulation of metabolism. Interestingly, BCR/ABL1 was found to activate several genes involved in negative feedback regulation (CISH, SOCS2, SOCS3, PIM1, DUSP6, and TNFAIP3), which may act to indirectly suppress the tumor promoting effects exerted by BCR/ABL1. In addition, several genes identified as deregulated upon BCR/ABL1 expression could be assigned to the TGFB and NFkB signaling pathways, as well as to reflect the metabolic adjustments needed for rapidly growing cells. Apart from providing important pathogenetic insights into BCR/ABL1 -mediated leukemogenesis, the present study also provides a number of pathways/individual genes that may provide attractive targets for future development of targeted therapies. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045,2257/suppmat. © 2008 Wiley-Liss, Inc. [source] Geochemical and mineralogical distinctions between Bonnin and Morris (Philadelphia, 1770,1772) porcelain and some contemporary British phosphatic waresGEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 7 2001J. Victor Owen The major element compositions of 15 ceramic sherds from the Bonnin and Morris factory site were determined by electron microprobe. Thirteen samples are phosphatic; the others consist of (a) "soapstone" (magnesian/plombian) and (b) true porcelain, and are interpreted as exotic artifacts, as is one compositionally distinct (relatively SiO2 -poor, P2O5+CaO-rich) phosphatic sample. Although long considered to be virtually indistinguishable from Bow porcelain (London: ca. 1747,1776), the phosphatic Philadelphia wares have a relatively low mean CaO/P2O5 ratio (3.3 versus 3.8; molecular proportions) and high alumina content (6.6 versus 5.4 wt % Al2O3). Furthermore, unlike Bow, the Bonnin and Morris samples contain calcic plagioclase (bytownite), and in some instances, an orthoclase-rich ternary feldspar. The preservation of calcic plagioclase indicates that Philadelphia porcelain was fired at (rather than above) the thermal minimum in the An-SiO2 -C3P system, although the presence of Na (and other fluxes) in these wares precludes the exact determination of the maximum firing temperature from this phase diagram. These wares are also distinctive insofar as the phosphate and melt phases can contain small amounts of lead; they have bulk lead contents of approximately 0.1,1.2 wt % PbO. This component has not been detected in the body of Bow or other contemporary British phosphatic porcelains. Their principal similarity lies in the fact that both wares contain sulfate. In addition, the glazes on Bonnin and Morris porcelain (e.g., PbO , 35,50 wt %; SnO2 , 1,2%) compositionally resemble those used at Bow. If feldspar is formed at all, then Al-poor phosphatic porcelain (or those with low CaO/P2O5 ratios) will have comparatively low modal calcic plagioclase contents, thereby allowing the rapid depletion of this mineral via resorption by the melt phase during vitrification. Such appears to have been the case for analyzed Bow porcelain, which is therefore interpreted to have been overfired (sensu lato) relative to its Philadelphia counterpart. Conceivably, calcic plagioclase could be preserved in low-Al wares that were fired only briefly at vitrification temperatures. Given the role of firing history in governing the mineralogy of porcelain, compositional criteria are more reliable for distinguishing these wares. © 2001 John Wiley & Sons, Inc. [source] A Surface-Based Approach to Measuring Spatial SegregationGEOGRAPHICAL ANALYSIS, Issue 2 2007David O'Sullivan Quantitative indices of residential segregation have been with us for half a century, but suffer significant limitations. While useful for comparison among regions, summary indices fail to reveal spatial aspects of segregation. Such measures generally consider only the population mix within zones, not between them. Zone boundaries are treated as impenetrable barriers to interaction between population subgroups, so that measurement of segregation is constrained by the zoning system, which bears no necessary relation to interaction among population subgroups. A segregation measurement approach less constrained by the chosen zoning system, which enables visualization of segregation levels at the local scale and accounts for the spatial dimension of segregation, is required. We propose a kernel density estimation approach to model spatial aspects of segregation. This provides an explicitly geographical framework for modeling and visualizing local spatial segregation. The density estimation approach lends itself to development of an index of spatial segregation with the advantage of functional