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Phenol Moiety (phenol + moiety)

Distribution by Scientific Domains

Chemistry	80%

Selected Abstracts

ChemInform Abstract: A Novel Nine-Membered Intramolecular Hydrogen Bonding in Methyl Naphthoate Bearing Phenol Moiety.

CHEMINFORM, Issue 27 2001
Yasuharu Yoshimi
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

The Presence of a Ferrocenyl Unit on an Estrogenic Molecule is Not Always Sufficient to Generate in,vitro Cytotoxicity

CHEMMEDCHEM, Issue 11 2006
Anne Vessières Dr.
Abstract We recently reported the dual (antihormonal and cytotoxic) functionality of ferrocifens, which are organometallic complexes derived from hydroxytamoxifen, the standard molecule in the treatment of hormone-dependent breast cancers. To test the hypothesis that the presence of a ferrocenyl substituent on molecules with an affinity for the estrogen receptor is sufficient to give them cytotoxic properties in,vitro, we prepared complexes derived from estradiol with a ferrocenyl substituent at positions 7, and 17,. The complexes thus obtained retain a satisfactory level of affinity for the estrogen receptor (RBA values higher than 12,%). At low concentrations (0.1,1,,M) the complexes show an estrogenic effect in,vitro equivalent to that of estradiol on hormone-dependent (MCF-7) breast cancer cells, and no cytotoxic effect on hormone-independent (MDA-MB-231) breast cancer cells. At high concentrations (up to 50,,M) the 17, -ethynylferrocenyl estradiol and 7, -ferrocenylmethylthio estradiol become cytotoxic (IC50=13.2,,M and 18.8,,m, respectively) while the 17, -ferrocenylestradiol remains non toxic. The low toxicity of these compounds support our hypothesis that electronic communication between the ferrocenyl and phenol moieties in the hydroxyferrocifens series is a key parameter in the generation of cytotoxic effects at submicromolar concentrations. [source]

Vinyl polymerization of norbornene by bis(nitro-substituted-salicylaldiminate)nickel(II)/methylaluminoxane catalysts

JOURNAL OF POLYMER SCIENCE (IN TWO SECTIONS), Issue 4 2006
Carlo Carlini
Abstract The polymerization of norbornene has been investigated in the presence of different bis(salicylaldiminate)nickel(II) precursors activated by methylaluminoxane. These systems are highly active in affording nonstereoregular vinyl-type polynorbornenes (PNBs) with high molecular weights. The productivity of the catalytic systems is strongly enhanced (up to 35,000 kg of PNB/mol of Ni × h) when electron-withdrawing nitro groups are introduced on the phenol moiety. On the contrary, the presence of bulky alkyl groups on the N -aryl moiety of the ligand does not substantially affect the activity or characteristics of the resulting PNBs. The catalytic performances are also markedly influenced by the reaction parameters, such as the nature of the solvent, the reaction time, and the monomer/Ni and Al/Ni molar ratios. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 1514,1521, 2006 [source]

Synthesis, characterization, and antimicrobial activity of cobalt(II), nickel(II), copper(II) and zinc(II) complexes with ferrocenyl Schiff bases containing a phenol moiety

APPLIED ORGANOMETALLIC CHEMISTRY, Issue 4 2004
Mokhles M. Abd-Elzaher
Abstract Three ferrocenyl Schiff bases containing a phenol moiety have been formed by 1:1 molar condensation of acetylferrocene with 2-aminophenol, 2-amino-5-picoline or 2-amino-5-chlorophenol. These ligands form 2:1 complexs with cobalt(II), copper(II), nickel(II), and zinc(II) ions. From the different spectral data, it was found that coordination of the ligands with the metal ions takes place via the azomethine nitrogen atoms and the deprotonated oxygen of the phenol groups. These ligands and their complexes have been characterized by IR, 1H NMR, 13C NMR, UV,Vis spectra, and elemental analysis. The spectral data of the ligands and their complexes are discussed in connection with the structural changes due to complexation. The complexes prepared showed good antimicrobial activity against Escherichia coli, Bacillus subtilus, and Candida albicans. Copyright © 2004 John Wiley & Sons, Ltd. [source]