compatibility with the most widely used index of segregation (the dissimilarity index D). We provide a short review of the literature on measuring segregation, briefly describe the kernel density estimation method, and illustrate how the method can be used for measuring segregation. Examples using a simulated landscape and two empirical cases in Washington, DC and Philadelphia, PA are presented. [source] The aging face: A systematic approach by Calvin M. Johnson, Jr, Ramsey Alsarraf, W. B. Saunders, Philadelphia, 2002, 160 ppHEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 3 2005J. Randall Jordan MD FACS No abstract is available for this article. [source] Decision making in ear, nose, and throat disorders, by Cuneyt M. Alper, Eugene N. Myers, David E. Eibling, W.B. Saunders, Philadelphia, 2001, 385 ppHEAD & NECK: JOURNAL FOR THE SCIENCES & SPECIALTIES OF THE HEAD AND NECK, Issue 2 2003Adair Blackledge MD No abstract is available for this article. [source] Efficient allocation of resources to prevent HIV infection among injection drug users: the Prevention Point Philadelphia (PPP) needle exchange programHEALTH ECONOMICS, Issue 2 2006Zoë K. Harris Abstract The objective of this study is to determine the allocation of resources within a multi-site needle exchange program (NEP) that achieves the largest possible reduction in new HIV infections at minimum cost. We present a model that relates the number of injection drug user (IDU) clients and the number of syringes exchanged per client to both the costs of the NEP and the expected reduction in HIV infections per unit time. We show that cost-effective allocation within a multi-site NEP requires that sites be located where the density of IDUs is highest, and that the number of syringes exchanged per client be equal across sites. We apply these optimal allocation rules to a specific multi-site needle exchange program, Prevention Point Philadelphia (PPP). This NEP, we find, needs to add 2 or 3 new sites in neighborhoods with the highest density of IDU AIDS cases, and to increase its total IDU client base by about 28%, from approximately 6400 to 8200 IDU clients. The case-study NEP also needs to increase its hours of operation at two existing sites, where the number of needles distributed per client is currently sub-optimal, by 50%. At the optimal allocation, the estimated cost per case of HIV averted would be $2800 (range $2300,$4200). Such a favorable cost-effectiveness ratio derives primarily from PPP's low marginal costs per distributed needle. Copyright © 2005 John Wiley & Sons, Ltd. [source] Benefit-Cost Analysis of Addiction Treatment: Methodological Guidelines and Empirical Application Using the DATCAP and ASIHEALTH SERVICES RESEARCH, Issue 2 2002Michael T. French Objective. To provide detailed methodological guidelines for using the Drug Abuse Treatment Cost Analysis Program (DATCAP) and Addiction Severity Index (ASI) in a benefit-cost analysis of addiction treatment. Data Sources/Study Setting. A representative benefit-cost analysis of three outpatient programs was conducted to demonstrate the feasibility and value of the methodological guidelines. Study Design. Procedures are outlined for using resource use and cost data collected with the DATCAP. Techniques are described for converting outcome measures from the ASI to economic (dollar) benefits of treatment. Finally, principles are advanced for conducting a benefit-cost analysis and a sensitivity analysis of the estimates. Data Collection/Extraction Methods. The DATCAP was administered at three outpatient drug-free programs in Philadelphia, PA, for 2 consecutive fiscal years (1996 and 1997). The ASI was administered to a sample of 178 treatment clients at treatment entry and at 7-months postadmission. Principal Findings. The DATCAP and ASI appear to have significant potential for contributing to an economic evaluation of addiction treatment. The benefit-cost analysis and subsequent sensitivity analysis all showed that total economic benefit was greater than total economic cost at the three outpatient programs, but this representative application is meant to stimulate future economic research rather than justifying treatment per se. Conclusions. This study used previously validated, research-proven instruments and methods to perform a practical benefit-cost analysis of real-world treatment programs. The study demonstrates one way to combine economic and clinical data and offers a methodological foundation for future economic evaluations of addiction treatment. [source] Clinical Genetics & Human Genome Variation: The 2008 Human Genome Variation Society Scientific MeetingHUMAN MUTATION, Issue 5 2009William S. Oetting Abstract The annual scientific meeting of the Human Genome Variation Society (HGVS) was held on 11 November 2008, in Philadelphia, PA. The major theme of this meeting was "Clinical Genetics & Human Genome Variation." For complex diseases, it is becoming evident that the contribution of most associated genetic variants to the disease process is small and, most likely, multiple variants are required to explain the predisposition and variation that is observed. As genome-wide association studies (GWASs) identify variants that are associated with a disease, there is a need to determine if the associated variants are causative, or simply in genetic disequilibrium with the true functional variant. New methods are being devised to help classify these genetic variants as either functional or nonfunctional. As study populations increase in size, there is also a need for better-constructed databases that can bring together the different genetic variants being identified, including SNPs, copy number variants (CNVs), and methylation differences, environmental risk factors, and the clinical information needed to construct useful phenotypes. These topics and others were discussed in this year's meeting. Hum Mutat 30, 852,856, 2009. © 2009 Wiley-Liss, Inc. [source] Fast implementations and rigorous models: Can both be accommodated in NMPC?INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL, Issue 8 2008Victor M. Zavala Abstract In less than two decades, nonlinear model predictive control has evolved from a conceptual framework to an attractive, general approach for the control of constrained nonlinear processes. These advances were realized both through better understanding of stability and robustness properties as well as improved algorithms for dynamic optimization. This study focuses on recent advances in optimization formulations and algorithms, particularly for the simultaneous collocation-based approach. Here, we contrast this approach with competing approaches for online application and discuss further advances to deal with applications of increasing size and complexity. To address these challenges, we adapt the real-time iteration concept, developed in the context of multiple shooting (Real-Time PDE-Constrained Optimization. SIAM: Philadelphia, PA, 2007; 25,52, 3,24), to a collocation-based approach with a full-space nonlinear programming solver. We show that straightforward sensitivity calculations from the Karush,Kuhn,Tucker system also lead to a real-time iteration strategy, with both direct and shifted variants. This approach is demonstrated on a large-scale polymer process, where online calculation effort is reduced by over two orders of magnitude. Copyright © 2007 John Wiley & Sons, Ltd. [source] Nonlinear output regulation,theory and applications, Jie Huang, SIAM, Philadelphia, 2004, 318pp.INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL, Issue 8 2006ISBN 0-89871-562- No abstract is available for this article. [source] Participation in Urban Contention and DeliberationINTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, Issue 3 2010HILARY SILVER Abstract Participation is a popular buzzword in contemporary urban studies. For some, it implies a deepening of democratic deliberation; for others, it represents grassroots resistance to powerful elites and neoliberalization. Rather than seeing participation as either consensus-building or conflicts of interest, as either a top-down or bottom-up process, the evidence suggests that it can be all of these. By adopting a more dynamic, pragmatic, and empirically informed perspective, seemingly opposite normative conceptions of democratic participation may be theorized as different ,moments' in the democratic process. Bottom-up mobilization may coincide with and complement top-down initiatives, each dominating different political phases of policymaking, implementation and monitoring. Case studies from Belfast, Berlin, Durban, Philadelphia and São Paulo illustrate the approach and provide insight into the urban as a social laboratory in which other scales of social life and multiple ways to perform democracy are constructed. Résumé La participation est un terme qui revient très souvent dans les études urbaines contemporaines. Pour certains, elle implique une réflexion démocratique approfondie, pour d'autres, une résistance des citoyens face à la puissance des élites et au néolibéralisme. Si la participation peut être vue comme un moyen de bâtir des consensus ou l'expression de conflits d'intérêts, ou comme un processus imposé par le haut ou bien par la base, les faits suggèrent qu'elle peut être tout cela. En adoptant une perspective pragmatique plus dynamique reposant sur des éléments empiriques, des concepts normatifs de la participation apparemment opposés sont susceptibles d'être formulés en tant que "moments" différents du processus démocratique. La mobilisation par la base peut venir en coïncidence et complément d'initiatives imposées par le haut, chaque forme dominant des phases politiques distinctes dans la prise de décision, la mise en ,uvre et le suivi. Des études de cas portant sur Belfast, Berlin, Durban, Philadelphie et São Paulo illustrent la démarche et font apparaître l'urbain comme un laboratoire où s'élaborent d'autres dimensions de la vie sociale et de multiples modalités d'exercice de la démocratie. [source] The Participant's Dilemma: Bringing Conflict and Representation Back InINTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, Issue 3 2010DEBBIE BECHER Abstract Innovations in democratic participation involving small-scale, long-term focused governing bodies have increased citizen influence in poor American urban neighborhoods. Scholars have described these emerging forms of participation as essentially cooperative in spirit and directly democratic in nature. I argue that the new participatory regimes continue to involve social processes of representation and conflict inherent to more traditional forms of engagement. Participants move dynamically between cooperation and conflict and between participating as individuals and representing constituencies. This article presents a careful study of how a single decision developed and was implemented in such a participatory experiment, the American Street Empowerment Zone in Philadelphia, Pennsylvania, USA, between 1994 and 2008. Archival and interview data support the general perspective shared by articles in this symposium , that participation involves dynamic movement between conflict and cooperation. This article suggests that the durability of the participatory regime depends not on the level of conflict but on how participants move between displaying identification with either government or their community constituents. This article uses the concept of intermediation to describe this kind of dynamism and to reflect the flexibility a participatory structure must nurture to endure. Résumé Les innovations en matière de participation démocratique qui impliquent des organes de gouvernement ,uvrant à petite échelle et à long terme ont accru l'influence des habitants dans les quartiers urbains pauvres américains. D'après certains auteurs, ces formes nouvelles de participation sont, dans l'esprit, essentiellement coopératives et, par nature, directement démocratique. Il est exposé ici que les nouveaux régimes participatifs font encore intervenir des processus sociaux de représentation et de conflit propres à des formes d'engagement plus traditionnelles. Les participants oscillent de manière dynamique entre coopération et conflit, et entre participation en tant qu'individus et représentation collective. Cet article présente une étude minutieuse de la manière dont une décision a étéélaborée et mise en ,uvre dans le cadre d'une expérience participative de ce type, ,American Street Empowerment Zone'à Philadelphie (Pennsylvanie), de 1994 à 1998. Des données issues d'archives et d'entretiens corroborent la perspective générale commune aux articles de ce symposium: la participation implique un mouvement dynamique entre conflit et coopération. L'article suggère que la pérennité du régime participatif dépend, non pas du niveau de conflit, mais de la façon dont les participants alternent dans leur manifestation d'une identification soit au gouvernement soit aux membres de leur communauté. Le concept d'intermédiation est utilisé pour décrire cette forme de dynamique et pour traduire la souplesse que doit garder une structure participative pour perdurer. [source] Exploring Diversity in Immigrant Assimilation and Transnationalism: Poles and Russian Jews in Philadelphia,INTERNATIONAL MIGRATION REVIEW, Issue 4 2004Ewa Morawska This article investigates different patterns of coexistence of assimilation and transnational engagements (A/T) among recent Polish and Jewish Russian immigrants in Philadelphia and the particular constellations of circumstances that generate these outcomes. It then integrates this analysis into a broader comparative examination of the simultaneity of A/T among residentially dispersed Asian Indians, first-wave Cubans in Miami, and Jamaicans, undocumented Chinese, and Dominicans in New York. The main factors shaping the most common A/T patterns in these seven immigrant groups at the global, sending and receiving society national, and local levels are identified. [source] 2006 Abstracts: Twenty-Eighth Annual Meeting of the American Society for Bone and Mineral Research: Pennsylvania Convention Convention Center Philadelphia, Pennsylvania, USA, September 15,19, 2006JOURNAL OF BONE AND MINERAL RESEARCH, Issue S1 2006Article first published online: 4 MAR 2010 First page of article [source] 2006 Abstracts: Twenty-Eighth Annual Meeting of the American Society for Bone and Mineral Research: Pennsylvania Convention Convention Center Philadelphia, Pennsylvania, USA, September 15,19, 2006JOURNAL OF BONE AND MINERAL RESEARCH, Issue S1 2006Article first published online: 4 MAR 2010 First page of article [source] Out-of-Office Blood Pressures,Are They Helpful in Guiding the Treatment of Hypertension Patients?JOURNAL OF CLINICAL HYPERTENSION, Issue 3 2006Marvin Moser MD Following a hypertension symposium in Philadelphia in September 2005, a roundtable was convened to discuss the significance of out-of-office blood pressure. Dr. Marvin Moser of the Yale School of Medicine, New Haven, CT, moderated the panel discussion. Participants included Dr. Raymond Townsend of the University of Pennsylvania School of Medicine, Philadelphia, PA, and Dr. Norman Kaplan of the University of Texas Health Science Center in Dallas, Dallas, TX. [source] Shelter Blues: Homelessness and Sanity in a Boston ShelterJOURNAL OF LINGUISTIC ANTHROPOLOGY, Issue 2 2000James M. Wilce Jr. Shelter Blues: Homelessness and Sanity in. Boston Shelter. Robert R. Desjarlais. Philadelphia: University of Pennsylvania Press, 1997. 320 pp. [source] A NEW PARADIGM FOR FRESHWATER FRAGILARIOID DIATOM CLASSIFICATION?JOURNAL OF PHYCOLOGY, Issue 2001A CRITIQUE OF LANGE-BERTALOT'S NEW SYSTEM Morales, E. A.1 & Trainor, F. R.2 1Phycology Section, Patrick Center for Environmental Research, The Academy of Natural Sciences of Philadelphia, PA 19103-1195 USA; 2Department of Ecology & Evolutionary Biology, University of Connecticut, Storrs, CT 06269-3043 USA In a recent study of freshwater diatoms from South America (Rumrich et al. 2000), Lange-Bertalot introduced a new paradigm for the classification of fragilarioid diatoms. This new system is antagonistic to that presented by Williams and Round (1987) because Lange-Bertalot recognizes a marked variability in the characters chosen and a supposed overall continuity of morphological features among the genera created by his English counterparts. Lange-Bertalot then proposes a partitioning of Fragilaria into two genera: Fragilaria and Staurosira mainly based on the presence/absence of rimoportulae and areolate girdle bands. The newly defined Fragilaria includes relatively large phytoplankters such as F. capucina and F. crotonensis. In turn, Staurosira includes, for the most part, small periphytic organisms, and contains several new species that were based on varieties of old Fragilaria taxa. This fragmentation of species and their varieties is based on a supposed morphological discontinuity. As a consequence an apparent increase in species diversity has occurred within the fragilarioid group. The present work analyzes Lange-Bertalot's new paradigm and confronts it with recent LM and SEM evidence. The incorporation of concepts such as plasticity, polymorphism, and parallel evolution in current classification systems is also discussed. It is concluded that Lange-Bertalot's system represents a step backward from that of Williams and Round. Some adjustments in the latter scheme could be sufficient to accommodate the diversity of fragilarioids known at present. [source] The Hispanic Americans Baseline Alcohol Survey (HABLAS): Predictors of Alcohol Attitudes and Expectancies in Hispanic National GroupsALCOHOLISM, Issue 5 2010Britain A. Mills Background:, Multiple theoretical frameworks identify attitudes and expectancies as important predictors of alcohol behavior. Few studies have examined demographic predictors of these evaluative and belief-based cognitive mediators in the general population, and none have examined them in large-scale studies of Hispanics, a group at higher risk for drinking behavior and problems. This study probes the extent to which dimensions of attitudes and expectancies share common demographic predictors in a large sample of Puerto Ricans, Cuban-Americans, Mexican-Americans, and South/Central Americans. Methods:, The 2006 Hispanic Americans Baseline Alcohol Survey (HABLAS) used a multistage cluster sample design to interview 5,224 individuals randomly selected from households in Miami, New York, Philadelphia, Houston, and Los Angeles. This study focused on 2,773 respondents self-identified as current drinkers. Multiple linear regression was used to identify predictors of positive and negative dimensions of attitudes and expectancies, controlling for various background variables. Results:, Religious affiliation selectively predicted alcohol attitudes, with Catholics having more positive and fewer negative attitudes than other religious groups. Hispanic group selectively predicted alcohol expectancies, with Cuban-Americans having less positive and less negative expectancies than other groups. Being U.S.-born or male predicted more positive attitudes and expectancies, but birthplace and gender did not predict negative dimensions of attitudes or expectancies. Higher acculturation and more education were linked to a decreased tendency to agree with any item. Age was positively and negatively associated with negative expectancies and positive attitudes, respectively, and having never been married, higher income, and unemployment were each linked to fewer negative attitudes. Conclusions:, Although there is some overlap, attitudes and expectancies are influenced by different sociodemographic variables. Positive and negative dimensions of those constructs also show distinct patterns of relations. Prevention and treatment programs targeting cognitive mediators of behavior should be mindful of these differential determinants and future modeling endeavors should incorporate them. [source] Alcohol Consumption, Alcohol Outlets, and the Risk of Being Assaulted With a GunALCOHOLISM, Issue 5 2009Charles C. Branas Background:, We conducted a population-based case,control study to better delineate the relationship between individual alcohol consumption, alcohol outlets in the surrounding environment, and being assaulted with a gun. Methods:, An incidence density sampled case,control study was conducted in the entire city of Philadelphia from 2003 to 2006. We enrolled 677 cases that had been shot in an assault and 684 population-based controls. The relationships between 2 independent variables of interest, alcohol consumption and alcohol outlet availability, and the outcome of being assaulted with a gun were analyzed. Conditional logistic regression was used to adjust for numerous confounding variables. Results:, After adjustment, heavy drinkers were 2.67 times as likely to be shot in an assault when compared with nondrinkers (p < 0.10) while light drinkers were not at significantly greater risk of being shot in an assault when compared with nondrinkers. Regression-adjusted analyses also demonstrated that being in an area of high off-premise alcohol outlet availability significantly increased the risk of being shot in an assault by 2.00 times (p < 0.05). Being in an area of high on-premise alcohol outlet availability did not significantly change this risk. Heavy drinkers in areas of high off-premise alcohol outlet availability were 9.34 times (p < 0.05) as likely to be shot in an assault. Conclusions:, This study finds that the gun assault risk to individuals who are near off-premise alcohol outlets is about the same as or statistically greater than the risk they incur from heavy drinking. The combination of heavy drinking and being near off-premise outlets resulted in greater risk than either factor alone. By comparison, light drinking and being near on-premise alcohol outlets were not associated with increased risks for gun assault. Cities should consider addressing alcohol-related factors, especially off-premise outlets, as highly modifiable and politically feasible approaches to reducing gun violence. [source] Dental Caries Status and Need for Dental Treatment of Pennsylvania Public School Children in Grades 1,3, 9, and 11JOURNAL OF PUBLIC HEALTH DENTISTRY, Issue 3 2004Robert J. Weyant DMD ABSTRACT Objectives: This cross-sectional study was designed to determine the caries status and provide a general evaluation of the level of dental treatment need of Pennsylvania public school children in grades 1, 3, 9, and 11 on a statewide and regional basis. Methods: Between September 1998 and May 2000, caries status and treatment need were assessed using a school-based dental examination, performed on a representative sample (n=6,040) of public school children in grades 1, 3, 9, and 11 (age range=6 to 21 years). Children's caries status in the primary and permanent dentition was assessed. Need for treatment was scored on a three-level categorical scale,no treatment need identified, routine treatment need, and urgent treatment need,and was based on the presence and severity of caries and other oral conditions. Population estimates of the prevalence of untreated dental caries, DMFT and dft scores, and treatment need were calculated by grade and geographically, using the six Pennsylvania health districts and the cities of Pittsburgh and Philadelphia. The inequality of caries distribution in the population was assessed for both permanent and primary caries using Lorenz curves and Gini coefficients. Results: Dental caries has remained highly prevalent among Pennsylvania's public school children. Caries levels varied considerably by health districts and city. Urgent treatment needs were significant and also varied by health district and city. Conclusions: Dental caries remains the most prevalent disease affecting Pennsylvania's schoolchildren. Caries status varies significantly by region of the state, suggesting that environmental, social, and demographic contextual factors may be important determinants of disease prevalence. [source] The Hispanic Americans Baseline Alcohol Survey: Alcoholic Beverage Preference Across Hispanic National GroupsALCOHOLISM, Issue 1 2009Raul Caetano Background:, U.S. Hispanics come from many countries in Latin America, which can lead to different beverage preferences in the United States. This paper examines choice for drinking wine, beer, and liquor across 4 Hispanic national groups: Mexican Americans, Puerto Ricans, Cuban Americans, and South/Central Americans. Methods:, A sample of 5,224 individuals 18 years of age and older was selected using multistage cluster procedures from the household population in 5 metropolitan areas of the United States: Miami, New York, Philadelphia, Houston, and Los Angeles. The survey weighted response rate was 76%. Face-to-face interviews lasting 1 hour on average were conducted in the respondents' homes either in English or Spanish. Results:, Among men, beer drinkers consume the highest mean number of drinks per week in all national groups. Among women, this is true only of Puerto Ricans and Mexican Americans. Among men who drink beer, beer drinking constitutes 52 to 72% of total alcohol consumption. Among women who drink beer, beer consumption is associated with 32 to 64% of total consumption. Beer is the beverage most associated with binge drinking among Puerto Rican and Mexican American women, while among Cuban Americans and South/Central Americans this is seen for wine. Regression analyses showed no significant differences by national group in the likelihood of drinking 2 or fewer drinks (vs. no drinks) of wine, beer, or liquor. Puerto Ricans were more likely (OR = 1.47; 95% CI = 1.00,2.14) than Cuban Americans to drink 3 or more drinks (compared with no drinks) of beer. There was no association between the likelihood of binge drinking and Hispanic national group. Conclusions:, Beverage preference across Hispanic national groups is similar. Beer is the preferred beverage. Alcohol control policies such as taxation and control of sales availability should apply equally to beer, liquor, and wine. Prevention interventions directed at different Hispanic national groups in the United States can be relatively uniform in their focus on the dangers associated with drinking different types of alcoholic beverages. [source] Medicaid's Role in Financing Health Care for Children With Behavioral Health Care Needs in the Special Education System: Implications of the Deficit Reduction ActJOURNAL OF SCHOOL HEALTH, Issue 10 2008David S. Mandell ScD ABSTRACT Background:, Recent changes to Medicaid policy may have unintended consequences in the education system. This study estimated the potential financial impact of the Deficit Reduction Act (DRA) on school districts by calculating Medicaid-reimbursed behavioral health care expenditures for school-aged children in general and children in special education in particular. Methods:, Medicaid claims and special education records of youth ages 6 to 18 years in Philadelphia, PA, were merged for calendar year 2002. Behavioral health care volume, type, and expenditures were compared between Medicaid-enrolled children receiving and not receiving special education. Results:, Significant overlap existed among the 126,533 children who were either Medicaid enrolled (114,257) or received special education (27,620). Medicaid-reimbursed behavioral health care was used by 21% of children receiving special education (37% of those Medicaid enrolled) and 15% of other Medicaid-enrolled children. Total expenditures were $197.8 million, 40% of which was spent on the 5728 children in special education and 60% of which was spent on 15,092 other children. Conclusions:, Medicaid-reimbursed behavioral health services disproportionately support special education students, with expenditures equivalent to 4% of Philadelphia's $2 billion education budget. The results suggest that special education programs depend on Medicaid-reimbursed services, the financing of which the DRA may jeopardize. [source] Assessing an author's influence using time series historiographic mapping: The oeuvre of conrad hal waddington (1905,1975)JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 4 2008Katherine W. McCain A modified approach to algorithmic historiography is used to investigate the changing influence of the work of Conrad Hal Waddington over the period 1945,2004. Overall, Waddington's publications were cited by almost 5,500 source items in the Web of Science (Thomson Scientific, formerly Thomson ISI, Philadelphia, PA). Rather than simply analyzing the data set as a whole, older works by Waddington are incorporated into a series of historiographic maps (networks of highly cited documents), which show long-term and short-term research themes grounded in Waddington's work. Analysis by 10,20-year periods and the use of social network analysis soft- ware reveals structures,thematic networks and subnetworks,that are hidden in a mapping of the entire 60-year period. Two major Waddington-related themes emerge,canalization/genetic assimilation and embryonic induction. The first persists over the 60 years studied while active, visible research in the second appears to have declined markedly between 1965 and 1984, only to reappear in conjunction with the emergence of a new research field,Evolutionary Developmental Biology. [source] Using the h -index to rank influential British researchers in information science and librarianshipJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 2 2007Charles Oppenheim The recently developed h -index has been applied to the literature produced by senior British-based academics in librarianship and information science. The majority of those evaluated currently hold senior positions in UK information science and librarianship departments; however, a small number of staff in other departments and retired "founding fathers" were analyzed as well. The analysis was carried out using the Web of Science (Thomson Scientific, Philadelphia, PA) for the years from 1992 to October 2005, and included both second-authored papers and self-citations. The top-ranking British information scientist, Peter Willett, has an h -index of 31. However, it was found that Eugene Garfield, the founder of modern citation studies, has an even higher h -index of 36. These results support other studies suggesting that the h -index is a useful tool in the armory of bibliometrics. [source] The place of serials in referencing practices: Comparing natural sciences and engineering with social sciences and humanitiesJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 8 2006Vincent Larivière Journal articles constitute the core documents for the diffusion of knowledge in the natural sciences. It has been argued that the same is not true for the social sciences and humanities where knowledge is more often disseminated in monographs that are not indexed in the journal-based databases used for bibliometric analysis. Previous studies have made only partial assessments of the role played by both serials and other types of literature. The importance of journal literature in the various scientific fields has therefore not been systematically characterized. The authors address this issue by providing a systematic measurement of the role played by journal literature in the building of knowledge in both the natural sciences and engineering and the social sciences and humanities. Using citation data from the CD-ROM versions of the Science Citation Index (SCI), Social Science Citation Index (SSCI), and Arts and Humanities Citation Index (AHCI) databases from 1981 to 2000 (Thomson ISI, Philadelphia, PA), the authors quantify the share of citations to both serials and other types of literature. Variations in time and between fields are also analyzed. The results show that journal literature is increasingly important in the natural and social sciences, but that its role in the humanities is stagnant and has even tended to diminish slightly in the 1990s. Journal literature accounts for less than 50% of the citations in several disciplines of the social sciences and humanities; hence, special care should be used when using bibliometric indicators that rely only on journal literature. [source] | ||||||||||||||||||||||||||||||||||